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Journal Article
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7403, pp. 405 - 409
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2012, Volume 45, Issue 3, pp. 330 - 343
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian... 
TRANSFORMATION | MAINTENANCE | ADULT HEMATOPOIESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEMATOPOIETIC STEM-CELLS | CBFA2 | MEGAKARYOCYTE | MICE | DIFFERENTIATION | RUNX1 | HAPLOINSUFFICIENCY | CELL BIOLOGY | Chromatin - metabolism | Thymocytes - metabolism | Protein Multimerization | Gene Expression Profiling | Core Binding Factor beta Subunit - genetics | Zebrafish - embryology | Gene Knockdown Techniques | T-Lymphocytes - metabolism | Hematopoietic Stem Cells - physiology | Repressor Proteins - isolation & purification | Megakaryocytes - metabolism | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Core Binding Factor beta Subunit - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Core Binding Factor Alpha 2 Subunit - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Polycomb-Group Proteins | Zebrafish - genetics | Mice, Knockout | Animals | Chromatography, Affinity | Polycomb Repressive Complex 1 | Protein Binding | Mice | Ubiquitin-Protein Ligases - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Cluster Analysis | Computer science | Employee recruitment | Chromatin | Genomics | Genes | Stem cells | Chemical properties | DNA binding proteins | Artificial intelligence | Genetic research | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 10/2015, Volume 16, Issue 11, pp. 1124 - 1133
Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses to external pathogens. While ILCs can be phenotypically classified... 
IMMUNITY | ROR-GAMMA-T | ARYL-HYDROCARBON RECEPTOR | TRANSCRIPTION FACTOR GATA3 | IFN-GAMMA | DRIVES | NOTCH | NKP46(+) CELLS | DIFFERENTIATION | IMMUNOLOGY | TISSUE INDUCER CELLS | Core Binding Factor Alpha 3 Subunit - metabolism | Core Binding Factor beta Subunit - deficiency | Citrobacter rodentium - pathogenicity | Core Binding Factor beta Subunit - genetics | Lymphocyte Subsets - immunology | Enterobacteriaceae Infections - immunology | Intestinal Mucosa - cytology | Lymphocyte Subsets - metabolism | Lymphocyte Subsets - cytology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Intestinal Mucosa - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Antigens, Ly - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - deficiency | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Core Binding Factor beta Subunit - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Citrobacter rodentium - immunology | Mice, Inbred C57BL | Receptors, Aryl Hydrocarbon - genetics | Enterobacteriaceae Infections - etiology | Immunity, Innate | Mice, Knockout | Cell Differentiation - immunology | Animals | Core Binding Factor Alpha 3 Subunit - deficiency | Interleukin-7 Receptor alpha Subunit - metabolism | Core Binding Factor Alpha 3 Subunit - genetics | Natural Cytotoxicity Triggering Receptor 1 - metabolism | Mice | Cell Lineage - immunology | Physiological aspects | Genetic aspects | Immune response | Research | B cells | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 371 - 375
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide(1,2). The aetiological role of infection with high-risk human papilloma... 
FUSION | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | HUMAN-PAPILLOMAVIRUS | SENSITIVE DETECTION | SAMPLES | DNA-SEQUENCING DATA | EXPRESSION | SOMATIC MUTATIONS | HUMAN CANCER | DISCOVERY | F-Box-WD Repeat-Containing Protein 7 | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Genomics | Humans | E1A-Associated p300 Protein - genetics | Core Binding Factor beta Subunit - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | DNA Mutational Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Cell Cycle Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Papillomaviridae - physiology | HLA-B Antigens - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-ets | Virus Integration - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Transcriptome - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Adenocarcinoma - virology | Genome, Human - genetics | Papillomavirus Infections - genetics | Exome - genetics | Uterine Cervical Neoplasms - virology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Prevention | Gene mutations | Oncology, Experimental | Exome sequencing | Genetic aspects | Research | Cervical cancer | Cancer | Human papillomavirus | Mutation | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8482 - 8487
The pathogenesis of cleidocranial dysplasia (CCD) as well as the specific role of core binding factor β (Cbfβ) and the Runt-related transcription factor... 
Phenotypes | Bone formation | Chondrocytes | Bones | Skull | Skeletal development | Mice | Promoter regions | Epiphyses | Osteoblasts | Endochondral bone formation | Growth plate formation | Chondrocyte differentiation | Ossification | Osteoblast differentiation | OSTEOBLAST | MULTIDISCIPLINARY SCIENCES | endochondral bone formation | BINDING-FACTOR-BETA | BONE-DEVELOPMENT | RUNX2 | growth plate formation | TOOTH DEVELOPMENT | osteoblast differentiation | INTERACTS | chondrocyte differentiation | ossification | DIFFERENTIATION | Osteogenesis - physiology | Protein Multimerization | Core Binding Factor beta Subunit - genetics | Mice, 129 Strain | Core Binding Factor Alpha 1 Subunit - metabolism | Promoter Regions, Genetic - genetics | Collagen Type I - genetics | Chondrocytes - physiology | Gene Expression Regulation, Developmental | Cleidocranial Dysplasia - physiopathology | Cleidocranial Dysplasia - metabolism | Chondrocytes - metabolism | Osteogenesis - genetics | Core Binding Factor beta Subunit - metabolism | Animals, Newborn | Skull - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Osteoblasts - physiology | Cells, Cultured | Activating Transcription Factor 4 - genetics | Core Binding Factor beta Subunit - physiology | Mice, Transgenic | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Microscopy, Confocal | Animals | Activating Transcription Factor 4 - metabolism | Cleidocranial Dysplasia - genetics | Skull - cytology | Sp7 Transcription Factor | Protein Binding | Osteoblasts - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Microscopy, Fluorescence | Index Medicus | Biological Sciences
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2011, Volume 9, Issue 6, pp. 541 - 552
Journal Article
Blood, ISSN 0006-4971, 05/2014, Volume 123, Issue 19, pp. 2968 - 2977
Runx1 and Cbf beta are critical for the establishment of definitive hematopoiesis and are implicated in leukemic transformation. Despite the absolute... 
LINEAGE COMMITMENT | STEM-CELLS | HUMAN BONE-MARROW | IN-VIVO | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY | TRANSCRIPTION FACTOR | COMMITTED PROGENITORS | EXPRESSION | FETAL LIVER HEMATOPOIESIS | BINDING-FACTOR | Core Binding Factor Alpha 3 Subunit - metabolism | Interferon Regulatory Factors - metabolism | Anemia - pathology | Myeloproliferative Disorders - pathology | Core Binding Factor beta Subunit - genetics | Stem Cells - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Myeloproliferative Disorders - genetics | Cell Differentiation - genetics | Anemia - genetics | Flow Cytometry | Myeloproliferative Disorders - metabolism | Granulocytes - metabolism | Dendritic Cells - metabolism | Core Binding Factor beta Subunit - metabolism | Gene Expression | Core Binding Factor Alpha 2 Subunit - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interferon Regulatory Factors - genetics | Hematopoiesis - genetics | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | fms-Like Tyrosine Kinase 3 - metabolism | Mice, Knockout | Anemia - metabolism | Animals | Core Binding Factor Alpha 3 Subunit - genetics | Mice | Core Binding Factor Alpha 2 Subunit - genetics | Bone Marrow Cells - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Index Medicus | Abridged Index Medicus | Hematopoiesis and Stem Cells
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 07/2016, Volume 30, Issue 7, pp. 733 - 747
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2017, Volume 114, Issue 38, pp. 10119 - 10124
The mechanism underlying how transcription factors regulate mesenchymal stem cell lineage commitment remains unclear. To determine the role of core-binding... 
Osteoblast | Cbfβ | Transcription factor | Wnt/β-catenin | Bone−fat interaction | transcription factor | PROGENITORS | bone-fat interaction | MULTIDISCIPLINARY SCIENCES | osteoblast | MESENCHYMAL STEM-CELLS | CARTILAGE | INHIBITION | CORE-BINDING-FACTOR | BONE-FORMATION | Wnt/beta-catenin | FAT | Cbf beta | MICE | DIFFERENTIATION | WNT | Wnt3A Protein - metabolism | Wnt3A Protein - genetics | Gene Expression Regulation | Adipocytes - cytology | Mice, Transgenic | Core Binding Factor beta Subunit - genetics | Wnt Proteins - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Mesenchymal Stem Cells - pathology | Animals | Wnt Proteins - genetics | Adipocytes - metabolism | Mice | Osteoblasts - cytology | Osteoblasts - metabolism | Mesenchymal Stem Cells - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Wnt Signaling Pathway | Adipogenesis | Core Binding Factor beta Subunit - metabolism | Cell culture | Cbfa-1 protein | Transcription factors | Animal models | Wnt protein | Mesenchyme | Stem cell transplantation | Paracrine signalling | Cell lineage | Adipocytes | Gene expression | Osteoblasts | Studies | Osteoporosis | β-catenin | Osteoblastogenesis | Allografts | Rodents | Stem cells | Bone marrow | Biocompatibility | Bone | Index Medicus | Biological Sciences | bone−fat interaction | Wnt
Journal Article
Journal Article