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1. Full Text The Ig V-H complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor
by Girola, Natalia and Matsuo, Alisson L and Figueiredo, Carlos R and Massaoka, Mariana H and Farias, Camyla F and Arruda, Denise C and Azevedo, Ricardo A and Monteiro, Hugo P and Resende-Lara, Pedro T and Cunha, Rodrigo L. O. R and Polonelli, Luciano and Travassos, Luiz R
Peptides (New York, N.Y. : 1980), ISSN 0196-9781, 11/2016, Volume 85, pp. 1 - 15
Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Complementarity Determining Regions - genetics | Sodium-Phosphate Cotransporter Proteins, Type IIb - immunology | Sodium-Phosphate Cotransporter Proteins, Type IIb - genetics | Melanoma, Experimental - drug therapy | Peptides - genetics | Immunoglobulin Variable Region - immunology | Cell Movement - genetics | Peptides - administration & dosage | Melanoma, Experimental - immunology | HSP90 Heat-Shock Proteins - immunology | HSP90 Heat-Shock Proteins - genetics | Neuropeptides - genetics | Antibodies, Monoclonal - immunology | Cell Adhesion - genetics | Peptides - immunology | Cell Adhesion - immunology | Antibodies, Monoclonal - genetics | Animals | Melanoma, Experimental - genetics | Complementarity Determining Regions - immunology | Immunoglobulin Variable Region - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Neoplasm Invasiveness - genetics | rac1 GTP-Binding Protein - genetics
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2. Full Text A point mutation in the heavy chain complementarity-determining region 3 (HCDR3) significantly enhances the specificity of an anti-ROS1 antibody
by Lee, Hwa Kyoung and Jin, Junyeong and Kim, Sang Il and Kang, Min Jueng and Yi, Eugene C and Kim, Ji Eun and Park, Jong Bae and Kim, Hyori and Chung, Junho
Biochemical and biophysical research communications, ISSN 0006-291X, 11/2017, Volume 493, Issue 1, pp. 325 - 331
Specificity | Mutation | Epitope | Antibody | ROS1 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Complementarity Determining Regions - genetics | Lung Neoplasms - drug therapy | Humans | Mutagenesis, Site-Directed - methods | Antineoplastic Agents - administration & dosage | Proto-Oncogenes | Tissue Distribution | Point Mutation - genetics | Drug Design | Adenocarcinoma - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Immunoglobulin Heavy Chains - immunology | Antibodies, Monoclonal - immunology | Lung Neoplasms - genetics | Arabidopsis Proteins - genetics | Antineoplastic Agents - immunology | Adenocarcinoma - immunology | Arabidopsis Proteins - immunology | Nuclear Proteins - immunology | Adenocarcinoma - drug therapy | Drug Synergism | Antibodies, Monoclonal - genetics | Lung Neoplasms - immunology | Antibodies, Monoclonal - administration & dosage | Complementarity Determining Regions - immunology | Immunoglobulin Heavy Chains - genetics | Proteins | Viral antibodies | Gene mutations | Analysis | Antibodies | Heat shock proteins | Genetic aspects | Index Medicus | ONCOGENES | RANDOMNESS | MUTAGENESIS | MONOCLONAL ANTIBODIES | SPECIFICITY | GENE MUTATIONS | LUNGS | ANIMAL TISSUES | 60 APPLIED LIFE SCIENCES | HEAT-SHOCK PROTEINS | CARCINOGENESIS | ALANINES | TYROSINE | AMINO ACID SEQUENCE | CARCINOMAS | ENZYME IMMUNOASSAY | PHOSPHOTRANSFERASES | PEROXIDASES
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3. Full Text Cross-neutralization of influenza A viruses mediated by a single antibody loop
by Ekiert, Damian C and Kashyap, Arun K and Steel, John and Rubrum, Adam and Bhabha, Gira and Khayat, Reza and Lee, Jeong Hyun and Dillon, Michael A and O'Neil, Ryann E and Faynboym, Aleksandr M and Horowitz, Michael and Horowitz, Lawrence and Ward, Andrew B and Palese, Peter and Webby, Richard and Lerner, Richard A and Bhatt, Ramesh R and Wilson, Ian A
Nature (London), ISSN 0028-0836, 09/2012, Volume 489, Issue 7417, pp. 526 - 532
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) | Microbiology | Applied microbiology | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Complementarity Determining Regions - genetics | Influenza A virus - chemistry | Cross Reactions - genetics | Molecular Sequence Data | Crystallography, X-Ray | Antibody Specificity - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Epitopes - immunology | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Complementarity Determining Regions - chemistry | Conserved Sequence | Influenza A virus - immunology | Binding Sites | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Enzyme-Linked Immunosorbent Assay | Models, Molecular | Antigens, Viral - chemistry | Antibodies, Neutralizing - genetics | Cross Reactions - immunology | Influenza A Virus, H3N2 Subtype - immunology | Mutation - genetics | Antigens, Viral - immunology | Animals | Influenza A Virus, H3N2 Subtype - chemistry | Influenza Vaccines - immunology | Antibodies, Neutralizing - chemistry | Antibodies, Viral - chemistry | Complementarity Determining Regions - immunology | Antibodies, Viral - immunology | Protein Conformation | Epitopes - chemistry | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Influenza A virus - classification | Orthomyxoviridae Infections - virology | Antibodies, Viral - genetics | Orthomyxoviridae Infections - immunology | Influenza viruses | Agglutinins | Viruses | Complementarity-determining regions | Research | Observations | Inactivation | Proteins | Infections | Binding sites | Index Medicus
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4. Full Text Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs
by Tiller, Kathryn E and Li, Lijuan and Kumar, Sandeep and Julian, Mark C and Garde, Shekhar and Tessier, Peter M
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 40, pp. 16638 - 16652
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Antibody Specificity | Complementarity Determining Regions - genetics | Humans | Models, Molecular | Antibody Affinity | Mutation, Missense | Arginine - chemistry | Single-Chain Antibodies - genetics | Amyloid beta-Peptides - genetics | Complementarity Determining Regions - chemistry | Arginine - genetics | Hydrophobic and Hydrophilic Interactions | Amyloid beta-Peptides - chemistry | Single-Chain Antibodies - chemistry | Amino Acid Substitution | Index Medicus | antibody engineering | Protein Structure and Folding | Alzheimer disease | complementarity determining regions | affinity maturation | amyloid-β (AB) | polyspecificity | monoclonal antibody | yeast surface display | protein stability | directed evolution
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5. Full Text Structural basis of a shared antibody response to SARS-CoV-2
by Yuan, Meng and Liu, Hejun and Wu, Nicholas C and Lee, Chang-Chun D and Zhu, Xueyong and Zhao, Fangzhu and Huang, Deli and Yu, Wenli and Hua, Yuanzi and Tien, Henry and Rogers, Thomas F and Landais, Elise and Sok, Devin and Jardine, Joseph G and Burton, Dennis R and Wilson, Ian A
Science (American Association for the Advancement of Science), ISSN 0036-8075, 08/2020, Volume 369, Issue 6507, pp. 1119 - 1123
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Coronavirus Infections - prevention & control | Complementarity Determining Regions - genetics | Humans | Pandemics - prevention & control | Viral Vaccines - genetics | Immunoglobulin Heavy Chains - chemistry | Crystallography, X-Ray | Betacoronavirus - immunology | COVID-19 | Antibodies, Neutralizing - immunology | SARS-CoV-2 | Complementarity Determining Regions - chemistry | Protein Domains | Binding Sites | Immunoglobulin Heavy Chains - immunology | Coronavirus Infections - genetics | Antibodies, Neutralizing - genetics | Coronavirus Infections - immunology | Pneumonia, Viral - immunology | Pneumonia, Viral - prevention & control | Antibodies, Neutralizing - chemistry | COVID-19 Vaccines | Antibodies, Viral - chemistry | Viral Vaccines - chemistry | Antibody Formation | Complementarity Determining Regions - immunology | Antibodies, Viral - immunology | Viral Vaccines - immunology | Antibodies, Viral - genetics | Immunoglobulin Heavy Chains - genetics | Analysis | Severe acute respiratory syndrome | Immunoglobulin G | Angiotensin converting enzyme | Crystals | Coronaviruses | Vaccines | Structure | Health aspects | Residues | IgG antibody | Variable region | Viral diseases | Antibodies | Chains | Drug development | Antibody response | Design | Proteins | Receptors | Complementarity-determining region | Crystal structure | Antigens | Immunoglobulins | Maturation | Spike protein | Angiotensin I | Severe acute respiratory syndrome coronavirus 2 | Domains | Neutralizing | Respiratory diseases | Angiotensin | Affinity | Mutation | Binding sites | Recognition | Index Medicus
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6. Full Text Landscape of tumor-infiltrating T cell repertoire of human cancers
by Li, Bo and Li, Taiwen and Pignon, Jean-Christophe and Wang, Binbin and Wang, Jinzeng and Shukla, Sachet A and Dou, Ruoxu and Chen, Qianming and Hodi, F Stephen and Choueiri, Toni K and Wu, Catherine and Hacohen, Nir and Signoretti, Sabina and Liu, Jun S and Liu, X. Shirley
Nature genetics, ISSN 1061-4036, 07/2016, Volume 48, Issue 7, pp. 725 - 732
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | T-Lymphocyte Subsets - immunology | Antigens, Neoplasm - genetics | Complementarity Determining Regions - genetics | Humans | HLA Antigens - genetics | Mutation - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | Neoplasms - genetics | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | High-Throughput Nucleotide Sequencing - methods | Neoplasm Proteins - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Gene mutations | Innovations | Genetic aspects | Complementarity-determining regions | Identification and classification | Carcinogenesis | Health aspects | Computational biology | Performance evaluation | Antigens | Statistical analysis | Sample size | Cloning | T cell receptors | Genomes | Lymphocytes | Immunotherapy | Mutation | Methods | Deoxyribonucleic acid--DNA | Tumors | Cancer | Index Medicus
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7. Full Text Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
by Doria-Rose, Nicole A and Schramm, Chaim A and Gorman, Jason and Moore, Penny L and Bhiman, Jinal N and Dekosky, Brandon J and Ernandes, Michael J and Georgiev, Ivelin S and Kim, Helen J and Pancera, Marie and Staupe, Ryan P and Altae-Tran, Han R and Bailer, Robert T and Crooks, Ema T and Cupo, Albert and z, Aliaksan and Garrett, Nigel J and Hoi, Kam H and Kong, Rui and Louder, Mark K and Longo, Nancy S and McKee, Krisha and Nonyane, Molati and O'Dell, Sijy and Roark, Ryan S and Rudicell, Rebecca S and Schmidt, Stephen D and Sheward, Daniel J and Soto, Cinque and Wibmer, Constantinos Kurt and Yang, Yongping and Zhang, Zhenhai and Mullikin, James C and Binley, James M and Sanders, Rogier W and Wilson, Ian A and Moore, John P and Ward, Anew B and Georgiou, George and Williamson, Carolyn and Abdool Karim, Salim S and Morris, Lynn and Kwong, Peter D and Shapiro, Lawrence and Mascola, John R and Becker, Jesse and Benjamin, Betty and Blakesley, Robert and Bouffard, Gerry and Brooks, Shelise and Coleman, Holly and Dekhtyar, Mila and Gregory, Michael and Guan, Xiaobin and Gupta, Jyoti and Han, Joel and Hargrove, April and Ho, Shi-ling and Johnson, Taccara and Legaspi, Richelle and Lovett, Sean and Maduro, Quino and Masiello, Cathy and Maskeri, Baishali and McDowell, Jenny and Montemayor, Casana and Mullikin, James and Park, Morgan and Riebow, Nancy and Schandler, Karen and Schmidt, Brian and Sison, Christina and Stantripop, Mal and Thomas, James and Thomas, Pam and Vemulapalli, Meg and Young, Alice and NISC Comparative Sequencing and NISC Comparative Sequencing Program
Nature (London), ISSN 0028-0836, 2014, Volume 509, Issue 7498, pp. 55 - 62
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Complementarity Determining Regions - genetics | Epitope Mapping | Epitopes, B-Lymphocyte - chemistry | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | Antibody Affinity - immunology | Neutralization Tests | Epitopes, B-Lymphocyte - immunology | HIV Antibodies - isolation & purification | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV Envelope Protein gp160 - chemistry | Complementarity Determining Regions - chemistry | HIV-1 - chemistry | Binding Sites - immunology | B-Lymphocytes - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | CD4 Antigens - immunology | B-Lymphocytes - cytology | Models, Molecular | Antibody Affinity - genetics | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Antibodies, Neutralizing - isolation & purification | Cell Lineage | HIV-1 - immunology | B-Lymphocytes - immunology | Antibodies, Neutralizing - chemistry | Complementarity Determining Regions - immunology | HIV Envelope Protein gp160 - immunology | HIV Antibodies - genetics | Somatic Hypermutation, Immunoglobulin - genetics | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | Antigen-antibody reactions | AIDS vaccines | AIDS (Disease) | Antibodies | Physiological aspects | Research | AIDS research | Cell culture | Genes | Human immunodeficiency virus--HIV | Phylogenetics | Amino acids | Infections | Genomes | Mutation | Index Medicus
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8. Full Text Shaping of human germline IgH repertoires revealed by deep sequencing
by Larimore, Kevin and McCormick, Michael W and Robins, Harlan S and Greenberg, Philip D
The Journal of immunology (1950), ISSN 0022-1767, 09/2012, Volume 189, Issue 6, pp. 3221 - 3230
Life Sciences & Biomedicine | Immunology | Science & Technology | Complementarity Determining Regions - genetics | Conserved Sequence - genetics | Immunoglobulin Heavy Chains - biosynthesis | Humans | Immunoglobulin Variable Region - biosynthesis | B-Lymphocyte Subsets - cytology | Gene Rearrangement, B-Lymphocyte - immunology | Immunoglobulin Joining Region - biosynthesis | Cell Differentiation - genetics | B-Lymphocyte Subsets - immunology | Conserved Sequence - immunology | Protein Precursors - genetics | Somatic Hypermutation, Immunoglobulin | Computational Biology | Antibodies, Neutralizing - genetics | Immunoglobulin Joining Region - genetics | HIV-1 - genetics | Cell Differentiation - immunology | Complementarity Determining Regions - biosynthesis | HIV-1 - immunology | B-Lymphocyte Subsets - metabolism | Antibodies, Neutralizing - biosynthesis | Protein Precursors - biosynthesis | Immunoglobulin Variable Region - genetics | Sequence Analysis, DNA - methods | Immunoglobulin Heavy Chains - genetics | Index Medicus | Abridged Index Medicus
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9. Full Text Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
by Steukers, Mieke and Hufton, Simon E and Rem, Louise and van Hegelsom, Rob and Nastri, Horacio G and Neer, Nicole Coolen-van and Pieters, Henk and Daukandt, Marc and Hogan, Shannon and Frans, Nicolas and Sexton, Daniel J and Viswanathan, Malini and Hoet, René Michael and Kent, Rachel Baribault and Rookey, Kristin and Nixon, Andrew E and Leeds, Jennifer A and Rondon, Isaac J and Schoonbroodt, Sonia and Huang, Lili and Devlin, Mary and Cohen, Edward H and Kashin, Irina and Kuang, Guannan and Ladner, Robert Charles and Hoogenboom, Hennie R
Nature biotechnology, ISSN 1087-0156, 03/2005, Volume 23, Issue 3, pp. 344 - 348
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Health. Pharmaceutical industry | Industrial applications and implications. Economical aspects | Other active biomolecules | Biological and medical sciences | Production of active biomolecules | Complementarity Determining Regions - genetics | Immunoglobulin Fab Fragments - genetics | Protein Engineering - methods | Humans | Antibody Affinity | Peptide Library | Immunoglobulin Fab Fragments - biosynthesis | Antibody Formation | Protein Binding | Recombination, Genetic - genetics | Genetic Variation - genetics | Immunoglobulin Fab Fragments - immunology | Tissue Donors | Index Medicus
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