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Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1897 - 1897
The cellular decision regarding whether to undergo proliferation or death is made at the restriction (R)-point, which is disrupted in nearly all tumors. The... 
UBIQUITINATION | AML1-ETO | ACETYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PROTEINS | QUANTITATIVE-ANALYSIS | POLYCOMB | CANCER | KINASES | FAMILY | Chromatin - metabolism | RNA, Small Interfering - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | TOR Serine-Threonine Kinases - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Polycomb-Group Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Cell Cycle Checkpoints - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Chromatin - chemistry | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Signal Transduction | Epithelial Cells - pathology | MAP Kinase Kinase 1 - metabolism | Imidazoles - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Cell Cycle Checkpoints - drug effects | Polycomb-Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA, Small Interfering - metabolism | ras Proteins - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Epithelial Cells - metabolism | Nitriles - pharmacology | Cyclin-Dependent Kinase 4 - genetics | Epithelial Cells - drug effects | ras Proteins - metabolism | Drosophila melanogaster - genetics | Chromatin Assembly and Disassembly - drug effects | Drosophila melanogaster - metabolism | MAP Kinase Kinase 1 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | HEK293 Cells | MAP Kinase Kinase 4 - antagonists & inhibitors | Chromatin - drug effects | Histone-Lysine N-Methyltransferase - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Sirolimus - pharmacology | Animals | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Core Binding Factor Alpha 3 Subunit - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Index Medicus
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2012, Volume 11, Issue 10, pp. 1938 - 1947
Journal Article
Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2009, Volume 108, Issue 2, pp. 378 - 387
Runx proteins are essential for a number of developmental processes and are aberrantly expressed in many human cancers. Runx factors bind DNA and co-factors to... 
RBM14 | Osteosarcoma | CoAM | Cbfa1 | Axin2 | Runx3 | AML3 | Runx1 | DNA-BINDING | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIBOSOMAL-RNA GENES | CANCER | CELL BIOLOGY | HUMAN OSTEOBLAST CELLS | OSTEOCALCIN GENE | POLYOMAVIRUS ENHANCER | MITOTIC CHROMOSOMES | OSTEOSARCOMA | DIFFERENTIATION | NUCLEAR RECEPTOR COACTIVATOR | Recombinant Fusion Proteins - isolation & purification | Core Binding Factor Alpha 3 Subunit - metabolism | Cell Proliferation | Core Binding Factor Alpha 1 Subunit - deficiency | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - metabolism | DNA-Binding Proteins - metabolism | Myoblasts - metabolism | Cytoskeletal Proteins - metabolism | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | Osteosarcoma - metabolism | Recombinant Fusion Proteins - biosynthesis | Cell Line | DNA-Binding Proteins - antagonists & inhibitors | Core Binding Factor Alpha 2 Subunit - metabolism | Cell Survival | Core Binding Factor Alpha 2 Subunit - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cells, Cultured | Rats | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Skull - cytology | Axin Protein | Cell Line, Tumor | Core Binding Factor Alpha 3 Subunit - genetics | Mice | RNA, Small Interfering | Osteoblasts - metabolism | Core Binding Factor Alpha 2 Subunit - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 10/2017, Volume 31, Issue 10, pp. 2219 - 2227
RUNX3, runt-domain transcription factor, is a master regulator of gene expression in major developmental pathways. It acts as a tumor suppressor in many... 
ONCOLOGY | FAMILY GENES | IN-VIVO | GROWTH | GENE-EXPRESSION PROFILES | C-MYC | TUMOR-SUPPRESSOR | PROTEIN MISLOCALIZATION | OVARIAN-CANCER | HEMATOLOGY | EPSTEIN-BARR-VIRUS | BET BROMODOMAINS | Nose Neoplasms - etiology | RNA, Small Interfering - genetics | Up-Regulation | Lymphoma, Extranodal NK-T-Cell - etiology | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Molecular Targeted Therapy | Recombinant Fusion Proteins - metabolism | Lymphoma, Extranodal NK-T-Cell - genetics | Proto-Oncogene Proteins c-myc - physiology | RNA Interference | Cell Transformation, Neoplastic - genetics | Cell Division | Nose Neoplasms - metabolism | Binding Sites | Genes, Reporter | Nose Neoplasms - pathology | Nose Neoplasms - genetics | Protein Interaction Mapping | Azepines - pharmacology | Core Binding Factor Alpha 3 Subunit - physiology | Triazoles - pharmacology | Enhancer Elements, Genetic | Lymphoma, Extranodal NK-T-Cell - pathology | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Line, Tumor | Core Binding Factor Alpha 3 Subunit - genetics | Transcription, Genetic - genetics | Genetic Vectors | Apoptosis | Lymphoma, Extranodal NK-T-Cell - metabolism | Transcription factors | Care and treatment | Development and progression | Lymphomas | Genetic aspects | Gene expression | Health aspects | Oncogenes | Cell proliferation | Biotechnology | Chromatin | Immunoprecipitation | Lymphocytes T | T cell receptors | Myc protein | Lymphoma | Transfection | Developmental stages | Cell lines | Tumor suppressor genes | Inhibition | Natural killer cells | Binding sites | Runx3 protein | T-cell lymphoma | Tumors | Index Medicus | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e86917 - e86917
RUNX3 (runt-related transcription factor-3) has been reported to suppress tumor tumorigenesis and metastasis in different human cancers. In this study, we used... 
BREAST-CANCER | INACTIVATION | MATRIX METALLOPROTEINASES | METHYLATION | GASTRIC-CANCER | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | TUMOR-METASTASIS | TISSUE INHIBITOR | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | RNA, Small Interfering - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Tissue Array Analysis | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Middle Aged | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Tumor Microenvironment | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Prostatic Neoplasms - genetics | Lung Neoplasms - secondary | Human Umbilical Vein Endothelial Cells - cytology | Aged, 80 and over | Adult | Carcinoma - secondary | Lung Neoplasms - blood supply | Lung Neoplasms - genetics | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Disease Progression | Matrix Metalloproteinase 2 - genetics | Animals | Mice, Nude | Core Binding Factor Alpha 3 Subunit - genetics | Carcinoma - genetics | Aged | Carcinoma - blood supply | Mice | Carcinoma - metabolism | Neoplasm Staging | Tissue Inhibitor of Metalloproteinase-2 - antagonists & inhibitors | Cell Movement | RNA, Small Interfering - metabolism | Research | Metastasis | Vascular endothelial growth factor | Prostate cancer | Oncology, Experimental | Cancer | Tissue inhibitor of metalloproteinase 2 | Matrix metalloproteinase | Tissues | Cancer therapies | Stomach cancer | Metastases | Angiogenesis | Restoration | Tumorigenesis | Metalloproteinase | Inhibition | Secretion | Breast cancer | Gene expression | Endothelial cells | Gelatinase A | Silence | Hospitals | DNA microarrays | Medical prognosis | Laboratory animals | Prostate | Cell migration | Runx3 protein | Tumors | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 01/2009, Volume 28, Issue 2, pp. 184 - 194
RUNX3 is a tumor suppressor that is silenced in cancer following hypermethylation of its promoter. The effects of hypoxia in tumor suppressor gene (TSG)... 
Hypoxia | Histone deacetylation | HDAC1 | Histone methylation | RUNX3 | G9a | hypoxia | HYPERMETHYLATION | DNA METHYLATION | CHROMATIN | DEACETYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | E-CADHERIN | MAMMALIAN-CELLS | CELL BIOLOGY | histone methylation | REPRESSION | ONCOLOGY | GROWTH | GENETICS & HEREDITY | GENE-EXPRESSION | histone deacetylation | HELICOBACTER-PYLORI | Core Binding Factor Alpha 3 Subunit - metabolism | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Recombinant Fusion Proteins - physiology | Stomach Neoplasms - metabolism | Neoplasm Proteins - antagonists & inhibitors | Stomach Neoplasms - pathology | Cell Line, Tumor - drug effects | Neoplasm Proteins - metabolism | Genes, Tumor Suppressor - drug effects | Protein Processing, Post-Translational - drug effects | Transcription, Genetic | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Cell Line, Tumor - metabolism | Hydroxamic Acids - pharmacology | Gene Expression Regulation, Neoplastic - genetics | Stomach Neoplasms - genetics | Down-Regulation | Histocompatibility Antigens - physiology | Gene Silencing | Azacitidine - analogs & derivatives | Disease Progression | Histone Deacetylase 1 | Azacitidine - pharmacology | Acetylation - drug effects | Methylation - drug effects | Histone Deacetylase Inhibitors | Histone Deacetylases - physiology | Cell Hypoxia - genetics | DNA Methylation - drug effects | Histone-Lysine N-Methyltransferase - physiology | Post-translational modification | Gene silencing | Care and treatment | Physiological aspects | Development and progression | Tumor suppressor genes | Genetic aspects | Research | Stomach cancer | Proteins | Cellular biology | Gastrointestinal diseases | Oncology | Gene expression | Cancer | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2015, Volume 466, Issue 3, pp. 592 - 598
This study investigated the effect of HCV core protein on the proliferation of hepatocytes and hepatocellular carcinoma cells (HCC), the influence of HCV core... 
NR4A1 | Hepatocellular carcinoma | RUNX3 | Oncogene | HCV core protein | Chemoresistance | EXPRESSION LEADS | RUNX3 GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | MEDIATED APOPTOSIS | CANCER | CELL-DEATH | HEPATOCELLULAR-CARCINOMA | BIOPHYSICS | HEPATITIS-C VIRUS | TUMOR-SUPPRESSOR | TRANSGENIC MICE | Cyclin D1 - metabolism | Core Binding Factor Alpha 3 Subunit - metabolism | Nuclear Receptor Subfamily 4, Group A, Member 1 - antagonists & inhibitors | Apoptosis - drug effects | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Drug Resistance, Viral | Hepacivirus - pathogenicity | Hepatocytes - pathology | Hepatocytes - metabolism | Viral Core Proteins - physiology | Carcinoma, Hepatocellular - drug therapy | Hepacivirus - physiology | Smad7 Protein - metabolism | Liver Neoplasms - virology | Cell Line | Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - virology | Cisplatin - pharmacology | Hep G2 Cells | Host-Pathogen Interactions | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Core Binding Factor Alpha 3 Subunit - genetics | Hepatocytes - virology | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Cell Proliferation - drug effects | Chemotherapy | Analysis | Bone morphogenetic proteins | Drug resistance | Hepatitis C virus | Transforming growth factors | Cancer | Index Medicus | ONCOGENES | TRANSCRIPTION FACTORS | APOPTOSIS | POLYMERASE CHAIN REACTION | HEPATOMAS | LIVER CELLS | SENSITIVITY | CELL PROLIFERATION | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | CHEMOTHERAPY
Journal Article
Journal Article
Clinical & Experimental Metastasis, ISSN 0262-0898, 2/2013, Volume 30, Issue 2, pp. 165 - 176
The function of tropomyosin receptor kinase (Trk) family including TrkA, TrkB, and TrkC in cancer remains unknown. The role of Trks in oral squamous cell... 
Angiogenesis | Biomedicine | Hematology | Cancer Research | Oncology | Oral squamous cell carcinoma | Trk | Lymphangiogenesis | Surgical Oncology | RUNX3 | Biomedicine general | CANCER-CELLS | NEUROTROPHIC FACTOR | SALIVARY-GLAND | NECK-CANCER | NERVE GROWTH-FACTOR | RECEPTOR TRKB | ONCOLOGY | POOR-PROGNOSIS | THYROID-CARCINOMA | HUMAN NEUROBLASTOMAS | GLYCATION END-PRODUCTS | Brain-Derived Neurotrophic Factor - genetics | RNA, Small Interfering - genetics | Core Binding Factor Alpha 3 Subunit - metabolism | Cell Proliferation | Prognosis | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Core Binding Factor Alpha 3 Subunit - antagonists & inhibitors | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Receptor, trkA - antagonists & inhibitors | Male | Mouth Neoplasms - metabolism | Immunoenzyme Techniques | Carcinoma, Squamous Cell - mortality | Adult | Female | Brain-Derived Neurotrophic Factor - metabolism | Real-Time Polymerase Chain Reaction | Enzyme-Linked Immunosorbent Assay | Neoplasm Invasiveness | Survival Rate | Lymphatic Metastasis | Cell Adhesion | Mouth Neoplasms - mortality | Blotting, Western | Disease Progression | DNA - genetics | Receptor, trkA - metabolism | Core Binding Factor Alpha 3 Subunit - genetics | Mouth Neoplasms - pathology | Receptor, trkA - genetics | Aged | Neoplasm Staging | Apoptosis | Cell Movement | Medical colleges | Squamous cell carcinoma | Analysis | Development and progression | Genetic aspects | Metastasis | Neovascularization | Muscle proteins | Methylation | Vascular endothelial growth factor | Index Medicus
Journal Article