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Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4712 - 4721
Cushing disease is a condition in which the pituitary gland releases excessive adrenocorticotropic hormone (ACTH) as a result of an adenoma arising from the... 
NUCLEAR-LOCALIZATION | MEDICINE, RESEARCH & EXPERIMENTAL | DEPENDENT CUSHINGS-SYNDROME | GEFITINIB INDUCES APOPTOSIS | CYCLE INHIBITOR P27(KIP1) | EPIDERMAL-GROWTH-FACTOR | CORTICOTROPH TUMORS | T-BOX FACTOR | FACTOR RECEPTOR | PROGNOSTIC VALUE | MICE LACKING | ACTH-Secreting Pituitary Adenoma - drug therapy | Neoplasm Transplantation | Humans | Cell Line, Tumor - drug effects | Molecular Targeted Therapy | Pituitary ACTH Hypersecretion - drug therapy | ACTH-Secreting Pituitary Adenoma - complications | Adenoma - enzymology | Adenoma - complications | Dog Diseases - drug therapy | Dog Diseases - etiology | Secretory Rate - drug effects | Adenoma - drug therapy | Corticosterone - blood | Gene Expression Regulation, Neoplastic - drug effects | Pro-Opiomelanocortin - genetics | Adenoma - veterinary | Promoter Regions, Genetic | Pituitary ACTH Hypersecretion - etiology | ACTH-Secreting Pituitary Adenoma - veterinary | Cell Line, Tumor - enzymology | Tumor Burden | Adrenocorticotropic Hormone - secretion | Pituitary ACTH Hypersecretion - blood | Adenoma - blood | Dog Diseases - blood | ACTH-Secreting Pituitary Adenoma - blood | Animals | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Dogs | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | ACTH-Secreting Pituitary Adenoma - enzymology | Pituitary ACTH Hypersecretion - veterinary | Quinazolines - pharmacology | Drug Screening Assays, Antitumor | Care and treatment | Pituitary gland tumors | ACTH | Drug targeting | Adenoma | Diagnosis | Research | Properties
Journal Article
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2825 - 2835
Context: Remission failure following transsphenoidal surgery in Cushing disease (CD) from pituitary corticotroph tumors (CtTs) remains clinically challenging.... 
IN-VITRO | RETINOIC ACID | LIPID-METABOLISM | THERAPY | CANCER CELLS | SUBEROYLANILIDE HYDROXAMIC ACID | GROWTH | ENDOCRINOLOGY & METABOLISM | TUMOR-CELLS | LARGE GENE LISTS | LIVER-X-RECEPTORS | ACTH-Secreting Pituitary Adenoma - drug therapy | Corticotrophs - drug effects | Apoptosis - drug effects | Adrenocorticotropic Hormone - drug effects | Humans | Gene Expression Profiling | Pituitary ACTH Hypersecretion - drug therapy | Flow Cytometry | Adenoma - drug therapy | Female | Pro-Opiomelanocortin - genetics | Hydroxamic Acids - pharmacology | Real-Time Polymerase Chain Reaction | Cell Survival - drug effects | Enzyme-Linked Immunosorbent Assay | Corticotrophs - cytology | Blotting, Western | Adrenocorticotropic Hormone - secretion | Xenograft Model Antitumor Assays | Animals | ACTH-Secreting Pituitary Adenoma - secretion | Mice, Nude | Adenoma - secretion | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Mice | In Vitro Techniques | Pro-Opiomelanocortin - drug effects | Drugs | Flow cytometry | Histone deacetylase | Bax protein | Transcription | Liver | Medical services | Proopiomelanocortin | Surgery | Xenografts | liver X receptors | Remission | Adrenocorticotropin (ACTH) | Enzyme-linked immunosorbent assay | Nervous system diseases | Cell survival | Effectiveness | Secretion | Tumor cells | Medical treatment | Hydroxamic acid | Pituitary (anterior) | Gene expression | Survival | Variance analysis | Adrenocorticotropic hormone | DNA microarrays | Pituitary | In vivo methods and tests | Viability | Tumors | Apoptosis
Journal Article
Oncogene, ISSN 0950-9232, 03/2013, Volume 32, Issue 13, pp. 1651 - 1659
MicroRNAs (miRNAs) have been involved in the pathogenesis of different types of cancer; however, their function in pituitary tumorigenesis remains poorly... 
microRNAs | Protein kinase A | Acromegaly | Pituitary hyperplasia | Carney complex | Growth-hormone producing adenomas | MICRORNA GENES | BMI-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | MCCUNE-ALBRIGHT-SYNDROME | growth-hormone producing adenomas | CELL BIOLOGY | BREAST-CANCER | pituitary hyperplasia | ONCOLOGY | CELL SELF-RENEWAL | GENETICS & HEREDITY | acromegaly | MUTATIONS | protein kinase A | EXPRESSION | ADENOMAS | Somatotrophs - metabolism | Somatotrophs - pathology | Oligonucleotide Array Sequence Analysis | Adenoma - genetics | Humans | Oncogene Protein v-akt - physiology | PTEN Phosphohydrolase - physiology | Growth Hormone-Secreting Pituitary Adenoma - genetics | Gene Expression Profiling | MicroRNAs - pharmacology | Prolactinoma - genetics | Somatotrophs - drug effects | Oncogene Protein v-akt - genetics | Gene Expression Regulation, Neoplastic - drug effects | Oncogene Protein v-akt - metabolism | Corticotrophs - metabolism | Gene Expression Regulation, Neoplastic - physiology | Prolactinoma - pathology | PTEN Phosphohydrolase - genetics | Corticotrophs - pathology | Cells, Cultured | PTEN Phosphohydrolase - metabolism | Rats | Signal Transduction - genetics | Animals | Signal Transduction - drug effects | Mice, Nude | Adenoma - pathology | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | MicroRNAs - physiology | Growth Hormone-Secreting Pituitary Adenoma - pathology | Proteins | Pathogenesis | Oncology | Growth hormones | Pituitary gland | Ribonucleic acid--RNA | Tumors | AKT protein | protein kinase B
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 09/2012, Volume 214, Issue 3, pp. 389 - 398
Journal Article
Journal Article
Journal of Neuroendocrinology, ISSN 0953-8194, 12/2016, Volume 28, Issue 12, pp. np - n/a
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 04/2012, Volume 97, Issue 4, pp. 1303 - 1310
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2014, Volume 394, Issue 1-2, pp. 37 - 46
Adrenocorticotropic hormone (ACTH) production by pituitary corticotroph adenomas is the main cause of Cushing’s disease. A drug that targets pituitary... 
POMC | ACTH | Treatment | Cushing’s disease | Pituitary tumor | Cushing's disease | SOMATOSTATIN ANALOGS | ANTERIOR-PITUITARY | MEDICAL-TREATMENT | CUSHINGS-DISEASE | PASIREOTIDE | DIFFERENTIAL REGULATION | PITUITARY-ADENOMAS | CELL BIOLOGY | MESSENGER-RNA | ENDOCRINOLOGY & METABOLISM | SECRETION | RECEPTORS | Adrenocorticotropic Hormone - antagonists & inhibitors | ACTH-Secreting Pituitary Adenoma - drug therapy | Corticotrophs - drug effects | Neoplasm Transplantation | RNA, Small Interfering - genetics | Pituitary Gland - metabolism | Humans | Male | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Somatostatin - pharmacology | Receptors, Somatostatin - genetics | ACTH-Secreting Pituitary Adenoma - genetics | Receptors, Somatostatin - antagonists & inhibitors | Receptors, Somatostatin - metabolism | Pro-Opiomelanocortin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Corticotrophs - metabolism | Somatostatin - analogs & derivatives | ACTH-Secreting Pituitary Adenoma - metabolism | Corticotrophs - pathology | Pituitary Gland - pathology | Pituitary Neoplasms - genetics | RNA, Messenger - genetics | Pituitary Neoplasms - pathology | Adrenocorticotropic Hormone - biosynthesis | Pituitary Neoplasms - metabolism | Pro-Opiomelanocortin - metabolism | Animals | Pituitary Neoplasms - drug therapy | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | ACTH-Secreting Pituitary Adenoma - pathology | Pituitary Gland - drug effects | RNA, Small Interfering - metabolism | Tumors
Journal Article
Journal Article