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Molecular Systems Biology, ISSN 1744-4292, 2013, Volume 9, Issue 1, pp. 637 - n/a
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 06/2013, Volume 1832, Issue 6, pp. 848 - 863
Sepsis is characterized by systematic inflammation and contributes to cardiac dysfunction. This study was designed to examine the effect of protein kinase B... 
Heart | ER stress | Sepsis | Akt | Contractile function | Apoptosis | OXIDATIVE STRESS | CONTRACTILE DYSFUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | ENDOPLASMIC-RETICULUM STRESS | AUTOPHAGY | GROWTH-FACTOR I | SIGNAL-TRANSDUCTION | SYNTHASE | BIOPHYSICS | INFLAMMATORY RESPONSE | NF-KAPPA-B | Caspase 9 - genetics | Apoptosis - drug effects | Calcium - metabolism | Heat-Shock Proteins - biosynthesis | Myocardial Contraction - drug effects | bcl-2-Associated X Protein - biosynthesis | Apoptosis - genetics | Glycogen Synthase Kinase 3 beta | Heat-Shock Proteins - genetics | Phosphorylation - genetics | Caspase 3 - genetics | Phosphorylation - drug effects | Transcription Factor CHOP - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Lipopolysaccharides - toxicity | Endoplasmic Reticulum Stress - drug effects | Mice, Transgenic | Glycogen Synthase Kinase 3 - genetics | Eukaryotic Initiation Factor-2 - genetics | Mice | Enzyme Activation - genetics | Transcription Factor CHOP - genetics | Eukaryotic Initiation Factor-2 - biosynthesis | Microtubule-Associated Proteins - genetics | bcl-X Protein - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Endoplasmic Reticulum Stress - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Myocardial Contraction - genetics | MAP Kinase Signaling System - genetics | Apoptosis Regulatory Proteins - genetics | Caspase 3 - biosynthesis | bcl-X Protein - biosynthesis | bcl-2-Associated X Protein - genetics | Beclin-1 | Gene Expression Regulation - genetics | Myocardium - pathology | Transcription Factors - biosynthesis | Transcription Factors - genetics | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Microtubule-Associated Proteins - biosynthesis | Gene Expression Regulation - drug effects | Autophagy-Related Protein 7 | Myocardium - enzymology | Animals | MAP Kinase Signaling System - drug effects | Caspase 9 - biosynthesis
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 12/2016, Volume 12, Issue 12, p. e1006531
Safeguarding the proteome is central to the health of the cell. In multi-cellular organisms, the composition of the proteome, and by extension, protein-folding... 
MYOD HOMOLOG HLH-1 | PROTEIN-QUALITY CONTROL | BODY-WALL MUSCLE | GENETICS & HEREDITY | MOLECULAR CHAPERONE | MUSCULAR-DYSTROPHY | C-ELEGANS | MISFOLDED PROTEINS | UNC-45 CHAPERONE | J-DOMAIN PROTEIN | FUNCTIONAL SPECIFICITY | Molecular Chaperones - metabolism | Caenorhabditis elegans Proteins - metabolism | Heat-Shock Proteins - biosynthesis | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Heat-Shock Proteins - genetics | Gene Expression Regulation, Developmental | HSP90 Heat-Shock Proteins - genetics | Binding Sites | Molecular Chaperones - biosynthesis | Promoter Regions, Genetic | HSP40 Heat-Shock Proteins - metabolism | Caenorhabditis elegans - growth & development | HSP40 Heat-Shock Proteins - genetics | Myogenic Regulatory Factors - genetics | Caenorhabditis elegans - genetics | Embryonic Development - genetics | Molecular Chaperones - genetics | Muscle Cells - metabolism | Myogenic Regulatory Factors - metabolism | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | HSP90 Heat-Shock Proteins - metabolism | Muscle Development - genetics | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans Proteins - biosynthesis | Biotechnology | Immunoglobulins | Transcription factors | Young adults | Funding | Genes | Colleges & universities | Experiments | Embryos | Proteins | Life sciences | Bioinformatics | Age
Journal Article
Genes and Development, ISSN 0890-9369, 11/2008, Volume 22, Issue 22, pp. 3205 - 3216
In both animal cells and fungi, cytokinesis proceeds via a contractile actomyosin ring (CAR). Many CAR components and regulators are evolutionarily conserved.... 
Contractile actomyosin ring | Mid1p/anillin | Cytokinesis | S. pombe | Septation initiation network | F-ACTIN | ACTIN RING | septation initiation network | cytokinesis | SPINDLE-POLE BODY | PROTEIN-KINASE | contractile actomyosin ring | DEVELOPMENTAL BIOLOGY | S-POMBE | DIVISION PLANE | CELL BIOLOGY | FISSION YEAST-CELL | GENETICS & HEREDITY | MITOTIC COMMITMENT | SEPTUM FORMATION | SCHIZOSACCHAROMYCES-POMBE | Cell Cycle - genetics | Contractile Proteins - genetics | GTP-Binding Proteins - genetics | Actomyosin - genetics | Schizosaccharomyces - genetics | Cytokinesis - genetics | Contractile Proteins - physiology | Cytokinesis - physiology | Actomyosin - physiology | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Contractile Proteins - metabolism | Schizosaccharomyces pombe Proteins - physiology | Protein-Serine-Threonine Kinases - metabolism | Gene Expression Regulation, Fungal | GTP-Binding Proteins - physiology | Schizosaccharomyces pombe Proteins - genetics | Protein-Serine-Threonine Kinases - physiology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Actomyosin - metabolism | Schizosaccharomyces - metabolism | Models, Biological | Cell Cycle - physiology | Cell Cycle Proteins - physiology | Schizosaccharomyces - cytology | GTP-Binding Proteins - metabolism | Genetic aspects | Yeast fungi | Analysis | Mutation (Biology) | Mid1p | Research Paper | anillin
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2010, Volume 30, Issue 6, pp. 1118 - 1126
OBJECTIVE—Regulation of vascular smooth muscle (VSM) proliferation and contractile differentiation is an important factor in vascular development and... 
Molecular biology | Contractile proteins | Vascular biology | Vascular muscle | molecular biology | ACTIVATION | PHENOTYPE | vascular biology | ACTIN DYNAMICS | PROLIFERATION | DICER | vascular muscle | MOUSE DEVELOPMENT | NEOINTIMAL LESION FORMATION | EMBRYONIC STEM-CELLS | SERUM RESPONSE FACTOR | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | contractile proteins | Endoribonucleases - genetics | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Transcriptional Activation | Actins - metabolism | Male | MicroRNAs - metabolism | Aorta - metabolism | Muscle, Smooth, Vascular - physiopathology | Muscle, Smooth, Vascular - embryology | Cell Differentiation - genetics | Vasodilation - genetics | Transfection | Gene Expression Regulation, Developmental | DEAD-box RNA Helicases - deficiency | Trans-Activators - genetics | Hemorrhage - embryology | Endoribonucleases - deficiency | Nuclear Proteins - genetics | Microfilament Proteins - genetics | Vasoconstriction - genetics | Liver Diseases - embryology | Hemorrhage - genetics | Liver Diseases - genetics | Umbilical Arteries - pathology | Muscle, Smooth, Vascular - ultrastructure | Cells, Cultured | Umbilical Arteries - embryology | Aorta - embryology | Genotype | Nuclear Proteins - metabolism | Hemorrhage - metabolism | Gestational Age | Mice, Knockout | Aorta - pathology | Muscle Proteins - genetics | DEAD-box RNA Helicases - genetics | Embryo Loss | Phenotype | Stress Fibers - metabolism | Animals | Ribonuclease III | Muscle Development - genetics | Trans-Activators - metabolism | Mice | Liver Diseases - metabolism | Integrases - genetics | Umbilical Arteries - metabolism
Journal Article
Aging Cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 976 - 987
Summary Aging is accompanied with unfavorable geometric and functional changes in the heart involving dysregulation of Akt and autophagy. This study examined... 
cardiac geometry | contractile function | autophagy | aging | Akt | RAPAMYCIN | PROTEIN-KINASE | DIASTOLIC DYSFUNCTION | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | HYPERTROPHY | LONGEVITY | OVEREXPRESSION | INSULIN-RESISTANCE | CALORIC RESTRICTION | SENESCENCE | MITOCHONDRIAL INJURY | Adaptation, Physiological | Protein Kinases - metabolism | Sirtuin 1 - metabolism | Phosphorylation | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Proto-Oncogene Proteins c-akt - deficiency | Atrial Remodeling - drug effects | Myocardial Contraction - drug effects | Cardiomegaly - pathology | Male | Mitochondrial Proteins - genetics | Sirtuin 1 - genetics | Autophagy - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Mitochondrial Proteins - metabolism | Myocardium - metabolism | Membrane Proteins - metabolism | Autophagy - genetics | Forkhead Box Protein O1 - metabolism | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Signal Transduction | Membrane Proteins - genetics | Gene Expression Regulation | Myocardium - pathology | Mitochondria - metabolism | Longevity - genetics | Mitochondria - pathology | Autophagy-Related Protein 7 - genetics | Sirolimus - pharmacology | Mice, Knockout | Animals | Cardiomegaly - prevention & control | Beclin-1 - genetics | Mice | Beclin-1 - metabolism | Cardiomegaly - genetics | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Forkhead Box Protein O1 - genetics | Cardiomegaly - metabolism | Heart | Laws, regulations and rules | Ablation (Surgery) | AKT protein | Autophagy | Ca2+-transporting ATPase | Mitochondria | FOXO1 protein | Aging | Oxidation | Fura-2 | Acetylation | Heart diseases | Calcium (intracellular) | Echocardiography | Contractility | AKT2 protein | Cardiomyocytes | Rapamycin | Insulin | Muscle contraction | BNIP3 protein | Life span | PTEN-induced putative kinase | Parkin protein | Intracellular | PTEN protein | Phagocytosis | Hypertrophy | Original
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2006, Volume 175, Issue 3, pp. 477 - 490
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2003, Volume 161, Issue 5, pp. 875 - 887
Journal Article