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1. Full Text Mesenchymal stem cells in the human corneal limbal stroma
by Branch, Matthew James and Hashmani, Khurram and Dhillon, Permesh and Jones, D. Rhodri E and Dua, Harminder Singh and Hopkinson, Andrew
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 08/2012, Volume 53, Issue 9, pp. 5109 - 5116
PURPOSE. Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties,... 
PROGENITOR CELLS | HUMAN FETAL LIVER | ADULT BONE-MARROW | IN-VITRO MODEL | GENE-EXPRESSION | OPHTHALMOLOGY | REPAIR PHENOTYPES | HUMAN UMBILICAL-CORD | DIFFERENTIATION | CHONDROGENESIS | KERATOCYTES | Biomarkers - metabolism | Antigens, CD34 - metabolism | Fetal Stem Cells - cytology | Corneal Stroma - metabolism | Fetal Stem Cells - metabolism | Humans | Mesenchymal Stromal Cells - metabolism | Proteoglycans - metabolism | Cell Adhesion | Gestational Age | Liver - embryology | Corneal Stroma - cytology | Mesenchymal Stromal Cells - cytology | Phenotype | Flow Cytometry | Cell Differentiation | Cell Culture Techniques | Limbus Corneae - cytology | Aldehyde Dehydrogenase - metabolism | Real-Time Polymerase Chain Reaction | Index Medicus
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2. Full Text Ultrastructure of the Posterior Corneal Stroma
by Schlötzer-Schrehardt, Ursula, PhD and Bachmann, Bjoern O., MD and Tourtas, Theofilos, MD and Torricelli, Andre A.M., MD and Singh, Arun, MD and González, Sheyla, PhD and Mei, Hua, PhD and Deng, Sophie X., MD, PhD and Wilson, Steven E., MD and Kruse, Friedrich E., MD
Ophthalmology, ISSN 0161-6420, 2015, Volume 122, Issue 4, pp. 693 - 699
Purpose To reinvestigate the ultrastructure of the posterior stroma of the human cornea and to correlate the findings with the stromal behavior after... 
Ophthalmology | ORGANIZATION | KERATOCONUS CORNEAS | MATRIX | MEMBRANE ENDOTHELIAL KERATOPLASTY | DUAS-LAYER | DISSECTION | OPHTHALMOLOGY | ELECTRON-MICROSCOPY | COLLAGEN FIBRILS | ANTERIOR LAMELLAR KERATOPLASTY | PRE-DESCEMETS-LAYER | Collagen Type IV - metabolism | Microscopy, Electron, Transmission | Descemet Stripping Endothelial Keratoplasty | Corneal Stroma - metabolism | Descemet Membrane - metabolism | Humans | Middle Aged | Collagen Type III - metabolism | Collagen Type VI - metabolism | Corneal Stroma - ultrastructure | Corneal Keratocytes - ultrastructure | Corneal Diseases - surgery | Descemet Membrane - ultrastructure | Corneal Stroma - surgery | Aged | Tissue Donors | Corneal Keratocytes - metabolism | Fluorescent Antibody Technique, Indirect | Organ Culture Techniques | Index Medicus
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3. Full Text Generation and characterization of a novel mouse line, keratocan-rtTA (KeraRT), for corneal stroma and tendon research
by Zhang, Yujin and Kao, Winston W. -Y and Hayashi, Yasuhito and Zhang, Lingling and Call, Mindy and Dong, Fei and Yuan, Yong and Zhang, Jianhua and Wang, Yen-Chiao and Yuka, Okada and Shiraishi, Atsushi and Liu, Chia-Yang
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 09/2017, Volume 58, Issue 11, pp. 4800 - 4808
PURPOSE. We created a novel inducible mouse line Keratocan-rtTA (Kera(RT)) that allows specific genetic modification in corneal keratocytes and tenocytes... 
GFP | Dox-inducible | Knock-in mouse model | Keratocan | Corneal stroma | FIBROSIS | RECOMBINASE | LUNG | ALPHA | MAMMALIAN-CELLS | INACTIVATION | corneal stroma | GENE | knock-in mouse model | keratocan | OPHTHALMOLOGY | MALFORMATION | EXPRESSION | TRANSGENIC MICE | Green Fluorescent Proteins - metabolism | Corneal Stroma - metabolism | Tendons - metabolism | Mice, Transgenic - genetics | Proteoglycans - metabolism | Gene Knockout Techniques | Transforming Growth Factor alpha - genetics | Gene Knock-In Techniques | Animals | Epithelium, Corneal - metabolism | Mice | Genetic Vectors | Transforming Growth Factor alpha - metabolism | Corneal Keratocytes - metabolism | Proteoglycans - genetics | Disease Models, Animal | Index Medicus | Cornea
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4. Full Text Corneal stroma demarcation line after standard and high-intensity collagen crosslinking determined with anterior segment optical coherence tomography
by Kymionis, George D., MD, PhD and Tsoulnaras, Konstantinos I., MD and Grentzelos, Michael A., MD and Plaka, Argyro D., MD, MSc and Mikropoulos, Dimitrios G., MD, PhD and Liakopoulos, Dimitrios A., MD and Tsakalis, Nikolaos G., MD and Pallikaris, Ioannis G., MD, PhD
Journal of Cataract and Refractive Surgery, ISSN 0886-3350, 2014, Volume 40, Issue 5, pp. 736 - 740
Purpose To use anterior segment optical coherence tomography (AS-OCT) to compare corneal stroma demarcation line depth after corneal collagen crosslinking... 
Ophthalmology | SURGERY | OPHTHALMOLOGY | PROGRESSIVE KERATOCONUS | Prospective Studies | Corneal Stroma - metabolism | Photosensitizing Agents - therapeutic use | Keratoconus - drug therapy | Riboflavin - therapeutic use | Tomography, Optical Coherence | Humans | Male | Keratoconus - metabolism | Young Adult | Collagen - metabolism | Ultraviolet Rays | Cross-Linking Reagents - therapeutic use | Adolescent | Corneal Stroma - pathology | Female | Corneal Pachymetry | Tomography | Crosslinked polymers | Collagen | Standards | Index Medicus
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5. Full Text Corneal crosslinking: Riboflavin concentration in corneal stroma exposed with and without epithelium
by Baiocchi, Stefano, MD, PhD and Mazzotta, Cosimo, MD, PhD and Cerretani, Daniela, PhD and Caporossi, Tomaso, MD and Caporossi, Aldo, MD, FRCS
Journal of Cataract and Refractive Surgery, ISSN 0886-3350, 2009, Volume 35, Issue 5, pp. 893 - 899
Purpose To evaluate intrastromal concentrations of riboflavin with and without epithelium to ensure the efficacy and safety of corneal crosslinking (CXL) by... 
Ophthalmology | SURGERY | COLLAGEN | THERAPY | PLASMA | IN-VIVO | OPHTHALMOLOGY | ULTRAVIOLET-A LIGHT | MICROSCOPY | KERATOCONUS | Corneal Stroma - metabolism | Humans | Middle Aged | Eye Banks | Biological Availability | Riboflavin - pharmacokinetics | Chromatography, High Pressure Liquid | Tissue Distribution | Young Adult | Collagen - metabolism | Debridement | Keratoconus - surgery | Keratoplasty, Penetrating | Epithelium, Corneal - metabolism | Photosensitizing Agents - pharmacokinetics | Adult | Tissue Donors | Epithelium | Crosslinked polymers | Index Medicus
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6. Full Text Multipotent Stem Cells in Human Corneal Stroma
by Du, Yiqin and Funderburgh, Martha L and Mann, Mary M and SundarRaj, Nirmala and Funderburgh, James L
STEM CELLS, ISSN 1066-5099, 10/2005, Volume 23, Issue 9, pp. 1266 - 1275
Keratocytes of the corneal stroma secrete a specialized extracellular matrix essential for vision. These quiescent cells exhibit limited capacity for... 
Cornea | Adult stem cells | Keratan sulfate | Keratocyte | Keratocan | PAX6 | Chondrogenesis | Progenitor cells | ABCG2 | Side population | Side population adult stem cells | MARROW | cornea | SIDE POPULATION CELLS | MOUSE | progenitor cells | keratansulfate | CONTAINS | ABCG2 TRANSPORTER | adult stem cells | CELL BIOLOGY | side population | BINDING CASSETTE TRANSPORTER | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | keratocan | keratocyte | METALLOPROTEINASE GELATINASE B | chondrogenesis | HEMATOLOGY | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Paired Box Transcription Factors - biosynthesis | Paired Box Transcription Factors - genetics | Humans | Multipotent Stem Cells - metabolism | Fibroblast Growth Factor 2 - pharmacology | Neoplasm Proteins - metabolism | Corneal Stroma - cytology | RNA, Messenger - biosynthesis | Flow Cytometry | Multipotent Stem Cells - drug effects | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Eye Proteins - genetics | Neoplasm Proteins - genetics | Cell Differentiation - physiology | Homeodomain Proteins - biosynthesis | Corneal Stroma - metabolism | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Cells, Cultured | Repressor Proteins - genetics | PAX6 Transcription Factor | Homeodomain Proteins - genetics | ATP-Binding Cassette Transporters - biosynthesis | Repressor Proteins - biosynthesis | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Eye Proteins - biosynthesis | Index Medicus
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7. Full Text Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma
by Priyadarsini, Shrestha and McKay, Tina B and Sarker-Nag, Akhee and Allegood, Jeremy and Chalfant, Charles and Ma, Jian-Xing and Karamichos, Dimitrios
Experimental Eye Research, ISSN 0014-4835, 12/2016, Volume 153, pp. 90 - 100
Prolonged hyperglycemia during diabetes mellitus can cause severe ophthalmic complications affecting both the anterior and posterior ocular segments leading to... 
Kynurenine | Lipidomics | Cellular metabolism | Corneal fibrosis | Diabetes mellitus | TRYPTOPHAN | ACTIVATION | COLLAGEN | KYNURENINE PATHWAY | 2-AMINOADIPIC ACID | MELLITUS | PREVALENCE | GLUCOSE | OPHTHALMOLOGY | COMPLICATIONS | BASEMENT-MEMBRANE | Biomarkers - metabolism | Corneal Stroma - metabolism | Corneal Diseases - etiology | Humans | Metabolome - physiology | Middle Aged | Collagen Type III - metabolism | Corneal Diseases - metabolism | Male | Diabetes Mellitus, Type 1 - complications | Corneal Diseases - diagnosis | Mass Spectrometry | Corneal Stroma - pathology | Aged, 80 and over | Adult | Female | Aged | Sphingosine - metabolism | Lipids - analysis | Diabetes Mellitus, Type 2 - complications | Phosphates | Medical colleges | Tryptophan | Cells | Glucose metabolism | Hyperglycemia | Metabolites | Collagen | Analysis | Sphingosine | Blindness | Physiological aspects | Diabetes | Molecular biology | Biological markers | Health aspects | Index Medicus | diabetes mellitus | kynurenine | corneal fibrosis | lipidomics | cellular metabolism
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8. Full Text Biobanking of Dehydrated Human Donor Corneal Stroma to Increase the Supply of Anterior Lamellar Grafts
by Romano, Vito and Levis, Hannah J and Gallon, Paola and Lace, Rebecca and Borroni, Davide and Ponzin, Diego and Ruzza, Alessandro and Kaye, Stephen B and Ferrari, Stefano and Parekh, Mohit
Cornea, ISSN 0277-3740, 04/2019, Volume 38, Issue 4, pp. 480 - 484
PURPOSE:To investigate the effect of dehydration on human donor corneal stroma for biobanking. METHODS:Epithelium and endothelium of research-grade human donor... 
PRESERVATION | EPIKERATOPHAKIA | biobanking | GLYCEROL | cornea | stroma | TISSUE | OPHTHALMOLOGY | dehydration | Corneal Stroma - cytology | Corneal Stroma - physiology | Corneal Transplantation | Tissue Preservation - methods | Tensile Strength - physiology | Corneal Stroma - metabolism | Biological Specimen Banks | Corneal Keratocytes - cytology | Humans | Actins - metabolism | Silica Gel | Dehydration | Index Medicus
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9. Full Text The Effect of Riboflavin/UVA Collagen Cross-linking Therapy on the Structure and Hydrodynamic Behaviour of the Ungulate and Rabbit Corneal Stroma
by Hayes, Sally and Kamma-Lorger, Christina S and Boote, Craig and Young, Robert D and Quantock, Andrew J and Rost, Anika and Khatib, Yasmeen and Harris, Jonathan and Yagi, Naoto and Terrill, Nicholas and Meek, Keith M
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e52860 - e52860
Purpose: To examine the effect of riboflavin/UVA corneal crosslinking on stromal ultrastructure and hydrodynamic behaviour. Methods: One hundred and seventeen... 
PORCINE CORNEA | FIBRILS | ULTRAVIOLET-A | MULTIDISCIPLINARY SCIENCES | ULTRASTRUCTURE | X-RAY-DIFFRACTION | ELECTRON-MICROSCOPY | BULLOUS KERATOPATHY | SCATTERING | HYDRATION | KERATOCONUS | Corneal Stroma - drug effects | Rabbits | Corneal Stroma - metabolism | Corneal Stroma - ultrastructure | Collagen - chemistry | Hydrodynamics | Riboflavin - pharmacology | Collagen - metabolism | Animals | Ultraviolet Rays | Corneal Stroma - radiation effects | Swine | X-Ray Diffraction | Sheep | In Vitro Techniques | Enzymes - metabolism | Enzymes | Crosslinked polymers | Collagen | Therapy | Cornea | Spatial discrimination | Riboflavin | Science | Eye | Proteins | X-ray scattering | Cross-linking | Ultrastructure | Vitamin B | Light | Eye (anatomy) | U.V. radiation | Periodicity | Stroma | Optometry | Crosslinking | Exposure | Digestion | Biophysics | Periodic variations | Epithelium | Biomechanics | X rays | Microscopy | X ray scattering | Index Medicus
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10. Full Text Functional Corneal Endothelium Derived from Corneal Stroma Stem Cells of Neural Crest Origin by Retinoic Acid and Wnt/β-Catenin Signaling
by Hatou, Shin and Yoshida, Satoru and Higa, Kazunari and Miyashita, Hideyuki and Inagaki, Emi and Okano, Hideyuki and Tsubota, Kazuo and Shimmura, Shigeto
Stem Cells and Development, ISSN 1547-3287, 03/2013, Volume 22, Issue 5, pp. 828 - 839
Corneal endothelial dysfunction remains a major indication for corneal transplantation. Both corneal endothelial cells and stromal cells originate from the... 
Original Research Reports | MEDICINE, RESEARCH & EXPERIMENTAL | PENETRATING KERATOPLASTY | MECHANISMS | DEPENDENT ATPASE ACTIVITY | TRANSPLANTATION | CELL & TISSUE ENGINEERING | EPITHELIUM | ANTERIOR SEGMENT DEVELOPMENT | OCULAR-SURFACE DISORDERS | HEMATOLOGY | EXPRESSION | PUMP FUNCTION | TGF-BETA-2 | Up-Regulation | Antigens, CD - biosynthesis | Humans | Wnt Proteins - metabolism | Cadherins - biosynthesis | Corneal Stroma - cytology | Multipotent Stem Cells | Nerve Tissue Proteins - pharmacology | Collagen Type IV - biosynthesis | Sodium-Bicarbonate Symporters - biosynthesis | Wnt Signaling Pathway | Tretinoin - pharmacology | Corneal Transplantation | Rabbits | Endothelium, Corneal - cytology | Endothelium, Corneal - physiology | Neural Crest - cytology | Homeodomain Proteins - biosynthesis | Tissue Engineering - methods | Corneal Stroma - metabolism | Cells, Cultured | Cell Communication | Collagen Type VIII - biosynthesis | Transcription Factors - biosynthesis | Neural Stem Cells | beta Catenin - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Sodium-Potassium-Exchanging ATPase - biosynthesis | Mice | Index Medicus
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11. Full Text Human cornea proteome: Identification and quantitation of the proteins of the three main layers including epithelium, stroma, and endothelium
by Dyrlund, Thomas F and Poulsen, Ebbe Toftgaard and Scavenius, Carsten and Nikolajsen, Camilla Lund and Thøgersen, Ida B and Vorum, Henrik and Enghild, Jan J
Journal of Proteome Research, ISSN 1535-3893, 08/2012, Volume 11, Issue 8, pp. 4231 - 4239
Diseases of the cornea are common and refer to conditions like infections, injuries and genetic defects. Morphologically, many corneal diseases affect only... 
endothelium | proteomics | stroma | TripleTOF 5600 | human cornea | epithelium | label free quantitation | HUMAN AQUEOUS-HUMOR | ANGIOGENESIS | LACTOFERRIN | BIOCHEMICAL RESEARCH METHODS | MACULAR DEGENERATION | HUMAN TEARS | DEFICIENT MICE | MASS-SPECTROMETRY | COMPLEMENT-SYSTEM | FACTOR-XIII | INHIBITOR | Chromatography, Ion Exchange | Corneal Stroma - metabolism | Humans | Molecular Sequence Annotation | Keratins - isolation & purification | Eye Proteins - isolation & purification | Male | Blood Proteins - metabolism | Collagen - metabolism | Cornea - metabolism | Endothelium, Corneal - metabolism | Tandem Mass Spectrometry | Keratins - metabolism | Eye Proteins - metabolism | Blood Proteins - isolation & purification | Collagen - isolation & purification | Aged, 80 and over | Epithelium, Corneal - metabolism | Cornea - cytology | Female | Aged | Proteome - isolation & purification | Proteome - metabolism | Index Medicus
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12. Full Text Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
by Yamaguchi, Hiroyuki and Yamaguchi, Hiroyuki and Takezawa, Toshiaki and Takezawa, Toshiaki
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 11/2018, Volume 46, Issue 11, pp. 1684 - 1691
A collagen vitrigel membrane (CVM) we developed can function as both a scaffold for cells and a pathway for chemicals. To extrapolate the corneal permeability... 
PHARMACOLOGY & PHARMACY | IN-VITRO | DRUG-DELIVERY | EQUIVALENT | SCAFFOLD | Dextrans - metabolism | Cell Line | Rabbits | Corneal Stroma - metabolism | Endothelial Cells - metabolism | Humans | Fluorescein-5-isothiocyanate - metabolism | Fluorescein-5-isothiocyanate - analogs & derivatives | Permeability | Collagen - metabolism | Cornea - metabolism | Animals | Epithelium, Corneal - metabolism | Fluorescein isothiocyanate | Cornea | Animal models | Epithelial cells | Membrane permeability | Collagens | Vitamin B12 | Fabrication | Dextrans | Mathematical models | Stroma | Isothiocyanate | Data processing | Permeability coefficient | Epithelium | Endothelial cells | Cyanocobalamin | Chemicals | Endothelium | Organic chemistry | Diffusion layers | Diffusion barriers | Collagen | Fluorescein | In vivo methods and tests | Index Medicus
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13. Full Text Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma
by Nicholas, Sarah E and Rowsey, Tyler G and Priyadarsini, Shrestha and Mandal, Nawajes A and Karamichos, Dimitrios
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0182390 - e0182390
Purpose To delineate the role of Sphingolipids (SPLs) in the human cornea and their cross-talks with transforming growth factor beta (TGF-beta) in order to... 
HUMAN HEPATIC MYOFIBROBLASTS | GROWTH-FACTOR-BETA | MULLER GLIAL-CELLS | CANCER CELLS | MULTIDISCIPLINARY SCIENCES | IN-VITRO MODEL | ENDOTHELIAL-CELL MIGRATION | EXTRACELLULAR-MATRIX | 1-PHOSPHATE STIMULATES PROLIFERATION | RECEPTOR EXPRESSION PROFILE | SPHINGOSINE 1-PHOSPHATE | Corneal Stroma - drug effects | Corneal Stroma - metabolism | Humans | Sphingolipids - metabolism | Blotting, Western | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Cell Movement - drug effects | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Sphingosine - analogs & derivatives | Protein Isoforms - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | Fibrosis | Lysophospholipids - pharmacology | Cell Extracts | Protein Kinase Inhibitors - pharmacology | Transforming Growth Factor beta - metabolism | Wound Healing - drug effects | Fibroblasts - metabolism | Phosphates | Health sciences | Neurosciences | Cornea | Collagen (type I) | Ascorbic acid | Leukocyte migration | Transforming growth factor-b | Smooth muscle | Stimulation | Sphingolipids | Kinases | Sphingosine 1-phosphate | Cell adhesion & migration | Angiogenesis | Actin | Vitamin C | Fibroblasts | Extracellular matrix | Assembly | Sphingosine kinase | Stroma | Data processing | Gene expression | Antibiotics | Isoforms | Cell migration | Cancer | Index Medicus
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