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Immunity (Cambridge, Mass.), ISSN 1074-7613, 2014, Volume 40, Issue 3, pp. 355 - 366
Journal Article
Nature immunology, ISSN 1529-2916, 2015, Volume 16, Issue 11, pp. 1124 - 1133
.... Here we report that the transcription factor Runx3 was essential for the normal development of ILC1 and ILC3 cells but not of ILC2 cells... 
IMMUNITY | ROR-GAMMA-T | ARYL-HYDROCARBON RECEPTOR | TRANSCRIPTION FACTOR GATA3 | IFN-GAMMA | DRIVES | NOTCH | NKP46(+) CELLS | DIFFERENTIATION | IMMUNOLOGY | TISSUE INDUCER CELLS | Core Binding Factor Alpha 3 Subunit - metabolism | Core Binding Factor beta Subunit - deficiency | Citrobacter rodentium - pathogenicity | Core Binding Factor beta Subunit - genetics | Lymphocyte Subsets - immunology | Enterobacteriaceae Infections - immunology | Intestinal Mucosa - cytology | Lymphocyte Subsets - metabolism | Lymphocyte Subsets - cytology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Intestinal Mucosa - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Antigens, Ly - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - deficiency | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Core Binding Factor beta Subunit - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Citrobacter rodentium - immunology | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Enterobacteriaceae Infections - etiology | Immunity, Innate | Mice, Knockout | Cell Differentiation - immunology | Animals | Core Binding Factor Alpha 3 Subunit - deficiency | Interleukin-7 Receptor alpha Subunit - metabolism | Core Binding Factor Alpha 3 Subunit - genetics | Natural Cytotoxicity Triggering Receptor 1 - metabolism | Mice | Cell Lineage - immunology | Physiological aspects | Genetic aspects | Immune response | Research | B cells
Journal Article
Blood, ISSN 0006-4971, 05/2014, Volume 123, Issue 19, pp. 2968 - 2977
.... Despite the absolute requirements for these factors in the development of hematopoietic stem cells and lymphocytes, their roles in the development of bone marrow progenitor subsets have not been... 
LINEAGE COMMITMENT | STEM-CELLS | HUMAN BONE-MARROW | IN-VIVO | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY | TRANSCRIPTION FACTOR | COMMITTED PROGENITORS | EXPRESSION | FETAL LIVER HEMATOPOIESIS | BINDING-FACTOR | Core Binding Factor Alpha 3 Subunit - metabolism | Interferon Regulatory Factors - metabolism | Anemia - pathology | Myeloproliferative Disorders - pathology | Core Binding Factor beta Subunit - genetics | Stem Cells - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Myeloproliferative Disorders - genetics | Cell Differentiation - genetics | Anemia - genetics | Flow Cytometry | Myeloproliferative Disorders - metabolism | Granulocytes - metabolism | Dendritic Cells - metabolism | Core Binding Factor beta Subunit - metabolism | Gene Expression | Core Binding Factor Alpha 2 Subunit - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interferon Regulatory Factors - genetics | Hematopoiesis - genetics | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | fms-Like Tyrosine Kinase 3 - metabolism | Mice, Knockout | Anemia - metabolism | Animals | Core Binding Factor Alpha 3 Subunit - genetics | Mice | Core Binding Factor Alpha 2 Subunit - genetics | Bone Marrow Cells - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Hematopoiesis and Stem Cells
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 07/2016, Volume 30, Issue 7, pp. 733 - 747
Journal Article
Molecular cell, ISSN 1097-2765, 2012, Volume 45, Issue 3, pp. 330 - 343
.... In this study we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds directly to the Runx1/CBFβ... 
TRANSFORMATION | MAINTENANCE | ADULT HEMATOPOIESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEMATOPOIETIC STEM-CELLS | CBFA2 | MEGAKARYOCYTE | MICE | DIFFERENTIATION | RUNX1 | HAPLOINSUFFICIENCY | CELL BIOLOGY | Chromatin - metabolism | Thymocytes - metabolism | Protein Multimerization | Gene Expression Profiling | Core Binding Factor beta Subunit - genetics | Zebrafish - embryology | Gene Knockdown Techniques | T-Lymphocytes - metabolism | Hematopoietic Stem Cells - physiology | Repressor Proteins - isolation & purification | Megakaryocytes - metabolism | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Core Binding Factor beta Subunit - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Polycomb-Group Proteins | Zebrafish - genetics | Mice, Knockout | Animals | Chromatography, Affinity | Polycomb Repressive Complex 1 | Protein Binding | Mice | Ubiquitin-Protein Ligases - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Cluster Analysis | Computer science | Employee recruitment | Chromatin | Genomics | Genes | Stem cells | Chemical properties | DNA binding proteins | Artificial intelligence | Genetic research
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2012, Volume 11, Issue 10, pp. 1938 - 1947
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 9, p. e46483
Background: Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1... 
OXYGEN | CAPACITY | STEM-CELLS | REPAIR | THERAPY | HIF | HUMAN BONE-MARROW | MULTIDISCIPLINARY SCIENCES | BIOLOGY | DIFFERENTIATION | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Transcriptional Activation | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Vascular Endothelial Growth Factor A - metabolism | PPAR gamma - metabolism | Vascular Endothelial Growth Factor A - genetics | Core Binding Factor Alpha 1 Subunit - metabolism | Antigens, CD - metabolism | Gene Knockdown Techniques | Cell Hypoxia | Phenotype | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Core Binding Factor Alpha 1 Subunit - genetics | Mesenchymal Stromal Cells - physiology | Osteogenesis | Adipogenesis | PPAR gamma - genetics | Growth | Stem cells | Physiological aspects | Hypoxia (Aquatic ecology) | Bones | Research | Gene expression | Vascular endothelial growth factor | Hypoxia-inducible factor 1 | Transcription factors | Mesenchyme | Arthritis | Adipocytes | Impact analysis | Recruitment | Angiogenesis | Hypoxia-inducible factor 1a | Immunology | Bone marrow | Biocompatibility | Conditioning | Cbfa-1 protein | Rheumatology | Bone healing | Yang, Cindy | Stromal cells | Hypoxia | Peroxisome proliferator-activated receptors | Differentiation | Surface markers | Hypoxia-inducible factors
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2007, Volume 282, Issue 19, pp. 14515 - 14524
Journal Article
Endocrinology, ISSN 0013-7227, 09/2013, Volume 154, Issue 9, pp. 3344 - 3352
... in several physiological and pathological processes, including cell proliferation, differentiation, and apoptosis (1, 2). The impact of miRNAs on cardiovascular diseases... 
TRANSCRIPTION FACTOR RUNX2 | CARDIOVASCULAR DEVELOPMENT | HUMAN ADIPOSE-TISSUE | STEM-CELLS | LINEAGE PROGRESSION | CORONARY-ARTERY CALCIFICATION | OSTEOBLAST DIFFERENTIATION | MYOCARDIAL-INFARCTION | IN-VIVO | ENDOCRINOLOGY & METABOLISM | RENAL-DISEASE | Osteocalcin - secretion | MicroRNAs - antagonists & inhibitors | Muscle, Smooth, Vascular - metabolism | Osteoblasts - secretion | Glycerophosphates - metabolism | MicroRNAs - metabolism | Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors | Recombinant Proteins - biosynthesis | Core Binding Factor Alpha 1 Subunit - metabolism | Vascular Calcification - metabolism | Cell Transdifferentiation - drug effects | Female | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Recombinant Proteins - metabolism | 3' Untranslated Regions - drug effects | Recombinant Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Osteoblasts - drug effects | Cells, Cultured | Gene Silencing | Vascular Calcification - prevention & control | Oligonucleotides, Antisense - adverse effects | Muscle, Smooth, Vascular - cytology | Vascular Calcification - pathology | Osteoblasts - pathology | Muscle, Smooth, Vascular - pathology | Animals | Core Binding Factor Alpha 1 Subunit - biosynthesis | Vascular Calcification - chemically induced | Genes, Reporter - drug effects | Mice | MicroRNAs - genetics | Mutation | Osteoblasts - metabolism | Core Binding Factor Alpha 1 Subunit - genetics
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8482 - 8487
The pathogenesis of cleidocranial dysplasia (CCD) as well as the specific role of core binding factor β (Cbfβ... 
Phenotypes | Bone formation | Chondrocytes | Bones | Skull | Skeletal development | Mice | Promoter regions | Epiphyses | Osteoblasts | Endochondral bone formation | Growth plate formation | Chondrocyte differentiation | Ossification | Osteoblast differentiation | OSTEOBLAST | MULTIDISCIPLINARY SCIENCES | endochondral bone formation | BINDING-FACTOR-BETA | BONE-DEVELOPMENT | RUNX2 | growth plate formation | TOOTH DEVELOPMENT | osteoblast differentiation | INTERACTS | chondrocyte differentiation | ossification | DIFFERENTIATION | Osteogenesis - physiology | Protein Multimerization | Core Binding Factor beta Subunit - genetics | Mice, 129 Strain | Core Binding Factor Alpha 1 Subunit - metabolism | Promoter Regions, Genetic - genetics | Collagen Type I - genetics | Chondrocytes - physiology | Gene Expression Regulation, Developmental | Cleidocranial Dysplasia - physiopathology | Cleidocranial Dysplasia - metabolism | Chondrocytes - metabolism | Osteogenesis - genetics | Core Binding Factor beta Subunit - metabolism | Animals, Newborn | Skull - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Osteoblasts - physiology | Cells, Cultured | Activating Transcription Factor 4 - genetics | Core Binding Factor beta Subunit - physiology | Mice, Transgenic | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Microscopy, Confocal | Animals | Activating Transcription Factor 4 - metabolism | Cleidocranial Dysplasia - genetics | Skull - cytology | Sp7 Transcription Factor | Protein Binding | Osteoblasts - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Microscopy, Fluorescence | Biological Sciences
Journal Article
Leukemia, ISSN 0887-6924, 2012, Volume 26, Issue 8, pp. 1829 - 1841
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 14, pp. 11960 - 11969
.... In addition to a highly conserved TEAD1 (TEA domain family member 1)-binding MCAT motif, nucleotide substitution revealed the consensus core sequence (WCYCCACCC... 
TRANSCRIPTION FACTORS | IMMUNOTOXIN SS1P | SERIAL ANALYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC CANCERS | CARCINOMAS | OVARIAN | TISSUE MICROARRAY | PROTEINS | PHASE-I | EXPRESSION | Core Binding Factor Alpha 3 Subunit - metabolism | Kruppel-Like Factor 6 | Humans | Sp1 Transcription Factor - metabolism | Neoplasm Proteins - metabolism | Phosphoproteins - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Promoter Regions, Genetic - genetics | Nucleic Acid Amplification Techniques | DNA-Binding Proteins - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Chromatin Immunoprecipitation | Neoplasms - genetics | Kruppel-Like Transcription Factors - metabolism | HEK293 Cells | Electrophoretic Mobility Shift Assay | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Mucin-1 - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Membrane Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Blotting, Western | GPI-Linked Proteins - metabolism | Transcription Factors - metabolism | Tissue Inhibitor of Metalloproteinase-1 - genetics | Cell Cycle | Sp1 Transcription Factor - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Core Binding Factor Alpha 3 Subunit - genetics | RNA, Small Interfering | Zinc Finger Protein GLI1 | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Core Binding Factor Alpha 2 Subunit - genetics | Kruppel-Like Transcription Factors - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Apoptosis | GPI-Linked Proteins - genetics | Mucin-1 - genetics | Gene Regulation | YAP1 | Transcription Regulation | KLF6 | Canscript | Mesothelin | Gene Structure | Tumor Promoter | Tumor Marker
Journal Article