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1. Full Text PD-L1 Expression in Mismatch Repair-deficient Endometrial Carcinomas, Including Lynch Syndrome-associated and MLH1 Promoter Hypermethylated Tumors
by Sloan, Emily A and Ring, Kari L and Willis, Brian C and Modesitt, Susan C and Mills, Anne M
The American journal of surgical pathology, ISSN 0147-5185, 03/2017, Volume 41, Issue 3, pp. 326 - 333
PD-L1 | mismatch repair | endometrial carcinoma | MLH1 hypermethylation | immunotherapy | Lynch syndrome | Pathology | Life Sciences & Biomedicine | Surgery | Science & Technology | Immunohistochemistry | Neoplastic Syndromes, Hereditary - pathology | Prognosis | Follow-Up Studies | Endometrial Neoplasms - mortality | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Brain Neoplasms - pathology | Endometrial Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Neoplastic Syndromes, Hereditary - metabolism | Brain Neoplasms - metabolism | Neoplastic Syndromes, Hereditary - mortality | Colorectal Neoplasms, Hereditary Nonpolyposis - mortality | DNA Methylation | Endometrial Neoplasms - genetics | DNA Mismatch Repair | Biomarkers, Tumor - metabolism | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Promoter Regions, Genetic | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Brain Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | B7-H1 Antigen - metabolism | MutL Protein Homolog 1 - genetics | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Index Medicus
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2. Full Text Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents
by Bodo, Sahra and Colas, Chrystelle and Buhard, Olivier and Collura, Ada and Tinat, Julie and Lavoine, Noémie and Guilloux, Agathe and Chalastanis, Alexandra and Lafitte, Philippe and Coulet, Florence and Buisine, Marie-Pierre and Ilencikova, Denisa and Ruiz-Ponte, Clara and Kinzel, Miriam and Grandjouan, Sophie and Brems, Hilde and Lejeune, Sophie and Blanché, Hélène and Wang, Qing and Caron, Olivier and Cabaret, Odile and Svrcek, Magali and Vidaud, Dominique and Parfait, Béatrice and Verloes, Alain and Knappe, Ulrich J and Soubrier, Florent and Mortemousque, Isabelle and Leis, Alexander and Auclair-Perrossier, Jessie and Frébourg, Thierry and Fléjou, Jean-François and Entz-Werle, Natacha and Leclerc, Julie and Malka, David and Cohen-Haguenauer, Odile and Goldberg, Yael and Gerdes, Anne-Marie and Fedhila, Faten and Mathieu-Dramard, Michèle and Hamelin, Richard and Wafaa, Badre and Gauthier-Villars, Marion and Bourdeaut, Franck and Sheridan, Eamonn and Vasen, Hans and Brugières, Laurence and Wimmer, Katharina and Muleris, Martine and Duval, Alex and European Consortium “Care for CMMRD” and European Consortium Care CMMRD
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 1017 - 1029.e3
Gastroenterology and Hepatology | Tumor | Colon Cancer | Predisposition | Functional Tests | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | MutL Protein Homolog 1 | Predictive Value of Tests | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Drug Resistance, Neoplasm | Male | Neoplastic Syndromes, Hereditary - metabolism | Colorectal Neoplasms - diagnosis | Young Adult | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Germ-Line Mutation | Mismatch Repair Endonuclease PMS2 | Neoplastic Syndromes, Hereditary - genetics | Caco-2 Cells | Lymphocytes - metabolism | Genetic Predisposition to Disease | Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy | Brain Neoplasms - diagnosis | HCT116 Cells | Brain Neoplasms - genetics | Neoplastic Syndromes, Hereditary - diagnosis | Heredity | MutS Homolog 2 Protein - genetics | Brain Neoplasms - drug therapy | Multiplex Polymerase Chain Reaction | Antineoplastic Agents, Alkylating - therapeutic use | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Phenotype | Adenosine Triphosphatases - genetics | Biomarkers, Tumor - genetics | Neoplastic Syndromes, Hereditary - drug therapy | Microsatellite Instability | Neoplastic Syndromes, Hereditary - pathology | Brain Neoplasms - pathology | DNA Repair Enzymes - genetics | Genetic Testing - methods | Brain Neoplasms - metabolism | Case-Control Studies | Transfection | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Adult | Female | Nuclear Proteins - genetics | Colorectal Neoplasms - metabolism | Reproducibility of Results | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | DNA-Binding Proteins - genetics | Lymphocytes - drug effects | Adaptor Proteins, Signal Transducing - genetics | Colorectal Neoplasms - pathology | Methylation | Lymphomas | Diagnosis | Gene mutations | Lymphocytes | Leukemia | Colorectal cancer | Index Medicus | Abridged Index Medicus
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3. Full Text Screening for the Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)
by Hampel, Heather and Frankel, Wendy L and Martin, Edward and Arnold, Mark and Khanduja, Karamjit and Kuebler, Philip and Nakagawa, Hidewaki and Sotamaa, Kaisa and Prior, Thomas W and Westman, Judith and Panescu, Jenny and Fix, Dan and Lockman, Janet and Comeras, Ilene and de la Chapelle, Albert
The New England journal of medicine, ISSN 0028-4793, 05/2005, Volume 352, Issue 18, pp. 1851 - 1860
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | General aspects | Medical sciences | Tumors | Immunohistochemistry | Genomic Instability | MutL Protein Homolog 1 | Adenocarcinoma - pathology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Base Pair Mismatch | DNA Repair - genetics | DNA Mutational Analysis - methods | DNA Methylation | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Aged, 80 and over | Germ-Line Mutation | Adult | Electrophoresis | Female | Adenocarcinoma - genetics | Neoplasm Proteins - genetics | Microsatellite Repeats | Carrier Proteins | Promoter Regions, Genetic | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Genotype | Nuclear Proteins | Adaptor Proteins, Signal Transducing | Neoplasm Proteins - analysis | Aged | Colorectal Neoplasms - pathology | Genetic aspects | Research | Diagnosis | Gene mutations | Colorectal cancer | Cancer | Mutation | Family medical history | Index Medicus | Abridged Index Medicus
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4. Full Text Correlation between density of CD8+ T-cell infiltrate in microsatellite unstable colorectal cancers and frameshift mutations: A rationale for personalized immunotherapy
by Maby, Pauline and Tougeron, David and Hamieh, Mohamad and Mlecnik, Bernhard and Kora, Hafid and Bindea, Gabriela and Angell, Helen K and Fredriksen, Tessa and Elie, Nicolas and Fauquembergue, Emilie and Drouet, Aurélie and Leprince, Jérôme and Benichou, Jacques and Mauillon, Jacques and Pessot, Florence Le and Sesboüé, Richard and Tuech, Jean-Jacques and Sabourin, Jean-Christophe and Michel, Pierre and Frébourg, Thierry and Galon, Jérôme and Latouche, Jean-Baptiste
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2015, Volume 75, Issue 17, pp. 3446 - 3455
Life Sciences & Biomedicine | Oncology | Science & Technology | Microsatellite Instability | CD8-Positive T-Lymphocytes - pathology | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Male | Colorectal Neoplasms, Hereditary Nonpolyposis - immunology | Forkhead Transcription Factors - genetics | Antigen-Presenting Cells - immunology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | Immunotherapy | Female | CD8-Positive T-Lymphocytes - immunology | Colorectal Neoplasms - pathology | Frameshift Mutation - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Precision Medicine | Index Medicus | Frameshift Mutation | Neurons and Cognition | Neurobiology | Pharmacology | Colorectal Neoplasms, Hereditary Nonpolyposis | Cellular Biology | Chemical Sciences | CD8-Positive T-Lymphocytes | Medicinal Chemistry | Life Sciences | Antigen-Presenting Cells | Lymphocytes, Tumor-Infiltrating | Colorectal Neoplasms | Forkhead Transcription Factors | Pharmaceutical sciences | Cell Behavior
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5. Full Text Extent of Pedigree Required to Screen for and Diagnose Hereditary Nonpolyposis Colorectal Cancer: Comparison of Simplified and Extended Pedigrees
by Heo, Yoonjung and Kim, Min Hyun and Kim, Duck-Woo and Lee, Sang A and Bang, Sukyung and Kim, Myung Jo and Oh, Heung-Kwon and Kang, Sung-Bum and Kang, Sung Il and Park, Ji Won and Ryoo, Seung-Bum and Jeong, Seung-Yong and Park, Kyu Joo
Diseases of the colon & rectum, ISSN 0012-3706, 02/2020, Volume 63, Issue 2, pp. 152 - 159
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Surgery | Science & Technology | Adenocarcinoma | Colorectal Neoplasms - surgery | Medical History Taking | Microsatellite Instability | Prevalence | Cross-Sectional Studies | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Male | Mass Screening - methods | Colorectal Neoplasms - diagnosis | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology | Pedigree | Adult | Female | Aged | Colorectal Neoplasms - pathology | Index Medicus
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6. Full Text Immunohistochemistry versus Microsatellite Instability Testing For Screening Colorectal Cancer Patients at Risk For Hereditary Nonpolyposis Colorectal Cancer Syndrome: Part I. The Utility of Immunohistochemistry
by Shia, Jinru
The Journal of molecular diagnostics : JMD, ISSN 1525-1578, 07/2008, Volume 10, Issue 4, pp. 293 - 300
Life Sciences & Biomedicine | Pathology | Science & Technology | Microsatellite Instability | Humans | Risk Factors | Mass Screening - methods | Colorectal Neoplasms - diagnosis | Syndrome | Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control | Immunohistochemistry - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Sensitivity and Specificity | Colorectal Neoplasms - complications | Colorectal Neoplasms, Hereditary Nonpolyposis - etiology | Colorectal Neoplasms - metabolism | Index Medicus | Counterpoint | Point
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7. Full Text Immune microenvironment in microsatellite-instable endometrial cancers: Hereditary or sporadic origin matters
by Pakish, Janelle B and Zhang, Qian and Chen, Zhongyuan and Liang, Han and Chisholm, Gary B and Yuan, Ying and Mok, Samuel C and Broaddus, Russell R and Lu, Karen H and Yates, Melinda S
Clinical cancer research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4473 - 4481
Life Sciences & Biomedicine | Oncology | Science & Technology | Microsatellite Instability | CD8-Positive T-Lymphocytes - pathology | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Colorectal Neoplasms, Hereditary Nonpolyposis - immunology | Endometrial Neoplasms - diagnosis | Colorectal Neoplasms - diagnosis | Microsatellite Repeats - genetics | Tumor Microenvironment - immunology | Endometrial Neoplasms - immunology | Colorectal Neoplasms - immunology | Tumor Microenvironment - genetics | Endometrial Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Immunotherapy | Endometrial Neoplasms - pathology | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Colorectal Neoplasms - pathology | Multiplexing | Populations | Endometrial cancer | CD8 antigen | Clinical trials | Fluorescence | Microsatellite instability | Macrophages | Metastases | Granzyme B | Compartments | Endometrium | Immune system | Medical research | Immune response | Stability | Stroma | Immunogenicity | Lymphocytes B | Experimental design | PD-L1 protein | Infiltration | Hormone replacement therapy | Health risk assessment | Tumors | Cancer | Index Medicus | microsatellite instability | immune microenvironment | Uterine cancer | hereditary cancers | Lynch syndrome
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8. Full Text Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: Later age of onset
by Hampel, Heather and Stephens, Julie A and Pukkala, Eero and Sankila, Risto and Aaltonen, Lauri A and Mecklin, Jukka-Pekka and De La Chapelle, Albert
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2005, Volume 129, Issue 2, pp. 415 - 421
MutL Protein Homolog 1 | Confidence Intervals | Age Distribution | Genetic Testing | Prognosis | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | DNA Mutational Analysis | Aged, 80 and over | Female | Precancerous Conditions - pathology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Carrier Proteins | Colorectal Neoplasms - epidemiology | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Probability | Precancerous Conditions - genetics | Adaptor Proteins, Signal Transducing | Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology | Age of Onset | Survival Analysis | Sex Distribution | Aged | Colorectal Neoplasms - pathology | Neoplasm Staging | Cohort Studies | Index Medicus | Abridged Index Medicus
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9. Full Text Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer Syndrome: Later Age of Onset
by Hampel, Heather and Stephens, Julie A and Pukkala, Eero and Sankila, Risto and Aaltonen, Lauri A and Mecklin, Jukka-Pekka and de la Chapelle, Albert
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2005, Volume 129, Issue 2, pp. 415 - 421
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Genetic aspects | Health aspects | Risk factors | Colorectal cancer
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10. Full Text Germline Mutation of RPS20 , Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency
by Nieminen, Taina T and O’Donohue, Marie-Françoise and Wu, Yunpeng and Lohi, Hannes and Scherer, Stephen W and Paterson, Andrew D and Ellonen, Pekka and Abdel-Rahman, Wael M and Valo, Satu and Mecklin, Jukka-Pekka and Järvinen, Heikki J and Gleizes, Pierre-Emmanuel and Peltomäki, Päivi
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2014, Volume 147, Issue 3, pp. 595 - 598.e5
Gastroenterology and Hepatology | Hereditary Nonpolyposis Colorectal Cancer | Ribosome | Exome Sequencing | Colon Cancer | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Genetic Predisposition to Disease | Ribosomal Proteins - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Middle Aged | Risk Factors | Male | Heredity | Exosomes | Genetic Testing - methods | Phenotype | DNA Mutational Analysis | Pedigree | DNA Mismatch Repair | Germ-Line Mutation | Female | Genetic Linkage | Colon cancer | Carcinoma | RNA | Gene mutations | Analysis | Genomics | DNA | Genetic research | Genetic aspects | Cancer | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology | FCCX, hereditary nonpolyposis colorectal cancer type X | Original Research | rRNA, ribosomal RNA
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11. Full Text Ureteroscopic management of upper tract urothelial carcinoma (UTUC) in patients with Lynch Syndrome (hereditary nonpolyposis colorectal cancer syndrome)
by Hubosky, Scott G and Boman, Bruce M and Charles, Sarah and Bibbo, Marluce and Bagley, Demetrius H
BJU international, ISSN 1464-4096, 10/2013, Volume 112, Issue 6, pp. 813 - 819
kidney neoplasms | Lynch Syndrome | ureteroscopy | ureteric neoplasms | hereditary nonpolyposis colorectal cancer | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Tumors of the urinary system | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Tumors | United States - epidemiology | Kidney Neoplasms - genetics | Follow-Up Studies | Humans | Middle Aged | Ureteral Neoplasms - pathology | Male | Neoplasms, Multiple Primary | Kidney Neoplasms - surgery | Colorectal Neoplasms, Hereditary Nonpolyposis - mortality | Neoplasm Grading | Nephrectomy | DNA Mutational Analysis | Adult | Female | Retrospective Studies | Ureteroscopy - methods | Carcinoma, Transitional Cell - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - surgery | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Treatment Outcome | MutS Homolog 2 Protein - genetics | Carcinoma, Transitional Cell - pathology | Ureteral Neoplasms - complications | Kidney Neoplasms - pathology | Aged | Carcinoma, Transitional Cell - surgery | DNA, Neoplasm - genetics | Mutation | Ureteral Neoplasms - surgery | Rare earth metals | Care and treatment | Ablation (Surgery) | Carcinoma | Gene mutations | Colorectal cancer | Medical genetics | Genetic aspects | Intermedin | Cancer | Lasers in medicine | Lasers | Index Medicus
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12. Full Text Combined microsatellite instability, MLH1 methylation analysis, and immunohistochemistry for Lynch syndrome screening in endometrial cancers from GOG210: An NRG Oncology and Gynecologic Oncology Group study
by Goodfellow, Paul J and Billingsley, Caroline C and Lankes, Heather A and Ali, Shamshad and Cohn, David E and Broaddus, Russell J and Ramirez, Nilsa and Pritchard, Colin C and Hampel, Heather and Chassen, Alexis S and Simmons, Luke V and Schmidt, Amy P and Gao, Feng and Brinton, Louise A and Backes, Floor and Landrum, Lisa M and Geller, Melissa A and DiSilvestro, Paul A and Pearl, Michael L and Lele, Shashikant B and Powell, Matthew A and Zaino, Richard J and Mutch, David