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STEM CELLS, ISSN 1066-5099, 05/2004, Volume 22, Issue 3, pp. 355 - 366
This study evaluated proposed molecular markers related to stem cell (SC) properties with the intention of characterizing a putative SC phenotype in human... 
Cornea | Limbus | Epithelium | Stem cell phenotype | Stem cells | LOCATION | stem cells | LOCALIZATION | TRANSPORTER | cornea | CORNEAL EPITHELIUM | stem cell phenotype | P53 HOMOLOG | P63 | CELL BIOLOGY | INVOLUCRIN SYNTHESIS | ONCOLOGY | TRANSIT AMPLIFYING CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | limbus | epithelium | HEMATOLOGY | HUMAN OCULAR SURFACE | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Nestin | Bacterial Capsules | Cadherins - metabolism | Humans | Phosphopyruvate Hydratase - metabolism | Epithelium - ultrastructure | Stem Cells - cytology | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Integrins - metabolism | Antigens, CD - metabolism | DNA-Binding Proteins - metabolism | Limbus Corneae - metabolism | ATP-Binding Cassette Transporters - metabolism | Biomarkers, Tumor - metabolism | Membrane Proteins - metabolism | Microscopy, Electron, Transmission | Tumor Suppressor Proteins - metabolism | Connexin 43 - metabolism | Epithelium - metabolism | Limbus Corneae - ultrastructure | Genes, erbB-1 - genetics | Polysaccharides, Bacterial - metabolism | Epithelium, Corneal - ultrastructure | Receptors, Transferrin - metabolism | Stem Cells - ultrastructure | Nerve Tissue Proteins - metabolism | Microscopy, Confocal | Epithelium, Corneal - metabolism | Intermediate Filament Proteins - metabolism | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 09/2011, Volume 109, Issue 7, pp. 724 - 728
RATIONALE:Transplantation of human CD34 stem cells to ischemic tissues has been associated with reduced angina, improved exercise time, and reduced amputation... 
cells | CD34 | angiogenesis | exosomes | paracrine factor | CARDIAC & CARDIOVASCULAR SYSTEMS | CD34(+) cells | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CD34 antigen | Cell proliferation | Flow cytometry | Cornea | Physical training | CD63 antigen | Light scattering | Clinical trials | Paracrine signalling | Cell lineage | Data processing | Immunoblotting | Leukocytes (mononuclear) | Endothelial cells | Angiogenesis | Ischemia | Stem cells | vascularization | Corneal Neovascularization - immunology | Exosomes - metabolism | Stem Cells - immunology | Antigens, CD34 - metabolism | Humans | Male | Stem Cells - metabolism | Antigens, CD - metabolism | DNA-Binding Proteins - metabolism | Flow Cytometry | Light | Platelet Membrane Glycoproteins - metabolism | Exosomes - immunology | Scattering, Radiation | Exosomes - ultrastructure | Biomarkers - metabolism | Microscopy, Electron, Transmission | Paracrine Communication | Endothelial Cells - metabolism | Phosphatidylserines - metabolism | Cells, Cultured | Endosomal Sorting Complexes Required for Transport - metabolism | Blotting, Western | Stem Cells - ultrastructure | Particle Size | Transcription Factors - metabolism | Animals | Corneal Neovascularization - metabolism | Tetraspanin 30 | Mice, Nude | Mice | Angiogenic Proteins - metabolism | Neovascularization, Physiologic | Culture Media, Conditioned - metabolism | Index Medicus
Journal Article
by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissue | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Lumican - metabolism | Glaucoma, Open-Angle - genetics | Humans | Corneal Diseases - metabolism | Corneal Dystrophies, Hereditary - ethnology | Corneal Diseases - genetics | Ehlers-Danlos Syndrome - genetics | Corneal Dystrophies, Hereditary - pathology | Loeys-Dietz Syndrome - metabolism | Mendelian Randomization Analysis | Fibrillin-1 - metabolism | Cornea - pathology | Keratoconus - pathology | Corneal Diseases - pathology | Decorin - genetics | Gene Expression | Eye Diseases, Hereditary - pathology | Lumican - genetics | ADAMTS Proteins - metabolism | Proteoglycans - metabolism | Ehlers-Danlos Syndrome - ethnology | European Continental Ancestry Group | Myopia - pathology | Cornea - metabolism | Myopia - ethnology | Loeys-Dietz Syndrome - pathology | Corneal Diseases - ethnology | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Cornea - abnormalities | Quantitative Trait Loci | Proteoglycans - genetics | ADAMTS Proteins - genetics | Transforming Growth Factor beta2 - metabolism | Corneal Dystrophies, Hereditary - genetics | Glaucoma, Open-Angle - pathology | Keratoconus - metabolism | Loeys-Dietz Syndrome - ethnology | Glaucoma, Open-Angle - ethnology | Myopia - metabolism | Ehlers-Danlos Syndrome - pathology | Marfan Syndrome - ethnology | Keratoconus - genetics | Glaucoma, Open-Angle - metabolism | Fibrillin-1 - genetics | Eye Diseases, Hereditary - ethnology | Genome-Wide Association Study | Quantitative Trait, Heritable | Corneal Dystrophies, Hereditary - metabolism | Marfan Syndrome - genetics | Eye Diseases, Hereditary - genetics | Myopia - genetics | Asian Continental Ancestry Group | Keratoconus - ethnology | Ehlers-Danlos Syndrome - metabolism | Loeys-Dietz Syndrome - genetics | Polymorphism, Single Nucleotide | Transforming Growth Factor beta2 - genetics | Genome, Human | Decorin - metabolism | Eye Diseases, Hereditary - metabolism | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2013, Volume 9, Issue 7, pp. e1003436 - e1003436
Filamentous fungi are an important cause of pulmonary and systemic morbidity and mortality, and also cause corneal blindness and visual impairment worldwide.... 
DEFERASIROX | MICROBIOLOGY | INNATE IMMUNE | VIRULENCE | STATINS | MUCORMYCOSIS | INVASIVE ASPERGILLOSIS | SIDEROPHORES | VIROLOGY | METABOLISM | GROWTH | STEM-CELL TRANSPLANTATION | PARASITOLOGY | Hepcidins - metabolism | Neutrophils - cytology | Humans | Fusarium - drug effects | Siderophores - biosynthesis | Lectins, C-Type - metabolism | Eye Infections, Fungal - prevention & control | Lipocalin 1 - therapeutic use | Aspergillosis - metabolism | Cornea - pathology | Siderophores - antagonists & inhibitors | Interleukin-6 - metabolism | Neutrophils - metabolism | Fusarium - metabolism | Antifungal Agents - pharmacology | Cornea - microbiology | Iron Chelating Agents - therapeutic use | Specific Pathogen-Free Organisms | Fusariosis - metabolism | Interleukin-6 - genetics | Neutrophils - drug effects | Iron - metabolism | Eye Infections, Fungal - microbiology | Fusarium - growth & development | Mice, Knockout | Bacterial Outer Membrane Proteins - metabolism | Aspergillosis - prevention & control | Aspergillus fumigatus - immunology | Aspergillosis - microbiology | Fusariosis - immunology | Aspergillus fumigatus - growth & development | Mice | Mutation | Eye Infections, Fungal - immunology | Fusariosis - microbiology | Receptors, Cell Surface - genetics | Aspergillus fumigatus - drug effects | Antifungal Agents - therapeutic use | Cornea - drug effects | Eye Infections, Fungal - metabolism | Aspergillus fumigatus - metabolism | Bacterial Outer Membrane Proteins - genetics | Lipocalin 1 - metabolism | Siderophores - metabolism | Mice, Inbred C57BL | Cells, Cultured | Neutrophils - immunology | Receptors, Cell Surface - metabolism | Fusariosis - prevention & control | Lipocalin 1 - pharmacology | Fusarium - immunology | Animals | Iron Chelating Agents - pharmacology | Aspergillosis - immunology | Aspergillus | Physiological aspects | Fusarium | Host-parasite relationships | Iron in the body | Research | Health aspects | Index Medicus | Fungi | Proteins | Enzymes | Statistical analysis | Microbiology | Ulcers | Software | Biosynthesis | Fungal infections
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7509, pp. 358 - 361
The surface of the cornea consists of a unique type of non-keratinized epithelial cells arranged in an orderly fashion, and this is essential for vision by... 
MORPHOGENESIS | LIMB | STEM-CELLS | PATHWAY | MULTIDISCIPLINARY SCIENCES | DIFFERENTIATION | SKIN | P63 | EXPRESSION | KERATINS | Cornea | Pathogenesis | Humans | Repressor Proteins | Homeostasis | Male | Wnt Proteins | Corneal Diseases | PAX6 protein | Stem Cell Transplantation | Stem Cells | Rodents | Cell Differentiation | Disease Models, Animal | TP63 protein, human | Medical research | Rabbits | Signal Transduction | Paired Box Transcription Factors | Epithelium, Corneal | Gene expression | Limbus Corneae | Cell Lineage | Animals | Homeodomain Proteins | Skin | Transcription Factors | Eye Proteins | Tumor Suppressor Proteins | WNT7A protein, human | Paired Box Transcription Factors - genetics | Skin - cytology | Epithelium, Corneal - cytology | Skin - metabolism | Homeodomain Proteins - metabolism | Corneal Diseases - metabolism | Stem Cells - cytology | Epithelium, Corneal - pathology | Stem Cells - metabolism | Wnt Proteins - metabolism | Wnt Proteins - genetics | Limbus Corneae - metabolism | Eye Proteins - genetics | Corneal Diseases - pathology | Repressor Proteins - metabolism | Skin - pathology | Tumor Suppressor Proteins - metabolism | Repressor Proteins - genetics | PAX6 Transcription Factor | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Eye Proteins - metabolism | Epithelium, Corneal - metabolism | Limbus Corneae - cytology | Paired Box Transcription Factors - metabolism | Genetic aspects | Epithelium | Cell differentiation | Growth | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2482 - 2498
Filamentous fungi are a common cause of blindness and visual impairment worldwide. Using both murine model systems and in vitro human neutrophils, we found... 
TRANSCRIPTIONAL REGULATOR | MEDICINE, RESEARCH & EXPERIMENTAL | ASPERGILLUS-FUMIGATUS | NADPH-OXIDASE | CANDIDA-ALBICANS | REACTIVE OXYGEN | BETA-GLUCAN | GLIOTOXIN PRODUCTION | CHRONIC GRANULOMATOUS-DISEASE | FUSARIUM KERATITIS | OXIDATIVE STRESS-RESPONSE | Keratitis - immunology | Keratitis - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Antioxidants - metabolism | Humans | NADPH Oxidases - metabolism | Neutrophil Infiltration | Aspergillosis - pathology | Fusarium - physiology | NADPH Oxidases - genetics | Thioredoxins - metabolism | Cornea - pathology | Fusarium - metabolism | Cornea - microbiology | Neutrophils - enzymology | Fusarium - enzymology | Aspergillus flavus - physiology | Mice, Knockout | CD18 Antigens - metabolism | Host-Pathogen Interactions | Antioxidants - physiology | Aspergillosis - microbiology | Fusariosis - immunology | Fusariosis - pathology | Mice | Enzyme Activation | Fusariosis - microbiology | Nitric Oxide Synthase Type II - metabolism | Aspergillus flavus - metabolism | Keratitis - microbiology | Aspergillus fumigatus - enzymology | Superoxide Dismutase - physiology | Aspergillus fumigatus - physiology | Aspergillus fumigatus - metabolism | Neutrophils - microbiology | Superoxide Dismutase - metabolism | Transcription Factors - physiology | Mice, Inbred C57BL | Cells, Cultured | Neutrophils - immunology | Microbial Viability | Aspergillus flavus - enzymology | Transcription Factors - metabolism | Fungal Proteins - physiology | Animals | Nitric Oxide - metabolism | Aspergillosis - immunology | Fungal Proteins - metabolism | Peroxidase - metabolism | Fungi | Neutrophils | Physiological aspects | Mycoses | Research | Drug therapy | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173301 - e0173301
We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-17A, IL-6 and IL-23, in protein and mRNA levels and their... 
TEARS | INTERLEUKIN-17 | SIGNS | MULTIDISCIPLINARY SCIENCES | PATHOGENIC T(H)17 CELLS | SYMPTOMS | DIAGNOSTIC-TESTS | DIFFERENTIATION | SJOGREN-SYNDROME | Pathogenesis | Chains (polymeric) | Assaying | Metastases | Eye | Proteins | Signal transduction | Histopathology | Surgery | Classification | Tubes | Eye (anatomy) | Breakup | Bioindicators | Diagnosis | Ophthalmology | Public health | Antigens | Bovine serum albumin | Evaluation | Eyes | Cytokines | Interleukin 12 | Time measurement | Epithelium | Gene expression | Patients | Interleukin 17 | Studies | Polymerase chain reaction | Beijing China | Hospitals | Biomarkers | Collection | Infiltration | Colitis | Cornea | Sjogren's syndrome | Conferences | Transforming growth factor-b | Glands | Antibodies | Staining | Clinical trials | Scoring | mRNA | Infections | Tissues | Inflammatory diseases | Interleukin 6 | Biomedical materials | Lymphocytes | Rodents | Quality | China | Interleukin 1 | Tumor necrosis factor-TNF | Children | Rubber | Interleukin 8 | Hypertension | Desiccants | Diabetes mellitus | Inflammation | Evaporation | Chronic fatigue syndrome | CD4 antigen | Blindness | Eye diseases | In vivo methods and tests | Sjogren syndrome | Differentiation | Biomarkers - metabolism | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Sjogren's Syndrome - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Conjunctiva - metabolism | Cornea - metabolism | Interleukin-17 - metabolism | Interleukin-23 - metabolism | Th17 Cells - metabolism | Dry Eye Syndromes - metabolism | Female | Aged | Interleukin-6 - metabolism | Fluorescein - metabolism | Care and treatment | Genetic aspects | Research | Interleukins | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e87368 - e87368
There are several animal models illustrating dry eye pathophysiology. Current study would like to establish an ex vivo tissue culture model for characterizing... 
OCULAR SURFACE EPITHELIUM | MATRIX METALLOPROTEINASES | MUCIN GENE-EXPRESSION | KERATOCONJUNCTIVITIS SICCA | MULTIDISCIPLINARY SCIENCES | CORNEAL EPITHELIAL-CELLS | SQUAMOUS METAPLASIA | LACRIMAL GLAND | FLOW-CYTOMETRIC ANALYSIS | BENZALKONIUM CHLORIDE | INFLAMMATORY MARKERS | Cell culture | Cornea | Animal models | Media (culture) | Wnt protein | Disease | Laboratories | Epithelial cells | Science | Tissue culture | Enzyme-linked immunoassays | Eye | Keratin | Signal transduction | Epidermal growth factor | China | Stratification | Air conditioners | MUC16 gene | Explants | Immunoglobulins | Air exposure | Eyes | Cultures | Inflammation | Tumor necrosis factor-α | IL-1β | Signalling | Epithelium | Cell differentiation | Gelatinase B | Pax6 protein | Metaplasia | Mucin | Antibiotics | Stromal cells | Eye diseases | Cholera | Apoptosis | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Epithelial Cells - metabolism | Homeodomain Proteins - metabolism | Humans | Keratin-10 - genetics | Keratin-16 - genetics | Conjunctiva - metabolism | Conjunctiva - pathology | Matrix Metalloproteinase 9 - metabolism | Time Factors | Interleukin-1beta - metabolism | Mucins - metabolism | Repressor Proteins - metabolism | Keratin-10 - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Mucin-4 - metabolism | Keratin-16 - metabolism | Dry Eye Syndromes - genetics | PAX6 Transcription Factor | Air | Reverse Transcriptase Polymerase Chain Reaction | Mucin-4 - genetics | Keratin-19 - genetics | Eye Proteins - metabolism | Dry Eye Syndromes - metabolism | Mucin 5AC - genetics | Mucin 5AC - metabolism | Keratin-19 - metabolism | Tissue Culture Techniques - methods | Mucins - genetics | Paired Box Transcription Factors - metabolism | Analysis | Mucins | Index Medicus
Journal Article
by Lee, J and Jung, E and Heur, M
MOLECULAR VISION, ISSN 1090-0535, 01/2019, Volume 25, Issue 1, pp. 22 - 34
Purpose: To determine whether the mouse corneal endothelium enters endothelial to mesenchymal transition (EndoMT) following surgical injury in vivo. Methods:... 
TRANSFORMATION | CELLS | COLLAGEN | PHOSPHATIDYLINOSITOL 3-KINASE | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR SNAIL | OPHTHALMOLOGY | FIBROBLAST-GROWTH-FACTOR | IL-1-BETA | NF-KAPPA-B | EXPRESSION | Oncogene Proteins - genetics | Interleukin-1beta - pharmacology | Vimentin - metabolism | Humans | Corneal Injuries - genetics | Fibroblast Growth Factor 2 - pharmacology | Epithelial-Mesenchymal Transition - drug effects | Aqueous Humor - chemistry | Interleukin-1beta - genetics | Cdh1 Proteins - genetics | Epithelial-Mesenchymal Transition - genetics | Zinc Finger E-box-Binding Homeobox 1 - genetics | Cyclin E - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Corneal Injuries - metabolism | Aqueous Humor - metabolism | Collagen Type I - genetics | Snail Family Transcription Factors - genetics | Interleukin-1beta - metabolism | Vimentin - genetics | Fibroblast Growth Factor 2 - metabolism | Cornea - pathology | Cdh1 Proteins - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Collagen Type I - metabolism | Snail Family Transcription Factors - metabolism | Corneal Injuries - pathology | Signal Transduction | Tissue Culture Techniques | Mice, Inbred C57BL | Endothelium - injuries | Gene Expression Regulation | Oncogene Proteins - metabolism | Cyclin-Dependent Kinase 2 - genetics | Fibronectins - metabolism | Cornea - metabolism | Endothelium - drug effects | Fibroblast Growth Factor 2 - antagonists & inhibitors | Animals | Endothelium - metabolism | Fibroblast Growth Factor 2 - genetics | Mice, Inbred NOD | Fibronectins - genetics | Mice | Cyclin E - metabolism | corneal endothelium | fibroblast growth factor
Journal Article