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Molecular Vision, ISSN 1090-0535, 2018, Volume 24, pp. 853 - 866
Purpose: Telocytes (TCs) are peculiar interstitial cells, characterized by their typical elongated and interconnected processes called telopodes. TCs are... 
PROGENITOR CELLS | NORMAL CONJUNCTIVA | PATHOGENESIS | SURVIVIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | JUNCTIONS | OPHTHALMOLOGY | CAJAL ICC | MESENCHYMAL STEM-CELLS | NESTIN EXPRESSION | INTERSTITIAL-CELLS | P53 | Immunohistochemistry | Antigens, CD34 - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Vimentin - metabolism | Humans | Middle Aged | Actins - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Conjunctiva - surgery | Proto-Oncogene Proteins c-kit - metabolism | Pterygium - genetics | Vascular Endothelial Growth Factor A - genetics | Formaldehyde | Actins - genetics | Conjunctiva - metabolism | Conjunctiva - pathology | S100 Proteins - genetics | Pterygium - surgery | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Vimentin - genetics | Nestin - genetics | Aged, 80 and over | Adult | Female | Immunophenotyping - methods | Proto-Oncogene Proteins c-kit - genetics | Tissue Fixation | Telocytes - metabolism | Gene Expression | AC133 Antigen - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | S100 Proteins - metabolism | Pterygium - pathology | Telocytes - pathology | Conjunctiva - abnormalities | Laminin - genetics | Nestin - metabolism | Pterygium - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | AC133 Antigen - metabolism | Telocytes - classification | Aged | Laminin - metabolism | Antigens, CD34 - genetics | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e87368 - e87368
There are several animal models illustrating dry eye pathophysiology. Current study would like to establish an ex vivo tissue culture model for characterizing... 
OCULAR SURFACE EPITHELIUM | MATRIX METALLOPROTEINASES | MUCIN GENE-EXPRESSION | KERATOCONJUNCTIVITIS SICCA | MULTIDISCIPLINARY SCIENCES | CORNEAL EPITHELIAL-CELLS | SQUAMOUS METAPLASIA | LACRIMAL GLAND | FLOW-CYTOMETRIC ANALYSIS | BENZALKONIUM CHLORIDE | INFLAMMATORY MARKERS | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Epithelial Cells - metabolism | Homeodomain Proteins - metabolism | Humans | Keratin-10 - genetics | Keratin-16 - genetics | Conjunctiva - metabolism | Conjunctiva - pathology | Matrix Metalloproteinase 9 - metabolism | Time Factors | Interleukin-1beta - metabolism | Mucins - metabolism | Repressor Proteins - metabolism | Keratin-10 - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Mucin-4 - metabolism | Keratin-16 - metabolism | Dry Eye Syndromes - genetics | PAX6 Transcription Factor | Air | Reverse Transcriptase Polymerase Chain Reaction | Mucin-4 - genetics | Keratin-19 - genetics | Eye Proteins - metabolism | Dry Eye Syndromes - metabolism | Mucin 5AC - genetics | Mucin 5AC - metabolism | Keratin-19 - metabolism | Tissue Culture Techniques - methods | Mucins - genetics | Paired Box Transcription Factors - metabolism | Apoptosis | Keratin | Analysis | Mucins | Cell culture | Cornea | Animal models | Media (culture) | Wnt protein | Disease | Laboratories | Science | Tissue culture | Eye | Signal transduction | Epidermal growth factor | Stratification | Air conditioners | MUC16 gene | Explants | Immunoglobulins | Air exposure | Cultures | Inflammation | Tumor necrosis factor-α | IL-1β | Gelatinase B | Pax6 protein | Metaplasia | Signaling | Mucin | Antibiotics | Stromal cells | Cholera | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173301 - e0173301
We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-17A, IL-6 and IL-23, in protein and mRNA levels and their... 
TEARS | INTERLEUKIN-17 | SIGNS | MULTIDISCIPLINARY SCIENCES | PATHOGENIC T(H)17 CELLS | SYMPTOMS | DIAGNOSTIC-TESTS | DIFFERENTIATION | SJOGREN-SYNDROME | Biomarkers - metabolism | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Sjogren's Syndrome - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Conjunctiva - metabolism | Cornea - metabolism | Interleukin-17 - metabolism | Interleukin-23 - metabolism | Th17 Cells - metabolism | Dry Eye Syndromes - metabolism | Female | Aged | Interleukin-6 - metabolism | Fluorescein - metabolism | Eye diseases | Care and treatment | Genetic aspects | Research | Interleukins | Gene expression | Pathogenesis | Chains (polymeric) | Assaying | Metastases | Eye | Proteins | Signal transduction | Histopathology | Surgery | Classification | Tubes | Eye (anatomy) | Breakup | Bioindicators | Diagnosis | Public health | Antigens | Bovine serum albumin | Evaluation | Cytokines | Interleukin 12 | Time measurement | Epithelium | Patients | Interleukin 17 | Studies | Hospitals | Biomarkers | Collection | Infiltration | Colitis | Cornea | Sjogren's syndrome | Conferences | Transforming growth factor-b | Glands | Antibodies | Staining | Clinical trials | Scoring | mRNA | Infections | Tissues | Inflammatory diseases | Interleukin 6 | Biomedical materials | Lymphocytes | Rodents | Quality | Interleukin 1 | Tumor necrosis factor-TNF | Children | Rubber | Interleukin 8 | Hypertension | Desiccants | Diabetes mellitus | Inflammation | Evaporation | Chronic fatigue syndrome | CD4 antigen | Blindness | In vivo methods and tests | Differentiation | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, pp. e74010 - e74010
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, pp. e29017 - e29017
Background: TGF-beta is a pleiotropic cytokine that can have pro- or anti-inflammatory effects depending on the context. Elevated levels of bioactive TGF-beta... 
BARRIER DISRUPTION | GROWTH-FACTOR-BETA | DESICCATING STRESS | TEAR FLUID | INTERFERON-GAMMA | EXPERIMENTAL DRY EYE | BIOLOGY | REGULATORY T-CELLS | SJOGRENS-SYNDROME | CORNEAL EPITHELIUM | SALIVARY-GLANDS | Eye - pathology | Inflammation - pathology | Homeodomain Proteins - metabolism | Humans | Aging - drug effects | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Conjunctiva - metabolism | Dry Eye Syndromes - pathology | Conjunctiva - pathology | Inflammation - metabolism | Transforming Growth Factor beta - drug effects | Keratoconjunctivitis Sicca - complications | Eye - drug effects | Mucous Membrane - drug effects | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Protein-Serine-Threonine Kinases - metabolism | Eye - metabolism | Epithelium - drug effects | Epithelium - pathology | Epithelium - metabolism | Receptors, Chemokine - metabolism | Autoimmune Diseases - complications | Keratoconjunctivitis Sicca - metabolism | Aging - pathology | Mice, Knockout | Mucous Membrane - metabolism | Cell Movement - drug effects | Transforming Growth Factor beta - pharmacology | Mucous Membrane - pathology | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Conjunctiva - drug effects | Dry Eye Syndromes - metabolism | Keratoconjunctivitis Sicca - pathology | Cell Proliferation - drug effects | Mice | Genes, Dominant - genetics | Transforming Growth Factor beta - metabolism | CD4-Positive T-Lymphocytes - drug effects | Cornea | Sjogren's syndrome | Physicians | Glands | Helper cells | Interleukin 23 | Lymphocytes T | Kinases | Cell density | Eye | Keratoconjunctivitis | Lymphocytes | Rodents | Age | Scopolamine | Cytokines | Desiccants | Salivary glands | Inflammation | Conjunctiva | Disease control | Smoothness | Gelatinase B | CD4 antigen | Medicine | Signaling | RAG1 protein | γ-Interferon | Eye diseases | Infiltration | Interferon | Disruption | Tears | Index Medicus
Journal Article
Development (Cambridge), ISSN 0950-1991, 02/2013, Volume 140, Issue 3, pp. 594 - 605
Conjunctival goblet cells primarily synthesize mucins to lubricate the ocular surface, which is essential for normal vision. Notch signaling has been known to... 
Goblet cell | Cell fate | Mouse | Notch signaling | Klf4/5 | Differentiation | Ocular surface | STEM-CELLS | ALLERGIC CONJUNCTIVITIS | DOWN-REGULATION | HUMAN CORNEAL | DEVELOPMENTAL BIOLOGY | OCULAR SURFACE EPITHELIUM | GOBLET CELLS | MUCIN GENE | IN-VIVO | GENE-EXPRESSION | MUCOUS METAPLASIA | Inflammation - pathology | Cell Proliferation | Cornea - embryology | Metaplasia - metabolism | Transcriptional Activation | Epithelium, Corneal - pathology | Conjunctiva - metabolism | Conjunctiva - pathology | Inflammation - metabolism | Hyperplasia - genetics | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - metabolism | Gene Deletion | Cell Differentiation | Cornea - pathology | Lacrimal Apparatus - pathology | Nuclear Proteins - genetics | Epithelium, Corneal - embryology | Promoter Regions, Genetic | Conjunctiva - embryology | Signal Transduction | Mice, Transgenic | Nuclear Proteins - metabolism | Receptor, Notch1 - metabolism | Transcription Factors - genetics | Lacrimal Apparatus - metabolism | Goblet Cells - metabolism | Metaplasia - pathology | Hyperplasia - pathology | Transcription Factors - metabolism | Cornea - metabolism | Phenotype | Animals | Mucin 5AC - genetics | Epithelium, Corneal - metabolism | Inflammation - genetics | Mucin 5AC - metabolism | Mice | Goblet Cells - pathology | Receptor, Notch1 - genetics | Kruppel-Like Transcription Factors - genetics | Index Medicus | s | 5 | Klf4
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 01/2015, Volume 308, Issue 1, pp. C79 - C87
Sodium/hydrogen exchanger (NHE) 8 is expressed at the apical membrane of the epithelial cells and plays important roles in neutral sodium absorption in the... 
NHE8 | Cornea | Lacrimal gland | Conjunctiva | Epithelia | PHYSIOLOGY | MUCIN GENE-EXPRESSION | cornea | conjunctiva | MUCOSAL PROTECTION | TEAR FILM | lacrimal gland | CELL BIOLOGY | TARGETED DISRUPTION | HUMAN TRANSGLUTAMINASE-1 | TISSUE DISTRIBUTION | MOLECULAR-CLONING | NA+/H+ EXCHANGER ISOFORM | epithelia | DRY EYE SYNDROME | CONJUNCTIVAL EPITHELIUM | Tumor Necrosis Factor-alpha - metabolism | Eye - pathology | Epithelial Cells - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Transglutaminases - genetics | Male | RNA, Messenger - metabolism | Sodium-Hydrogen Exchangers - metabolism | Conjunctiva - metabolism | Cornea - secretion | Epithelial Cells - secretion | Conjunctiva - pathology | Matrix Metalloproteinase 9 - metabolism | Cornified Envelope Proline-Rich Proteins - genetics | Matrix Metalloproteinase 9 - genetics | Lacrimal Apparatus - secretion | Antiporters - genetics | Female | Sodium-Hydrogen Exchangers - genetics | Cornea - pathology | Lacrimal Apparatus - pathology | Eye - metabolism | Down-Regulation | Antiporters - metabolism | Epithelial Cells - pathology | Genotype | Conjunctiva - secretion | Lacrimal Apparatus - metabolism | Mice, Knockout | Cornea - metabolism | Phenotype | Animals | Transglutaminases - metabolism | Cornified Envelope Proline-Rich Proteins - metabolism | Tears - secretion | Eye - secretion | Hydrogen-Ion Concentration | Proteins | Physiological aspects | Epithelial cells | Identification and classification | Health aspects | Immunohistochemistry | Membranes | Gene expression | Genes | Rodents | Cells | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e61833 - e61833
Corneal epithelial stem cells or limbal stem cells (LSCs) are responsible for the maintenance of the corneal epithelium in humans. The exact location of LSCs... 
EPITHELIAL STEM-CELLS | GROWTH-FACTOR-BETA | HUMAN CORNEA | SIDE POPULATION CELLS | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | STEM/PROGENITOR CELLS | PROLIFERATION | OCULAR SURFACE EPITHELIA | EXPRESSION | BASAL-CELLS | Sialoglycoproteins - genetics | Tenascin - genetics | Homeodomain Proteins - metabolism | Humans | Middle Aged | Sialoglycoproteins - metabolism | Transcriptome | Gene Expression Profiling | Gene Regulatory Networks | Tenascin - metabolism | Conjunctiva - metabolism | Young Adult | Bone Morphogenetic Proteins - metabolism | Limbus Corneae - metabolism | Adult | Extracellular Matrix Proteins - metabolism | Wnt Signaling Pathway | Fibromodulin | Stem Cell Niche | Extracellular Matrix Proteins - genetics | Molecular Sequence Annotation | Gene Expression Regulation | Frizzled Receptors - metabolism | Proteoglycans - metabolism | Transcription Factors - genetics | Organ Specificity | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Cornea - metabolism | Adult Stem Cells - metabolism | Frizzled Receptors - genetics | Aged | Limbus Corneae - cytology | Transforming Growth Factor beta - metabolism | Proteoglycans - genetics | Bone morphogenetic proteins | Transforming growth factors | Analysis | Genes | Stem cells | Tenascin | Cornea | Wnt protein | Tenascin C | Frizzled protein | Regulatory sequences | Conjunctiva | Gene expression | Epithelium | Biological activity | Homeobox | Proteins | Signaling | Network analysis | Cell adhesion | Localization | Growth factors | Index Medicus
Journal Article