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International Journal of Oncology, ISSN 1019-6439, 04/2014, Volume 44, Issue 4, pp. 1259 - 1267
GYY4137, a hydrogen sulfide (H2S) donor, exhibits anticancer activity by a combination of cell cycle arrest and promoting apoptosis, and inhibits tumor growth,... 
GYY4137 | Hepatocellular carcinoma | STAT3 pathway | Hydrogen sulfide donor | hydrogen sulfide donor | APOPTOSIS | CANCER CELLS | CYCLIN D1 | CONSTITUTIVE ACTIVATION | PROTEIN-KINASE | VEGF EXPRESSION | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | GROWTH | SQUAMOUS-CELL CARCINOMA | hepatocellular carcinoma | SIGNAL TRANSDUCER
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 6, pp. 3630 - 3641
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2005, Volume 201, Issue 1, pp. 105 - 115
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These... 
PROGRAMMED CELL-DEATH | MEDICINE, RESEARCH & EXPERIMENTAL | CONSTITUTIVE APOPTOSIS | TUMOR-NECROSIS-FACTOR | INDUCIBLE FACTOR-1-ALPHA | PROTEIN | IMMUNOLOGY | O-2 HOMEOSTASIS | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GENE | HIF-ALPHA | EXPRESSION | FACTOR-ALPHA
Journal Article
1990, SPIE milestone series, ISBN 9780819404350, Volume v. MS 15., xxiv, 600
Book
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e80391
Scoparone, a natural compound isolated from Artemisia capillaris, has been used in Chinese herbal medicine to treat neonatal jaundice. Signal transducer and... 
APOPTOSIS | CONSTITUTIVE ACTIVATION | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | EPIDERMAL-GROWTH-FACTOR | TRANSCRIPTION | BETA-CATENIN | FACTOR RECEPTOR | EXPRESSION | PROGRESSION | SIGNAL TRANSDUCER | Cyclin D1 - metabolism | Prostatic Neoplasms - metabolism | Transcription, Genetic - drug effects | Humans | Male | G1 Phase - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | MCF-7 Cells | Janus Kinase 2 - metabolism | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Phosphorylation - drug effects | Interleukin-6 - metabolism | Prostatic Neoplasms - drug therapy | Artemisia - chemistry | HCT116 Cells | Proto-Oncogene Proteins c-myc - metabolism | Hep G2 Cells | Coumarins - pharmacology | HT29 Cells | Suppressor of Cytokine Signaling 3 Protein | Animals | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | HeLa Cells | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Prevention | Oncology, Experimental | Cancer cells | Research | Genetic transcription | Prostate cancer | Cancer | Tumors | Cell proliferation | Neonates | Phosphorylation | Bcl-2 protein | Xenotransplantation | c-Myc protein | Metastasis | Myc protein | Kinases | Cyclin D1 | Cancer therapies | Anticancer properties | Interleukin 6 | Proteins | Antitumor agents | Transfection | Epidermal growth factor | Mouse devices | Rodents | Transcription activation | Janus kinase 2 | Xenografts | Cell cycle | Aging | Janus kinase | Inhibition | G1 phase | Jaundice | Cytokines | Internal medicine | Stat3 protein | Agar | Breast cancer | Survivin | Metabolism | Medicine | Herbal medicine | Androgens | Antibiotics | Natural products | Computer applications | Prostate | Apoptosis
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2016, Volume 12, Issue 4, p. e1006016
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2016, Volume 291, Issue 53, pp. 27279 - 27288
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 18, pp. 7391 - 7396
S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using... 
Cell growth | Carcinoma | NIH 3T3 cells | Fibroblasts | Antibodies | Transformed cell line | Monomers | Chemicals | Tumors | Apoptosis | CANCER-CELLS | MOLECULAR TARGETS | APOPTOSIS | ACCURATE DOCKING | SRC | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | GENE-REGULATION | TRANSCRIPTION FACTOR | DNA-BINDING ACTIVITY | SIGNAL TRANSDUCER | Neoplasms - metabolism | Humans | Antineoplastic Agents - therapeutic use | Benzenesulfonates - therapeutic use | STAT3 Transcription Factor - chemistry | Aminosalicylic Acid - metabolism | Aminosalicylic Acid - therapeutic use | Phosphotyrosine - metabolism | Antineoplastic Agents - metabolism | Neoplasms - genetics | Aminosalicylic Acid - chemistry | Drug Evaluation, Preclinical | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Protein Structure, Tertiary | Cell Line | Aminosalicylic Acids | Computational Biology | Gene Expression Regulation | Models, Molecular | DNA - metabolism | Antineoplastic Agents - chemistry | Benzenesulfonates - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | DNA - chemistry | Animals | Benzenesulfonates - chemistry | Protein Binding | Mice | Transcription, Genetic - genetics | Neoplasms - pathology | STAT3 Transcription Factor - antagonists & inhibitors | Genetic aspects | Research | Structure | Crystals | Antineoplastic antibiotics | Biological Sciences
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 04/2019, Volume 141, Issue 13, pp. 5252 - 5260
Activity-based probes have greatly improved our understanding of the intrinsic roles and expression levels of various proteins within cells. To be useful in... 
20S PROTEASOME | TARGET | OXIDATIVE STRESS | INTERFERON-GAMMA | TUMOR-ANTIGENS | CONSTITUTIVE PROTEASOME | CRYSTAL-STRUCTURE | COMPLEXES | INHIBITOR | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
JOURNAL OF NEUROPHYSIOLOGY, ISSN 0022-3077, 05/2019, Volume 121, Issue 5, pp. 1591 - 1608
The monosynaptic stretch reflex (MSR) plays an important role in feedback control of movement and posture but can also lead to unstable oscillations associated... 
spinal cord injury | pain | PHYSIOLOGY | SYNAPTIC-TRANSMISSION | PERSISTENT INWARD CURRENTS | CONSTITUTIVE ACTIVITY | AFFINITY STATE | LONG-LASTING REFLEXES | MOTONEURON EXCITABILITY | NEUROSCIENCES | MUSCLE SPASMS | serotonin | BASIC SCIENCE | PARTIAL AGONIST | motoneuron | nociceptive | spasticity | SPINAL-CORD-INJURY
Journal Article