Molecular and Cellular Biochemistry, ISSN 0300-8177, 1/2018, Volume 437, Issue 1, pp. 13 - 36
Liver cancer is the sixth most common cancer worldwide and 3rd most common cause of cancer-related death. Hepatocellular carcinoma (HCC) represents more than...
Life Sciences | Biochemistry, general | Molecular targets | Immunostimulation | Immunotherapy | Combinational therapy | Virotherapy | Cellular targets | Medical Biochemistry | Oncology | Hepatocellular carcinoma | Cardiology | NATURAL-KILLER-CELLS | DENDRITIC CELLS | HEPATITIS-C-VIRUS | HEPARANASE INHIBITOR PI-88 | CYTOTOXIC T-LYMPHOCYTES | CELL BIOLOGY | APOPTOSIS-INDUCING LIGAND | VESICULAR STOMATITIS-VIRUS | ONCOLYTIC ADENOVIRUS | TUMOR-ASSOCIATED ANTIGEN | RADIOFREQUENCY ABLATION | Antigens | Immune response | Liver diseases | Dendritic cells | Radiation | Development and progression | Hepatoma | T cells | Radiotherapy | Proteins | Killer cells | Chemotherapy | Drug therapy | Health aspects | Cancer | Pathogenesis | Liver | Effector cells | Cytotoxicity | Activation | Lymphocytes T | Cancer therapies | Liver cancer | Receptors | Lymphocytes | Hepatology | Natural killer cells | Public health | Immune system | Proteoglycans | Cytokines | Immunomodulation | MiRNA | T cell receptors | Ribonucleic acid--RNA | Lymphocytes B | Cellular biology | Antigen-presenting cells | Biomarkers | Solid tumors | Chemokines | Tumors
Life Sciences | Biochemistry, general | Molecular targets | Immunostimulation | Immunotherapy | Combinational therapy | Virotherapy | Cellular targets | Medical Biochemistry | Oncology | Hepatocellular carcinoma | Cardiology | NATURAL-KILLER-CELLS | DENDRITIC CELLS | HEPATITIS-C-VIRUS | HEPARANASE INHIBITOR PI-88 | CYTOTOXIC T-LYMPHOCYTES | CELL BIOLOGY | APOPTOSIS-INDUCING LIGAND | VESICULAR STOMATITIS-VIRUS | ONCOLYTIC ADENOVIRUS | TUMOR-ASSOCIATED ANTIGEN | RADIOFREQUENCY ABLATION | Antigens | Immune response | Liver diseases | Dendritic cells | Radiation | Development and progression | Hepatoma | T cells | Radiotherapy | Proteins | Killer cells | Chemotherapy | Drug therapy | Health aspects | Cancer | Pathogenesis | Liver | Effector cells | Cytotoxicity | Activation | Lymphocytes T | Cancer therapies | Liver cancer | Receptors | Lymphocytes | Hepatology | Natural killer cells | Public health | Immune system | Proteoglycans | Cytokines | Immunomodulation | MiRNA | T cell receptors | Ribonucleic acid--RNA | Lymphocytes B | Cellular biology | Antigen-presenting cells | Biomarkers | Solid tumors | Chemokines | Tumors
Journal Article
Advanced Science, ISSN 2198-3844, 05/2018, Volume 5, Issue 5, pp. 1700891 - n/a
The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth of light. Combining PTT with immunotherapy provides strategies...
combinational therapy | indoleamine 2,3‐dioxygenase (IDO) inhibitors | nanoparticles | ineffective photothermal therapy | immunotherapy | indoleamine 2,3-dioxygenase (IDO) inhibitors | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | INDOLEAMINE 2,3-DIOXYGENASE | GOLD NANORODS | NANOSCIENCE & NANOTECHNOLOGY | INFRARED THERMAL THERAPY | COMBINATION | CHEMISTRY, MULTIDISCIPLINARY | CHECKPOINT BLOCKADE | BREAST-CANCER | DOCETAXEL DELIVERY | TUMOR MICROENVIRONMENT | Antigens | Immunoglobulins | Cloning | Breast cancer | Radiation therapy | Bioavailability | Metabolism | Cancer therapies | Variance analysis | Nanoparticles | Studies | Proteins | Chemotherapy | Lasers | Immunotherapy | Immune system | Tumors
combinational therapy | indoleamine 2,3‐dioxygenase (IDO) inhibitors | nanoparticles | ineffective photothermal therapy | immunotherapy | indoleamine 2,3-dioxygenase (IDO) inhibitors | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | INDOLEAMINE 2,3-DIOXYGENASE | GOLD NANORODS | NANOSCIENCE & NANOTECHNOLOGY | INFRARED THERMAL THERAPY | COMBINATION | CHEMISTRY, MULTIDISCIPLINARY | CHECKPOINT BLOCKADE | BREAST-CANCER | DOCETAXEL DELIVERY | TUMOR MICROENVIRONMENT | Antigens | Immunoglobulins | Cloning | Breast cancer | Radiation therapy | Bioavailability | Metabolism | Cancer therapies | Variance analysis | Nanoparticles | Studies | Proteins | Chemotherapy | Lasers | Immunotherapy | Immune system | Tumors
Journal Article
Cancer Letters, ISSN 0304-3835, 08/2019, Volume 456, pp. 23 - 28
As a new hallmark of cancer, immune surveillance evading plays a critical role in carcinogenesis. Through modulating the immune checkpoints, immune cells in...
Ani-PD-1/L1 | Immune checkpoint modulators | Combinational immunotherapy | Anti-CTLA-4 | Therapy | PD-1 protein | Crosstalk | Clinical trials | Antibodies | Editing | Homeostasis | Carcinogenesis | Modulators | Anticancer properties | Proteins | Carcinogens | Lymphocytes | Immunotherapy | New combinations | Fibroblasts | Conflicts of interest | Tumor necrosis factor-TNF | Immune system | Medical research | Antigens | Immunoglobulins | Immunomodulation | Melanoma | Immunosurveillance | Immune checkpoint | Response rates | Biomarkers | Antitumor activity | Ligands | Autoimmune diseases | Cancer | Apoptosis
Ani-PD-1/L1 | Immune checkpoint modulators | Combinational immunotherapy | Anti-CTLA-4 | Therapy | PD-1 protein | Crosstalk | Clinical trials | Antibodies | Editing | Homeostasis | Carcinogenesis | Modulators | Anticancer properties | Proteins | Carcinogens | Lymphocytes | Immunotherapy | New combinations | Fibroblasts | Conflicts of interest | Tumor necrosis factor-TNF | Immune system | Medical research | Antigens | Immunoglobulins | Immunomodulation | Melanoma | Immunosurveillance | Immune checkpoint | Response rates | Biomarkers | Antitumor activity | Ligands | Autoimmune diseases | Cancer | Apoptosis
Journal Article
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, ISSN 1758-8340, 07/2019, Volume 11, p. 1758835919862692
The introduction of immunotherapies has been a major development in the treatment of many advanced cancers, including hepatocellular carcinoma (HCC). We are...
GLYPICAN-3 | DENDRITIC CELLS | CLINICAL-TRIAL | PD-1 BLOCKADE | combinational immunotherapy | immune checkpoints | IN-VITRO | ONCOLOGY | immune cell-based therapy | immunotherapy | CHIMERIC-ANTIGEN-RECEPTOR | CTLA-4 | TUMOR MUTATIONAL BURDEN | PHASE-I | hepatocellular carcinoma | T-CELLS
GLYPICAN-3 | DENDRITIC CELLS | CLINICAL-TRIAL | PD-1 BLOCKADE | combinational immunotherapy | immune checkpoints | IN-VITRO | ONCOLOGY | immune cell-based therapy | immunotherapy | CHIMERIC-ANTIGEN-RECEPTOR | CTLA-4 | TUMOR MUTATIONAL BURDEN | PHASE-I | hepatocellular carcinoma | T-CELLS
Journal Article
Advanced Science, ISSN 2198-3844, 05/2018, Volume 5, Issue 5, pp. 1870031 - n/a
Reinvigorating the tumor infiltrating lymphocytes (TILs) is critical for tumor immunotherapy, and photothermal therapy (PTT) and regulation of tumor cell...
combinational therapy | indoleamine 2,3‐dioxygenase (IDO) inhibitors | nanoparticles | ineffective photothermal therapy | immunotherapy
combinational therapy | indoleamine 2,3‐dioxygenase (IDO) inhibitors | nanoparticles | ineffective photothermal therapy | immunotherapy
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 08/2019, Volume 307, pp. 108 - 138
Colorectal cancer (CRC) is among the five most commonly diagnosed cancers worldwide, constituting 6% of all cancers and the third leading cause of cancer...
Tumor immune microenvironment | Combinational schemes | Immunotherapy | Nanotechnology | Colorectal cancer | TARGETING DENDRITIC CELLS | RANDOMIZED CONTROLLED-TRIAL | KRAS WILD-TYPE | CHEMISTRY, MULTIDISCIPLINARY | RESECTABLE LIVER METASTASES | METASTATIC COLON-CANCER | PHASE-III TRIAL | CLINICAL-PRACTICE GUIDELINES | FUNCTIONALIZED POLYMERIC NANOPARTICLES | CETUXIMAB PLUS IRINOTECAN | PHARMACOLOGY & PHARMACY | SOLID-LIPID NANOPARTICLES | Prevention | Chemotherapy | Relapse | Biological products | Analysis | Drug therapy | Diseases | Cancer
Tumor immune microenvironment | Combinational schemes | Immunotherapy | Nanotechnology | Colorectal cancer | TARGETING DENDRITIC CELLS | RANDOMIZED CONTROLLED-TRIAL | KRAS WILD-TYPE | CHEMISTRY, MULTIDISCIPLINARY | RESECTABLE LIVER METASTASES | METASTATIC COLON-CANCER | PHASE-III TRIAL | CLINICAL-PRACTICE GUIDELINES | FUNCTIONALIZED POLYMERIC NANOPARTICLES | CETUXIMAB PLUS IRINOTECAN | PHARMACOLOGY & PHARMACY | SOLID-LIPID NANOPARTICLES | Prevention | Chemotherapy | Relapse | Biological products | Analysis | Drug therapy | Diseases | Cancer
Journal Article
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 2013, Volume 1, Issue 1, p. 15
One of the significant tumor immune escape mechanisms and substantial barrier for successful immunotherapy is tumor-mediated inhibition of immune response...
Combinational immunotherapy | Listeria-based vaccine | PD-1 | Immunotherapy | Cancer vaccines | Cell interaction | Cell receptors | Immune response | Dendritic cells | Analysis | Immunity | Biotechnology industry
Combinational immunotherapy | Listeria-based vaccine | PD-1 | Immunotherapy | Cancer vaccines | Cell interaction | Cell receptors | Immune response | Dendritic cells | Analysis | Immunity | Biotechnology industry
Journal Article
Immunotherapy, ISSN 1750-743X, 08/2012, Volume 4, Issue 8, pp. 807 - 840
A major role of chemokines is to mediate leukocyte migration through interaction with G-protein-coupled receptors. Various delivery systems have been developed...
combinational therapy | chemokine delivery system | chemokine | cancer | immunotherapy | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | NATURAL-KILLER-CELLS | GAMMA-INDUCIBLE PROTEIN-10 | DEPENDENT ANTITUMOR RESPONSES | POLY D,L-2,4-DIAMINOBUTYRIC ACID | LYMPHOTACTIN TRANSGENE EXPRESSION | IMMUNOLOGY | DNA VACCINE POTENCY | HERPES-SIMPLEX-VIRUS | MONOCYTE CHEMOTACTIC PROTEIN-3 | LYMPHOID-TISSUE CHEMOKINE | Recombinant Fusion Proteins - immunology | Immunotherapy - methods | Antigens, Neoplasm - immunology | Humans | Combined Modality Therapy | Receptors, Chemokine - immunology | Chemokines - genetics | Neoplasms - therapy | Animals | Recombinant Fusion Proteins - genetics | Genetic Vectors | Chemokines - immunology | Genetic Therapy - methods | Proteins | Angiogenesis | Chemokines | Cancer | Immune system | G protein-coupled receptors | Immune response | Dendritic cells | Leukocyte migration | Tumor cells | Immunotherapy | Antibodies | Adjuvants | Antitumor activity | Chemokine receptors
combinational therapy | chemokine delivery system | chemokine | cancer | immunotherapy | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | NATURAL-KILLER-CELLS | GAMMA-INDUCIBLE PROTEIN-10 | DEPENDENT ANTITUMOR RESPONSES | POLY D,L-2,4-DIAMINOBUTYRIC ACID | LYMPHOTACTIN TRANSGENE EXPRESSION | IMMUNOLOGY | DNA VACCINE POTENCY | HERPES-SIMPLEX-VIRUS | MONOCYTE CHEMOTACTIC PROTEIN-3 | LYMPHOID-TISSUE CHEMOKINE | Recombinant Fusion Proteins - immunology | Immunotherapy - methods | Antigens, Neoplasm - immunology | Humans | Combined Modality Therapy | Receptors, Chemokine - immunology | Chemokines - genetics | Neoplasms - therapy | Animals | Recombinant Fusion Proteins - genetics | Genetic Vectors | Chemokines - immunology | Genetic Therapy - methods | Proteins | Angiogenesis | Chemokines | Cancer | Immune system | G protein-coupled receptors | Immune response | Dendritic cells | Leukocyte migration | Tumor cells | Immunotherapy | Antibodies | Adjuvants | Antitumor activity | Chemokine receptors
Journal Article
Immunity, ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 773 - 786.e5
The molecular mechanisms whereby CD8 T cells become “exhausted” in the tumor microenvironment remain unclear. Programmed death ligand-1 (PD-L1) is upregulated...
T cell exhaustion | Eomes | tumor immunity | B7S1 | PD-1 | combinational blockade of immune checkpoints | SURVIVAL | PATHWAYS | FAMILY-MEMBER | IMMUNOLOGY | RECEPTORS | CANCER | EXHAUSTION | B7-H4 | PD-1 protein | CD8 antigen | Cytotoxicity | Hepatocellular carcinoma | Infections | Lymphocytes T | B7 antigen | Liver cancer | Cell activation | Lymphocytes | Immunotherapy | Antigens | Myeloid cells | Statistical analysis | Immune response | Tumor cells | Melanoma | Gene expression | Mucin | Molecular modelling | Exhaustion | PD-L1 protein | Epigenetics | Combinatorial analysis | Tumors | Apoptosis
T cell exhaustion | Eomes | tumor immunity | B7S1 | PD-1 | combinational blockade of immune checkpoints | SURVIVAL | PATHWAYS | FAMILY-MEMBER | IMMUNOLOGY | RECEPTORS | CANCER | EXHAUSTION | B7-H4 | PD-1 protein | CD8 antigen | Cytotoxicity | Hepatocellular carcinoma | Infections | Lymphocytes T | B7 antigen | Liver cancer | Cell activation | Lymphocytes | Immunotherapy | Antigens | Myeloid cells | Statistical analysis | Immune response | Tumor cells | Melanoma | Gene expression | Mucin | Molecular modelling | Exhaustion | PD-L1 protein | Epigenetics | Combinatorial analysis | Tumors | Apoptosis
Journal Article
Biomaterials, ISSN 0142-9612, 07/2018, Volume 171, pp. 178 - 197
The clinical outcomes of conventional mono-chemotherapy of cancers are usually far from satisfactory due to some issues such as tumor heterogeneity and...
Multidrug resistance (MDR) | Combinational mechanism | Cancer therapy | Therapeutic effect | SYNERGISTIC ANTITUMOR-ACTIVITY | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | CHEMO-PHOTOTHERMAL THERAPY | MESOPOROUS SILICA NANOPARTICLES | MULTIDRUG-RESISTANT CANCER | INDEPENDENT PROSTATE-CANCER | METASTATIC COLORECTAL-CANCER | NEGATIVE BREAST-CANCER | CELL LUNG-CANCER | PHASE-III TRIAL | MOLECULE ANTICANCER DRUGS | Genetic Therapy | Neoplasms - immunology | Humans | Immunotherapy | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Neoplasms - drug therapy | Phototherapy | Antimitotic agents | Drug resistance in microorganisms | Chemotherapy | Development and progression | Drug therapy, Combination | Antineoplastic agents | Cancer
Multidrug resistance (MDR) | Combinational mechanism | Cancer therapy | Therapeutic effect | SYNERGISTIC ANTITUMOR-ACTIVITY | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | CHEMO-PHOTOTHERMAL THERAPY | MESOPOROUS SILICA NANOPARTICLES | MULTIDRUG-RESISTANT CANCER | INDEPENDENT PROSTATE-CANCER | METASTATIC COLORECTAL-CANCER | NEGATIVE BREAST-CANCER | CELL LUNG-CANCER | PHASE-III TRIAL | MOLECULE ANTICANCER DRUGS | Genetic Therapy | Neoplasms - immunology | Humans | Immunotherapy | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Neoplasms - drug therapy | Phototherapy | Antimitotic agents | Drug resistance in microorganisms | Chemotherapy | Development and progression | Drug therapy, Combination | Antineoplastic agents | Cancer
Journal Article