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Publication DateBlood, ISSN 0006-4971, 01/2007, Volume 109, Issue 1, pp. 228 - 234
The molecular mechanisms by which mesenchymal stem cells (MSCs) suppress T-cell proliferation are poorly understood, and whether a soluble factor plays a major...
SYNTHASE | RESPONSES | ENGRAFTMENT | ACTIVATION | PATHWAY | IMMUNOSUPPRESSION | GROWTH | HEMATOLOGY | MARROW STROMAL CELLS | INHIBIT | TRANSPLANTATION | CD8-Positive T-Lymphocytes - cytology | Dinoprostone - physiology | Humans | B-Lymphocyte Subsets - cytology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Phosphorylation - drug effects | Macrophages - physiology | B-Lymphocyte Subsets - drug effects | Nitric Oxide - biosynthesis | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | Cell Division - drug effects | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | B-Lymphocyte Subsets - metabolism | Mice | Tryptophan - pharmacology | HeLa Cells | Interleukin-2 - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Nitric Oxide Synthase Type II - metabolism | Tetradecanoylphorbol Acetate - pharmacology | T-Lymphocyte Subsets - cytology | Concanavalin A - pharmacology | Nitric Oxide - pharmacology | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Tryptophan - analogs & derivatives | Enzyme Induction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Mesenchymal Stromal Cells - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Transforming Growth Factor beta - immunology | Cell Line | Antigens, CD19 - analysis | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide - physiology | Cyclooxygenase Inhibitors - pharmacology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Ionomycin - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interferon-gamma - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology
SYNTHASE | RESPONSES | ENGRAFTMENT | ACTIVATION | PATHWAY | IMMUNOSUPPRESSION | GROWTH | HEMATOLOGY | MARROW STROMAL CELLS | INHIBIT | TRANSPLANTATION | CD8-Positive T-Lymphocytes - cytology | Dinoprostone - physiology | Humans | B-Lymphocyte Subsets - cytology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Phosphorylation - drug effects | Macrophages - physiology | B-Lymphocyte Subsets - drug effects | Nitric Oxide - biosynthesis | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | Cell Division - drug effects | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | B-Lymphocyte Subsets - metabolism | Mice | Tryptophan - pharmacology | HeLa Cells | Interleukin-2 - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Nitric Oxide Synthase Type II - metabolism | Tetradecanoylphorbol Acetate - pharmacology | T-Lymphocyte Subsets - cytology | Concanavalin A - pharmacology | Nitric Oxide - pharmacology | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Tryptophan - analogs & derivatives | Enzyme Induction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Mesenchymal Stromal Cells - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Transforming Growth Factor beta - immunology | Cell Line | Antigens, CD19 - analysis | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide - physiology | Cyclooxygenase Inhibitors - pharmacology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Ionomycin - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interferon-gamma - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology
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Loading RightsMolecular Immunology, ISSN 0161-5890, 12/2013, Volume 56, Issue 4, pp. 328 - 339
Estrogen is a key hormone in facilitating ovulation and maintenance of pregnancy in young females and subsequent decline in its production contributes to the...
Estrogen receptor | CREB | Nitric oxide | Cytokine | 17β-Estradiol | Akt | ERK | SIGNALING PATHWAYS | OXIDATIVE STRESS | SEX-HORMONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAUMA-HEMORRHAGE | IMMUNOLOGY | 17-BETA-ESTRADIOL | BREAST-CANCER | CYTOKINE PRODUCTION | INTERFERON-GAMMA | ALPHA EXPRESSION | BACOPA-MONNIERI | 17 beta-Estradiol | Propionates - pharmacology | Estradiol - analogs & derivatives | Estrogens - pharmacology | Nitriles - pharmacology | Concanavalin A - pharmacology | Antioxidants - metabolism | Estrogen Antagonists - pharmacology | Dose-Response Relationship, Drug | Estrogen Receptor beta - metabolism | Intracellular Space - enzymology | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Estrogen Receptor alpha - metabolism | Estrogen Receptor beta - antagonists & inhibitors | Estradiol - pharmacology | Superoxide Dismutase - metabolism | Phenols - pharmacology | Pyrazoles - pharmacology | Glutathione Peroxidase - metabolism | Intracellular Space - drug effects | Cytokines - metabolism | Cells, Cultured | Rats | Estrogen Receptor alpha - antagonists & inhibitors | Spleen - cytology | Rats, Sprague-Dawley | Catalase - metabolism | Animals | Tamoxifen - pharmacology | Cell Proliferation - drug effects | Nitric Oxide - metabolism | Antioxidants | Phenols | Enzymes | T cells | Estrogen
Estrogen receptor | CREB | Nitric oxide | Cytokine | 17β-Estradiol | Akt | ERK | SIGNALING PATHWAYS | OXIDATIVE STRESS | SEX-HORMONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAUMA-HEMORRHAGE | IMMUNOLOGY | 17-BETA-ESTRADIOL | BREAST-CANCER | CYTOKINE PRODUCTION | INTERFERON-GAMMA | ALPHA EXPRESSION | BACOPA-MONNIERI | 17 beta-Estradiol | Propionates - pharmacology | Estradiol - analogs & derivatives | Estrogens - pharmacology | Nitriles - pharmacology | Concanavalin A - pharmacology | Antioxidants - metabolism | Estrogen Antagonists - pharmacology | Dose-Response Relationship, Drug | Estrogen Receptor beta - metabolism | Intracellular Space - enzymology | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Estrogen Receptor alpha - metabolism | Estrogen Receptor beta - antagonists & inhibitors | Estradiol - pharmacology | Superoxide Dismutase - metabolism | Phenols - pharmacology | Pyrazoles - pharmacology | Glutathione Peroxidase - metabolism | Intracellular Space - drug effects | Cytokines - metabolism | Cells, Cultured | Rats | Estrogen Receptor alpha - antagonists & inhibitors | Spleen - cytology | Rats, Sprague-Dawley | Catalase - metabolism | Animals | Tamoxifen - pharmacology | Cell Proliferation - drug effects | Nitric Oxide - metabolism | Antioxidants | Phenols | Enzymes | T cells | Estrogen
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Loading RightsProceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2002, Volume 99, Issue 5, pp. 2995 - 3000
Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar molecule; SAHA specifically binds to and inhibits the activity of histone...
Biological Sciences | Messenger RNA | Antiinflammatories | Cytokines | Butyrates | Secretion | Cell lines | Histones | Mice | Macrophages | Tumors | CELLS | APOPTOSIS | ACTIVATION | ACETYLATION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | BUTYRATE | INDUCTION | DIFFERENTIATION | TRICHOSTATIN-A | Leukocytes, Mononuclear - metabolism | Mitogens - pharmacology | Concanavalin A - pharmacology | Humans | Antineoplastic Agents - administration & dosage | RNA, Messenger - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Enzyme Inhibitors - administration & dosage | Liver - injuries | Liver - drug effects | Hydroxamic Acids - administration & dosage | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Cytokines - genetics | Hydroxamic Acids - pharmacology | Macrophages, Peritoneal - drug effects | Hepatocytes - drug effects | Interleukin-12 - biosynthesis | Nitric Oxide - biosynthesis | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Interferon-gamma - secretion | Tumor Necrosis Factor-alpha - secretion | Cells, Cultured | Enzyme Inhibitors - pharmacology | CD3 Complex - metabolism | Cell Division - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Lipopolysaccharides - pharmacology | Leukocytes, Mononuclear - cytology | Histone Deacetylase Inhibitors | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Interleukin-1 - secretion | Interferon-gamma - pharmacology | Usage | Immunocytochemistry | Physiological aspects | Inflammation | Research | Liver cells | lipopolysaccharides | suberoylanilide hydroxamic acid | histone deacetylase inhibitors
Biological Sciences | Messenger RNA | Antiinflammatories | Cytokines | Butyrates | Secretion | Cell lines | Histones | Mice | Macrophages | Tumors | CELLS | APOPTOSIS | ACTIVATION | ACETYLATION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | BUTYRATE | INDUCTION | DIFFERENTIATION | TRICHOSTATIN-A | Leukocytes, Mononuclear - metabolism | Mitogens - pharmacology | Concanavalin A - pharmacology | Humans | Antineoplastic Agents - administration & dosage | RNA, Messenger - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Enzyme Inhibitors - administration & dosage | Liver - injuries | Liver - drug effects | Hydroxamic Acids - administration & dosage | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Cytokines - genetics | Hydroxamic Acids - pharmacology | Macrophages, Peritoneal - drug effects | Hepatocytes - drug effects | Interleukin-12 - biosynthesis | Nitric Oxide - biosynthesis | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Interferon-gamma - secretion | Tumor Necrosis Factor-alpha - secretion | Cells, Cultured | Enzyme Inhibitors - pharmacology | CD3 Complex - metabolism | Cell Division - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Lipopolysaccharides - pharmacology | Leukocytes, Mononuclear - cytology | Histone Deacetylase Inhibitors | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Interleukin-1 - secretion | Interferon-gamma - pharmacology | Usage | Immunocytochemistry | Physiological aspects | Inflammation | Research | Liver cells | lipopolysaccharides | suberoylanilide hydroxamic acid | histone deacetylase inhibitors
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Loading RightsPLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31318
Background: Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries,...
SIGNAL-TRANSDUCTION | RESPONSES | ACTIVATION | CYCLOSPORINE-A | CELL-RECEPTOR STIMULATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FACTOR-ALPHA GENE | INHALED CORTICOSTEROIDS | T-CELLS | OLEANOLIC ACID | CD8-Positive T-Lymphocytes - cytology | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Mitogens - pharmacology | Concanavalin A - pharmacology | NF-kappa B - metabolism | CD4-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - immunology | Transcription Factor AP-1 - metabolism | Lymphocyte Activation - genetics | Macrophages - secretion | B-Lymphocytes - secretion | Oxidation-Reduction - drug effects | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | CD4-Positive T-Lymphocytes - cytology | NFATC Transcription Factors - metabolism | Cytokines - secretion | CD28 Antigens - immunology | Antioxidants - pharmacology | Macrophages - cytology | CD8-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - pathology | Up-Regulation - drug effects | B-Lymphocytes - drug effects | Animals | CD4-Positive T-Lymphocytes - secretion | CD8-Positive T-Lymphocytes - secretion | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | CD3 Complex - immunology | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | CD4-Positive T-Lymphocytes - drug effects | Mitogen-Activated Protein Kinases - metabolism | Graft-versus-host reaction | Transcription factors | Oregano | Cancer therapies | Cranberries | Anticancer properties | Proteins | Antioxidants | Cell activation | Cell growth | Inhibition | Enzymes | NF-κB protein | Cytokines | Albinism | Immunoregulation | Activator protein 1 | Peppermint | Prunes | JNK protein | T cell receptors | Carboxylic acids | Serum levels | Apples | γ-Interferon | Rosemary | Ursolic acid | Cell proliferation | Health sciences | Phosphorylation | Ordination | Homeostasis | Lymphocytes T | Transplantation | Biology | Activation | NF-AT protein | Kinases | Macrophages | Inflammatory diseases | Interleukin 6 | Lymphocytes | Transcription activation | Cell cycle | Tumor necrosis factor-TNF | Statistical analysis | Antiinflammatory agents | Secretion | Extracellular signal-regulated kinase | Inflammation | Pharmacology | Acids | Lymphocytes B | Interferon | Alzheimers disease | Apoptosis
SIGNAL-TRANSDUCTION | RESPONSES | ACTIVATION | CYCLOSPORINE-A | CELL-RECEPTOR STIMULATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FACTOR-ALPHA GENE | INHALED CORTICOSTEROIDS | T-CELLS | OLEANOLIC ACID | CD8-Positive T-Lymphocytes - cytology | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Mitogens - pharmacology | Concanavalin A - pharmacology | NF-kappa B - metabolism | CD4-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - immunology | Transcription Factor AP-1 - metabolism | Lymphocyte Activation - genetics | Macrophages - secretion | B-Lymphocytes - secretion | Oxidation-Reduction - drug effects | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | CD4-Positive T-Lymphocytes - cytology | NFATC Transcription Factors - metabolism | Cytokines - secretion | CD28 Antigens - immunology | Antioxidants - pharmacology | Macrophages - cytology | CD8-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - pathology | Up-Regulation - drug effects | B-Lymphocytes - drug effects | Animals | CD4-Positive T-Lymphocytes - secretion | CD8-Positive T-Lymphocytes - secretion | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | CD3 Complex - immunology | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | CD4-Positive T-Lymphocytes - drug effects | Mitogen-Activated Protein Kinases - metabolism | Graft-versus-host reaction | Transcription factors | Oregano | Cancer therapies | Cranberries | Anticancer properties | Proteins | Antioxidants | Cell activation | Cell growth | Inhibition | Enzymes | NF-κB protein | Cytokines | Albinism | Immunoregulation | Activator protein 1 | Peppermint | Prunes | JNK protein | T cell receptors | Carboxylic acids | Serum levels | Apples | γ-Interferon | Rosemary | Ursolic acid | Cell proliferation | Health sciences | Phosphorylation | Ordination | Homeostasis | Lymphocytes T | Transplantation | Biology | Activation | NF-AT protein | Kinases | Macrophages | Inflammatory diseases | Interleukin 6 | Lymphocytes | Transcription activation | Cell cycle | Tumor necrosis factor-TNF | Statistical analysis | Antiinflammatory agents | Secretion | Extracellular signal-regulated kinase | Inflammation | Pharmacology | Acids | Lymphocytes B | Interferon | Alzheimers disease | Apoptosis
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Leading tip drives soma translocation via forward F-actin flow during neuronal migration
Journal of Neuroscience, ISSN 0270-6474, 08/2010, Volume 30, Issue 32, pp. 10885 - 10898
Neuronal migration involves coordinated extension of the leading process and translocation of the soma, but the relative contribution of different subcellular...
ANIMAL-CELLS | DOUBLECORTIN | SIGNALING PATHWAY | CENTROSOME | LIGHT-CHAIN | RHO-KINASE | CORTICAL FLOW | MYOSIN-II | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | GROWTH CONE | Mitogens - pharmacology | Concanavalin A - pharmacology | Tubulin Modulators - pharmacology | Actins - metabolism | Nocodazole - pharmacology | Protein Transport - physiology | Green Fluorescent Proteins - genetics | Protein Transport - drug effects | Cell Movement - physiology | Actins - genetics | Microtubules - metabolism | Drug Interactions | Transfection - methods | Time Factors | Neurons - physiology | Neurons - drug effects | Thiazolidines - pharmacology | Animals, Newborn | Growth Cones - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Microscopy, Confocal - methods | Rats, Sprague-Dawley | Cell Movement - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Cerebellum - cytology | Myosin Light Chains - metabolism
ANIMAL-CELLS | DOUBLECORTIN | SIGNALING PATHWAY | CENTROSOME | LIGHT-CHAIN | RHO-KINASE | CORTICAL FLOW | MYOSIN-II | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | GROWTH CONE | Mitogens - pharmacology | Concanavalin A - pharmacology | Tubulin Modulators - pharmacology | Actins - metabolism | Nocodazole - pharmacology | Protein Transport - physiology | Green Fluorescent Proteins - genetics | Protein Transport - drug effects | Cell Movement - physiology | Actins - genetics | Microtubules - metabolism | Drug Interactions | Transfection - methods | Time Factors | Neurons - physiology | Neurons - drug effects | Thiazolidines - pharmacology | Animals, Newborn | Growth Cones - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Microscopy, Confocal - methods | Rats, Sprague-Dawley | Cell Movement - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Cerebellum - cytology | Myosin Light Chains - metabolism
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Loading RightsInternational Immunopharmacology, ISSN 1567-5769, 01/2013, Volume 15, Issue 1, pp. 160 - 166
Many anticancer agents currently used are considered to be cytotoxic not only to cancer cells but also to functional immune cells. To learn more about the...
T cell mitogen | Peripheral blood mononuclear cells | Anticancer agents | CD4+CD25+Foxp3+ regulatory T cells | Cytokine | regulatory T cells | CD4 | CD25 | Foxp3 | CD4(+)CD25(+)Foxp3(+) regulatory T cells | PHARMACODYNAMICS | IMMUNOLOGY | CANCER | SUPERANTIGEN | 5-FLUOROURACIL | DISEASE | DRUGS | PHARMACOLOGY & PHARMACY | SUPPRESSIVE EFFICACY | MODULATION | Methotrexate - pharmacology | Cell Survival - drug effects | Mitogens - pharmacology | Concanavalin A - pharmacology | Arsenicals - pharmacology | Humans | Male | T-Lymphocytes, Regulatory - immunology | Young Adult | Oxides - pharmacology | T-Lymphocytes, Regulatory - drug effects | Dacarbazine - pharmacology | Adolescent | Adult | Female | Leukocytes, Mononuclear - cytology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Immunosuppressive Agents - pharmacology | Cytokines - immunology
T cell mitogen | Peripheral blood mononuclear cells | Anticancer agents | CD4+CD25+Foxp3+ regulatory T cells | Cytokine | regulatory T cells | CD4 | CD25 | Foxp3 | CD4(+)CD25(+)Foxp3(+) regulatory T cells | PHARMACODYNAMICS | IMMUNOLOGY | CANCER | SUPERANTIGEN | 5-FLUOROURACIL | DISEASE | DRUGS | PHARMACOLOGY & PHARMACY | SUPPRESSIVE EFFICACY | MODULATION | Methotrexate - pharmacology | Cell Survival - drug effects | Mitogens - pharmacology | Concanavalin A - pharmacology | Arsenicals - pharmacology | Humans | Male | T-Lymphocytes, Regulatory - immunology | Young Adult | Oxides - pharmacology | T-Lymphocytes, Regulatory - drug effects | Dacarbazine - pharmacology | Adolescent | Adult | Female | Leukocytes, Mononuclear - cytology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Immunosuppressive Agents - pharmacology | Cytokines - immunology
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Loading RightsToxicology and Applied Pharmacology, ISSN 0041-008X, 07/2006, Volume 214, Issue 2, pp. 166 - 177
Although uranium is a well-characterized nephrotoxic agent, very little is known at the cellular and molecular level about the mechanisms underlying the uptake...
Sodium-dependent phosphate co-transport | Uranium | NaPi | Cytotoxicity | LLC-PK | MDCK | Uranyl | Speciation | RENAL EPITHELIAL-CELLS | LLC-PK1 | NITRATE | RAT-KIDNEY | uranyl | DOWN-REGULATION | speciation | sodium-dependent phosphate co-transport | INORGANIC ANION-EXCHANGER | PARATHYROID-HORMONE | I-COTRANSPORTER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | uranium | PROXIMAL TUBULE | APICAL MEMBRANE | ADAPTIVE RESPONSE | cytotoxicity | Colchicine - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Foscarnet - pharmacology | Concanavalin A - pharmacology | Maleimides - pharmacology | Carbonates - pharmacology | Cytochalasin D - pharmacology | Tetradecanoylphorbol Acetate - antagonists & inhibitors | Sodium-Phosphate Cotransporter Proteins, Type IIa - metabolism | Dose-Response Relationship, Drug | LLC-PK1 Cells | Uranium - toxicity | Dexamethasone - pharmacology | Swine | Computer Simulation | Indoles - pharmacology | Sodium-Phosphate Cotransporter Proteins, Type IIb - physiology | Phosphates - pharmacology | Cell Survival - drug effects | Kidney Tubules, Proximal - cytology | Cadmium - toxicity | Phosphates - physiology | Meglumine - analogs & derivatives | Calcium Chloride - pharmacology | Animals | Meglumine - pharmacology | Uranium Compounds | Phosphates - antagonists & inhibitors | Kidney Tubules, Proximal - metabolism | Kidney Tubules, Proximal - drug effects
Sodium-dependent phosphate co-transport | Uranium | NaPi | Cytotoxicity | LLC-PK | MDCK | Uranyl | Speciation | RENAL EPITHELIAL-CELLS | LLC-PK1 | NITRATE | RAT-KIDNEY | uranyl | DOWN-REGULATION | speciation | sodium-dependent phosphate co-transport | INORGANIC ANION-EXCHANGER | PARATHYROID-HORMONE | I-COTRANSPORTER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | uranium | PROXIMAL TUBULE | APICAL MEMBRANE | ADAPTIVE RESPONSE | cytotoxicity | Colchicine - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Foscarnet - pharmacology | Concanavalin A - pharmacology | Maleimides - pharmacology | Carbonates - pharmacology | Cytochalasin D - pharmacology | Tetradecanoylphorbol Acetate - antagonists & inhibitors | Sodium-Phosphate Cotransporter Proteins, Type IIa - metabolism | Dose-Response Relationship, Drug | LLC-PK1 Cells | Uranium - toxicity | Dexamethasone - pharmacology | Swine | Computer Simulation | Indoles - pharmacology | Sodium-Phosphate Cotransporter Proteins, Type IIb - physiology | Phosphates - pharmacology | Cell Survival - drug effects | Kidney Tubules, Proximal - cytology | Cadmium - toxicity | Phosphates - physiology | Meglumine - analogs & derivatives | Calcium Chloride - pharmacology | Animals | Meglumine - pharmacology | Uranium Compounds | Phosphates - antagonists & inhibitors | Kidney Tubules, Proximal - metabolism | Kidney Tubules, Proximal - drug effects
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Loading RightsBrain Research, ISSN 0006-8993, 2004, Volume 1006, Issue 1, pp. 8 - 17
Primary cultures of neocortical neurons exhibit spontaneous Ca oscillations under zero or low extracellular [Mg ] conditions. We find that mature murine...
Calcium oscillation | AMPA receptor | Magnesium | NMDA receptor | Neocortical neuron | Metabotropic glutamate receptor | Excitatory amino acid receptors: physiology, pharmacology and modulation | Neurotransmitters, modulators, transporters and receptors | SPECIFICITY | metabotropic glutamate receptor | magnesium | NEUROSCIENCES | CULTURED CORTICAL-NEURONS | TRANSIENTS | FREQUENCY | GENE-EXPRESSION | CHANNELS | neocortical neuron | RAT-BRAIN | DIFFERENTIATION | calcium oscillation | BINDING | Antihypertensive Agents - pharmacology | Receptors, Glutamate - classification | Aniline Compounds - metabolism | Concanavalin A - pharmacology | Embryo, Mammalian | Calcium Signaling - physiology | Anesthetics, Local - pharmacology | Dose-Response Relationship, Drug | Xanthenes - metabolism | Magnesium - physiology | Neurons - metabolism | Tetrodotoxin - pharmacology | Nifedipine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Benzothiadiazines - pharmacology | Veratridine - pharmacology | Animals | Calcium Signaling - drug effects | Thapsigargin - pharmacology | Neocortex - cytology | Mice | Receptors, Glutamate - physiology
Calcium oscillation | AMPA receptor | Magnesium | NMDA receptor | Neocortical neuron | Metabotropic glutamate receptor | Excitatory amino acid receptors: physiology, pharmacology and modulation | Neurotransmitters, modulators, transporters and receptors | SPECIFICITY | metabotropic glutamate receptor | magnesium | NEUROSCIENCES | CULTURED CORTICAL-NEURONS | TRANSIENTS | FREQUENCY | GENE-EXPRESSION | CHANNELS | neocortical neuron | RAT-BRAIN | DIFFERENTIATION | calcium oscillation | BINDING | Antihypertensive Agents - pharmacology | Receptors, Glutamate - classification | Aniline Compounds - metabolism | Concanavalin A - pharmacology | Embryo, Mammalian | Calcium Signaling - physiology | Anesthetics, Local - pharmacology | Dose-Response Relationship, Drug | Xanthenes - metabolism | Magnesium - physiology | Neurons - metabolism | Tetrodotoxin - pharmacology | Nifedipine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Benzothiadiazines - pharmacology | Veratridine - pharmacology | Animals | Calcium Signaling - drug effects | Thapsigargin - pharmacology | Neocortex - cytology | Mice | Receptors, Glutamate - physiology
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Loading RightsFood & Function, ISSN 2042-6496, 2010, Volume 1, Issue 3, pp. 254 - 261
An assay was developed to study inflammation-related immune responses of food compounds on monocytes and macrophages derived from THP-1 cell line. First...
SIGNALING PATHWAYS | CYTOKINE PRODUCTION | MESSENGER-RNA | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | GENE-EXPRESSION | NECROSIS-FACTOR-ALPHA | TNF-ALPHA | CITRUS PECTIN | NF-KAPPA-B | BLOOD MONONUCLEAR-CELLS | Mitogens - pharmacology | Concanavalin A - pharmacology | Monocytes - cytology | Humans | Citrus - chemistry | Gene Expression Profiling | Hordeum - chemistry | Nitric Oxide Synthase Type II - immunology | Cyclooxygenase 2 - genetics | Monocytes - physiology | Transcription Factors - immunology | Cyclooxygenase 2 - immunology | Cytokines - genetics | Cytokines - immunology | Macrophages - physiology | Glucans - pharmacology | Macrophages - cytology | Transcription Factors - genetics | Monocytes - drug effects | Pectins - pharmacology | Nitric Oxide Synthase Type II - genetics | Quercetin - pharmacology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Immunologic Factors - pharmacology | necrosis-factor-alpha | cytokine production | signaling pathways | blood mononuclear-cells | citrus pectin | messenger-rna | gene-expression | nf-kappa-b | nitric-oxide synthase | tnf-alpha
SIGNALING PATHWAYS | CYTOKINE PRODUCTION | MESSENGER-RNA | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | GENE-EXPRESSION | NECROSIS-FACTOR-ALPHA | TNF-ALPHA | CITRUS PECTIN | NF-KAPPA-B | BLOOD MONONUCLEAR-CELLS | Mitogens - pharmacology | Concanavalin A - pharmacology | Monocytes - cytology | Humans | Citrus - chemistry | Gene Expression Profiling | Hordeum - chemistry | Nitric Oxide Synthase Type II - immunology | Cyclooxygenase 2 - genetics | Monocytes - physiology | Transcription Factors - immunology | Cyclooxygenase 2 - immunology | Cytokines - genetics | Cytokines - immunology | Macrophages - physiology | Glucans - pharmacology | Macrophages - cytology | Transcription Factors - genetics | Monocytes - drug effects | Pectins - pharmacology | Nitric Oxide Synthase Type II - genetics | Quercetin - pharmacology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Immunologic Factors - pharmacology | necrosis-factor-alpha | cytokine production | signaling pathways | blood mononuclear-cells | citrus pectin | messenger-rna | gene-expression | nf-kappa-b | nitric-oxide synthase | tnf-alpha
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Loading RightsInternational Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 2011, Volume 43, Issue 10, pp. 1442 - 1449
Lectins, a group of highly diverse, carbohydrate-binding proteins of non-immune origin that are ubiquitously distributed in plants, animals and fungi, are...
Autophagy | Plant lectin | Cancer | Programmed cell death (PCD) | Apoptosis | CANCER-CELLS | KOREAN MISTLETOE | POLYGONATUM-CYRTONEMA LECTIN | MISTLETOE LECTINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | A-INDUCED APOPTOSIS | CONCANAVALIN-A | IN-VITRO | MELANOMA A375 CELLS | SIGNAL-REGULATED KINASE | MOLECULAR-MECHANISMS | Ricin - therapeutic use | Apoptosis - drug effects | Concanavalin A - pharmacology | Mistletoe - chemistry | Humans | Mannose-Binding Lectins - pharmacology | Plant Lectins - pharmacology | Antineoplastic Agents - therapeutic use | Concanavalin A - therapeutic use | Antineoplastic Agents - chemistry | Plant Lectins - therapeutic use | Autophagy - drug effects | Mannose-Binding Lectins - chemistry | Mannose-Binding Lectins - therapeutic use | Ricin - pharmacology | Ricin - chemistry | Concanavalin A - chemistry | Polygonatum - chemistry | Antineoplastic Agents - pharmacology | Plant Lectins - chemistry | Legumes | Antigens | Care and treatment | Oncology, Experimental | Biochemistry | Plant lectins | Research | Antineoplastic agents | Mimosaceae | Antimitotic agents | Beans | Mitogens | Protein kinases
Autophagy | Plant lectin | Cancer | Programmed cell death (PCD) | Apoptosis | CANCER-CELLS | KOREAN MISTLETOE | POLYGONATUM-CYRTONEMA LECTIN | MISTLETOE LECTINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | A-INDUCED APOPTOSIS | CONCANAVALIN-A | IN-VITRO | MELANOMA A375 CELLS | SIGNAL-REGULATED KINASE | MOLECULAR-MECHANISMS | Ricin - therapeutic use | Apoptosis - drug effects | Concanavalin A - pharmacology | Mistletoe - chemistry | Humans | Mannose-Binding Lectins - pharmacology | Plant Lectins - pharmacology | Antineoplastic Agents - therapeutic use | Concanavalin A - therapeutic use | Antineoplastic Agents - chemistry | Plant Lectins - therapeutic use | Autophagy - drug effects | Mannose-Binding Lectins - chemistry | Mannose-Binding Lectins - therapeutic use | Ricin - pharmacology | Ricin - chemistry | Concanavalin A - chemistry | Polygonatum - chemistry | Antineoplastic Agents - pharmacology | Plant Lectins - chemistry | Legumes | Antigens | Care and treatment | Oncology, Experimental | Biochemistry | Plant lectins | Research | Antineoplastic agents | Mimosaceae | Antimitotic agents | Beans | Mitogens | Protein kinases
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Loading RightsBioMed Research International, ISSN 2314-6133, 2014, Volume 2014, pp. 179865 - 179865
This study explored the antioxidant and immunomodulatory potential of ethnomedicinally valuable species, namely, Arisaema jacquemontii of north-western...
MEDICINE, RESEARCH & EXPERIMENTAL | MICE | ASSAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HYPERSENSITIVITY | Plant Leaves - chemistry | Arisaema - chemistry | Concanavalin A - pharmacology | Plant Extracts - pharmacology | Rats | Male | Lymphocytes - cytology | Antioxidants - pharmacology | Iron - metabolism | Reducing Agents - pharmacology | Animals | Immunity, Cellular - drug effects | Iron Chelating Agents - pharmacology | Lymphocytes - drug effects | Ferrous Compounds - metabolism | Lipopolysaccharides - pharmacology | Immunity, Humoral - drug effects | Cell Proliferation - drug effects | Mice | Methanol - chemistry | Phytochemicals - pharmacology | Immunologic Factors - pharmacology | Usage | Immune response | Araceae | Regulation | Observations | Health aspects | Materia medica, Vegetable | Plant extracts | Antioxidants | Herbal medicine | Oxidative stress | Phytochemicals | Free radicals | Metabolites | Natural products | Mortality | Colleges & universities | Drug dosages | Index Medicus
MEDICINE, RESEARCH & EXPERIMENTAL | MICE | ASSAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HYPERSENSITIVITY | Plant Leaves - chemistry | Arisaema - chemistry | Concanavalin A - pharmacology | Plant Extracts - pharmacology | Rats | Male | Lymphocytes - cytology | Antioxidants - pharmacology | Iron - metabolism | Reducing Agents - pharmacology | Animals | Immunity, Cellular - drug effects | Iron Chelating Agents - pharmacology | Lymphocytes - drug effects | Ferrous Compounds - metabolism | Lipopolysaccharides - pharmacology | Immunity, Humoral - drug effects | Cell Proliferation - drug effects | Mice | Methanol - chemistry | Phytochemicals - pharmacology | Immunologic Factors - pharmacology | Usage | Immune response | Araceae | Regulation | Observations | Health aspects | Materia medica, Vegetable | Plant extracts | Antioxidants | Herbal medicine | Oxidative stress | Phytochemicals | Free radicals | Metabolites | Natural products | Mortality | Colleges & universities | Drug dosages | Index Medicus
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Loading RightsJournal of Experimental Botany, ISSN 0022-0957, 1/2012, Volume 63, Issue 12, pp. 4631 - 4645
Cell wall isolated from pea roots was used to separate and characterize two fractions possessing class III peroxidase activity: (i) ionically bound proteins...
Portable media players | Protein isoforms | Oxidases | Peas | Gels | Cell walls | Root growth | Plant roots | Biochemistry | Plants | RESEARCH PAPER | Cell wall peroxidase | Auxin | IEF-PAGE | Elicitor | Pisum sativum | Pea root | pea root | LOCALIZATION | INDOLEACETIC-ACID | cell wall peroxidase | elicitor | OXIDATIVE BURST | SUBERIZATION | HORSERADISH-PEROXIDASE | ISOENZYMES | PLANT SCIENCES | LIGNIFICATION | HYDROGEN-PEROXIDE | GENERATION | IEFPAGE | EXPRESSION | Molecular Weight | Concanavalin A - pharmacology | Cations - metabolism | Isoelectric Focusing | Isoenzymes - chemistry | Cell Wall - enzymology | Peroxidase - chemistry | Isoenzymes - isolation & purification | Plant Roots - drug effects | Isoenzymes - metabolism | Plant Proteins - chemistry | Plant Proteins - antagonists & inhibitors | Chitosan - pharmacology | Plant Proteins - metabolism | Plant Roots - growth & development | Peroxidase - antagonists & inhibitors | Plant Proteins - isolation & purification | Peas - enzymology | Oxidation-Reduction | Peas - growth & development | Electrophoresis, Polyacrylamide Gel | Enzyme Inhibitors - pharmacology | Peas - drug effects | Lectins - pharmacology | Glycosylation | Chelating Agents - pharmacology | Peroxidase - isolation & purification | Anions - metabolism | Indoleacetic Acids - pharmacology | Plant Roots - enzymology | Kinetics | Plant Growth Regulators - pharmacology | Isoenzymes - antagonists & inhibitors | Peroxidase - metabolism | IEF–PAGE | Research Paper
Portable media players | Protein isoforms | Oxidases | Peas | Gels | Cell walls | Root growth | Plant roots | Biochemistry | Plants | RESEARCH PAPER | Cell wall peroxidase | Auxin | IEF-PAGE | Elicitor | Pisum sativum | Pea root | pea root | LOCALIZATION | INDOLEACETIC-ACID | cell wall peroxidase | elicitor | OXIDATIVE BURST | SUBERIZATION | HORSERADISH-PEROXIDASE | ISOENZYMES | PLANT SCIENCES | LIGNIFICATION | HYDROGEN-PEROXIDE | GENERATION | IEFPAGE | EXPRESSION | Molecular Weight | Concanavalin A - pharmacology | Cations - metabolism | Isoelectric Focusing | Isoenzymes - chemistry | Cell Wall - enzymology | Peroxidase - chemistry | Isoenzymes - isolation & purification | Plant Roots - drug effects | Isoenzymes - metabolism | Plant Proteins - chemistry | Plant Proteins - antagonists & inhibitors | Chitosan - pharmacology | Plant Proteins - metabolism | Plant Roots - growth & development | Peroxidase - antagonists & inhibitors | Plant Proteins - isolation & purification | Peas - enzymology | Oxidation-Reduction | Peas - growth & development | Electrophoresis, Polyacrylamide Gel | Enzyme Inhibitors - pharmacology | Peas - drug effects | Lectins - pharmacology | Glycosylation | Chelating Agents - pharmacology | Peroxidase - isolation & purification | Anions - metabolism | Indoleacetic Acids - pharmacology | Plant Roots - enzymology | Kinetics | Plant Growth Regulators - pharmacology | Isoenzymes - antagonists & inhibitors | Peroxidase - metabolism | IEF–PAGE | Research Paper
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Loading RightsMolecular Nutrition & Food Research, ISSN 1613-4125, 06/2008, Volume 52, Issue 6, pp. 664 - 673
The plant sterols campesterol, β‐sitosterol and β‐sitostanol were investigated for potential immunomodulatory effects in Jurkat T cells. Treatments involved...
Jurkat cells | Protein kinase C | cAMP | Cytokine production | Phytosterol | cytokine production | PROTEIN-KINASE-C | INTERLEUKIN-2 PRODUCTION | FOOD SCIENCE & TECHNOLOGY | SPHINGOMYELIN CYCLE | FATTY-ACID PROFILE | phytosterol | BREAST-CANCER CELLS | CYCLIC-AMP | BETA-SITOSTEROL | CYCLOSPORINE-A | DIETARY PHYTOSTEROLS | DOCOSAHEXAENOIC ACID | protein kinase C | Cholesterol - analogs & derivatives | Tetradecanoylphorbol Acetate - pharmacology | Cell Survival | Concanavalin A - pharmacology | Jurkat Cells | Lymphocyte Activation | Humans | Sitosterols - pharmacology | Enzyme Inhibitors - pharmacology | Maleimides - pharmacology | Protein Kinase C - antagonists & inhibitors | Interleukin-2 - antagonists & inhibitors | Phytosterols - pharmacology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Cell Division | Tacrolimus - pharmacology | Cholesterol - pharmacology | Indoles - pharmacology | T-Lymphocytes - immunology | Interleukin-2 - biosynthesis | Immunosuppressive Agents - pharmacology | Cytokines - biosynthesis | Immunologic Factors - pharmacology | Index Medicus
Jurkat cells | Protein kinase C | cAMP | Cytokine production | Phytosterol | cytokine production | PROTEIN-KINASE-C | INTERLEUKIN-2 PRODUCTION | FOOD SCIENCE & TECHNOLOGY | SPHINGOMYELIN CYCLE | FATTY-ACID PROFILE | phytosterol | BREAST-CANCER CELLS | CYCLIC-AMP | BETA-SITOSTEROL | CYCLOSPORINE-A | DIETARY PHYTOSTEROLS | DOCOSAHEXAENOIC ACID | protein kinase C | Cholesterol - analogs & derivatives | Tetradecanoylphorbol Acetate - pharmacology | Cell Survival | Concanavalin A - pharmacology | Jurkat Cells | Lymphocyte Activation | Humans | Sitosterols - pharmacology | Enzyme Inhibitors - pharmacology | Maleimides - pharmacology | Protein Kinase C - antagonists & inhibitors | Interleukin-2 - antagonists & inhibitors | Phytosterols - pharmacology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Cell Division | Tacrolimus - pharmacology | Cholesterol - pharmacology | Indoles - pharmacology | T-Lymphocytes - immunology | Interleukin-2 - biosynthesis | Immunosuppressive Agents - pharmacology | Cytokines - biosynthesis | Immunologic Factors - pharmacology | Index Medicus
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