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Lancet Oncology, The, ISSN 1470-2045, 2014, Volume 15, Issue 8, pp. 819 - 828
Summary Background Gemcitabine plus a platinum-based agent (eg, cisplatin or oxaliplatin) is the standard of care for advanced biliary cancers. We investigated... 
Hematology, Oncology and Palliative Medicine | GROWTH-FACTOR RECEPTOR | MULTICENTER | CISPLATIN | ONCOLOGY | COLORECTAL-CANCER | CLINICAL-TRIALS | GALLBLADDER | COMBINATION | TUMORS | CHEMOTHERAPY | GALL-BLADDER CANCER | ras Proteins - genetics | Peripheral Nervous System Diseases - chemically induced | Proto-Oncogene Proteins p21(ras) | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Alanine Transaminase - blood | Organoplatinum Compounds - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Oxaliplatin | Common Bile Duct Neoplasms - drug therapy | Adult | Bile Ducts, Intrahepatic | Female | Bile Duct Neoplasms - genetics | Cetuximab | Neutropenia - chemically induced | Common Bile Duct Neoplasms - genetics | Bile Duct Neoplasms - drug therapy | Carcinoma - drug therapy | Antibodies, Monoclonal, Humanized - adverse effects | Deoxycytidine - administration & dosage | Gallbladder Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Disease-Free Survival | Gallbladder Neoplasms - drug therapy | Aspartate Aminotransferases - blood | Cholangiocarcinoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Intention to Treat Analysis | Cholangiocarcinoma - genetics | Carcinoma - genetics | Aged | Mutation | Deoxycytidine - analogs & derivatives | Chemotherapy | Product development | Gemcitabine | Comparative analysis | Cancer | Index Medicus
Journal Article
Gastrointestinal Endoscopy, ISSN 0016-5107, 2015, Volume 83, Issue 6, pp. 1228 - 1235
Journal Article
The Journal of Pathology, ISSN 0022-3417, 07/2005, Volume 206, Issue 3, pp. 356 - 365
Journal Article
Modern Pathology, ISSN 0893-3952, 12/2012, Volume 25, Issue 12, pp. 1609 - 1622
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 380, Issue 1, pp. 163 - 173
Highlights • We established a novel PDX mouse model bearing an FGFR2-CCDC6 fusion protein from a metastatic lung nodule of an iCCA patient. • FGFR inhibitors,... 
Hematology, Oncology and Palliative Medicine | Dovitinib | Ponatinib | Intrahepatic cholangiocarcinoma | FGFR2 fusion | BGJ398 | TARGETED THERAPY | MORTALITY | TYROSINE KINASE | RENAL-CELL CARCINOMA | GENE FUSIONS | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | GROWTH | BILIARY-TRACT CANCERS | Lung Neoplasms - drug therapy | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Lung Neoplasms - metabolism | Quinolones - pharmacology | Cholangiocarcinoma - metabolism | Pyridazines - pharmacology | Matrix Metalloproteinase 9 - metabolism | Lung Neoplasms - secondary | Time Factors | Cytoskeletal Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Bile Duct Neoplasms - genetics | Bile Duct Neoplasms - drug therapy | Lung Neoplasms - genetics | Bile Duct Neoplasms - metabolism | Cholangiocarcinoma - secondary | Matrix Metalloproteinase 2 - metabolism | Gene Fusion | Matrix Metalloproteinase 3 - metabolism | Imidazoles - pharmacology | Pyrimidines - pharmacology | Mice, SCID | Interleukin Receptor Common gamma Subunit - genetics | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Xenograft Model Antitumor Assays | Animals | Cholangiocarcinoma - drug therapy | Signal Transduction - drug effects | Tumor Burden - drug effects | Cholangiocarcinoma - genetics | Benzimidazoles - pharmacology | Mice, Inbred NOD | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Bile Duct Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Chemotherapy | Analysis | Cancer | Cloning | Clinical trials | Artificial chromosomes | Metastasis | Kinases | Cancer therapies | Patients | Studies | Proteins | Pharmaceuticals | Tumors | Index Medicus | Intrahepatic Cholangiocarcinoma
Journal Article
Surgery: Official Journal of the Society of University Surgeons, Central Surgical Association, and the American Association of Endocrine Surgeons, ISSN 0039-6060, 2015, Volume 158, Issue 1, pp. 151 - 161
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 05/2009, Volume 33, Issue 5, pp. 691 - 704
The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of... 
Long-term survival | MSI | Histomorphology | Ampullary neoplasm | Prognostic factor | Microsatellite instability | Molecular characteristics | GENE-MUTATIONS | SURGERY | microsatellite instability | ampullary neoplasm | prognostic factor | DNA-REPLICATION ERRORS | molecular characteristics | ADENOMA-CARCINOMA SEQUENCE | GROWTH-FACTOR RECEPTORS | BILIARY-TRACT | PATHOLOGY | TUMOR-INFILTRATING LYMPHOCYTES | COLON-CANCER | K-RAS MUTATION | COLORECTAL-CANCER | long-term survival | histomorphology | Immunohistochemistry | MutL Protein Homolog 1 | Adenocarcinoma - pathology | Adenocarcinoma, Mucinous - pathology | Adenoma - genetics | Adenoma - mortality | Humans | Middle Aged | Carcinoma - mortality | Male | Precancerous Conditions - mortality | DNA Mismatch Repair | Gene Deletion | Aged, 80 and over | Cell Differentiation | Ampulla of Vater - pathology | Risk Assessment | Europe | Genotype | MutS Homolog 2 Protein - genetics | Ampulla of Vater - chemistry | Phenotype | Precancerous Conditions - chemistry | Carcinoma - genetics | Adenocarcinoma, Mucinous - genetics | Common Bile Duct Neoplasms - mortality | Carcinoma, Papillary - genetics | Microsatellite Instability | Gene Expression Regulation, Neoplastic | Common Bile Duct Neoplasms - therapy | Adenoma - therapy | DNA Methylation | Polymerase Chain Reaction | Adult | Female | Precancerous Conditions - pathology | Adenocarcinoma - genetics | Carcinoma - pathology | Nuclear Proteins - genetics | Common Bile Duct Neoplasms - genetics | Promoter Regions, Genetic | Precancerous Conditions - therapy | Neoplasm Invasiveness | Kaplan-Meier Estimate | Proportional Hazards Models | Common Bile Duct Neoplasms - chemistry | Treatment Outcome | Adenoma - chemistry | DNA-Binding Proteins - genetics | Carcinoma, Papillary - pathology | Precancerous Conditions - genetics | Adaptor Proteins, Signal Transducing - genetics | Adenoma - pathology | Carcinoma - therapy | Aged | Neoplasm Staging | Common Bile Duct Neoplasms - pathology | Index Medicus
Journal Article
Modern Pathology, ISSN 0893-3952, 2014, Volume 27, Issue 5, pp. 665 - 674
Our objective was to explore alteration of the epidermal growth factor receptor (EGFR) signaling pathway in ampullary carcinoma. lmmunohistochemical studies... 
epidermal growth factor receptor pathway | KRAS | PIK3CA | ampullary carcinoma | TARGETED THERAPY | PIK3CA MUTATIONS | PATHOLOGY | PANCREATIC-CARCINOMA | MOLECULAR ANALYSIS | COLON-CANCER | AMPHIREGULIN | K-RAS | COLORECTAL-CANCER | ONCOGENIC MUTATIONS | PlK3CA | DPC4/SMAD4 GENE | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Humans | Middle Aged | ras Proteins - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | DNA Mutational Analysis | Ampulla of Vater - metabolism | Female | Adenocarcinoma - genetics | Proto-Oncogene Proteins c-akt - metabolism | Common Bile Duct Neoplasms - genetics | Duodenal Neoplasms - pathology | Proto-Oncogene Proteins B-raf - metabolism | Ampulla of Vater - pathology | PTEN Phosphohydrolase - genetics | Pancreatic Neoplasms - pathology | Duodenal Neoplasms - genetics | PTEN Phosphohydrolase - metabolism | Pancreatic Neoplasms - genetics | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins B-raf - genetics | Common Bile Duct Neoplasms - metabolism | Duodenal Neoplasms - metabolism | Signal Transduction - physiology | Aged | Common Bile Duct Neoplasms - pathology | Index Medicus | Ampullary carcinoma | Epidermal growth factor receptor pathway
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 34, pp. 54526 - 54536
Journal Article
Journal Article