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Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 1017 - 1029.e3
Background & Aims Patients with bi-allelic germline mutations in mismatch repair (MMR) genes ( MLH1 , MSH2 , MSH6 , or PMS2 ) develop a rare but severe variant... 
Gastroenterology and Hepatology | Tumor | Colon Cancer | Predisposition | Functional Tests | SYSTEM | CELLS | BIALLELIC MUTATIONS | SOMATIC MUTATIONS | HEREDITARY | COLORECTAL-CANCER | PMS2 | MSH6 MUTATIONS | GASTROENTEROLOGY & HEPATOLOGY | GOLD STANDARD | NEUROFIBROMATOSIS TYPE-1 | MutL Protein Homolog 1 | Predictive Value of Tests | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Drug Resistance, Neoplasm | Male | Neoplastic Syndromes, Hereditary - metabolism | Colorectal Neoplasms - diagnosis | Young Adult | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Germ-Line Mutation | Mismatch Repair Endonuclease PMS2 | Neoplastic Syndromes, Hereditary - genetics | Caco-2 Cells | Lymphocytes - metabolism | Genetic Predisposition to Disease | Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy | Brain Neoplasms - diagnosis | HCT116 Cells | Brain Neoplasms - genetics | Neoplastic Syndromes, Hereditary - diagnosis | Heredity | MutS Homolog 2 Protein - genetics | Brain Neoplasms - drug therapy | Multiplex Polymerase Chain Reaction | Antineoplastic Agents, Alkylating - therapeutic use | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Phenotype | Adenosine Triphosphatases - genetics | Biomarkers, Tumor - genetics | Neoplastic Syndromes, Hereditary - drug therapy | Microsatellite Instability | Neoplastic Syndromes, Hereditary - pathology | Brain Neoplasms - pathology | DNA Repair Enzymes - genetics | Genetic Testing - methods | Brain Neoplasms - metabolism | Case-Control Studies | Transfection | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Adult | Female | Nuclear Proteins - genetics | Colorectal Neoplasms - metabolism | Reproducibility of Results | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | DNA-Binding Proteins - genetics | Lymphocytes - drug effects | Adaptor Proteins, Signal Transducing - genetics | Colorectal Neoplasms - pathology | Methylation | Lymphomas | Diagnosis | Gene mutations | Lymphocytes | Leukemia | Colorectal cancer | Index Medicus | Abridged Index Medicus
Journal Article
Gut, ISSN 0017-5749, 08/2016, Volume 65, Issue 8, pp. 1296 - 1305
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2008, Volume 359, Issue 24, pp. 2567 - 2578
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 138, Issue 3, pp. 993 - 1002.e1
Background & Aims Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndromes I and II and sporadic colorectal cancers. Msh2 null mice... 
Gastroenterology and Hepatology | Mismatch Repair | Chemotherapy | Tumorigenesis | Msh2 | NONPOLYPOSIS COLORECTAL-CANCER | GASTROINTESTINAL-TRACT | MICROSATELLITE-INSTABILITY | TUMORS | DEFICIENCY | COLON-CANCER | INACTIVATION | DNA MISMATCH REPAIR | MICE | GASTROENTEROLOGY & HEPATOLOGY | APC MUTATIONS | Immunohistochemistry | Microsatellite Instability | Adenocarcinoma - pathology | Adenoma - genetics | Apoptosis - drug effects | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Gene Expression Regulation, Neoplastic | Organoplatinum Compounds - pharmacology | Adenoma - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Genes, APC | Adenocarcinoma - metabolism | Time Factors | MutS Homolog 2 Protein - deficiency | Adenoma - drug therapy | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Intestinal Neoplasms - genetics | Microfilament Proteins - genetics | Disease Models, Animal | Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Intestinal Neoplasms - metabolism | Mice, Inbred C57BL | Gene Silencing | Genotype | MutS Homolog 2 Protein - genetics | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Intestinal Neoplasms - pathology | Mice, Knockout | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Magnetic Resonance Imaging | Drug Resistance, Neoplasm - genetics | Phenotype | Animals | Tumor Burden - drug effects | Adenoma - pathology | Fluorouracil - pharmacology | Mice | Mutation | Integrases - genetics | Intestinal Neoplasms - drug therapy | Leucovorin - pharmacology | Medical colleges | Care and treatment | Molecular genetics | Oncology, Experimental | Environmental health | Colorectal cancer | Lymphomas | Research | Cancer | Fluorouracil | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 10/2007, Volume 14, Issue 10, pp. 2759 - 2765
Journal Article
Cancer Science, ISSN 1347-9032, 02/2017, Volume 108, Issue 2, pp. 243 - 249
Lynch syndrome ( LS ) and familial adenomatous polyposis ( FAP ) are major sources of hereditary colorectal cancer ( CRC ) and are associated with other... 
screening | Disease management | familial adenomatous polyposis | Japanese | Lynch syndrome | NONPOLYPOSIS COLORECTAL-CANCER | GUIDELINES | TOTAL PROCTOCOLECTOMY | FOLLOW-UP | RISK | MODEL | ONCOLOGY | TOTAL COLECTOMY | POUCH-ANAL ANASTOMOSIS | DESMOID TUMORS | Colorectal Neoplasms, Hereditary Nonpolyposis - surgery | Japan - epidemiology | Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy | Guideline Adherence - statistics & numerical data | Humans | Adenomatous Polyposis Coli - epidemiology | Adenomatous Polyposis Coli - surgery | Male | Cancer Care Facilities - statistics & numerical data | Referral and Consultation - statistics & numerical data | Fibromatosis, Aggressive | Genetic Counseling - statistics & numerical data | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology | Hospitals - statistics & numerical data | Adenomatous Polyposis Coli - drug therapy | Colectomy - statistics & numerical data | Female | Surveys and Questionnaires | Proctocolectomy, Restorative - statistics & numerical data | Health Care Surveys - statistics & numerical data | Surveys | Fluocinolone acetonide | Oncology, Experimental | Colorectal cancer | Strategic planning (Business) | Polyposis, Familial | Genetic aspects | Research | Health aspects | Cancer | Medical research | Genetic disorders | Endometrial cancer | Colorectal carcinoma | Familial adenomatous polyposis | Inflammation | Family medical history | Management | Cancer therapies | Patients | Abdomen | Hospitals | Genetic counseling | Surgery | Questionnaires | Genetic counselling | Index Medicus | Original
Journal Article
Familial Cancer, ISSN 1389-9600, 7/2016, Volume 15, Issue 3, pp. 493 - 496
Cancer risk assessment, genetic counseling and genetic testing have experienced advances and changes over the past two decades due to improved technology,... 
Human Genetics | Cancer genetics | Biomedicine | Genetic counseling | Hereditary cancer | Cancer Research | Hereditary breast–ovarian cancer | Genetic testing | Epidemiology | Biomedicine general | Lynch syndrome | SURGERY | Hereditary breast-ovarian cancer | ONCOLOGY | COLORECTAL-CANCER | FAMILIES | GENETICS & HEREDITY | BLOCKADE | Risk Assessment - methods | Genetic Counseling - psychology | Genetic Counseling - legislation & jurisprudence | Hereditary Breast and Ovarian Cancer Syndrome - diagnosis | Insurance Coverage - trends | United States | Humans | Colorectal Neoplasms, Hereditary Nonpolyposis - psychology | DNA Repair Enzymes - genetics | DNA Mismatch Repair - genetics | Molecular Targeted Therapy | Risk Assessment - legislation & jurisprudence | Insurance Coverage - legislation & jurisprudence | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Hereditary Breast and Ovarian Cancer Syndrome - psychology | Genetic Counseling - economics | Genetic Testing - trends | Insurance Coverage - economics | Hereditary Breast and Ovarian Cancer Syndrome - genetics | Genetic Predisposition to Disease | Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy | Insurance, Health - trends | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Genetic Testing - legislation & jurisprudence | Hereditary Breast and Ovarian Cancer Syndrome - drug therapy | Insurance, Health - legislation & jurisprudence | BRCA1 Protein - genetics | Genetic Counseling - trends | Genetic Testing - economics | Risk Assessment - trends | BRCA2 Protein - genetics | Insurance, Health - economics | Risk assessment | Medical genetics | Genetic research | Health aspects | Cancer | Ovarian cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 1, pp. 246 - 251
MSH2 is required for DNA mismatch repair recognition in eukaryotes. Deleterious mutations in human MSH2 account for approximately half of the alíeles... 
Yeasts | Cell growth | Plasmids | Ubiquitins | Immunoblotting | Genetic mutation | DNA mismatch repair | Lynch syndrome II | Cancer | Tumors | MutS | Hereditary nonpolyposis clorectal cancer | Mutator | Lynch syndrome | MUTANT | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | MISSENSE MUTATIONS | GENE | PATHWAY | COLORECTAL-CANCER | IN-VIVO | RESISTANCE | DEGRADATION | mutator | hereditary nonpolyposis clorectal cancer | Immunohistochemistry | Ubiquitin | Immunoprecipitation | Humans | DNA Primers - genetics | DNA Mismatch Repair - genetics | Mutation, Missense - genetics | Plasmids - genetics | Polymerase Chain Reaction | Gene Dosage - genetics | Bortezomib | Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy | Gene Expression Regulation - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | DNA Mismatch Repair - drug effects | Models, Molecular | MutS Homolog 2 Protein - genetics | Saccharomyces cerevisiae Proteins - genetics | MutS Homolog 2 Protein - chemistry | Cisplatin | DNA Sequence, Unstable - genetics | Proteasome Endopeptidase Complex - metabolism | Pyrazines - pharmacology | Ubiquitin-Protein Ligases - genetics | Saccharomyces cerevisiae | Boronic Acids - pharmacology | Saccharomyces cerevisiae Proteins - chemistry | Genetic variation | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Health aspects | DNA repair | Proteins | Eukaryotes | Chemotherapy | Yeast | Mutation | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences
Journal Article