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1. Full Text Curcumin—From Molecule to Biological Function
by Esatbeyoglu, Tuba and Huebbe, Patricia and Ernst, Insa M. A and Chin, Dawn and Wagner, Anika E and Rimbach, Gerald
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2012, Volume 51, Issue 22, pp. 5308 - 5332
Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in curry and gives curry powder its characteristic yellow color.... 
cancer | total synthesis | neuroprotection | gene expression | curcumin | Animals | Antioxidants - chemistry | Curcumin - chemistry | Humans | Curcumin - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antineoplastic Agents - pharmacology | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antioxidants | Coloring | Color | Spices | Organisms | Foods | Biological | Gene expression
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2. Full Text Diketopyrrolopyrrole‐Porphyrin Conjugates with High Two‐Photon Absorption and Singlet Oxygen Generation for Two‐Photon Photodynamic Therapy
by Schmitt, Julie and Heitz, Valérie and Sour, Angélique and Bolze, Frédéric and Ftouni, Hussein and Nicoud, Jean‐Francois and Flamigni, Lucia and Ventura, Barbara
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2015, Volume 54, Issue 1, pp. 169 - 173
Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and... 
dyes/pigments | two‐photon absorption | diketopyrroles | singlet oxygen | photodynamic therapy | porphyrins | Dyes/pigments | Two-photon absorption | Diketopyrroles | Photodynamic therapy | Singlet oxygen | Porphyrins | EXCITATION | ZINC PORPHYRIN | MICROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | OLIGOMERS | MOLECULES | SENSITIZED SOLAR-CELLS | FLUORESCENCE | NONLINEAR-OPTICAL PROPERTIES | POLYMER | two-photon absorption | PI-EXPANDED DIKETOPYRROLOPYRROLES | Cell Survival - drug effects | Photosensitizing Agents - chemistry | Coloring Agents - pharmacology | Humans | Porphyrins - chemistry | Photons | Porphyrins - pharmacology | Photochemotherapy | Photosensitizing Agents - pharmacology | Pyrroles - pharmacology | Singlet Oxygen - chemistry | HEK293 Cells | Pyrroles - chemistry | HeLa Cells | Coloring Agents - chemistry | Active oxygen | Cancer | Oxygen | Index Medicus | Conjugates | Biotechnology | Dyes | Absorption | Excitation | Cross sections
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3. Full Text Current clinical and preclinical photosensitizers for use in photodynamic therapy
by Detty, Michael R and Gibson, Scott L and Wagner, Stephen J
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2004, Volume 47, Issue 16, pp. 3897 - 3915
PERIPHERAL BENZODIAZEPINE RECEPTOR | ANTITUMOR AGENT AA1 | BREAST-CANCER CELLS | IN-VITRO | CHEMISTRY, MEDICINAL | CORE-MODIFIED PORPHYRINS | BASAL-CELL CARCINOMA | HUMAN-IMMUNODEFICIENCY-VIRUS | WAVELENGTH-ABSORBING SENSITIZERS | SULFONATED ALUMINUM PHTHALOCYANINES | TOPICAL METHYL AMINOLEVULINATE | Cations - chemistry | Photosensitizing Agents - chemistry | Porphyrins - therapeutic use | Photosensitizing Agents - therapeutic use | Coloring Agents - pharmacology | Photochemotherapy - methods | Humans | Porphyrins - chemistry | Porphyrins - pharmacology | Macular Degeneration - drug therapy | Erythrocytes - drug effects | Neoplasms - drug therapy | Erythrocytes - microbiology | Photosensitizing Agents - pharmacology | Animals | Coloring Agents - therapeutic use | Drug Evaluation, Preclinical | Coloring Agents - chemistry
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4. Full Text Ultrasonically assisted hydrothermal synthesis of activated carbon–HKUST-1-MOF hybrid for efficient simultaneous ultrasound-assisted removal of ternary organic dyes and antibacterial investigation: Taguchi optimization
by Azad, F. Nasiri and Ghaedi, M and Dashtian, K and Hajati, S and Pezeshkpour, V
Ultrasonics - Sonochemistry, ISSN 1350-4177, 07/2016, Volume 31, pp. 383 - 393
Activated carbon (AC) composite with HKUST-1 metal organic framework (AC–HKUST-1 MOF) was prepared by ultrasonically assisted hydrothermal method and... 
Metal organic framework | Ultrasonically assisted hydrothermal synthesis | Crystal violet | Antibacterial | Quinoline yellow | Disulfine blue | METHYLENE-BLUE | ARTIFICIAL NEURAL-NETWORK | CHEMISTRY, MULTIDISCIPLINARY | AQUEOUS-SOLUTION | ACOUSTICS | DERIVATIVE SPECTROPHOTOMETRY | CENTRAL COMPOSITE DESIGN | PSEUDOMONAS-AERUGINOSA | FRAMEWORK HKUST-1 | SUNSET YELLOW | SOLID-PHASE EXTRACTION | MALACHITE GREEN | Microbial Sensitivity Tests | Microscopy, Electron, Transmission | Adsorption | Coloring Agents - pharmacology | Coloring Agents - isolation & purification | Anti-Bacterial Agents - pharmacology | Kinetics | Spectroscopy, Fourier Transform Infrared | Ultrasonics | Antibacterial agents | Organic dyes | Investigations | Alkaloids | Analysis | Quinoline | Bacteria
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5. Full Text Novel guar gum/Al2O3 nanocomposite as an effective photocatalyst for the degradation of malachite green dye
by Pathania, Deepak and Katwal, Rishu and Sharma, Gaurav and Naushad, Mu and Khan, Mohammad Rizwan and Al-Muhtaseb, Ala’a H
International Journal of Biological Macromolecules, ISSN 0141-8130, 06/2016, Volume 87, pp. 366 - 374
Guar gum/Al O (GG/AO) nanocomposite was prepared using simple and cost effective sol–gel method. This nanocomposite was characterized by several analytical... 
Photodegradation | Antibacterial activity | Nanocomposite | Dyes | Galactans - chemistry | Rosaniline Dyes - chemistry | Nanocomposites - chemistry | Nanoparticles - chemistry | Galactans - pharmacology | Plant Gums - chemistry | Plant Gums - pharmacology | Mannans - pharmacology | Adsorption | Mannans - chemistry | Photolysis | Anti-Bacterial Agents - chemistry | Rosaniline Dyes - isolation & purification | Sunlight | Anti-Bacterial Agents - pharmacology | Catalysis | Aluminum Oxide - chemistry | Staphylococcus aureus - drug effects | Coloring Agents - chemistry
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6. Full Text Screening of anti-cancer agent using zebrafish: Comparison with the MTT assay
by Li, Yigen and Huang, Cheng and Huang, Wenjin and Huang, Shenyuan and Du, Jiulin
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2012, Volume 422, Issue 1, pp. 85 - 90
► We compare zebrafish and MTT assay for anti-cancer drug screening. ► The anti-cancer compounds induce apoptosis and activate p53 pathway in zebrafish. ►... 
Zebrafish | Anti-cancer drug | MTT assay | Apoptosis | p53 | P53 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | MODEL | INDUCTION | IDENTIFICATION | CANCER | BIOPHYSICS | DISEASE | INHIBITORS | EMBRYOGENESIS | Emodin - pharmacology | Gene Expression - drug effects | Apoptosis - drug effects | Humans | Transcriptional Activation | Dimethyl Sulfoxide - pharmacology | Naphthoquinones - pharmacology | Tetrazolium Salts - chemistry | Lignans - pharmacology | Tumor Suppressor Protein p53 - genetics | Animals | Biphenyl Compounds - pharmacology | Antineoplastic Agents - isolation & purification | Rotenone - pharmacology | Cell Line, Tumor | Thiazoles - chemistry | Antineoplastic Agents - pharmacology | Camptothecin - pharmacology | Coloring Agents - chemistry | Drug Screening Assays, Antitumor | Antimitotic agents | Usage | Care and treatment | Analysis | Medicine, Chinese | Diagnosis | Antineoplastic agents | Tumor proteins | Cancer
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7. Full Text Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
by Lianne Fuino and Purva Bali and Sylvie Wittmann and Sreenivas Donapaty and Fei Guo and Hirohito Yamaguchi and Hong-Gang Wang and Peter Atadja and Kapil Bhalla
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2003, Volume 2, Issue 10, pp. 971 - 984
Histone deacetylase inhibitors induce hyperacetylation of the amino-terminal lysine residues of the core nucleosomal histones, which results in chromatin... 
SIGNAL-TRANSDUCTION | ACUTE-LEUKEMIA CELLS | ONCOLOGY | ACETYLATION | RESISTANCE | RECEPTOR | RAF-1 | MONOCLONAL-ANTIBODY | OVARIAN-CANCER | TAXOL-INDUCED APOPTOSIS | HSP90 FUNCTION | Chromatin - metabolism | Phosphorylation | Taxoids - pharmacology | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Epothilones - pharmacology | Multienzyme Complexes - metabolism | Deoxycytidine - pharmacology | Proteasome Endopeptidase Complex | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sepharose - pharmacology | Cysteine Endopeptidases - metabolism | Flow Cytometry | Cyclins - metabolism | Time Factors | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Detergents - pharmacology | Receptor, ErbB-2 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 | Antibodies, Monoclonal - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Tetrazolium Salts - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Blotting, Western | Precipitin Tests | Blotting, Northern | Cell Line, Tumor | Histone Deacetylase Inhibitors | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Deoxycytidine - analogs & derivatives | Microscopy, Fluorescence | Trastuzumab | Apoptosis
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8. Full Text Synergistic photoactivated antimicrobial effects of carbon dots combined with dye photosensitizers
by Dong, Xiuli and Bond, Ambrose E and Pan, Nengyu and Coleman, Montrez and Tang, Yongan and Sun, Ya-Ping and Yang, Liju
International Journal of Nanomedicine, ISSN 1176-9114, 2018, Volume 13, pp. 8025 - 8035
Background: Carbon quantum dots (CDots) have recently been reported as a new class of visible light activated antimicrobial nanomaterials. This study reports... 
Reactive oxygen species | Toluidine blue | Synergistic antimicrobial effect | Carbon quantum dots | Photosensitizer | Methylene blue | synergistic antimicrobial effect | PHOTODYNAMIC THERAPY | PERMEABILITY | GRAPHENE | NANOSCIENCE & NANOTECHNOLOGY | BIOFILM | COMBINATION | toluidine blue | photosensitizer | QUANTUM DOTS | AGENT | methylene blue | carbon quantum dots | reactive oxygen species | PHARMACOLOGY & PHARMACY | Reactive Oxygen Species - metabolism | Microbial Viability - drug effects | Coloring Agents - pharmacology | Anti-Infective Agents - pharmacology | Escherichia coli - drug effects | Fluorescence | Methylene Blue - pharmacology | Microbial Sensitivity Tests | Photosensitizing Agents - pharmacology | Quantum Dots - chemistry | Tolonium Chloride - pharmacology | Anti-Bacterial Agents - pharmacology | Escherichia coli - ultrastructure | Carbon - pharmacology | Analysis | Escherichia coli | Bacterial infections | Photodynamic therapy | Laboratories | Quantum dots | Cytotoxicity | Staphylococcus infections | Antimicrobial agents | Nanomaterials | Permeability | Drug resistance | Carbon | Cancer therapies | Nanoparticles | Antibiotics | Graphene | Light | Bacteria | Public health | Nanotechnology
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9. Full Text Oxidative metabolites of curcumin poison human type II topoisomerases
by Ketron, Adam C and Gordon, Odaine N and Schneider, Claus and Osheroff, Neil
Biochemistry, ISSN 0006-2960, 01/2013, Volume 52, Issue 1, pp. 221 - 227
The polyphenol curcumin is the principal flavor and color component of the spice turmeric. Beyond its culinary uses, curcumin is believed to positively impact... 
TEA | POLYPHENOLS | STIMULATION | ANTICANCER | MECHANISM | MEDIATED DNA CLEAVAGE | DEGRADATION-PRODUCTS | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | BLOCKING | DNA Topoisomerases, Type II - metabolism | Plant Extracts - chemistry | Oxidation-Reduction | Coloring Agents - pharmacology | Plant Extracts - pharmacology | Curcumin - chemistry | Humans | Curcumin - pharmacology | Curcumin - metabolism | Antineoplastic Agents - chemistry | DNA Cleavage - drug effects | Antineoplastic Agents - metabolism | Curcuma - metabolism | Plant Extracts - metabolism | Coloring Agents - metabolism | Antineoplastic Agents - pharmacology | Coloring Agents - chemistry | Curcuma - chemistry | Enzymes | Topoisomerases | Synthesis | DNA | Analysis | Oxidation-reduction reaction | Research | Chemical properties | Structure | Index Medicus
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10. Full Text Lymphocyte Sequestration through S1P Lyase Inhibition and Disruption of S1P Gradients
by Susan R. Schwab and João P. Pereira and Mehrdad Matloubian and Ying Xu and Yong Huang and Jason G. Cyster
Science, ISSN 0036-8075, 9/2005, Volume 309, Issue 5741, pp. 1735 - 1739
Lymphocyte egress from the thymus and from peripheral lymphoid organs depends on sphingosine 1-phosphate (S1P) receptor-1 and is thought to occur in response... 
Spleen | T lymphocytes | Thymocytes | Lymphocytes | B lymphocytes | Reports | Lymphoid tissue | Blood | Lymph nodes | Lymph | Blood plasma | EMIGRATION | MIGRATION | THYMUS | PYRIDOXINE | AMMONIA PROCESS | METABOLISM | MULTIDISCIPLINARY SCIENCES | SPHINGOSINE-1-PHOSPHATE | RECEPTOR | T-CELLS | SPHINGOSINE 1-PHOSPHATE | Chemotaxis, Leukocyte | Lysophospholipids - metabolism | T-Lymphocytes - physiology | Vitamin B 6 - pharmacology | Lymph - immunology | Pyridoxine - analogs & derivatives | Lymphoid Tissue - immunology | RNA Interference | Lymph - metabolism | Hematopoietic Stem Cells - physiology | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Receptors, Lysosphingolipid - metabolism | Thymus Gland - metabolism | Immunosuppressive Agents - pharmacology | Pyridoxine - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | B-Lymphocytes - physiology | Lymphoid Tissue - metabolism | Food Coloring Agents - pharmacology | Aldehyde-Lyases - antagonists & inhibitors | Imidazoles - pharmacology | Lysophospholipids - blood | Lymph Nodes - immunology | Sphingosine - analogs & derivatives | Animals | B-Lymphocytes - immunology | Aldehyde-Lyases - metabolism | Sphingosine - blood | T-Lymphocytes - immunology | Thymus Gland - immunology | Mice | Lymphopenia - chemically induced | Lyases | Research | Observations | Lymphocyte receptors | Enzymes | Lymphatic system | Rodents
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11. Full Text The effect of bleaching agents on the degradation of vitamins and carotenoids in spray-dried whey protein concentrate
by Stout, M.A and Park, C.W and Drake, M.A
Journal of Dairy Science, ISSN 0022-0302, 10/2017, Volume 100, Issue 10, pp. 7922 - 7932
Previous research has shown that bleaching affects flavor and functionality of whey proteins. The role of different bleaching agents on vitamin and carotenoid... 
whey | degradation | vitamin | bleaching | DAIRY INGREDIENTS | SOY PROTEIN | AGRICULTURE, DAIRY & ANIMAL SCIENCE | FOOD SCIENCE & TECHNOLOGY | SHORT-COMMUNICATION | ANTIOXIDANT PROPERTIES | PERFORMANCE LIQUID-CHROMATOGRAPHY | BETA-CAROTENE | SOLIDS CONCENTRATION | CHEDDAR CHEESE | BENZOYL PEROXIDE | FLUID WHEY | Carotenoids - analysis | Plant Extracts - pharmacology | Vitamins - analysis | Color | Hydrogen Peroxide - pharmacology | Food Coloring Agents - pharmacology | Cheese | Milk Proteins - drug effects | Carotenoids - pharmacology | Bixaceae | Animals | Whey Proteins - drug effects | Bleaching Agents - pharmacology | Taste | Carotenoids | Bleaching | Chemical properties | Whey | Production processes | Methods | Vitamins | Bleaching materials | Chemical research | Research | Decomposition (Chemistry)
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