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1. Full Text Skeletal phenotype of the neuropeptide Y knockout mouse
by Wee, Natalie K.Y and Sinder, Benjamin P and Novak, Sanja and Wang, Xi and Stoddard, Chris and Matthews, Brya G and Kalajzic, Ivo
Neuropeptides, ISSN 0143-4179, 02/2019, Volume 73, pp. 78 - 88
Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to... 
Conditional mouse | Neuropeptide Y (NPY) | Bone | Bone strength | Cortical bone | INBRED STRAINS | SEX | INCREASES BONE MASS | RECEPTOR | STRENGTH | NEUROSCIENCES | REGULATE BONE | NPY | ENDOCRINOLOGY & METABOLISM | FAT | DIFFERENTIATION | MODULATOR | Neuropeptide Y | CRISPR | Alkaline phosphatase | Energy metabolism | Phenotypes | Femur | Osteocalcin | Adipose tissue | Transcription | Bone sialoprotein | Neuropeptides | Hypoxanthine phosphoribosyltransferase | Bone turnover | Bone mass | Clonal deletion | Stromal cells | Rodents | Bone marrow | Hypoxanthine | Phosphoribosyltransferase | Skeleton | Index Medicus
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2. Full Text Easi-CRISPR protocol for creating knock-in and conditional knockout mouse models using long ssDNA donors
by Miura, Hiromi and Quadros, Rolen M and Gurumurthy, Channabasavaiah B and Ohtsuka, Masato
Nature protocols, ISSN 1754-2189, 1/2018, Volume 13, Issue 1, pp. 195 - 215
CRISPR/Cas9-based genome editing can easily generate knockout mouse models by disrupting the gene sequence, but its efficiency for creating models that require... 
CRISPR | Easi-CRISPR | ivTRT (in vitro Transcription and Reverse Transcription) | Homology directed repair | Long ssDNA donors | CRISPR ribonucleoproteins | Cas9 | Reporter and recombinase knock-in mice | Artificial microRNA | Conditional knockout mice | Cre-LoxP
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3. Full Text Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy
by Rubio-Fernández, Marcos and Uribe, Mary Luz and Vicente-Tejedor, Javier and Germain, Francisco and Susín-Lara, Cristina and Quereda, Cristina and Montoliu, Lluis and De La Villa, Pedro and Martín-Nieto, José and Cruces, Jesús
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 8543 - 15
Hypoglycosylation of alpha-dystroglycan (alpha-DG) resulting from deficiency of protein alpha-mannosyltransferase 1(POMT1) may cause severe neuromuscular... 
RETINAL PHOTORECEPTOR | ALPHA-DYSTROGLYCAN | BIPOLAR CELLS | DYSTROPHIN-GLYCOPROTEIN COMPLEX | MULTIDISCIPLINARY SCIENCES | WALKER-WARBURG-SYNDROME | MUSCULAR-DYSTROPHIES | MUSCLE | EYE-BRAIN DISEASE | HOMEOBOX GENE | BASEMENT-MEMBRANE | Dystroglycan | Dolichyl-phosphate-mannose-protein mannosyltransferase | Exons | Retina | Rods | Recombinase | Protein deficiency | CRX protein | Cre recombinase | Optokinetic response | Homeobox | Laminin | Clonal deletion | Cones | Bipolar cells | Photoreceptors | Synaptic ribbons
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4. Full Text An analysis of skeletal development in osteoblast‐specific and chondrocyte‐specific runt‐related transcription factor‐2 (Runx2) knockout mice
by Takarada, Takeshi and Hinoi, Eiichi and Nakazato, Ryota and Ochi, Hiroki and Xu, Cheng and Tsuchikane, Azusa and Takeda, Shu and Karsenty, Gerard and Abe, Takaya and Kiyonari, Hiroshi and Yoneda, Yukio
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2013, Volume 28, Issue 10, pp. 2064 - 2069
Global gene deletion studies in mice and humans have established the pivotal role of runt related transcription factor-2 (Runx2) in both intramembranous and... 
OSTEOBLAST | SKELETOGENESIS | RUNX2 | CHONDROCYTE | CONDITIONAL KNOCKOUT | skeletogenesis | chondrocyte | osteoblast | conditional knockout | Runx2 | CLEIDOCRANIAL DYSPLASIA | OVEREXPRESSION | BONE-FORMATION | BIOLOGY | ENDOCRINOLOGY & METABOLISM | CBFA1 | DIFFERENTIATION | OSF2/CBFA1 | Phenotype | Animals | Core Binding Factor Alpha 1 Subunit - deficiency | Mice, Inbred C57BL | Female | Integrases - metabolism | Mice | Bone Development | Osteoblasts - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Chondrocytes - metabolism | Mice, Knockout | Genetic research | Genetic engineering | Analysis | Collagen | Index Medicus
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5. Full Text Generation and Characterization of Fibroblast-Specific Basigin Knockout Mice
by Wu, Xiao-Dong and Zhang, Meng-Yao and Chen, Ya-Tong and Yao, Hui and Zhang, Qing and Wang, Wen-Jing and Fu, Da-Fu and Wei, Ren-Ji and Zhang, Jia-Yu and Li, Yin and Dang, Dan and Bian, Hui-Jie and Xu, Jing and Chen, Zhi-Nan
Molecular Biotechnology, ISSN 1073-6085, 2/2019, Volume 61, Issue 2, pp. 111 - 121
Basigin is a well-known extracellular stimulator of fibroblasts and may confer resistance to apoptosis of fibroblasts in vitro under some pathological status,... 
Biochemistry, general | Protein Science | Human Genetics | Basigin | Biotechnology | Chemistry | Biological Techniques | Cre-loxp | Fibroblast | Conditional gene knockout mice | Cell Biology | Apoptosis | IMMUNOGLOBULIN SUPERFAMILY | CANCER-ASSOCIATED FIBROBLASTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | INVASION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMMPRIN/CD147 | MELANOMA-CELLS | CD147 | MODULATOR | EXPRESSION | Mice, Knockout - genetics | Gene Targeting | Basigin - deficiency | Mice, Inbred C57BL | Genotype | Male | Mice, Transgenic | Mice, Knockout - growth & development | Animals | Basigin - genetics | Fertility | Gene Deletion | Basigin - metabolism | Female | Fibroblasts - cytology | Mice | Mice, Inbred BALB C | Mice, Knockout - physiology | Fibroblasts - metabolism | Liver | Analysis | Cells | Index Medicus
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6. Full Text Nr5a1-Cre-mediated Tspo conditional knockout mice with low growth rate and prediabetes symptoms – A mouse model of stress diabetes
by Fan, Jinjiang and Campioli, Enrico and Papadopoulos, Vassilios
BBA - Molecular Basis of Disease, ISSN 0925-4439, 01/2019, Volume 1865, Issue 1, pp. 56 - 62
Translocator protein (TSPO) is a high-affinity cholesterol- and drug-binding mitochondrial protein. Nuclear receptor subfamily 5 group A member 1 or... 
Tspo | Conditional knockout | Nr5a1-Cre | Hyperglycemia | Low growth rate | Prediabetes | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIRTH-WEIGHT | BENZODIAZEPINE-RECEPTOR | BIOPHYSICS | PROTEIN 18 KDA | GLUCONEOGENESIS | METABOLISM | INSULIN-RESISTANCE | ANIMAL-MODELS | HYPOGLYCEMIA | ASSOCIATION | EPINEPHRINE | Type 2 diabetes | Epinephrine | Medical research | Medical examination | Growth | Blood sugar | Liver | Genes | Cytochrome P-450 | Glycosylated hemoglobin | ACTH | Gene expression | Blood | Analysis | Medicine, Experimental | Prediabetic state | Protein binding
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7. Full Text Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
by Soukup, Garrett A and Fritzsch, Bernd and Pierce, Marsha L and Weston, Michael D and Jahan, Israt and McManus, Michael T and Harfe, Brian D
Developmental Biology, ISSN 0012-1606, 04/2009, Volume 328, Issue 2, pp. 328 - 341
Inner ear development requires coordinated transformation of a uniform sheet of cells into a labyrinth with multiple cell types. While numerous regulatory... 
Floxed Dicer | RNA interference | MicroRNA | Hair cell | Inner ear development | Conditional knockout | Sensory epithelium | CRANIAL SENSORY GANGLIA | MOUSE | INNERVATION | DEVELOPMENTAL BIOLOGY | MORPHOGENESIS | EPITHELIA | GENE-EXPRESSION | NEURONS | NULL MICE | HAIR-CELL-DIFFERENTIATION | ENZYME DICER | Hair Cells, Auditory - cytology | Cochlea - embryology | Ear, Inner - innervation | Endoribonucleases - genetics | Fibroblast Growth Factor 10 - metabolism | Ear, Inner - embryology | Ear, Inner - cytology | Epithelium - innervation | MicroRNAs - biosynthesis | Cochlea - cytology | Cochlea - innervation | Endoribonucleases - physiology | Mice, Knockout | Organogenesis | DEAD-box RNA Helicases - genetics | DEAD-box RNA Helicases - physiology | Epithelium - embryology | Animals | Ribonuclease III | Ear, Inner - abnormalities | Cell Differentiation | Mice | RNA | Fibroblast growth factors | Index Medicus | floxed Dicer | sensory epithelium | hair cell | microRNA | inner ear development | conditional knockout
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8. Full Text In vivo proton MR spectroscopy of pancreatic neuroendocrine tumors in a multiple endocrine neoplasia type 1 conditional knockout mouse model
by Cui, Min‐Hui and Branch, Craig A and Cahill, Sean M and Quinn, Thomas J and Adem, Asha and Libutti, Steven K and Yuan, Ziqiang
Magnetic Resonance in Medicine, ISSN 0740-3194, 11/2015, Volume 74, Issue 5, pp. 1221 - 1226
PurposeMR spectroscopy (MRS) can improve diagnosis and follow treatment in cancer. However, no study has yet reported application of in vivo H-1-MRS in... 
pancreatic neuroendocrine tumors | total choline levels | in vivo proton MR spectroscopy | Men1 | conditional knockout mouse model | Men1 conditional knockout mouse model | PROSTATE | ADVANCED BREAST-CANCER | CHOLINE | RESOLUTION | TISSUE | MAGNETIC-RESONANCE-SPECTROSCOPY | NEOADJUVANT CHEMOTHERAPY | METABOLISM | THERAPEUTIC RESPONSE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | Choline - metabolism | Pancreatic Neoplasms - chemistry | Pancreatic Neoplasms - diagnosis | Pancreatic Neoplasms - pathology | Magnetic Resonance Imaging - methods | Choline - analysis | Male | Multiple Endocrine Neoplasia Type 1 - diagnosis | Transcription Factors - genetics | Choline - chemistry | Mice, Knockout | Multiple Endocrine Neoplasia Type 1 - chemistry | Animals | Multiple Endocrine Neoplasia Type 1 - pathology | Female | Mice | Pancreatic cancer | Choline | Spectrum analysis | Index Medicus
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9. Full Text Development and characterization of cell-specific androgen receptor knockout mice
by O’Hara, Laura and Smith, Lee B
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1443, pp. 219 - 248
Conditional gene targeting has revolutionized molecular genetic analysis of nuclear receptor proteins, however development and analysis of such conditional... 
Transgenic | Conditional knockout | ARKO | Mouse | Cre/lox | Androgen receptor | Gene Targeting - methods | Testis - metabolism | Real-Time Polymerase Chain Reaction - methods | Genotype | Male | Mice, Knockout | Animals | Receptors, Androgen - genetics | Hormones - metabolism | Immunoenzyme Techniques - methods | Microscopy, Fluorescence - methods | Integrases - metabolism | Mice | Transgenes | Receptors, Androgen - physiology | Genes, Reporter | Index Medicus
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10. Full Text Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice
by Cai, L and Bian, M and Liu, M and Sheng, Z and Suo, H and Wang, Z and Huang, F and Fei, J
Neuroscience, ISSN 0306-4522, 2011, Volume 181, pp. 196 - 205
Abstract The transcription regulator, neuron-restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor (REST), plays... 
Neurology | Fetal alcohol syndrome | Ethanol | Caspase-3 | Nrsf conditional knockout | Apoptosis | GROWTH SPURT | PURKINJE-CELL LOSS | apoptosis | DEVELOPING MOUSE-BRAIN | ethanol | NEUROSCIENCES | CEREBELLAR PURKINJE | TARGET GENES | INDUCED APOPTOTIC NEURODEGENERATION | nrsf conditional knockout | IN-VIVO | GENE-EXPRESSION | BETA-GALACTOSIDASE | fetal alcohol syndrome | caspase-3 | Ethanol - toxicity | Mice, Inbred C57BL | Nerve Degeneration - physiopathology | Repressor Proteins - genetics | Male | Mice, Transgenic | Nerve Degeneration - chemically induced | Nerve Degeneration - metabolism | Mice, Knockout | Alcohol-Induced Disorders, Nervous System - metabolism | Pregnancy | Animals | Repressor Proteins - deficiency | Alcohol-Induced Disorders, Nervous System - physiopathology | Female | Alcohol-Induced Disorders, Nervous System - genetics | Mice | Disease Models, Animal | Brain | Neurosciences | Huntington's chorea | Neurons | Cell death | Analysis | Epilepsy | Effect of alcohol on | Fetus | Universities and colleges | Index Medicus
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11. Full Text Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse
by Parajuli, Nirmala and Marine, Akira and Simmons, Sloane and Saba, Hamida and Mitchell, Tanecia and Shimizu, Takahiko and Shirasawa, Takuji and MacMillan-Crow, Lee Ann
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2011, Volume 51, Issue 2, pp. 406 - 416
Inactivation of manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant, has been associated with renal disorders and often results in detrimental... 
Cre-Lox technology | Superoxide | Nitrotyrosine | Kidney | Cre recombinase | MnSOD | OXIDATIVE STRESS | MNSOD GENE | CAST FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONDITIONAL KNOCKOUT | CARDIOMYOPATHY | TAMM-HORSFALL PROTEIN | DEFICIENT MICE | DISEASE | ENDOCRINOLOGY & METABOLISM | DYSFUNCTION | TYROSINE NITRATION | Immunohistochemistry | Superoxide Dismutase - genetics | Blood Glucose - analysis | Kidney - enzymology | Superoxide Dismutase - antagonists & inhibitors | Mice, Transgenic | DNA Primers | Animals | Base Sequence | Creatinine - blood | Female | Mice | Superoxide Dismutase - metabolism | Nitration | Chemical properties | Analysis | Index Medicus
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12. Full Text Generation of Fgfr3 conditional knockout mice
by Su, Nan and Xu, Xiaoling and Li, Cuiling and He, Qifen and Zhao, Ling and Li, Can and Chen, Siyu and Luo, Fengtao and Yi, Lingxian and Du, Xiaolan and Huang, Haiyang and Deng, Chuxia and Chen, Lin
International Journal of Biological Sciences, ISSN 1449-2288, 2010, Volume 6, Issue 4, pp. 327 - 332
Fibroblast growth factor receptor 3 (FGFR3), highly conserved in both humans and murine, is one of key tyrosine kinase receptors for FGF. FGFR3 is expressed in... 
Gene targeting | Conditional knock out | FGFR3 | Cre-Loxp | DEFECTS | conditional knock out | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | gene targeting | BONE-DEVELOPMENT | ACHONDROPLASIA | GENE | GROWTH-FACTOR RECEPTOR-3 | SKELETAL OVERGROWTH | MUTATIONS | DIFFERENTIATION | DWARFISM | Index Medicus
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13. Full Text Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model
by Quinn, Thomas J., BS and Yuan, Ziqiang, MD and Adem, Asha, BS and Geha, Rula, MD and Vrikshajanani, Chakravarthy, MD and Koba, Wade, BS and Fine, Eugene, MD and Hughes, David T., MD and Schmid, Herbert A., PhD and Libutti, Steven K., MD
Surgery: Official Journal of the Society of University Surgeons, Central Surgical Association, and the American Association of Endocrine Surgeons, ISSN 0039-6060, 2012, Volume 152, Issue 6, pp. 1068 - 1077
Background Pasireotide (SOM230), a long-acting somatostatin analogue (LAR), has improved agonist activity at somatostatin receptors. We tested the effect of... 
Surgery | SURGERY | OCTREOTIDE | SOMATOSTATIN ANALOG | MANAGEMENT | DIAZOXIDE | INSULINOMA | Neuroendocrine Tumors - pathology | Pancreatic Neoplasms - blood | Neuroendocrine Tumors - blood | Somatostatin - analogs & derivatives | Blood Glucose - analysis | Multiple Endocrine Neoplasia Type 1 - drug therapy | Pancreatic Neoplasms - pathology | Tomography, X-Ray Computed | Positron-Emission Tomography | Insulin - blood | Multiple Endocrine Neoplasia Type 1 - genetics | Mice, Knockout | Pancreatic Neoplasms - drug therapy | Multimodal Imaging | Animals | Neuroendocrine Tumors - diagnostic imaging | Neuroendocrine Tumors - drug therapy | Mice | Somatostatin - therapeutic use | Pancreatic Neoplasms - diagnostic imaging | Apoptosis | Medical colleges | Glucose | Drug therapy | Analysis | Dextrose | Tumors | Index Medicus | Abridged Index Medicus | SOM230 | conditional knockout mice | PNETs
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14. Full Text In Vivo Proton Magnetic Resonance Spectroscopy of Pancreatic Neuroendocrine Tumors (PNETs) in a Multiple Endocrine Neoplasia Type 1 (MEN1) Conditional Knockout Mouse Model
by Cui, Min-Hui and Branch, Craig A and Cahill, Sean M and Quinn, Thomas J and Adem, Asha and Libutti, Steven K and Yuan, Ziqiang
Magnetic resonance in medicine, ISSN 0740-3194, 11/2015, Volume 74, Issue 5, pp. 1221 - 1226
Men1 conditional knockout mouse model | Pancreatic neuroendocrine tumors | In vivo proton magnetic resonance spectroscopy | Total choline levels
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15. Full Text A facile one-step strategy for the generation of conditional knockout mice to explore the role of Notch1 in oroesophageal tumorigenesis
by Mandasari, Masita and Sawangarun, Wanlada and Katsube, Ken-ichi and Kayamori, Kou and Yamaguchi, Akira and Sakamoto, Kei
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2016, Volume 469, Issue 3, pp. 761 - 767
NOTCH1 plays an important role in epithelial differentiation and carcinogenesis. To investigate the impact of inactivation in oroesophageal epithelium, we... 
Transgenic mouse | CRISPR/Cas9 | Conditional knockout mouse | Notch1 | Esophageal cancer | HEAD | HAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOPHYSICS | DNA | SQUAMOUS-CELL CARCINOMA | SKIN | DIFFERENTIATION | EXPRESSION | TRANSGENIC MICE | Mice, Knockout - genetics | Mice, Knockout - immunology | Receptor, Notch1 - metabolism | Carcinogenesis - metabolism | Mice, Knockout - metabolism | Esophageal Neoplasms - pathology | Carcinogenesis - pathology | Animals | Esophageal Neoplasms - genetics | Esophageal Neoplasms - metabolism | Cell Line, Tumor | Mice | Receptor, Notch1 - genetics | Disease Models, Animal | Tumors | Index Medicus
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16. Full Text Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: Failure of Stat5 activation and functional differentiation in the absence of Elf5
by Choi, Yeon Sook and Chakrabarti, Rumela and Escamilla-Hernandez, Rosalba and Sinha, Satrajit
Developmental Biology, ISSN 0012-1606, 2009, Volume 329, Issue 2, pp. 227 - 241
The transcription factor Elf5 plays an important role in mammary gland development. However, because of the embryonic lethality of Elf5 straight knockout mice,... 
Conditional knockout | Transcription | Elf5 | Alveologenesis | Stat5 | SIGNAL | PROLACTIN RECEPTOR | DOMAIN | TRANSCRIPTION FACTOR FAMILY | PROTEIN | DEVELOPMENTAL BIOLOGY | GLAND DEVELOPMENT | BREAST-CANCER | EPITHELIAL-CELLS | GENE-EXPRESSION | EWING TUMORS | Immunohistochemistry | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Humans | STAT5 Transcription Factor - physiology | Molecular Sequence Data | Transcription Factors - genetics | DNA Primers | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Mammary Glands, Animal - embryology | Mice, Knockout | Down-Regulation - physiology | Transcription, Genetic - physiology | Animals | Base Sequence | Mice | Animal experimentation | Keratin | Progesterone | Peptide hormones | Prolactin | Analysis | Index Medicus
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17. Full Text Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system
by Nakagawa, Yoshimi and Oikawa, Fusaka and Mizuno, Seiya and Ohno, Hiroshi and Yagishita, Yuka and Satoh, Aoi and Osaki, Yoshinori and Takei, Kenta and Kikuchi, Takuya and Han, Song-Iee and Matsuzaka, Takashi and Iwasaki, Hitoshi and Kobayashi, Kazuto and Yatoh, Shigeru and Yahagi, Naoya and Isaka, Masaaki and Suzuki, Hiroaki and Sone, Hirohito and Takahashi, Satoru and Yamada, Nobuhiro and Shimano, Hitoshi
Scientific Reports, ISSN 2045-2322, 06/2016, Volume 6, Issue 1, pp. 27857 - 27857
cAMP responsive element binding protein 3-like 3 (CREB3L3), a transcription factor expressed in the liver and small intestine, governs fasting-response energy... 
THERMOGENESIS | HOMEOSTASIS | METABOLISM | LIPOLYSIS | TRANSCRIPTION FACTOR CREBH | MULTIDISCIPLINARY SCIENCES | ATHEROSCLEROSIS | ELEMENT-BINDING PROTEIN | CAS9 | STRESS | CONDITIONAL ALLELES | Index Medicus
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