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Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2280 - 14
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia ( FA) is a rare disease characterized by bone... 
UBIQUITINATION | DAMAGE RESPONSE | CHROMATIN | CROSS-LINK REPAIR | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | BRCA1 | ENRICHMENT ANALYSIS | ASSOCIATION | NUCLEASE | Genetic Therapy | Ubiquitin-Specific Proteases - genetics | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | DNA Repair - physiology | DNA Repair - genetics | Fanconi Anemia Complementation Group C Protein - genetics | Fanconi Anemia Complementation Group A Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - deficiency | Fanconi Anemia Complementation Group A Protein - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Fanconi Anemia Complementation Group G Protein - genetics | Ubiquitin-Specific Proteases - deficiency | Fanconi Anemia Complementation Group G Protein - deficiency | BRCA1 Protein - metabolism | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Chromosomal Instability | Rad51 Recombinase - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - deficiency | Fanconi Anemia Complementation Group Proteins - genetics | Fanconi Anemia Complementation Group G Protein - metabolism | Gene Knockout Techniques | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Fanconi Anemia Complementation Group A Protein - deficiency | CRISPR-Cas Systems | Fanconi Anemia Complementation Group C Protein - deficiency | Fanconi Anemia - therapy | DNA Damage | Histones - metabolism | Mutation | Phenotypes | Stability | Deactivation | BRCA1 protein | Anemia | Abnormalities | DNA damage | Genotoxicity | Health risks | Crosslinking | Breast cancer | Genomes | Inactivation | Fanconi syndrome | DNA repair | Screens | Genomic instability | FANCC protein | Bone cancer | Bone marrow | Repair | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 65, Issue 2, pp. 247 - 259
Monoubiquitination and deubiquitination of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that is defective in the cancer predisposition... 
core complex | RING E3 | Fanconi anemia | FANCD2 | deubiquitination | FANCB | enzyme mechanism | monoubiquitination | DNA repair | NUCLEAR ACCUMULATION | MONOUBIQUITINATED FANCD2 | TARGETED DISRUPTION | COMPLEX | DNA-REPAIR PATHWAY | CROSS-LINK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS | DAMAGE | COMPLEMENTATION GROUP-B | LIGASE | CELL BIOLOGY | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | Multiprotein Complexes | Protein Multimerization | Substrate Specificity | Fanconi Anemia Complementation Group A Protein - metabolism | DNA-Binding Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Transfection | Time Factors | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Recombinant Proteins - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - genetics | Nuclear Proteins - metabolism | Fanconi Anemia Complementation Group G Protein - metabolism | DNA - metabolism | Inhibitor of Differentiation Protein 2 - metabolism | DNA - genetics | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Protein Binding | Fanconi Anemia Complementation Group L Protein - metabolism | Fanconi Anemia Complementation Group E Protein - metabolism | Ubiquitin | Chemotherapy | Ligases | Genomics | Research institutes | Cancer | Fanconi's anemia | Proteins | Medical research | Molecular genetics | Medicine, Experimental
Journal Article
Blood, ISSN 0006-4971, 09/2006, Volume 108, Issue 6, pp. 2072 - 2080
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 2, pp. 388 - 404
Journal Article
Journal of biomedical science, ISSN 1021-7770, 09/2015, Volume 22, Issue 1, p. 77
Background: Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development... 
RNA interference | Fanconi anemia/BRCA pathway | Lung cancer | Cisplatin | Chemoresistance | Core complex | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTEIN | CHEMOTHERAPY | CELL BIOLOGY | CROSS-LINK REPAIR | MUTATIONS | EXPRESSION | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Fanconi Anemia Complementation Group D2 Protein - genetics | Humans | Lung Neoplasms - metabolism | Fanconi Anemia Complementation Group F Protein - metabolism | Fanconi Anemia Complementation Group L Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - antagonists & inhibitors | Lung Neoplasms - pathology | Signal Transduction - genetics | Cisplatin - pharmacology | Fanconi Anemia Complementation Group F Protein - genetics | Fanconi Anemia Complementation Group L Protein - antagonists & inhibitors | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | BRCA1 Protein - antagonists & inhibitors | Fanconi Anemia Complementation Group D2 Protein - metabolism | RNA Interference | Signal Transduction - drug effects | BRCA1 Protein - metabolism | Fanconi Anemia Complementation Group F Protein - antagonists & inhibitors | Cell Line, Tumor | Fanconi Anemia Complementation Group L Protein - metabolism | Drug Resistance, Neoplasm - drug effects | RNA | DNA damage | Genes | Respiratory agents | Drug resistance | Antineoplastic agents | Fanconi's anemia | Antimitotic agents | Prevention | Chemotherapy | Cancer cells | Genetic research | Genetic aspects | Drug therapy | Health aspects | Cancer | Ribonucleic acid--RNA | Anemia
Journal Article
Molecular cell, ISSN 1097-2765, 2018, Volume 71, Issue 4, pp. 621 - 628.e4
FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report... 
FANCA | strand exchange | DNA double-strand break repair | Fanconi anemia | single-strand annealing | UBIQUITINATION | COMPLEX | RESECTION | REPLICATION PROTEIN-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | HUMAN RAD52 PROTEIN | ANEMIA PATHWAY | LIGASE RFWD3 | HOMOLOGOUS RECOMBINATION | ACCUMULATION | CELL BIOLOGY | Epithelial Cells - metabolism | Baculoviridae - metabolism | Humans | Baculoviridae - genetics | Moths | DNA Breaks, Double-Stranded | Fanconi Anemia Complementation Group A Protein - genetics | Fanconi Anemia Complementation Group A Protein - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Fanconi Anemia Complementation Group G Protein - genetics | Rad52 DNA Repair and Recombination Protein - metabolism | DNA End-Joining Repair | DNA Mismatch Repair | Cloning, Molecular | Osteoblasts - cytology | Epithelial Cells - cytology | Recombinant Proteins - metabolism | Gene Expression | Recombinational DNA Repair | Genetic Vectors - chemistry | Fanconi Anemia Complementation Group Proteins - genetics | Genetic Vectors - metabolism | Fanconi Anemia Complementation Group G Protein - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | DNA - genetics | Animals | Cell Line, Tumor | Osteoblasts - metabolism | Yuan (China) | Medical colleges | Annealing | DNA | Genetic research | Molecular biology | Fanconi's anemia | DNA double strand break repair
Journal Article
Blood, ISSN 0006-4971, 05/2013, Volume 121, Issue 22, pp. e138 - 148
Journal Article
Clinical cancer research, ISSN 1557-3265, 2005, Volume 11, Issue 20, pp. 7508 - 7515
Purpose: BRCA2, FANCC , and FANCG gene mutations are present in a subset of pancreatic cancer. Defects in these genes could lead to hypersensitivity to... 
BRCA1, BRCA2 | Xenograft models | DNA damage and repair mechanisms | Pharmacogenetics/pharmacogenomics | Gastrointestinal cancers: other | GENE-MUTATIONS | LUNG-CANCER | FUNCTIONAL-ACTIVITY | ONCOLOGY | ABL TYROSINE KINASE | MITOMYCIN-C | PANCREATIC-CANCER | RANDOMIZED-TRIAL | PHASE-II | COMPLEMENTATION GROUP | CARCINOMA | Paclitaxel - pharmacology | Apoptosis - drug effects | Cross-Linking Reagents - pharmacology | Humans | Deoxycytidine - pharmacology | Chlorambucil - pharmacology | Fanconi Anemia Complementation Group C Protein - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Caspases - metabolism | Fanconi Anemia Complementation Group G Protein - genetics | Time Factors | Cross-Linking Reagents - therapeutic use | Fanconi Anemia Complementation Group G Protein - deficiency | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Cell Survival - drug effects | Fanconi Anemia Complementation Group Proteins - deficiency | Mitomycin - therapeutic use | Pancreatic Neoplasms - pathology | Fanconi Anemia Complementation Group Proteins - genetics | Etoposide - pharmacology | Pancreatic Neoplasms - genetics | Cisplatin - pharmacology | Xenograft Model Antitumor Assays - methods | Mitomycin - pharmacology | Animals | Mice, Nude | Cell Line, Tumor | Fanconi Anemia Complementation Group C Protein - deficiency | BRCA2 Protein - deficiency |