Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (9835) 9835
Publication (1193) 1193
Book Review (104) 104
Book Chapter (72) 72
Book / eBook (48) 48
Conference Proceeding (27) 27
Dissertation (9) 9
Data Set (6) 6
Web Resource (5) 5
Streaming Video (3) 3
Magazine Article (2) 2
Newsletter (1) 1
Paper (1) 1
Report (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (6593) 6593
animals (4646) 4646
index medicus (3609) 3609
male (2524) 2524
complement (2473) 2473
complement activation (2239) 2239
immunology (2211) 2211
female (2096) 2096
mice (1824) 1824
complement activation - drug effects (1752) 1752
activation (1443) 1443
inflammation (1110) 1110
adult (1049) 1049
rats (1002) 1002
middle aged (993) 993
proteins (891) 891
research article (814) 814
cells, cultured (760) 760
biochemistry & molecular biology (743) 743
research (743) 743
pharmacology & pharmacy (700) 700
expression (663) 663
aged (654) 654
medicine (645) 645
in vitro techniques (609) 609
hematology (589) 589
analysis (577) 577
article (570) 570
medicine, research & experimental (559) 559
cell biology (558) 558
disease models, animal (554) 554
neutrophils - drug effects (548) 548
dose-response relationship, drug (543) 543
health aspects (535) 535
multidisciplinary sciences (521) 521
complement system proteins - immunology (486) 486
time factors (486) 486
complement system proteins - metabolism (481) 481
mice, inbred c57bl (481) 481
cytokines (460) 460
rabbits (449) 449
surgery (441) 441
cells (439) 439
antibodies (438) 438
complement c3 - metabolism (435) 435
physiological aspects (423) 423
in-vitro (418) 418
science (415) 415
disease (410) 410
transplantation (405) 405
care and treatment (404) 404
cell line (400) 400
neurosciences (396) 396
gene expression (389) 389
immune system (382) 382
in-vivo (376) 376
phagocytosis (376) 376
neutrophils (359) 359
flow cytometry (352) 352
macrophages (350) 350
apoptosis (344) 344
risk factors (342) 342
complement pathway, alternative - drug effects (332) 332
biology (331) 331
kinetics (329) 329
complement system (328) 328
hemolysis - drug effects (327) 327
guinea pigs (326) 326
signal transduction (323) 323
oncology (318) 318
inhibition (316) 316
complement c5a - pharmacology (314) 314
complement activation - immunology (311) 311
blood (310) 310
binding (309) 309
urology & nephrology (308) 308
neutrophils - immunology (307) 307
pathology (306) 306
immunoglobulins (304) 304
enzyme-linked immunosorbent assay (301) 301
genetic aspects (299) 299
immune response (299) 299
neutrophils - metabolism (297) 297
physiology (296) 296
treatment outcome (293) 293
innate immunity (291) 291
protein binding (289) 289
adolescent (288) 288
pathogenesis (288) 288
cardiopulmonary bypass (287) 287
mice, inbred balb c (287) 287
microbiology (285) 285
alternative pathway (284) 284
cancer (283) 283
lymphocyte activation - drug effects (282) 282
receptor (279) 279
neutrophils - physiology (276) 276
swine (275) 275
phagocytosis - drug effects (272) 272
rodents (272) 272
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (32) 32
Collection Dvlpm't (Acquisitions) - Vendor file (8) 8
Online Resources - Online (4) 4
Gerstein Science - Reference (2) 2
UofT at Mississauga - Stacks (2) 2
Gerstein Science - Circulation Desk (1) 1
Robarts - Stacks (1) 1
Trinity College (John W Graham) - Stacks (1) 1
Trinity College (John W Graham) - Storage (1) 1
UTL at Downsview - May be requested (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9675) 9675
Russian (61) 61
German (55) 55
Japanese (39) 39
French (32) 32
Chinese (24) 24
Italian (14) 14
Spanish (14) 14
Polish (10) 10
Portuguese (7) 7
Romanian (5) 5
Bulgarian (3) 3
Danish (2) 2
Hungarian (2) 2
Slovak (2) 2
Ukrainian (2) 2
Arabic (1) 1
Croatian (1) 1
Dutch (1) 1
Slovenian (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System
by Kishimoto, Takashi Kei and Viswanathan, Karthik and Ganguly, Tanmoy and Elankumaran, Subbiah and Smith, Sean and Pelzer, Kevin and Lansing, Jonathan C and Sriranganathan, Nammalwar and Zhao, Ganlin and Galcheva-Gargova, Zoya and Al-Hakim, Ali and Bailey, Gregory Scott and Fraser, Blair and Roy, Sucharita and Rogers-Cotrone, Thomas and Buhse, Lucinda and Whary, Mark and Fox, James and Nasr, Moheb and Dal Pan, Gerald J and Shriver, Zachary and Langer, Robert S and Venkataraman, Ganesh and Austen, K. Frank and Woodcock, Janet and Sasisekharan, Ram
The New England Journal of Medicine, ISSN 0028-4793, 06/2008, Volume 358, Issue 23, pp. 2457 - 2467
Recently the heparin supply in 12 countries was found to be contaminated with a substance that caused hypotension and, in some cases, death. The contaminant... 
MEDICINE, GENERAL & INTERNAL | PLASMA KALLIKREIN | COMPLEMENT | DEXTRAN SULFATE | INHIBITION | ALTERNATIVE PATHWAY | HAGEMAN-FACTOR | ANTITHROMBIN | COFACTOR | RABBIT | FACTOR-XII | Complement C3a - drug effects | United States | Humans | Middle Aged | Complement C5a - biosynthesis | Heparin - adverse effects | Complement C5a - drug effects | Chondroitin Sulfates - adverse effects | Anaphylaxis - chemically induced | China | Chondroitin Sulfates - analysis | Female | Complement Activation - drug effects | United States Food and Drug Administration | Complement C3a - biosynthesis | Drug Industry | Chondroitin Sulfates - pharmacology | Hypotension - chemically induced | Animals | Kallikreins - drug effects | Sus scrofa | Drug Contamination | Germany | Heparin - chemistry | Kallikreins - metabolism | Composition | Heparin | Health aspects | Chondroitin | Drug therapy | Hemodialysis | Family medical history | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
by Samstad, Eivind O and Niyonzima, Nathalie and Nymo, Stig and Aune, Marie H and Ryan, Liv and Bakke, Siril S and Lappegård, Knut T and Brekke, Ole-Lars and Lambris, John D and Damås, Jan K and Latz, Eicke and Mollnes, Tom E and Espevik, Terje
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2837 - 2845
Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark of atherosclerotic... 
ATHEROSCLEROTIC LESIONS | TUMOR-NECROSIS-FACTOR | C5A RECEPTOR | MEMBRANE ATTACK | STERILE INFLAMMATION | EPITHELIAL-CELLS | CARDIOVASCULAR EVENTS | INTERLEUKIN-1-BETA | OXIDATIVE BURST | ANAPHYLATOXINS | IMMUNOLOGY | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Complement C1q - immunology | Humans | Complement Pathway, Classical - drug effects | Complement C5a - metabolism | Complement System Proteins - immunology | Caspase 1 - metabolism | Monocytes - metabolism | Caspase 1 - immunology | Macrophage-1 Antigen - immunology | Monocytes - immunology | Interleukin-1beta - genetics | Complement Activation - immunology | Complement C1q - metabolism | Complement System Proteins - metabolism | Inflammasomes - drug effects | Reactive Oxygen Species - immunology | Complement C5 - immunology | Tumor Necrosis Factor-alpha - immunology | Macrophage-1 Antigen - metabolism | Complement Activation - drug effects | Cytokines - immunology | Interleukin-1beta - secretion | Complement C5 - metabolism | Tumor Necrosis Factor-alpha - secretion | Cells, Cultured | Cytokines - secretion | Phagocytosis - immunology | Interleukin-1beta - immunology | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Monocytes - drug effects | Complement Pathway, Classical - immunology | Microscopy, Confocal | Complement Pathway, Alternative - drug effects | Complement Pathway, Alternative - immunology | Inflammasomes - immunology | Cholesterol - pharmacology | Complement C5a - immunology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention
by Szebeni, Janos and Muggia, Franco and Gabizon, Alberto and Barenholz, Yechezkel
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2011, Volume 63, Issue 12, pp. 1020 - 1030
Some therapeutic liposomes and lipid excipient-based anticancer drugs are recognized by the immune system as foreign, leading to a variety of adverse immune... 
Allergy | Cancer chemotherapy | Nanomedicines | Immune toxicity | Adverse drug effects | CARPA | Hypersensitivity reactions | DEPENDENT IMMUNE DAMAGE | MODEL MEMBRANE | STERICALLY STABILIZED LIPOSOMES | REPEATED INJECTION | ALTERNATIVE PATHWAY | PHASE-I TRIAL | ACCELERATED BLOOD CLEARANCE | ENCAPSULATED DAUNORUBICIN | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | Drug Hypersensitivity - etiology | Antineoplastic Agents - immunology | Liposomes - administration & dosage | Humans | Complement System Proteins - immunology | Lipids - immunology | Lipids - administration & dosage | Antineoplastic Agents - administration & dosage | Complement Activation - immunology | Excipients - administration & dosage | Animals | Drug Hypersensitivity - immunology | Complement Activation - drug effects | Liposomes - immunology | Prevention | Drugs | Chemotherapy | Anthracyclines | Drug delivery systems | Sulfates | Allergic reaction | Health aspects | Cancer | Vehicles | Animal models
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria
by Risitano, Antonio M and Ricklin, Daniel and Huang, Yijun and Reis, Edimara S and Chen, Hui and Ricci, Patrizia and Lin, Zhuoer and Pascariello, Caterina and Raia, Maddalena and Sica, Michela and Del Vecchio, Luigi and Pane, Fabrizio and Lupu, Florea and Notaro, Rosario and Resuello, Ranillo R. G and DeAngelis, Robert A and Lambris, John D
Blood, ISSN 0006-4971, 03/2014, Volume 123, Issue 13, pp. 2094 - 2101
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and CD59 on affected... 
ECULIZUMAB | IMMUNE | ERYTHROCYTES | PROTECTION | HEMOLYSIS | COMPSTATIN | HEMATOLOGY | Hemolysis - drug effects | Hemoglobinuria, Paroxysmal - metabolism | Humans | Half-Life | Macaca fascicularis | Peptides, Cyclic - pharmacology | Polyethylene Glycols - therapeutic use | Peptides, Cyclic - chemistry | Erythrocytes - drug effects | Complement C3 - antagonists & inhibitors | Peptide Fragments - chemistry | Animals | Drug Design | Hemoglobinuria, Paroxysmal - drug therapy | Peptides, Cyclic - therapeutic use | Erythrocytes - physiology | Peptide Fragments - therapeutic use | Complement Activation - drug effects | Polyethylene Glycols - pharmacology | Red Cells, Iron, and Erythropoiesis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Material properties in complement activation
by Moghimi, S. Moein and Andersen, Alina J and Ahmadvand, Davoud and Wibroe, Peter P and Andresen, Thomas L and Hunter, A. Christy
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2011, Volume 63, Issue 12, pp. 1000 - 1007
Uncontrolled complement activation can induce many inflammatory and life threatening conditions. Accordingly, the role of complement in initiation of adverse... 
Acute allergic reactions | Nanospheres | Liposomes | Polymers | Nanotoxicology | Nanomedicine | PEGYLATED LIPOSOMAL DOXORUBICIN | CREMOPHOR-EL | 2 PARTS | WALLED CARBON NANOTUBES | INDEPENDENT MANNER | ALTERNATIVE PATHWAY TURNOVER | PROTEIN ADSORPTION | IN-VIVO | PHARMACOLOGY & PHARMACY | HYPERSENSITIVITY REACTIONS | POLYMER SURFACE | Animals | Humans | Nanomedicine - methods | Polymers - pharmacology | Complement System Proteins - immunology | Biocompatible Materials - pharmacology | Complement Activation - immunology | Complement Activation - drug effects | Drugs | Drug delivery systems | Nanotechnology | Vehicles
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Incomplete inhibition by eculizumab: Mechanistic evidence for residual C5 activity during strong complement activation
by Harder, Markus J and Kuhn, Nadine and Schrezenmeier, Hubert and Höchsmann, Britta and Von Zabern, Inge and Weinstock, Christof and Simmet, Thomas and Ricklin, Daniel and Lambris, John D and Skerra, Arne and Anliker, Markus and Schmidt, Christoph Q
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 8, pp. 970 - 980
Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation of the complement protein C5 and shows remarkable clinical benefits in... 
HEMOLYTIC-UREMIC SYNDROME | C3 GLOMERULOPATHY | ALTERNATIVE PATHWAY | ERYTHROCYTES | PROTECTION | THROMBOSIS | TICK ORNITHODOROS-MOUBATA | FACTOR-H | CONVERTASE ENZYMES | PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA | HEMATOLOGY | Hemoglobinuria, Paroxysmal - immunology | Hemolysis - drug effects | Antibodies, Monoclonal, Humanized - therapeutic use | Complement Pathway, Alternative - drug effects | Antibodies, Monoclonal, Humanized - pharmacology | Complement C5 - immunology | Humans | Hemoglobinuria, Paroxysmal - drug therapy | Complement C5 - antagonists & inhibitors | Complement Activation - drug effects | Complement C3b - immunology | Immunobiology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Dynamics of complement activation in aHUS and how to monitor eculizumab therapy
by Noris, Marina and Galbusera, Miriam and Gastoldi, Sara and Macor, Paolo and Banterla, Federica and Bresin, Elena and Tripodo, Claudio and Bettoni, Serena and Donadelli, Roberta and Valoti, Elisabetta and Tedesco, Francesco and Amore, Alessandro and Coppo, Rosanna and Ruggenenti, Piero and Gotti, Eliana and Remuzzi, Giuseppe
Blood, ISSN 0006-4971, 2014, Volume 124, Issue 11, pp. 1715 - 1726
Atypical hemolytic-uremic syndrome (aHUS) is associated with genetic complement abnormalities/anti-complement factor H antibodies, which paved the way to... 
C3 MUTATION | HEMOLYTIC-UREMIC SYNDROME | ATYPICAL HUS | RECOGNITION | ENDOTHELIAL-CELLS | LEADS | FACTOR-H | HEMATOLOGY | CLINICAL PHENOTYPE | GAIN | REVEALS | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations | 101
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Eculizumab reduces complement activation, inflammation, endothelial damage, thrombosis, and renal injury markers in aHUS
by Cofiell, Roxanne and Kukreja, Anjli and Bedard, Krystin and Yan, Yan and Mickle, Angela P and Ogawa, Masayo and Bedrosian, Camille L and Faas, Susan J
Blood, ISSN 0006-4971, 2015, Volume 125, Issue 21, pp. 3253 - 3262
Atypical hemolytic uremic syndrome (aHUS) is a genetic, life-threatening disease characterized by uncontrolled complement activation, systemic thrombotic... 
TUMOR-NECROSIS-FACTOR | URINARY CLUSTERIN | HEMOLYTIC-UREMIC SYNDROME | INHIBITOR ECULIZUMAB | ACID-BINDING PROTEIN | CYSTATIN-C | ADHESION MOLECULES | TNF-ALPHA | HEMATOLOGY | TISSUE FACTOR | FACTOR-ALPHA | Atypical Hemolytic Uremic Syndrome - complications | Antibodies, Monoclonal, Humanized - therapeutic use | Acute Kidney Injury - drug therapy | Humans | Endothelium, Vascular - drug effects | Male | Biomarkers - blood | Inflammation - etiology | Inflammation - drug therapy | Thrombosis - etiology | Adult | Female | Thrombosis - drug therapy | Atypical Hemolytic Uremic Syndrome - drug therapy | Acute Kidney Injury - etiology | Complement Activation - drug effects | Atypical Hemolytic Uremic Syndrome - blood | Clinical Trials and Observations
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text An integrated assessment of morphology, size, and complement activation of the PEGylated liposomal doxorubicin products Doxil®, Caelyx®, DOXOrubicin, and SinaDoxosome
by Wibroe, Peter P and Ahmadvand, Davoud and Oghabian, Mohammad Ali and Yaghmur, Anan and Moghimi, S. Moein
Journal of Controlled Release, ISSN 0168-3659, 01/2016, Volume 221, pp. 1 - 8
In order to improve patient's benefit and safety, comprehensive regulatory guidelines on specificities of Non-Biological Complex Drugs (NBCDs), such as... 
Complement system | Non-biological complex drugs | Cryo-TEM | Nanomedicine | Nanosimilars | SHAPE | PHARMACOLOGY & PHARMACY | LESSONS | FUTURE | CHEMISTRY, MULTIDISCIPLINARY | FLOW | HYPERSENSITIVITY | Humans | Polyethylene Glycols - chemistry | Doxorubicin - chemistry | Polyethylene Glycols - administration & dosage | Antibiotics, Antineoplastic - administration & dosage | Particle Size | Liposomes - chemistry | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - immunology | Doxorubicin - analogs & derivatives | Liposomes - ultrastructure | Complement Activation - drug effects | Doxorubicin - immunology | Doxorubicin - administration & dosage | Liposomes - immunology | Anthracyclines
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Complement alternative pathway acts as a positive feedback amplification of neutrophil activation
by Camous, Laurent and Roumenina, Lubka and Bigot, Sylvain and Brachemi, Soumeya and Frémeaux-Bacchi, Véronique and Lesavre, Philippe and Halbwachs-Mecarelli, Lise
Blood, ISSN 0006-4971, 01/2011, Volume 117, Issue 4, pp. 1340 - 1349
Complement alternative pathway plays an important, but not clearly understood, role in neutrophil-mediated diseases. We here show that neutrophils themselves... 
SYSTEM | MEMBRANE ATTACK | C5A RECEPTOR | PHAGOCYTOSIS | ENDOTHELIAL-CELLS | APOPTOTIC CELLS | DECAY-ACCELERATING FACTOR | MODEL | MICROPARTICLES | HEMATOLOGY | PROPERDIN BINDS | Neutrophil Activation - immunology | Complement C5 - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Complement C3 - metabolism | Humans | Neutrophils - drug effects | Blood - immunology | Cells, Cultured | Neutrophil Activation - drug effects | Neutrophils - immunology | Neutrophils - physiology | Blood - drug effects | Neutrophil Activation - physiology | N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives | Tumor Necrosis Factor-alpha - pharmacology | Complement Pathway, Alternative - drug effects | Complement Pathway, Alternative - physiology | N-Formylmethionine Leucyl-Phenylalanine - pharmacology | Feedback, Physiological - drug effects | Feedback, Physiological - physiology | Neutrophils - metabolism | Complement Activation - drug effects | Complement Activation - physiology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: Implications for stealth nanoparticle engineering
by Hamad, Islam and Al-Hanbali, Othman and Hunter, A. Christy and Rutt, Kenneth J and Andresen, Thomas L and Moghimi, S. Moein
ACS Nano, ISSN 1936-0851, 11/2010, Volume 4, Issue 11, pp. 6629 - 6638
Nanoparticles with surface projected polyethyleneoxide (PEO) chains in 'mushroom-brush' and "brush" configurations display stealth properties in systemic... 
Poloxamine 908 | Stealth nanoparticles | Complement activation | Nanomedicine | Block copolymers | block copolymers | PROTEIN | MATERIALS SCIENCE, MULTIDISCIPLINARY | SURFACE MODIFICATION | CHEMISTRY, PHYSICAL | nanomedicine | NANOSCIENCE & NANOTECHNOLOGY | MODEL | CHEMISTRY, MULTIDISCIPLINARY | CARBON NANOTUBES | poloxamine 908 | stealth nanoparticles | complement activation | LIPOSOMAL DOXORUBICIN | IN-VIVO | POLOXAMINE-908 | ANAPHYLATOXIN | PROPERDIN | STERICALLY-STABILIZED MICROSPHERES | Rats, Wistar | Ethylenediamines - chemistry | Humans | Nanospheres - chemistry | Serum - drug effects | Polyethylene Glycols - pharmacokinetics | Rats | Male | Polyethylene Glycols - chemistry | Structure-Activity Relationship | Serum - immunology | Lectins - metabolism | Animals | Adsorption | Complement Activation - drug effects | Engineering - methods | Polyethylene Glycols - pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights