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by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissue | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Lumican - metabolism | Glaucoma, Open-Angle - genetics | Humans | Corneal Diseases - metabolism | Corneal Dystrophies, Hereditary - ethnology | Corneal Diseases - genetics | Ehlers-Danlos Syndrome - genetics | Corneal Dystrophies, Hereditary - pathology | Loeys-Dietz Syndrome - metabolism | Mendelian Randomization Analysis | Fibrillin-1 - metabolism | Cornea - pathology | Keratoconus - pathology | Corneal Diseases - pathology | Decorin - genetics | Gene Expression | Eye Diseases, Hereditary - pathology | Lumican - genetics | ADAMTS Proteins - metabolism | Proteoglycans - metabolism | Ehlers-Danlos Syndrome - ethnology | European Continental Ancestry Group | Myopia - pathology | Cornea - metabolism | Myopia - ethnology | Loeys-Dietz Syndrome - pathology | Corneal Diseases - ethnology | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Cornea - abnormalities | Quantitative Trait Loci | Proteoglycans - genetics | ADAMTS Proteins - genetics | Transforming Growth Factor beta2 - metabolism | Corneal Dystrophies, Hereditary - genetics | Glaucoma, Open-Angle - pathology | Keratoconus - metabolism | Loeys-Dietz Syndrome - ethnology | Glaucoma, Open-Angle - ethnology | Myopia - metabolism | Ehlers-Danlos Syndrome - pathology | Marfan Syndrome - ethnology | Keratoconus - genetics | Glaucoma, Open-Angle - metabolism | Fibrillin-1 - genetics | Eye Diseases, Hereditary - ethnology | Genome-Wide Association Study | Quantitative Trait, Heritable | Corneal Dystrophies, Hereditary - metabolism | Marfan Syndrome - genetics | Eye Diseases, Hereditary - genetics | Myopia - genetics | Asian Continental Ancestry Group | Keratoconus - ethnology | Ehlers-Danlos Syndrome - metabolism | Loeys-Dietz Syndrome - genetics | Polymorphism, Single Nucleotide | Transforming Growth Factor beta2 - genetics | Genome, Human | Decorin - metabolism | Eye Diseases, Hereditary - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138701 - e0138701
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 2014, Volume 63, Issue 7, pp. 2454 - 2463
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, pp. e29017 - e29017
Background: TGF-beta is a pleiotropic cytokine that can have pro- or anti-inflammatory effects depending on the context. Elevated levels of bioactive TGF-beta... 
BARRIER DISRUPTION | GROWTH-FACTOR-BETA | DESICCATING STRESS | TEAR FLUID | INTERFERON-GAMMA | EXPERIMENTAL DRY EYE | BIOLOGY | REGULATORY T-CELLS | SJOGRENS-SYNDROME | CORNEAL EPITHELIUM | SALIVARY-GLANDS | Cornea | Sjogren's syndrome | Physicians | Glands | Helper cells | Interleukin 23 | Lymphocytes T | Kinases | T cells | Adoptive transfer | Cell density | Eye | Keratoconjunctivitis | Lymphocytes | Rodents | Age | Scopolamine | Eyes | Cytokines | Desiccants | Salivary glands | United States--US | Inflammation | Conjunctiva | Signalling | Disease control | Smoothness | Gelatinase B | CD4 antigen | Medicine | Mouse models | RAG1 protein | γ-Interferon | Texas | Muridae | Eye diseases | Mice | Infiltration | Interferon | Cell staining | Disruption | Tears | Eye - pathology | Inflammation - pathology | Homeodomain Proteins - metabolism | Humans | Aging - drug effects | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Conjunctiva - metabolism | Dry Eye Syndromes - pathology | Conjunctiva - pathology | Inflammation - metabolism | Transforming Growth Factor beta - drug effects | Keratoconjunctivitis Sicca - complications | Eye - drug effects | Mucous Membrane - drug effects | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Protein-Serine-Threonine Kinases - metabolism | Eye - metabolism | Epithelium - drug effects | Epithelium - pathology | Epithelium - metabolism | Receptors, Chemokine - metabolism | Autoimmune Diseases - complications | Keratoconjunctivitis Sicca - metabolism | Aging - pathology | Mice, Knockout | Mucous Membrane - metabolism | Cell Movement - drug effects | Transforming Growth Factor beta - pharmacology | Mucous Membrane - pathology | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Conjunctiva - drug effects | Dry Eye Syndromes - metabolism | Keratoconjunctivitis Sicca - pathology | Cell Proliferation - drug effects | Genes, Dominant - genetics | Transforming Growth Factor beta - metabolism | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 6, pp. 2015 - 2020
Normal vision requires the precise control of vascular growth to maintain corneal transparency. Here we provide evidence for a unique mechanism by which the... 
Angiogenesis | Cornea | Blood vessels | Mice | Physical trauma | Lymphatic vessels | Corneal neovascularization | Genetic mutation | Embryos | Endothelial cells | Soluble form of VEGF receptor 1 | VEGF bioavailablility | Avascularity | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | KEY PLAYERS | CARDIOVASCULAR DEVELOPMENT | MATRIX METALLOPROTEINASES | AXENFELD-RIEGER-SYNDROME | RETINOIC ACID | ENDOTHELIAL-CELLS | soluble form of VEGF receptor 1 | avascularity | EXTRACELLULAR-MATRIX | NEURAL CREST | HELIX GENE | Mutation | Rodents | Blood Vessels - growth & development | Blood Vessels - pathology | Neural Crest - pathology | Vascular Endothelial Growth Factor A - metabolism | Anterior Eye Segment - abnormalities | Neovascularization, Pathologic - pathology | Neural Crest - metabolism | Anterior Eye Segment - metabolism | Pupil | Cornea - blood supply | Forkhead Transcription Factors - metabolism | Cornea - pathology | Corneal Stroma - enzymology | Lymphangiogenesis | Eye Abnormalities - metabolism | Alkalies | Haploinsufficiency - genetics | Signal Transduction | Anterior Eye Segment - pathology | Mutation - genetics | Phenotype | Animals | Eye Abnormalities - pathology | Burns - pathology | Corneal Stroma - pathology | Heterozygote | Neovascularization, Pathologic - metabolism | Matrix Metalloproteinases - metabolism | Eye Abnormalities - complications | Transcription factors | Physiological aspects | Genetic aspects | Neovascularization | Research | Vascular endothelial growth factor | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0131921 - e0131921
Damage to the eye from blast exposure can occur as a result of the overpressure air-wave (primary injury), flying debris (secondary injury), blunt force trauma... 
EYE | GLOBE | COMMOTIO-RETINAE | COMBAT OCULAR TRAUMA | MULTIDISCIPLINARY SCIENCES | INJURY | ETHANOL | MICE | MODEL | GLAUCOMA | Glaucoma | Oxidative stress | Retinal detachment | Cornea | Traumatic brain injury | Laboratories | Traumatic injury | Flight | Retina | Blast | Acuity | Eye | Wave propagation | Neurodegeneration | Eye injuries | Rodents | Nerves | Burns (injuries) | Optic nerve | Eyes | Overpressure | Quaternary | Mortality | Visual acuity | Histology | Housing | Epithelium | Trauma | Strain | Studies | Brain research | Optical Coherence Tomography | Damage detection | Cell death | Photoreceptors | Olfactory epithelium | Apoptosis | Microglia - metabolism | Optic Nerve - pathology | Wounds, Nonpenetrating - complications | Blindness - physiopathology | Oxidative Stress - physiology | Nerve Degeneration - physiopathology | Blindness - pathology | Blast Injuries - complications | Eye Injuries - pathology | Microglia - pathology | Mice, Inbred DBA | Optic Nerve - physiopathology | Disease Models, Animal | Electroretinography | Eye Injuries - complications | Mice, Inbred C57BL | Retina - physiopathology | Olfactory Mucosa - physiopathology | Explosions | Nerve Degeneration - pathology | Blast Injuries - pathology | Eye Injuries - physiopathology | Animals | Olfactory Mucosa - pathology | Mice | Wounds, Nonpenetrating - pathology | Nerve Degeneration - etiology | Wounds, Nonpenetrating - physiopathology | Blindness - etiology | Retina - pathology | Blast Injuries - physiopathology | Index Medicus
Journal Article