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1. Full Text Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
by Weismann, David and Hartvigsen, Karsten and Lauer, Nadine and Bennett, Keiryn L and Scholl, Hendrik P. N and Issa, Peter Charbel and Cano, Marisol and Brandstätter, Hubert and Tsimikas, Sotirios and Skerka, Christine and Superti-Furga, Giulio and Handa, James T and Zipfel, Peter F and Witztum, Joseph L and Binder, Christoph J
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7367, pp. 76 - 81
Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular degeneration (AMD). AMD is the... 
PHAGOCYTOSIS | MULTIDISCIPLINARY SCIENCES | APOPTOTIC CELLS | MACULAR DEGENERATION | RISK | PHOSPHOLIPIDS | PROTEINS | END-PRODUCTS | RETINAL-PIGMENT EPITHELIUM | INNATE IMMUNITY | AGE | Inflammation - pathology | Protein Binding - genetics | Retina - metabolism | Epitopes - metabolism | Oxidative Stress | Humans | Malondialdehyde - chemistry | Complement System Proteins - immunology | Male | Complement System Proteins - metabolism | Necrosis | Inflammation - metabolism | Female | Malondialdehyde - metabolism | Protein Structure, Tertiary | Complement Factor H - immunology | Complement Inactivator Proteins - metabolism | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Complement Inactivator Proteins - immunology | Inflammation - immunology | Binding Sites - genetics | Mutation - genetics | Macular Degeneration - metabolism | Animals | Complement Factor H - metabolism | Malondialdehyde - immunology | Epitopes - chemistry | Mice | Complement Factor H - genetics | Lipid Peroxidation | Macrophages, Peritoneal - metabolism | Malondialdehyde - antagonists & inhibitors | Apoptosis | Complement Inactivator Proteins - genetics | Macular Degeneration - pathology | Macular degeneration | Oxidative stress | Complement factor H | Care and treatment | Physiological aspects | Research | Health aspects | Risk factors | Proteins | Flow cytometry | Plasma | Pathogenesis | Low density lipoprotein | Mass spectrometry | Molecular weight | Binding sites
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2. Full Text Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation
by Heinen, Stefan and Hartmann, Andrea and Lauer, Nadine and Wiehl, Ulrike and Dahse, Hans-Martin and Schirmer, Sylvia and Gropp, Katharina and Enghardt, Tina and Wallich, Reinhard and Hälbich, Steffi and Mihlan, Michael and Schlötzer-Schrehardt, Ursula and Zipfel, Peter F and Skerka, Christine
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 12, pp. 2439 - 2447
Homozygous deletion of a 84-kb genomic fragment in human chromosome 1 that encompasses the CFHR1 and CFHR3 genes represents a risk factor for hemolytic uremic... 
AUTOANTIBODIES | DENSE DEPOSIT DISEASE | HEMOLYTIC-UREMIC SYNDROME | RECOGNITION FUNCTIONS | ALTERNATIVE PATHWAY | BINDING-PROTEIN | SURFACE | MACULAR DEGENERATION | MOLECULAR-CLONING | 2 PARTS | HEMATOLOGY | Endothelium, Vascular - cytology | Retina - metabolism | Immunoprecipitation | Complement Membrane Attack Complex - metabolism | Humans | Immunoenzyme Techniques | Complement C3d - metabolism | Complement C3b - metabolism | Kidney - metabolism | Flow Cytometry | Retina - cytology | Umbilical Veins - cytology | Complement C3-C5 Convertases - metabolism | Enzyme-Linked Immunosorbent Assay | Cells, Cultured | Kidney - cytology | Complement C3-C5 Convertases - antagonists & inhibitors | Complement C3b Inactivator Proteins - physiology | Microscopy, Confocal | Animals | Complement Factor H - metabolism | Endothelium, Vascular - metabolism | Erythrocytes - metabolism | Fluorescent Antibody Technique | Sheep | Umbilical Veins - metabolism
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3. Full Text Structural basis for sialic acid-mediated self-recognition by complement factor H
by Blaum, Bärbel S and Blaum, Bärbel S and Hannan, Jonathan P and Herbert, Andrew P and Kavanagh, David and Uhrín, Dušan and Stehle, Thilo
Nature chemical biology, ISSN 1552-4450, 01/2015, Volume 11, Issue 1, pp. 77 - 82
The serum protein complement factor H (FH) ensures downregulation of the complement alternative pathway, a branch of innate immunity, upon interaction with... 
CELLS | ACTIVATION | ALTERNATIVE PATHWAY | DISCRIMINATION | NMR-SPECTROSCOPY | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | C3 CONVERTASE | HOST | POLYANION BINDING-SITE | PROTEINS | Carbohydrate Sequence | Hemolysis - drug effects | Humans | Models, Molecular | Molecular Sequence Data | N-Acetylneuraminic Acid - metabolism | Polysaccharides - pharmacology | N-Acetylneuraminic Acid - chemistry | Hemolytic-Uremic Syndrome - genetics | Complement C3b - metabolism | Animals | Complement Factor H - metabolism | Complement Pathway, Alternative - drug effects | Conserved Sequence | Sheep | Mice | Binding Sites | Complement Factor H - chemistry | Proteins | Cellular biology | Molecular biology | Binding sites | Crystal structure
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4. Full Text Complement factor H related proteins (CFHRs)
by Skerka, Christine and Chen, Qian and Fremeaux-Bacchi, Veronique and Roumenina, Lubka T
Molecular Immunology, ISSN 0161-5890, 12/2013, Volume 56, Issue 3, pp. 170 - 180
Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2, CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central... 
BORRELIA-BURGDORFERI | DENSE DEPOSIT DISEASE | HEMOLYTIC-UREMIC SYNDROME | CANDIDA-ALBICANS | PSEUDOMONAS-AERUGINOSA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SHORT CONSENSUS REPEAT | IMMUNOLOGY | REGULATORS FACTOR-H | C-REACTIVE-PROTEIN | GENOME-WIDE ASSOCIATION | IMMUNE EVASION | Complement Factor H - immunology | Multigene Family | Macular Degeneration - immunology | Apolipoproteins - metabolism | Humans | Complement C3b Inactivator Proteins - genetics | Complement System Proteins - immunology | Apolipoproteins - immunology | Hemolytic-Uremic Syndrome - immunology | Complement System Proteins - metabolism | Complement C3b Inactivator Proteins - metabolism | Glomerulonephritis, Membranoproliferative - genetics | Hemolytic-Uremic Syndrome - genetics | Glomerulonephritis, Membranoproliferative - immunology | Complement Factor H - metabolism | Macular Degeneration - genetics | Apolipoproteins - genetics | Complement Factor H - genetics | Complement C3b Inactivator Proteins - immunology | Macular degeneration | Proteins | Systemic lupus erythematosus | Immunoglobulin A
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5. Full Text Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
by Moore, Iain and Strain, Lisa and Pappworth, Isabel and Kavanagh, David and Barlow, Paul N and Herbert, Andrew P and Schmidt, Christoph Q and Staniforth, Scott J and Holmes, Lucy V and Ward, Roy and Morgan, Lynn and Goodship, Timothy H. J and Marchbank, Kevin J
Blood, ISSN 0006-4971, 01/2010, Volume 115, Issue 2, pp. 379 - 387
Factor H autoantibodies have been reported in approximately 10% of patients with atypical hemolytic uremic syndrome (aHUS) and are associated with deficiency... 
COMPLEMENT FACTOR-H | CELLS | FACTOR-B | GENE | RECOGNITION | SURFACE | MACULAR DEGENERATION | PREDISPOSE | CLUSTER | HEMATOLOGY | BINDING | Sequence Deletion | Autoantibodies - blood | Humans | Hemolytic-Uremic Syndrome - blood | Child, Preschool | Complement C3b Inactivator Proteins - genetics | Blood Proteins - immunology | Infant | Male | Blood Proteins - metabolism | Complement C3b Inactivator Proteins - metabolism | Hemolytic-Uremic Syndrome - genetics | Apolipoproteins - genetics | Blood Proteins - genetics | Female | Membrane Cofactor Protein - metabolism | Child | Complement C3 - genetics | Complement Factor H - immunology | Complement Factor I - immunology | Complement C3 - metabolism | Apolipoproteins - metabolism | Complement Factor I - genetics | Gene Dosage | Apolipoproteins - immunology | Hemolytic-Uremic Syndrome - immunology | Complement C3 - immunology | Autoantibodies - immunology | Complement Factor H - metabolism | Membrane Cofactor Protein - genetics | Complement Factor H - genetics | Complement Factor I - metabolism | Membrane Cofactor Protein - immunology | Cohort Studies | Complement C3b Inactivator Proteins - immunology | Thrombosis and Hemostasis
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6. Full Text Glycerol-3-Phosphate Dehydrogenase 2 Is a Novel Factor H—, Factor H—like Protein 1—, and Plasminogen-Binding Surface Protein of Candida albicans
by Shanshan Luo and Ralf Hoffmann and Christine Skerka and Peter F. Zipfel
The Journal of Infectious Diseases, ISSN 0022-1899, 2/2013, Volume 207, Issue 4, pp. 594 - 603
Candida albicans uses human complement regulators such as factor H and factor H—like protein 1 (FHL-1) for immune evasion. To define the whole panel of fungal... 
Candida albicans | Yeasts | Human umbilical vein endothelial cells | MAJOR ARTICLES AND BRIEF REPORTS | Epithelial cells | Cell walls | Hyphae | Washing | Immune evasion | Regulator genes | Membrane proteins | SYSTEM | BORRELIA-BURGDORFERI | INFECTIOUS DISEASES | OXIDATIVE STRESS | ACTIVATION | MACULAR DEGENERATION | MICROBIOLOGY | complement evasion | IMMUNOLOGY | REGULATORS FACTOR-H | EVASION | human regulators | COMPLEMENT FACTOR-H | C. albicans | Gpd2 | EPIDEMIOLOGY | INNATE IMMUNITY | Cell Line | Complement C3b Inactivator Proteins - metabolism | Glycerolphosphate Dehydrogenase - metabolism | Complement Factor H - metabolism | Epithelial Cells - metabolism | Endothelial Cells - metabolism | U937 Cells | Humans | Plasminogen - metabolism | Membrane Proteins - metabolism | Fungal Proteins - metabolism | Sugar esters | Complement factor H | Genetic aspects | Research | Oxidoreductases | Binding proteins
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7. Full Text Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies
by Servais, Aude and Noël, Laure-Hélène and Roumenina, Lubka T and Le Quintrec, Moglie and Ngo, Stephanie and Dragon-Durey, Marie-Agnès and Macher, Marie-Alice and Zuber, Julien and Karras, Alexandre and Provot, François and Moulin, Bruno and Grünfeld, Jean-Pierre and Niaudet, Patrick and Lesavre, Philippe and Frémeaux-Bacchi, Véronique
Kidney International, ISSN 0085-2538, 08/2012, Volume 82, Issue 4, pp. 454 - 464
Dense deposit disease and glomerulonephritis with isolated C3 deposits are glomerulopathies characterized by deposits of C3 within or along the glomerular... 
complement | glomerulonephritis | clinical immunology | membranoproliferative glomerulonephritis (MPGN) | LONG-TERM | HEMOLYTIC-UREMIC SYNDROME | MESANGIOCAPILLARY GLOMERULONEPHRITIS | GLOMERULONEPHRITIS TYPE-II | MACULAR DEGENERATION | FACTOR-H DEFICIENCY | GLOMERULAR-FILTRATION-RATE | UROLOGY & NEPHROLOGY | MUTATIONS | MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS | MEMBRANE COFACTOR PROTEIN | Humans | Child, Preschool | Male | Complement System Proteins - metabolism | Young Adult | Time Factors | DNA Mutational Analysis | Renal Insufficiency - immunology | Child | Glomerulonephritis, Membranoproliferative - pathology | Genetic Predisposition to Disease | Risk Assessment | Complement C3 - metabolism | Gene Frequency | Risk Factors | Glomerulonephritis - genetics | Glomerulonephritis - immunology | Glomerulonephritis - mortality | Biomarkers - blood | Kidney Glomerulus - pathology | Disease Progression | Glomerulonephritis, Membranoproliferative - genetics | Glomerulonephritis, Membranoproliferative - immunology | Phenotype | Complement Factor H - metabolism | Glomerulonephritis, Membranoproliferative - mortality | Glomerulonephritis - pathology | Adolescent | Age of Onset | Membrane Cofactor Protein - genetics | Kidney Glomerulus - immunology | Mutation | Complement Factor I - metabolism | Haplotypes | Complement C3 Nephritic Factor - genetics | Glomerulonephritis - therapy | Infant | Case-Control Studies | Adult | Complement System Proteins - genetics | Female | Membrane Cofactor Protein - metabolism | Complement Pathway, Alternative - genetics | France | Renal Insufficiency - genetics | Kaplan-Meier Estimate | Complement Factor I - genetics | Treatment Outcome | Chi-Square Distribution | Glomerulonephritis, Membranoproliferative - therapy | Biopsy | Complement C3 Nephritic Factor - metabolism | Complement Factor H - genetics
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8. Full Text The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance
by Madico, Guillermo and Welsch, Jo Anne and Lewis, Lisa A and McNaughton, Anne and Perlman, David H and Costello, Catherine E and Ngampasutadol, Jutamas and Vogel, Ulrich and Granoff, Dan M and Ram, Sanjay
The Journal of Immunology, ISSN 0022-1767, 07/2006, Volume 177, Issue 1, pp. 501 - 510
Neisseria meningitidis binds factor H (M), a key regulator of the alternative complement pathway. A similar to 29 kD fH-binding protein expressed in the... 
MOLECULAR-MECHANISM | OUTER-MEMBRANE PROTEINS | GENETIC-ANALYSIS | AMPLIFICATION CONVERTASE | SEROGROUP-B | DEFICIENCY STATES | SIALIC-ACID | IMMUNOLOGY | BACTERICIDAL ANTIBODIES | MONOCLONAL-ANTIBODIES | B NEISSERIA-MENINGITIDIS | Complement Factor H - antagonists & inhibitors | Vaccines, DNA - genetics | Neisseria meningitidis - metabolism | Humans | Antigens, Bacterial - immunology | Porins - metabolism | Vaccines, DNA - immunology | Molecular Sequence Data | Antigens, Bacterial - genetics | Blood Bactericidal Activity - genetics | Genetic Variation | Neisseria meningitidis - immunology | Gene Deletion | Adjuvants, Immunologic - metabolism | Adjuvants, Immunologic - genetics | Adult | Neisseria meningitidis - genetics | Bacterial Proteins - immunology | Complement Pathway, Alternative - genetics | Binding, Competitive - immunology | Amino Acid Sequence | Complement Factor H - immunology | Meningococcal Vaccines - genetics | Bacterial Adhesion - immunology | Meningococcal Vaccines - metabolism | Bacterial Proteins - genetics | Blood Bactericidal Activity - immunology | Complement Factor H - metabolism | Bacterial Outer Membrane Proteins - metabolism | Complement Pathway, Alternative - immunology | Bacterial Proteins - metabolism | Ligands | Antibodies, Monoclonal - metabolism | Meningococcal Vaccines - immunology | Binding Sites, Antibody | Vaccines, DNA - metabolism | Antigens, Bacterial - metabolism
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9. Full Text Structure of complement fragment C3b-factor H and implications for host protection by complement regulators
by Wu, Jin and Wu, You-Qiang and Ricklin, Daniel and Janssen, Bert J.C and Lambris, John D and Gros, Piet
Nature Immunology, ISSN 1529-2908, 2009, Volume 10, Issue 7, pp. 728 - 733
Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insight into the... 
TRANSLATIONAL MINIREVIEW SERIES | DENSE DEPOSIT DISEASE | CONFORMATIONAL-CHANGES | FACTOR-B | DECAY-ACCELERATING FACTOR | MACULAR DEGENERATION | HEMOLYTIC-UREMIC-SYNDROME | MEMBRANOPROLIFERATIVE-GLOMERULONEPHRITIS | FACTOR-I | IMMUNOLOGY | MEMBRANE COFACTOR PROTEIN | Protein Structure, Tertiary | Humans | Models, Molecular | Crystallography, X-Ray | Complement C3b - metabolism | Complement Factor H - metabolism | Macromolecular Substances - chemistry | Protein Binding | Complement C3b - genetics | Mutation | Complement Factor H - genetics | Binding Sites | Macromolecular Substances - metabolism | Complement C3b - chemistry | Complement Factor H - chemistry | Physiological aspects | Complement factor H | Glycosaminoglycans | Membrane proteins
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10. Full Text The complement factor H‐related proteins
by Medjeral‐Thomas, Nicholas and Pickering, Matthew C
Immunological Reviews, ISSN 0105-2896, 11/2016, Volume 274, Issue 1, pp. 191 - 201
The role of the complement factor H‐related ( FHR ) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable... 
kidney | infection | complementinflammation | ACTIVATION | HEMOLYTIC-UREMIC SYNDROME | BINDING-PROTEIN | MACULAR DEGENERATION | IMMUNOLOGY | C-REACTIVE-PROTEIN | REGULATORY PROTEINS | CANDIDA-ALBICANS | CONVERTASE | ALTERNATIVE PATHWAY | IGA NEPHROPATHY | Autoimmunity | Complement Factor H - immunology | Animals | Complement Factor H - metabolism | Complement Activation | Complement C3 - metabolism | Humans | Homeostasis | Blood Proteins - immunology | Blood Proteins - metabolism | Immunity, Innate | Proteins
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