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Journal Article
Molecular Therapy, ISSN 1525-0016, 10/2000, Volume 2, Issue 4, pp. 404 - 414
We exploited the ability of lentiviral vectors to govern the stable transduction of cells irrespective of their cycling status to induce the reversible... 
SV40 large T | pancreatic beta cell | telomerase | gene transfer | insulin | lentiviral vectors | conditional immortalization | Bmi-1 | gene therapy | reversible immortalization | LoxP-Cre | HIV vectors | Gene transfer | Reversible immortalization | Pancreatic beta cell | Lentiviral vectors | Conditional immortalization | Gene therapy | Insulin | Telomerase | MEDICINE, RESEARCH & EXPERIMENTAL | SIMIAN VIRUS-40 | SITE-SPECIFIC RECOMBINATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SINUSOIDAL ENDOTHELIAL-CELLS | RAT EMBRYO FIBROBLASTS | GENETICS & HEREDITY | MAMMALIAN-CELLS | HUMAN-DIPLOID FIBROBLASTS | LENTIVIRAL VECTOR | IN-VIVO | LARGE-T-ANTIGEN | TRANSGENIC MICE | Endothelium, Vascular - cytology | Immunohistochemistry | Humans | HeLa Cells - metabolism | DNA Primers - chemistry | Flow Cytometry | Telomerase - genetics | Nuclear Proteins - biosynthesis | Islets of Langerhans - metabolism | Recombination, Genetic | Cell Division | Islets of Langerhans - cytology | Polymerase Chain Reaction | Integrases - metabolism | Lentivirus - genetics | Telomerase - metabolism | Cell Differentiation | Gene Transfer Techniques | Antigens, Polyomavirus Transforming - genetics | Antigens, Polyomavirus Transforming - metabolism | Liver - metabolism | Cell Transplantation | Nuclear Proteins - metabolism | Blotting, Western | Animals | Biopsy | Endothelium, Vascular - metabolism | Mice, Nude | Islets of Langerhans - virology | Liver - cytology | Mice | HeLa Cells - cytology | Genetic Vectors | Cell Transformation, Viral | Genetic Therapy - methods
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2019, Volume 517, Issue 1, pp. 49 - 56
Patient-derived xenografts (PDXs) are widely recognised as a more physiologically relevant preclinical model than standard cell lines, but are expensive and... 
Conditional reprogramming | Drug discovery | Patient derived xenograft | Bladder cancer | Cell line models | TRANSFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CISPLATIN RESISTANCE | CULTURE | PLURIPOTENT STEM-CELLS | IN-VITRO | BIOPHYSICS | EPITHELIAL-CELLS | INHIBITOR | IMMORTALIZATION | REPROGRAMMED CELLS | XENOGRAFTS | Medical colleges | Analysis
Journal Article
Cardiovascular Research, ISSN 0008-6363, 12/2018, Volume 114, Issue 14, pp. 1848 - 1859
Abstract Aims The generation of homogeneous cardiomyocyte populations from fresh tissue or stem cells is laborious and costly. A potential solution to this... 
ARRHYTHMIAS | VOLTAGE | CARDIAC & CARDIOVASCULAR SYSTEMS | HL-1 cells | Cardiomyogenic differentiation | Atrial cardiomyocyte | Conditional immortalization | CELL-DERIVED CARDIOMYOCYTES | PROLIFERATION | CULTURE | HEART | TEMPERATURE-SENSITIVE MUTANT | CALCIUM | Large T antigen | TERMINATION | EXPRESSION | Original
Journal Article
Experimental Eye Research, ISSN 0014-4835, 11/2018, Volume 176, pp. 188 - 195
Optic nerve astrocytes play a major role in axonal degeneration and regeneration. Astrocyte lines are an important tool to elucidate the responsible cellular... 
Conditional immortalization | Optic nerve astrocyte | Cell line | TRANSFORMATION | SIMIAN-VIRUS-40 | OPHTHALMOLOGY | CELL-LINES | LARGE T-ANTIGEN | EXPRESSION | FIBROBLASTS | Neurosciences | RNA | Analysis | Fluorescence | Genetic engineering | Interferon | Biological response modifiers | Tumor proteins | Chromosomes | cell line | conditional immortalization | optic nerve astrocyte
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 12/2019, Volume 1864, Issue 12, p. 158511
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2018, Volume 499, Issue 4, pp. 735 - 742
Journal Article
Experimental Cell Research, ISSN 0014-4827, 01/2015, Volume 330, Issue 2, pp. 300 - 310
Pancreatic stellate cells (PSCs) play a key role in the dense desmoplastic stroma associated with pancreatic ductal adenocarcinoma. Studies on human PSCs have... 
Conditional immortalization | IGF | Human pancreatic stellate cells | Temperature-sensitive SV40LT | Pancreatic cancer | Temperature-sensitive SV4OLT | TUMOR PROGRESSION | CANCER CELLS | DUCTAL ADENOCARCINOMA | IDENTIFICATION | CULTURE | FIBROBLASTS | CELL BIOLOGY | INSULIN | INHIBITION | ONCOLOGY | ENDOTHELIAL-CELLS | EXPRESSION | Insulin-Like Growth Factor I - pharmacology | Cell Proliferation | Antigens, Polyomavirus Transforming - genetics | Vimentin - biosynthesis | Humans | Pancreatic Neoplasms - pathology | Pancreatic Ducts - pathology | Carcinoma, Pancreatic Ductal - pathology | Insulin-Like Growth Factor Binding Protein 2 - metabolism | Glial Fibrillary Acidic Protein - biosynthesis | Smad Proteins - biosynthesis | Telomerase - genetics | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Neoplasm Invasiveness - pathology | Cell Cycle - physiology | Cell Culture Techniques | Primary Cell Culture | Tumor Cells, Cultured | Desmin - biosynthesis | Insulin-Like Growth Factor I - metabolism | Cell Movement | Pancreatic Stellate Cells - metabolism | Binding proteins | Intermediate filament proteins | Telomerase | Analysis | Tumor antigens | Protein binding | Protein expression | Cell growth | Insulin-like growth factors | Cell adhesion & migration | GROWTH FACTORS | CARCINOMAS | PANCREAS | PHENOTYPE | CELL PROLIFERATION | ANTIGENS | VITAMIN A | 60 APPLIED LIFE SCIENCES | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Surgery | Klinisk medicin | Cancer and Oncology | Kirurgi | Cancer och onkologi
Journal Article