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Revue de Medecine Interne, ISSN 0248-8663, 09/2018, Volume 39, Issue 9, pp. 699 - 710
Ocular drug side effects are very varied and can affect all the structures of the eye. The purpose of this review is to help clinicians: (i) to evoke this... 
Cornea | Side effects | Keratitis | Retinopathy | Ocular | Toxicity | Optic neuritis | Uveitis | Anti-TNF | Kerathopathy | Drug-induced | Tyrosine kinase inhibitors
Journal Article
Diabetes, ISSN 0012-1797, 12/2014, Volume 63, Issue 12, pp. 4262 - 4274
Substance P (SP) is a neuropeptide, predominantly released from sensory nerve fibers, with a potentially protective role in diabetic corneal epithelial wound... 
OCULAR SURFACE | RABBIT CORNEA | NEUROTROPHIC KERATOPATHY | CELLS | OXIDATIVE STRESS | ACTIVATION | ENDOCRINOLOGY & METABOLISM | NK1 RECEPTOR | COMPLICATIONS | MELLITUS | GROWTH-FACTOR-I | Sirtuin 1 - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Epithelial Cells - drug effects | Receptor, Epidermal Growth Factor - drug effects | Male | Substance P - pharmacology | Corneal Injuries - metabolism | Receptor, Epidermal Growth Factor - metabolism | Cornea - drug effects | Diabetes Mellitus, Experimental | Neurotransmitter Agents - pharmacology | Diabetes Mellitus, Type 1 | Receptors, Neurokinin-1 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Wound Healing - drug effects | Cell Line | Mice, Inbred C57BL | Touch - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Hyperglycemia - metabolism | Cornea - metabolism | Receptors, Neurokinin-1 - drug effects | Animals | Sirtuin 1 - drug effects | Mice | Wound Healing - physiology | Touch - physiology | Proto-Oncogene Proteins c-akt - drug effects | Complications and side effects | Corneal diseases | Wound healing | Diabetes | Health aspects | Risk factors | Hyperglycemia | Rodents | Homeostasis | Glucose | Cells | Index Medicus | Abridged Index Medicus | Annan medicinsk grundvetenskap | Basic Medicine | Other Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33245 - e33245
Background: Low temperature plasmas have been proposed in medicine as agents for tissue disinfection and have received increasing attention due to the... 
STREPTOCOCCUS-MUTANS | OXYGEN | STERILIZATION | INACTIVATION | OXIDATIVE STRESS | BACTERIA | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | KERATITIS | STAPHYLOCOCCUS-AUREUS | EXPRESSION | Transcription, Genetic - drug effects | Reactive Oxygen Species - metabolism | Humans | Virus Inactivation - drug effects | Atmospheric Pressure | Exocytosis - drug effects | Plasma Gases - pharmacology | Respiratory Burst - drug effects | Time Factors | Adult | Eye - drug effects | Corneal Keratocytes - metabolism | Deoxyguanosine - analogs & derivatives | Conjunctiva - cytology | Cell Survival - drug effects | Microbial Viability - drug effects | Phosphatidylserines - metabolism | Eye - cytology | Corneal Keratocytes - cytology | Fibroblasts - drug effects | Acetylcysteine - pharmacology | Disinfection - methods | Deoxyguanosine - metabolism | Protein Biosynthesis - drug effects | Fibroblasts - cytology | Cell Cycle - drug effects | Drug resistance in microorganisms | Antibiotics | Analysis | Escherichia coli | Innovations | Cells | Infection control | Oxidative stress | Plasma | Flow cytometry | Neurosciences | Cornea | Pathogenesis | DNA damage | Herpes simplex | Viruses | Tissues | Proteins | Fungi | Microorganisms | Cell growth | Fibroblasts | Pseudomonas aeruginosa | Bacteria | Plasmas | Drug dosages | Deoxyribonucleic acid--DNA | Low temperature | Cold pressing | Thymine | Forming | Disinfection | Cultures | Histology | Liquid chromatography | Metabolism | Mammals | Gene expression | Helium | High-performance liquid chromatography | Pressure | Microscopy | Insects | Low temperature resistance | OGG1 protein | Portable equipment | Dimers | Intracellular | Mutation | Disinfection & disinfectants | Viability | Immunoassays | Cell culture | Pathogens | Reactive oxygen species | Western blotting | Disinfectants | Temperature effects | Probes | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 8, pp. e0183873 - e0183873
Accumulating evidence indicates that cannabinoid CB1 receptor ligands play a pivotal role in seizures, not only in preclinical studies on animals, but also in... 
ELECTROSHOCK-INDUCED SEIZURES | CB1 RECEPTOR AGONIST | WIN 55,212-2 MESYLATE | 6 HZ | ANTICONVULSANT ACTIVITY | MULTIDISCIPLINARY SCIENCES | ENDOGENOUS CANNABINOID SYSTEM | INDUCED SEIZURE MODEL | PENTYLENETETRAZOLE-INDUCED SEIZURE | ISOBOLOGRAPHIC ANALYSIS | HOT-PLATE TEST | Phenobarbital - pharmacology | Cornea | Acetamides - pharmacology | Epilepsy, Complex Partial - physiopathology | Male | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Receptor, Cannabinoid, CB1 - agonists | Piracetam - pharmacology | Phenylmethylsulfonyl Fluoride - pharmacology | Drug Therapy, Combination | Nipecotic Acids - pharmacology | Epilepsy, Complex Partial - metabolism | Disease Models, Animal | Benzodiazepines - pharmacology | Psychomotor Performance - drug effects | Arachidonic Acids - pharmacology | Drug Synergism | Animals | Piracetam - analogs & derivatives | Electroshock - methods | Avoidance Learning - drug effects | Mice | Muscle Strength - drug effects | Epilepsy, Complex Partial - drug therapy | Physiological aspects | Anticonvulsants | Seizures (Medicine) | Drug therapy | Testing | Drugs | Brain | Laboratories | Epilepsy | Memory | Stimulation | Antiepileptic agents | Motor task performance | Experiments | Tiagabine | Convulsions & seizures | Fluoride | Muscular strength | Drug dosages | Seizures | Seizing | Phenylmethylsulfonyl fluoride | Pharmacology | Liquid chromatography | Cannabinoid CB1 receptors | Valproic acid | High-performance liquid chromatography | Medical screening | Etiracetam | Side effects | Phenobarbital | Psychomotor performance | Neurotransmission | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 48, pp. 17272 - 17277
VEGF-B primarily provides neuroprotection and improves survival in CNS-derived neurons. However, its actions on the peripheral nervous system have been less... 
Sensation | Debridement | Cornea | Neurites | Neurons | Nerves | Peripheral nerves | Mice | Epithelium | Nerve regeneration | Nerve injury | Neuronal growth | VEGF-B | neuronal growth | cornea | nerve injury | ANGIOGENESIS | PERMEABILITY | ENDOTHELIAL-GROWTH-FACTOR | MULTIDISCIPLINARY SCIENCES | ISCHEMIA | DEFICIENT MICE | KNOCKOUT MICE | RECOVERY | DISPLAY | PATHWAY | DISEASE | Neurites - physiology | Receptors, Notch - metabolism | Nerve Regeneration - physiology | Cell Survival - genetics | Phosphatidylinositol 3-Kinases - metabolism | Peripheral Nerves - drug effects | Cornea - drug effects | Peripheral Nerve Injuries - physiopathology | Neurons - physiology | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Neurites - drug effects | Nerve Regeneration - genetics | Cell Survival - drug effects | Trigeminal Ganglion - cytology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Peripheral Nerves - pathology | Blotting, Western | Mice, Knockout | Peripheral Nerves - physiopathology | Vascular Endothelial Growth Factor B - pharmacology | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Nerve Regeneration - drug effects | Cornea - innervation | Vascular Endothelial Growth Factor B - genetics | Cell Proliferation - drug effects | Cornea - physiopathology | Peripheral Nerve Injuries - genetics | Microscopy, Fluorescence | Sensory receptors | Vascular endothelial growth factor | Health aspects | Nervous system | Cell growth | Rodents | Index Medicus | Biological Sciences
Journal Article
ACS Nano, ISSN 1936-0851, 02/2015, Volume 9, Issue 2, pp. 1749 - 1758
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 04/2015, Volume 91, pp. 82 - 90
The unique structure and protective mechanisms of the eye result in low bioavailability of ocular drugs. Using a mucoadhesive material is an efficient solution... 
Cell culture | Sustained release | Silk fibroin | Liposomes | Coating | Ocular drug delivery | PROTEIN | VEHICLE | RELEASE | GELATION | NANOPARTICLES | PEPTIDES | FORMULATIONS | SYSTEMS | PHARMACOLOGY & PHARMACY | SUBMICRON EMULSION | PERMEATION | Administration, Ophthalmic | Fibroins - chemistry | Pupa - chemistry | Bombyx - chemistry | Humans | Excipients - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Delayed-Action Preparations - chemistry | Delayed-Action Preparations - administration & dosage | Cornea - drug effects | Ibuprofen - chemistry | Ocular Absorption | Excipients - chemistry | Surface Properties | Drug Compounding | Cornea - cytology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Cell Survival - drug effects | Fibroins - isolation & purification | Protein Structure, Secondary | Adhesiveness | Cells, Cultured | Ibuprofen - administration & dosage | Fibroins - adverse effects | Ibuprofen - metabolism | Particle Size | Cornea - metabolism | Delayed-Action Preparations - metabolism | Excipients - isolation & purification | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Delayed-Action Preparations - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Drug Liberation | Ibuprofen - adverse effects | Drug Delivery Systems - adverse effects | Drugs | Silk | Drug delivery systems | Ophthalmic drugs | Vehicles | Index Medicus
Journal Article
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 08/2012, Volume 125, Issue 15, pp. 3636 - 3648
Contact inhibition ubiquitously exists in non-transformed cells that are in contact with neighboring cells. This phenomenon explains the poor regenerative... 
Contact inhibition | Kaiso | ORGAN SIZE CONTROL | E-CADHERIN EXPRESSION | HIPPO PATHWAY | CELL-ADHESION | Proliferation | BETA-CATENIN | Human corneal endothelium | P120-CATENIN | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | p120 catenin | MYOFIBROBLAST TRANSFORMATION | MEDIATED TRANSCRIPTIONAL REPRESSION | Endothelial-mesenchymal transformation | RHO-GTPASES | RNA, Small Interfering - genetics | Humans | Middle Aged | Fibroblast Growth Factor 2 - pharmacology | Cell Growth Processes - physiology | Epithelial-Mesenchymal Transition - drug effects | rhoA GTP-Binding Protein - metabolism | Wnt Proteins - metabolism | Contact Inhibition - drug effects | Young Adult | Catenins - metabolism | Cornea - drug effects | Transfection | rho-Associated Kinases - metabolism | Edetic Acid - pharmacology | Aged, 80 and over | Adult | Cornea - cytology | Transforming Growth Factor beta1 - pharmacology | Catenins - physiology | Endothelium, Corneal - cytology | Cell Growth Processes - drug effects | Cells, Cultured | Endothelium, Corneal - drug effects | Endothelium, Corneal - ultrastructure | Cell Adhesion - drug effects | Catenins - genetics | Contact Inhibition - physiology | Transcription Factors - metabolism | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Adherens Junctions - physiology | Cell Adhesion - physiology | Adherens Junctions - drug effects | Adolescent | Aged | RNA, Small Interfering - administration & dosage | Index Medicus | Endothelial–mesenchymal transformation
Journal Article