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1. Full Text Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents
by Bodo, Sahra and Colas, Chrystelle and Buhard, Olivier and Collura, Ada and Tinat, Julie and Lavoine, Noémie and Guilloux, Agathe and Chalastanis, Alexandra and Lafitte, Philippe and Coulet, Florence and Buisine, Marie-Pierre and Ilencikova, Denisa and Ruiz-Ponte, Clara and Kinzel, Miriam and Grandjouan, Sophie and Brems, Hilde and Lejeune, Sophie and Blanché, Hélène and Wang, Qing and Caron, Olivier and Cabaret, Odile and Svrcek, Magali and Vidaud, Dominique and Parfait, Béatrice and Verloes, Alain and Knappe, Ulrich J and Soubrier, Florent and Mortemousque, Isabelle and Leis, Alexander and Auclair-Perrossier, Jessie and Frébourg, Thierry and Fléjou, Jean-François and Entz-Werle, Natacha and Leclerc, Julie and Malka, David and Cohen-Haguenauer, Odile and Goldberg, Yael and Gerdes, Anne-Marie and Fedhila, Faten and Mathieu-Dramard, Michèle and Hamelin, Richard and Wafaa, Badre and Gauthier-Villars, Marion and Bourdeaut, Franck and Sheridan, Eamonn and Vasen, Hans and Brugières, Laurence and Wimmer, Katharina and Muleris, Martine and Duval, Alex and European Consortium Care CMMRD and European Consortium “Care for CMMRD”
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 1017 - 1029.e3
Background & Aims Patients with bi-allelic germline mutations in mismatch repair (MMR) genes ( MLH1 , MSH2 , MSH6 , or PMS2 ) develop a rare but severe variant... 
Gastroenterology and Hepatology | Tumor | Colon Cancer | Predisposition | Functional Tests | SYSTEM | CELLS | BIALLELIC MUTATIONS | SOMATIC MUTATIONS | HEREDITARY | COLORECTAL-CANCER | PMS2 | MSH6 MUTATIONS | GASTROENTEROLOGY & HEPATOLOGY | GOLD STANDARD | NEUROFIBROMATOSIS TYPE-1 | MutL Protein Homolog 1 | Predictive Value of Tests | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Drug Resistance, Neoplasm | Male | Neoplastic Syndromes, Hereditary - metabolism | Colorectal Neoplasms - diagnosis | Young Adult | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Germ-Line Mutation | Mismatch Repair Endonuclease PMS2 | Neoplastic Syndromes, Hereditary - genetics | Caco-2 Cells | Lymphocytes - metabolism | Genetic Predisposition to Disease | Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy | Brain Neoplasms - diagnosis | HCT116 Cells | Brain Neoplasms - genetics | Neoplastic Syndromes, Hereditary - diagnosis | Heredity | MutS Homolog 2 Protein - genetics | Brain Neoplasms - drug therapy | Multiplex Polymerase Chain Reaction | Antineoplastic Agents, Alkylating - therapeutic use | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Phenotype | Adenosine Triphosphatases - genetics | Biomarkers, Tumor - genetics | Neoplastic Syndromes, Hereditary - drug therapy | Microsatellite Instability | Neoplastic Syndromes, Hereditary - pathology | Brain Neoplasms - pathology | DNA Repair Enzymes - genetics | Genetic Testing - methods | Brain Neoplasms - metabolism | Case-Control Studies | Transfection | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Adult | Female | Nuclear Proteins - genetics | Colorectal Neoplasms - metabolism | Reproducibility of Results | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | DNA-Binding Proteins - genetics | Lymphocytes - drug effects | Adaptor Proteins, Signal Transducing - genetics | Colorectal Neoplasms - pathology | Methylation | Lymphomas | Diagnosis | Gene mutations | Lymphocytes | Leukemia | Colorectal cancer | Index Medicus | Abridged Index Medicus
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2. Full Text PD-L1 Expression in Mismatch Repair-deficient Endometrial Carcinomas, Including Lynch Syndrome-associated and MLH1 Promoter Hypermethylated Tumors
by Sloan, Emily A and Ring, Kari L and Willis, Brian C and Modesitt, Susan C and Mills, Anne M
The American Journal of Surgical Pathology, ISSN 0147-5185, 03/2017, Volume 41, Issue 3, pp. 326 - 333
Mismatch repair (MMR)-deficient endometrial carcinomas (ECs) bearing Lynch syndrome (LS)-associated germline mutations or sporadic MLH1 promoter... 
PD-L1 | mismatch repair | endometrial carcinoma | MLH1 hypermethylation | immunotherapy | Lynch syndrome | SURGERY | MICROSATELLITE INSTABILITY | INFILTRATING LYMPHOCYTES | IMMUNOSCORE | PATHOLOGY | LUNG-CANCER | PROGNOSTIC-FACTOR | IMMUNE-SYSTEM | MICROENVIRONMENT | COLORECTAL-CANCER | BLOCKADE | Immunohistochemistry | Neoplastic Syndromes, Hereditary - pathology | Prognosis | Follow-Up Studies | Endometrial Neoplasms - mortality | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Brain Neoplasms - pathology | Endometrial Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Neoplastic Syndromes, Hereditary - metabolism | Brain Neoplasms - metabolism | Neoplastic Syndromes, Hereditary - mortality | Colorectal Neoplasms, Hereditary Nonpolyposis - mortality | DNA Methylation | Endometrial Neoplasms - genetics | DNA Mismatch Repair | Biomarkers, Tumor - metabolism | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Promoter Regions, Genetic | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Brain Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | B7-H1 Antigen - metabolism | MutL Protein Homolog 1 - genetics | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Index Medicus
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3. Full Text Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: Later age of onset
by Hampel, Heather and Stephens, Julie A and Pukkala, Eero and Sankila, Risto and Aaltonen, Lauri A and Mecklin, Jukka-Pekka and De La Chapelle, Albert
Gastroenterology, ISSN 0016-5085, 2005, Volume 129, Issue 2, pp. 415 - 421
Background & Aims: Mutations in the mismatch repair genes cause hereditary nonpolyposis colorectal cancer (HNPCC) syndrome and convey high lifetime cancer... 
MutL Protein Homolog 1 | Confidence Intervals | Age Distribution | Genetic Testing | Prognosis | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | DNA Mutational Analysis | Aged, 80 and over | Female | Precancerous Conditions - pathology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Carrier Proteins | Colorectal Neoplasms - epidemiology | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Probability | Precancerous Conditions - genetics | Adaptor Proteins, Signal Transducing | Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology | Age of Onset | Survival Analysis | Sex Distribution | Aged | Colorectal Neoplasms - pathology | Neoplasm Staging | Cohort Studies | Index Medicus | Abridged Index Medicus
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4. Full Text Combined microsatellite instability, MLH1 methylation analysis, and immunohistochemistry for Lynch syndrome screening in endometrial cancers from GOG210: An NRG Oncology and Gynecologic Oncology Group study
by Goodfellow, Paul J and Billingsley, Caroline C and Lankes, Heather A and Ali, Shamshad and Cohn, David E and Broaddus, Russell J and Ramirez, Nilsa and Pritchard, Colin C and Hampel, Heather and Chassen, Alexis S and Simmons, Luke V and Schmidt, Amy P and Gao, Feng and Brinton, Louise A and Backes, Floor and Landrum, Lisa M and Geller, Melissa A and DiSilvestro, Paul A and Pearl, Michael L and Lele, Shashikant B and Powell, Matthew A and Zaino, Richard J and Mutch, David
Journal of Clinical Oncology, ISSN 0732-183X, 12/2015, Volume 33, Issue 36, pp. 4301 - 4308
Purpose The best screening practice for Lynch syndrome (LS) in endometrial cancer (EC) remains unknown. We sought to determine whether tumor microsatellite... 
DNA MISMATCH REPAIR | WOMEN | GERMLINE MUTATION | ONCOLOGY | NONPOLYPOSIS COLORECTAL-CANCER | PERFORMANCE | RISK | PMS2 | MSH6 MUTATION | FAMILY-HISTORY | IDENTIFICATION | Immunohistochemistry | MutL Protein Homolog 1 | Predictive Value of Tests | Microsatellite Instability | Age Factors | Early Detection of Cancer - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | DNA Repair Enzymes - genetics | Gene Expression Regulation, Neoplastic | DNA Mismatch Repair - genetics | Genetic Testing - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control | DNA Methylation | Endometrial Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Germ-Line Mutation | Adult | Female | Mismatch Repair Endonuclease PMS2 | Nuclear Proteins - genetics | Population Surveillance - methods | Early Detection of Cancer - standards | Endometrial Neoplasms - chemistry | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | MutS Homolog 2 Protein - genetics | DNA-Binding Proteins - genetics | Pedigree | Adaptor Proteins, Signal Transducing - genetics | Endometrial Neoplasms - pathology | Adenosine Triphosphatases - genetics | Aged | Index Medicus | Gync13 | ORIGINAL REPORTS
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5. Full Text Correlation between density of CD8+ T-cell infiltrate in microsatellite unstable colorectal cancers and frameshift mutations: A rationale for personalized immunotherapy
by Maby, Pauline and Tougeron, David and Hamieh, Mohamad and Mlecnik, Bernhard and Kora, Hafid and Bindea, Gabriela and Angell, Helen K and Fredriksen, Tessa and Elie, Nicolas and Fauquembergue, Emilie and Drouet, Aurélie and Leprince, Jérôme and Benichou, Jacques and Mauillon, Jacques and Pessot, Florence Le and Sesboüé, Richard and Tuech, Jean-Jacques and Sabourin, Jean-Christophe and Michel, Pierre and Frébourg, Thierry and Galon, Jérôme and Latouche, Jean-Baptiste
Cancer Research, ISSN 0008-5472, 09/2015, Volume 75, Issue 17, pp. 3446 - 3455
Colorectal cancers with microsatellite instability (MSI) represent 15% of all colorectal cancers, including Lynch syndrome as the most frequent hereditary form... 
COLON-CANCER | IMMUNE CELLS | INSTABILITY | PEPTIDES | ONCOLOGY | PROGNOSIS | MISMATCH REPAIR-DEFICIENT | TUMOR-SPECIFIC ANTIGENS | CARCINOMAS | IDENTIFICATION | LYMPHOCYTES | Microsatellite Instability | CD8-Positive T-Lymphocytes - pathology | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Male | Colorectal Neoplasms, Hereditary Nonpolyposis - immunology | Forkhead Transcription Factors - genetics | Antigen-Presenting Cells - immunology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | Immunotherapy | Female | CD8-Positive T-Lymphocytes - immunology | Colorectal Neoplasms - pathology | Frameshift Mutation - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Precision Medicine | Index Medicus | Frameshift Mutation | Neurons and Cognition | Neurobiology | Pharmacology | Colorectal Neoplasms, Hereditary Nonpolyposis | Cellular Biology | Chemical Sciences | CD8-Positive T-Lymphocytes | Medicinal Chemistry | Life Sciences | Antigen-Presenting Cells | Lymphocytes, Tumor-Infiltrating | Colorectal Neoplasms | Forkhead Transcription Factors | Pharmaceutical sciences | Cell Behavior
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6. Full Text The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations
by Senter, Leigha and Clendenning, Mark and Sotamaa, Kaisa and Hampel, Heather and Green, Jane and Potter, John D and Lindblom, Annika and Lagerstedt, Kristina and Thibodeau, Stephen N and Lindor, Noralane M and Young, Joanne and Winship, Ingrid and Dowty, James G and White, Darren M and Hopper, John L and Baglietto, Laura and Jenkins, Mark A and de la Chapelle, Albert
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 2, pp. 419 - 428.e1
Background & Aims: Although the clinical phenotype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer) has been well described, little... 
Gastroenterology and Hepatology | BETHESDA GUIDELINES | COLON-CANCER | DNA MISMATCH REPAIR | CHILDHOOD-CANCER | NONPOLYPOSIS COLORECTAL-CANCER | MICROSATELLITE INSTABILITY | HETEROZYGOUS MUTATIONS | GASTROENTEROLOGY & HEPATOLOGY | CONSTITUTIVE DEFICIENCY | ENDOMETRIAL CANCER | GENE PMS2 | Immunohistochemistry | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | DNA Repair Enzymes - genetics | Gene Expression Regulation, Neoplastic | Colorectal Neoplasms - chemistry | DNA-Binding Proteins - analysis | Male | DNA Mutational Analysis - methods | Endometrial Neoplasms - genetics | Ligase Chain Reaction | Adenosine Triphosphatases - analysis | Polymerase Chain Reaction | Germ-Line Mutation | Adult | Female | Mismatch Repair Endonuclease PMS2 | Odds Ratio | Endometrial Neoplasms - chemistry | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Genotype | Penetrance | DNA-Binding Proteins - genetics | DNA Repair Enzymes - analysis | Phenotype | Proto-Oncogene Proteins B-raf - genetics | Endometrial Neoplasms - pathology | Heterozygote | Adenosine Triphosphatases - genetics | Aged | Colorectal Neoplasms, Hereditary Nonpolyposis - chemistry | Colorectal Neoplasms - pathology | Genetic aspects | Research | Oncology, Experimental | Colorectal cancer | Cancer | Index Medicus | Abridged Index Medicus
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7. Full Text Lynch Syndrome Screening Should Be Considered for All Patients With Newly Diagnosed Endometrial Cancer
by Mills, Anne M and Liou, Sofia and Ford, James M and Berek, Jonathan S and Pai, Reetesh K and Longacre, Teri A
The American Journal of Surgical Pathology, ISSN 0147-5185, 11/2014, Volume 38, Issue 11, pp. 1501 - 1509
Lynch syndrome (LS) is an autosomal dominant inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Mutation carriers are at... 
Microsatellite instability | Endometrial adenocarcinoma | Lynch syndrome | Mismatch-repair deficiency | SURGERY | mismatch-repair deficiency | microsatellite instability | NONPOLYPOSIS COLORECTAL-CANCER | REPAIR PROTEIN IMMUNOHISTOCHEMISTRY | RISK | GENE MUTATION | endometrial adenocarcinoma | PATHOLOGY | CLINICAL-CRITERIA | ACADEMIC-MEDICAL-CENTER | TUMOR MORPHOLOGY | GERMLINE MUTATIONS | GYNECOLOGIC CANCERS | Immunohistochemistry | MutL Protein Homolog 1 | Predictive Value of Tests | Microsatellite Instability | Biomarkers, Tumor - deficiency | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | DNA Mismatch Repair - genetics | Mass Screening - methods | DNA-Binding Proteins - deficiency | Neoplasm Grading | Endometrial Neoplasms - genetics | DNA Mutational Analysis | MutS Homolog 2 Protein - deficiency | Nuclear Proteins - deficiency | Aged, 80 and over | Adult | Female | Mismatch Repair Endonuclease PMS2 | DNA Repair Enzymes - deficiency | Adenosine Triphosphatases - deficiency | Endometrial Neoplasms - chemistry | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Risk Factors | California | Biopsy | Adaptor Proteins, Signal Transducing - deficiency | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - chemistry | Index Medicus
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8. Full Text Immune microenvironment in microsatellite-instable endometrial cancers: Hereditary or sporadic origin matters
by Pakish, Janelle B and Zhang, Qian and Chen, Zhongyuan and Liang, Han and Chisholm, Gary B and Yuan, Ying and Mok, Samuel C and Broaddus, Russell R and Lu, Karen H and Yates, Melinda S
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4473 - 4481
Purpose: Recent studies show that colorectal tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy... 
ISLAND METHYLATOR PHENOTYPE | TUMOR-INFILTRATING LYMPHOCYTES | INSTABILITY | ONCOLOGY | COLORECTAL-CANCER | LYNCH SYNDROME | MUTATIONS | EXPRESSION | Microsatellite Instability | CD8-Positive T-Lymphocytes - pathology | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Colorectal Neoplasms, Hereditary Nonpolyposis - immunology | Endometrial Neoplasms - diagnosis | Colorectal Neoplasms - diagnosis | Microsatellite Repeats - genetics | Tumor Microenvironment - immunology | Endometrial Neoplasms - immunology | Colorectal Neoplasms - immunology | Tumor Microenvironment - genetics | Endometrial Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Immunotherapy | Endometrial Neoplasms - pathology | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Colorectal Neoplasms - pathology | Multiplexing | Populations | Endometrial cancer | CD8 antigen | Clinical trials | Fluorescence | Microsatellite instability | Macrophages | Metastases | Granzyme B | Compartments | Endometrium | Medical research | Immune response | Microsatellites | Stability | Stroma | Immune systems | Immunogenicity | Lymphocytes B | Experimental design | PD-L1 protein | Infiltration | Hormone replacement therapy | Health risk assessment | Tumors | Cancer | Index Medicus | microsatellite instability | immune microenvironment | Uterine cancer | hereditary cancers | Lynch syndrome
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9. Full Text Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
by Lo, Michelle WS and Tsui, Wai Yin and Ng, Wai Fu and Chan, Annie SY and Chan, Yee Wai and Li, Vivian SW and Kong, Chi Kwan and Yuen, Siu Tsan and Tam, Wing Yip and Leung, Suet Yi and Chan, Tsun Leung
Nature Genetics, ISSN 1061-4036, 10/2006, Volume 38, Issue 10, pp. 1178 - 1183
Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring... 
PROMOTER HYPERMETHYLATION | METHYLATION | MICROSATELLITE INSTABILITY | GENETICS & HEREDITY | HMLH1 | MUTATIONS | MLH1 | EXPRESSION | CARCINOMA | PYROSEQUENCING(TM) | ADENOMAS | DNA Methylation | Pedigree | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Germ-Line Mutation | Adult | Female | Male | MutS Homolog 2 Protein - genetics | Care and treatment | Gene mutations | Colorectal cancer | Genetic aspects | Research | Health aspects | Risk factors | Genetic disorders | Mutation | Medical diagnosis | Index Medicus
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10. Full Text Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome
by Adar, Tomer and Rodgers, Linda H and Shannon, Kristen M and Yoshida, Makoto and Ma, Tianle and Mattia, Anthony and Lauwers, Gregory Y and Iafrate, Anthony J and Hartford, Nicole M and Oliva, Esther and Chung, Daniel C
Cancer, ISSN 0008-543X, 08/2018, Volume 124, Issue 15, pp. 3145 - 3153
A combined approach that includes both endometrial and colorectal tumors in a universal screening program for Lynch syndrome enhances the detection of families... 
endometrial cancer | colorectal cancer | universal screening | hereditary cancer syndromes | Lynch syndrome | COST-EFFECTIVENESS | FEASIBILITY | NONPOLYPOSIS COLORECTAL-CANCER | GUIDELINES | IMPLEMENTATION | VALIDATION | IDENTIFICATION | STRATEGIES | ACADEMIC-MEDICAL-CENTER | ONCOLOGY | GERMLINE MUTATIONS | Immunohistochemistry | Colonic Neoplasms - genetics | Genetic Testing | Early Detection of Cancer - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Colonic Neoplasms - diagnosis | Gene Expression Regulation, Neoplastic | Male | Endometrial Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Female | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colonic Neoplasms - epidemiology | MutS Homolog 2 Protein - genetics | Endometrial Neoplasms - epidemiology | DNA-Binding Proteins - genetics | Endometrial Neoplasms - diagnosis | Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology | Colonic Neoplasms - pathology | MutL Protein Homolog 1 - genetics | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Mutation | Mismatch Repair Endonuclease PMS2 - genetics | Animal models | Colorectal carcinoma | Homology | Criteria | Genetic screening | MSH6 protein | Prediction models | Risk assessment | DNA methylation | Mathematical models | Colon | Endometrium | Calculators | Sarcoma | MLH1 protein | MSH2 protein | Patients | Screening | Software | Added value | Methylation | Cancer | Tumors | Index Medicus | Abridged Index Medicus
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11. Full Text The Histomorphology of Lynch Syndrome–associated Ovarian Carcinomas: Toward a Subtype-specific Screening Strategy
by Chui, Michael Herman and Ryan, Paul and Radigan, Jordan and Ferguson, Sarah E and Pollett, Aaron and Aronson, Melyssa and Semotiuk, Kara and Holter, Spring and Sy, Keiyan and Kwon, Janice S and Soma, Anita and Singh, Naveena and Gallinger, Steven and Shaw, Patricia and Arseneau, Jocelyne and Foulkes, William D and Gilks, C Blake and Clarke, Blaise A
The American Journal of Surgical Pathology, ISSN 0147-5185, 09/2014, Volume 38, Issue 9, pp. 1173 - 1181
Women with Lynch syndrome (LS) are at increased risk for the development of epithelial ovarian cancer (OC). Analogous to previous studies on BRCA1/2 mutation... 
ovarian cancer | mismatch repair | Lynch syndrome | CELL-TYPE | SURGERY | RISKS | SYNCHRONOUS PRIMARY CANCERS | ENDOMETRIAL CARCINOMA | BRCA1 | PATHOLOGY | WOMEN | FREQUENCY | GENES | GYNECOLOGIC CANCERS | MUTATIONS | Colorectal Neoplasms, Hereditary Nonpolyposis - classification | Immunohistochemistry | Predictive Value of Tests | Microsatellite Instability | Carcinoma, Endometrioid - classification | Genetic Testing | Early Detection of Cancer - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Ovarian Neoplasms - genetics | Ovarian Neoplasms - classification | Carcinoma, Endometrioid - chemistry | Neoplasm Grading | DNA Mutational Analysis | DNA Mismatch Repair | Germ-Line Mutation | Adult | Female | Registries | Carcinoma, Endometrioid - genetics | Genetic Predisposition to Disease | Ovarian Neoplasms - chemistry | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Heredity | BRCA1 Protein - genetics | Canada | Phenotype | Lymphocytes, Tumor-Infiltrating - pathology | Biopsy | Pedigree | Aged | Colorectal Neoplasms, Hereditary Nonpolyposis - chemistry | BRCA2 Protein - genetics | Carcinoma, Endometrioid - pathology | Index Medicus
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12. Full Text Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome
by Stoffel, Elena and Mukherjee, Bhramar and Raymond, Victoria M and Tayob, Nabihah and Kastrinos, Fay and Sparr, Jennifer and Wang, Fei and Bandipalliam, Prathap and Syngal, Sapna and Gruber, Stephen B
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 5, pp. 1621 - 1627
Background & Aims Lynch syndrome is the most common hereditary colorectal cancer (CRC) syndrome. Some previous estimates of lifetime risk for CRC and... 
Gastroenterology and Hepatology | INDIVIDUALS | HNPCC | GENE | ASCERTAINMENT | FAMILY-HISTORY | MLH1 | GASTROENTEROLOGY & HEPATOLOGY | MSH2 MUTATION CARRIERS | ONSET | ACCURACY | MutL Protein Homolog 1 | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Male | MutS Homolog 2 Protein - genetics | Endometrial Neoplasms - epidemiology | DNA Mismatch Repair - genetics | Mutation - genetics | Young Adult | Endometrial Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology | Adaptor Proteins, Signal Transducing - genetics | Adult | Endometrial Neoplasms - pathology | Female | Aged | Retrospective Studies | Nuclear Proteins - genetics | Cohort Studies | Cancer patients | Endometrial cancer | Public health | Colorectal cancer | Index Medicus | Abridged Index Medicus | Lynch Syndrome | cumulative risk | penetrance
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13. Full Text Adrenocortical Carcinoma Is a Lynch Syndrome–Associated Cancer
by Victoria M. Raymond and Jessica N. Everett and Larissa V. Furtado and Shanna L. Gustafson and Chelsy R. Jungbluth and Stephen B. Gruber and Gary D. Hammer and Elena M. Stoffel and Joel K. Greenson and Thomas J. Giordano and Tobias Else
Journal of Clinical Oncology, ISSN 0732-183X, 08/2013, Volume 31, Issue 24, pp. 3012 - 3018
Purpose Adrenocortical carcinoma (ACC) is an endocrine malignancy with a poor prognosis. The association of adult-onset ACC with inherited cancer... 
GERMLINE TP53 MUTATIONS | ONCOLOGY | NONPOLYPOSIS COLORECTAL-CANCER | MICROSATELLITE INSTABILITY | FAMILIES | RISK | MSH6 MUTATIONS | IDENTIFICATION | TUMORS | ENDOMETRIAL CANCER | IMMUNOHISTOCHEMISTRY | Immunohistochemistry | Genetic Predisposition to Disease | Prospective Studies | Adrenocortical Carcinoma - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Adrenocortical Carcinoma - etiology | Male | Adrenal Cortex Neoplasms - pathology | Adrenal Cortex Neoplasms - genetics | Young Adult | Adrenocortical Carcinoma - pathology | Colorectal Neoplasms, Hereditary Nonpolyposis - complications | Adult | Female | Adrenal Cortex Neoplasms - etiology | Index Medicus | Rare | Original Reports | Endo1
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