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Stem cells (Dayton, Ohio), ISSN 1066-5099, 2004, Volume 22, Issue 3, pp. 355 - 366
This study evaluated proposed molecular markers related to stem cell (SC) properties with the intention of characterizing a putative SC phenotype in human... 
Cornea | Limbus | Epithelium | Stem cell phenotype | Stem cells | LOCATION | stem cells | LOCALIZATION | TRANSPORTER | cornea | CORNEAL EPITHELIUM | stem cell phenotype | P53 HOMOLOG | P63 | CELL BIOLOGY | INVOLUCRIN SYNTHESIS | ONCOLOGY | TRANSIT AMPLIFYING CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | limbus | epithelium | HEMATOLOGY | HUMAN OCULAR SURFACE | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Nestin | Bacterial Capsules | Cadherins - metabolism | Humans | Phosphopyruvate Hydratase - metabolism | Epithelium - ultrastructure | Stem Cells - cytology | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Integrins - metabolism | Antigens, CD - metabolism | DNA-Binding Proteins - metabolism | Limbus Corneae - metabolism | ATP-Binding Cassette Transporters - metabolism | Biomarkers, Tumor - metabolism | Membrane Proteins - metabolism | Microscopy, Electron, Transmission | Tumor Suppressor Proteins - metabolism | Connexin 43 - metabolism | Epithelium - metabolism | Limbus Corneae - ultrastructure | Genes, erbB-1 - genetics | Polysaccharides, Bacterial - metabolism | Epithelium, Corneal - ultrastructure | Receptors, Transferrin - metabolism | Stem Cells - ultrastructure | Nerve Tissue Proteins - metabolism | Microscopy, Confocal | Epithelium, Corneal - metabolism | Intermediate Filament Proteins - metabolism
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 1864 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Lumican - metabolism | Glaucoma, Open-Angle - genetics | Humans | Corneal Diseases - metabolism | Corneal Dystrophies, Hereditary - ethnology | Corneal Diseases - genetics | Ehlers-Danlos Syndrome - genetics | Corneal Dystrophies, Hereditary - pathology | Loeys-Dietz Syndrome - metabolism | Mendelian Randomization Analysis | Fibrillin-1 - metabolism | Cornea - pathology | Keratoconus - pathology | Corneal Diseases - pathology | Decorin - genetics | Gene Expression | Eye Diseases, Hereditary - pathology | Lumican - genetics | ADAMTS Proteins - metabolism | Proteoglycans - metabolism | Ehlers-Danlos Syndrome - ethnology | European Continental Ancestry Group | Myopia - pathology | Cornea - metabolism | Myopia - ethnology | Loeys-Dietz Syndrome - pathology | Corneal Diseases - ethnology | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Cornea - abnormalities | Quantitative Trait Loci | Proteoglycans - genetics | ADAMTS Proteins - genetics | Transforming Growth Factor beta2 - metabolism | Corneal Dystrophies, Hereditary - genetics | Glaucoma, Open-Angle - pathology | Keratoconus - metabolism | Loeys-Dietz Syndrome - ethnology | Glaucoma, Open-Angle - ethnology | Myopia - metabolism | Ehlers-Danlos Syndrome - pathology | Marfan Syndrome - ethnology | Keratoconus - genetics | Glaucoma, Open-Angle - metabolism | Fibrillin-1 - genetics | Eye Diseases, Hereditary - ethnology | Genome-Wide Association Study | Quantitative Trait, Heritable | Corneal Dystrophies, Hereditary - metabolism | Marfan Syndrome - genetics | Eye Diseases, Hereditary - genetics | Myopia - genetics | Asian Continental Ancestry Group | Keratoconus - ethnology | Ehlers-Danlos Syndrome - metabolism | Loeys-Dietz Syndrome - genetics | Polymorphism, Single Nucleotide | Transforming Growth Factor beta2 - genetics | Genome, Human | Decorin - metabolism | Eye Diseases, Hereditary - metabolism | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 17763 - 11
We investigated the effect of a peroxisome proliferator-activated receptor alpha (PPAR?alpha) agonist ophthalmic solution in wound healing using a rat corneal... 
GAMMA | PPAR-ALPHA | CELLS | LIPID-METABOLISM | COLLAGEN | TIE2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FACTOR-KAPPA-B | EXPRESSION | BASEMENT-MEMBRANE | Eye Burns - drug therapy | Ophthalmic Solutions - pharmacology | Burns, Chemical - metabolism | Corneal Neovascularization - drug therapy | Collagen Type III - metabolism | Male | Angiopoietin-1 - metabolism | RNA, Messenger - metabolism | Angiopoietin-2 - metabolism | Corneal Injuries - metabolism | Myofibroblasts - metabolism | Cicatrix - metabolism | Fenofibrate - pharmacology | Cornea - drug effects | Alkalies - pharmacology | Neutrophils - metabolism | Wound Healing - drug effects | Disease Models, Animal | Endothelial Cells - metabolism | Neutrophils - drug effects | Rats | Myofibroblasts - drug effects | Up-Regulation - drug effects | Cornea - metabolism | Cicatrix - drug therapy | Macrophages - metabolism | Animals | Corneal Neovascularization - metabolism | Neovascularization, Pathologic - drug therapy | Burns, Chemical - drug therapy | Eye Burns - metabolism | Macrophages - drug effects | PPAR alpha - agonists | Vascular Endothelial Growth Factors - metabolism | Neovascularization, Pathologic - metabolism | Corneal Injuries - drug therapy | Cornea | Wound healing | Angiopoietin | Stroma | Collagen (type III) | Leukocytes (neutrophilic) | Inflammation | Gene expression | Macrophages | Endothelial cells | Vascularization | Fenofibrate | Rodents | Vascular endothelial growth factor
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0188398
Epithelial and stromal stem cells are required to maintain corneal transparency. The aim of the study was to develop a new method to isolate and grow both... 
PROGENITOR CELLS | THERAPY | NEURAL CREST DERIVATIVES | MULTIDISCIPLINARY SCIENCES | CULTURE-CONDITIONS | TISSUE | NICHE | PAX6 | EXPRESSION | TRANSPLANTATION | Cell Proliferation | Humans | Adipocytes - drug effects | Spheroids, Cellular - cytology | PAX6 Transcription Factor - genetics | Limbus Corneae - drug effects | Corneal Stroma - cytology | Polycomb Repressive Complex 1 - genetics | Limbus Corneae - metabolism | Epithelium, Corneal - drug effects | Cell Differentiation | Neurons - metabolism | Culture Media - chemistry | Neoplasm Proteins - genetics | Fibroblasts - metabolism | Biomarkers - metabolism | Corneal Stroma - drug effects | SOX9 Transcription Factor - metabolism | Gene Expression | Corneal Stroma - metabolism | Spheroids, Cellular - metabolism | Keratinocytes - drug effects | Keratinocytes - metabolism | Fibroblasts - drug effects | Fibroblasts - cytology | Chondrocytes - cytology | Epithelial Cells - metabolism | Epithelium, Corneal - cytology | Polycomb Repressive Complex 1 - metabolism | Epithelial Cells - drug effects | Adipocytes - cytology | Neurons - cytology | Stem Cells - cytology | Neoplasm Proteins - metabolism | Stem Cells - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Chondrocytes - drug effects | Nestin - genetics | Spheroids, Cellular - drug effects | Epithelial Cells - cytology | Neurons - drug effects | Chondrocytes - metabolism | PAX6 Transcription Factor - metabolism | Keratinocytes - cytology | Cell Separation - methods | Nestin - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Adipocytes - metabolism | Culture Media - pharmacology | Epithelium, Corneal - metabolism | Stem Cells - drug effects | Primary Cell Culture | Limbus Corneae - cytology | SOX9 Transcription Factor - genetics | Physiological aspects | Cornea | Genetic aspects | Research | Stem cells | Vimentin | Bioengineering | Cell culture | Nestin | Transparency | Media (culture) | Transplants & implants | Sox9 protein | Osteocytes | Adipocytes | Scraping | Biomedical materials | Epidermal growth factor | Fibroblasts | Biocompatibility | Chondrogenesis | Explants | Second harmonic generation | Colonies | Fibrils | Forming | Collagenase | Sox10 protein | Studies | Pax6 protein | Microscopy | Biopsy | Collagen | Chondrocytes | Differentiation | Methods | Life Sciences | Cellular Biology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2482 - 2498
Filamentous fungi are a common cause of blindness and visual impairment worldwide. Using both murine model systems and in vitro human neutrophils, we found... 
TRANSCRIPTIONAL REGULATOR | MEDICINE, RESEARCH & EXPERIMENTAL | ASPERGILLUS-FUMIGATUS | OXIDATIVE STRESS | RESPIRATORY BURST | CANDIDA-ALBICANS | BETA-GLUCAN | GLIOTOXIN PRODUCTION | CHRONIC GRANULOMATOUS-DISEASE | MICROBIAL KERATITIS | FUSARIUM KERATITIS | Keratitis - immunology | Keratitis - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Antioxidants - metabolism | Humans | NADPH Oxidases - metabolism | Neutrophil Infiltration | Aspergillosis - pathology | Fusarium - physiology | NADPH Oxidases - genetics | Thioredoxins - metabolism | Cornea - pathology | Fusarium - metabolism | Cornea - microbiology | Neutrophils - enzymology | Fusarium - enzymology | Aspergillus flavus - physiology | Mice, Knockout | CD18 Antigens - metabolism | Host-Pathogen Interactions | Antioxidants - physiology | Aspergillosis - microbiology | Fusariosis - immunology | Fusariosis - pathology | Mice | Enzyme Activation | Fusariosis - microbiology | Nitric Oxide Synthase Type II - metabolism | Aspergillus flavus - metabolism | Keratitis - microbiology | Aspergillus fumigatus - enzymology | Superoxide Dismutase - physiology | Aspergillus fumigatus - physiology | Aspergillus fumigatus - metabolism | Neutrophils - microbiology | Superoxide Dismutase - metabolism | Transcription Factors - physiology | Mice, Inbred C57BL | Cells, Cultured | Neutrophils - immunology | Microbial Viability | Aspergillus flavus - enzymology | Transcription Factors - metabolism | Fungal Proteins - physiology | Animals | Nitric Oxide - metabolism | Aspergillosis - immunology | Fungal Proteins - metabolism | Peroxidase - metabolism | Fungi | Neutrophils | Physiological aspects | Mycoses | Research | Drug therapy | Health aspects
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7509, pp. 358 - 361
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2018, Volume 19, Issue 2, p. 464
Following injury, corneal stromal keratocytes transform into repair-phenotype of activated stromal fibroblasts (SFs) and participate in wound repair.... 
Cornea | Antibody microarray | Stromal fibroblasts | EMT-like changes | Epithelial cells | CANCER-CELLS | CLAUDIN-1 EXPRESSION | SIGNALING PATHWAYS | TGF-BETA | cornea | antibody microarray | NEUROTROPHIC FACTOR | INTEGRIN EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | epithelial cells | MESENCHYMAL TRANSITION | CHEMISTRY, MULTIDISCIPLINARY | stromal fibroblasts | ADHESION MOLECULE | SUBSTANCE-P | GROWTH-FACTOR-I | Paxillin - metabolism | Focal Adhesion Kinase 1 - genetics | Paxillin - genetics | Stromal Cells - pathology | Humans | Zinc Finger E-box-Binding Homeobox 1 - genetics | Corneal Injuries - metabolism | Snail Family Transcription Factors - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cornea - pathology | Focal Adhesion Kinase 1 - metabolism | Corneal Injuries - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Epithelial Cells - pathology | Corneal Injuries - rehabilitation | Fibroblasts - pathology | Cell Adhesion Molecules - metabolism | beta Catenin - metabolism | Cornea - metabolism | Stromal Cells - secretion | Mitogen-Activated Protein Kinase 3 - metabolism | Models, Biological | Integrin beta1 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Cell Adhesion Molecules - genetics | Fibroblasts - secretion | Epithelial Cells - metabolism | Vimentin - metabolism | Epithelial Cells - drug effects | Antibodies | Culture Media, Conditioned - pharmacology | Substance P - pharmacology | Phosphoproteins - metabolism | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Cornea - drug effects | Protein Isoforms - metabolism | Vimentin - genetics | Microfilament Proteins - metabolism | Wound Healing - genetics | Microfilament Proteins - genetics | Wound Healing - drug effects | Cell Line | Snail Family Transcription Factors - metabolism | Phosphoproteins - genetics | beta Catenin - genetics | Gene Expression Regulation - drug effects | Integrin beta1 - metabolism | Protein Array Analysis | Primary Cell Culture | Protein Isoforms - genetics | Cell proliferation | Phosphorylation | Transcription factors | Mesenchyme | Activation | Kinases | Cell surface | Cell adhesion & migration | Proteins | Signal transduction | Genotype & phenotype | CD44 antigen | Cascades | Fibroblasts | Conditioning | Repair | Interleukin 8 | Phenotypes | Wound healing | Cytokines | Intercellular adhesion molecule 1 | Tissue engineering | Antibody microarrays | Extracellular signal-regulated kinase | MAP kinase | Interleukin 15 | Adhesion | Regeneration | Signaling | Brain-derived neurotrophic factor | DNA microarrays | Healing | Focal adhesion kinase | Surface markers | Paxillin | Cell migration | Integrins
Journal Article
by Yang, L and Di, G and Qi, X and Qu, M and Wang, Y and Duan, H and Danielson, P and Xie, L and Zhou, Q
Diabetes (New York, N.Y.), ISSN 1939-327X, 2014, Volume 63, Issue 12, pp. 4262 - 4274
Journal Article