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1. Corynebacterium glutamicum
: biology and biotechnology
by Yukawa, Hideaki and Inui, Masayuki
2013, Microbiology monographs, ISBN 3642298567, Volume 23
Biotechnology | Corynebacterium glutamicum
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2. Full Text From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production
by Becker, Judith and Zelder, Oskar and Häfner, Stefan and Schröder, Hartwig and Wittmann, Christoph
Metabolic Engineering, ISSN 1096-7176, 2011, Volume 13, Issue 2, pp. 159 - 168
Here, we describe the development of a genetically defined strain of -lysine hyperproducing by systems metabolic engineering of the wild type. Implementation... 
In silico design | Rational strain optimization | Systems biology | Metabolic flux analysis | MUTANT | ESCHERICHIA-COLI | PATHWAY FLUXES | STRAIN IMPROVEMENT | PYRUVATE-KINASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | CARBON-SOURCES | IN-VIVO | EXPRESSION | CONTINUOUS-CULTURE | Corynebacterium glutamicum - metabolism | Lysine - genetics | Metabolic Networks and Pathways - genetics | Genetic Engineering | Lysine - biosynthesis | Corynebacterium glutamicum - genetics | Fermentation - genetics | Models, Biological | Glucose - metabolism | Industrial Microbiology - methods | Glucose metabolism | Enzymes | Lysine | Analysis | Glucose | Mathematical optimization | Dextrose | Index Medicus
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3. Full Text Corynebacterium glutamicum Tailored for Efficient Isobutanol Production
by Bastian Blombach and Tanja Riester and Stefan Wieschalka and Christian Ziert and Jung-Won Youn and Volker F. Wendisch and Bernhard J. Eikmanns
Applied and Environmental Microbiology, ISSN 0099-2240, 05/2011, Volume 77, Issue 10, pp. 3300 - 3310
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
OXYGEN-DEPRIVATION | TRANSFORMATION | ENGINEERED ESCHERICHIA-COLI | SUCCINATE PRODUCTION | L-LYSINE PRODUCTION | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | MICROBIOLOGY | EXPRESSION | PYRUVATE-DEHYDROGENASE COMPLEX | CARBON-FLUX DISTRIBUTION | Anaerobiosis | Lactococcus lactis - genetics | Recombinant Proteins - metabolism | Butanols - metabolism | Lactococcus lactis - enzymology | Chromosomes, Bacterial - genetics | Escherichia coli - enzymology | Corynebacterium glutamicum - genetics | Saccharomyces cerevisiae - genetics | Bacterial Proteins - genetics | Corynebacterium glutamicum - enzymology | Recombinant Proteins - genetics | Fungal Proteins - genetics | Corynebacterium glutamicum - metabolism | Metabolic Networks and Pathways - genetics | Escherichia coli - genetics | Plasmids | Glucose - metabolism | Saccharomyces cerevisiae - enzymology | Bacterial Proteins - metabolism | Fungal Proteins - metabolism | Corynebacteria | Escherichia coli | Analysis | Microbial respiration | Physiological aspects | Research | Enzyme activation | Enzymes | Microbiology | E coli | Genes | Glucose | Organic chemicals | Fermentation | Gene expression | Index Medicus | Biotechnology
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4. Full Text Engineering Corynebacterium glutamicum for isobutanol production
by Smith, Kevin Michael and Cho, Kwang-Myung and Liao, James C
Applied Microbiology and Biotechnology, ISSN 0175-7598, 7/2010, Volume 87, Issue 3, pp. 1045 - 1055
The production of isobutanol in microorganisms has recently been achieved by harnessing the highly active 2-keto acid pathways. Since these 2-keto acids are... 
Biotechnology | Chemistry | Microbiology | Microbial Genetics and Genomics | Biofuel | C. glutamicum | Isobutanol | ESCHERICHIA-COLI | LYSINE FORMATION | ACETOLACTATE SYNTHASE | CELL-WALL | BACILLUS-SUBTILIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES | VALINE PRODUCTION | glutamicum | EXPRESSION | STRAIN | ACETOBUTYLICUM | Butanols - metabolism | Corynebacterium glutamicum - metabolism | Bacterial Proteins - metabolism | Genetic Engineering | Corynebacterium glutamicum - genetics | Bacterial Proteins - genetics | Biomass energy | Analysis | Escherichia coli | Studies | Microorganisms | Research & development--R&D | Biodiesel fuels | Genomics | Bacteria | Index Medicus | Alcohol dehydrogenase | Applied Genetics and Molecular Biotechnology
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5. Full Text CO2/HCO3 − perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum
by Buchholz, Jens and Graf, Michaela and Freund, Andreas and Busche, Tobias and Kalinowski, Jörn and Blombach, Bastian and Takors, Ralf
Applied Microbiology and Biotechnology, ISSN 0175-7598, 10/2014, Volume 98, Issue 20, pp. 8563 - 8572
The exploration of scale-down models to imitate the influence of large scale bioreactor inhomogeneities on cellular metabolism is a topic with increasing... 
Life Sciences | Biotechnology | Cascade reactor | Microbiology | Microbial Genetics and Genomics | Corynebacterium glutamicum | Scale-down | Process inhomogeneity | Gradients | Dissolved carbon dioxide | CO2 SENSITIVITY | RECOMBINANT ESCHERICHIA-COLI | DISSOLVED CARBON-DIOXIDE | BATCH CULTURES | BIOREACTORS | METABOLIC-RESPONSE | FERMENTATION PROCESSES | NUTRIENT CONSUMPTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | PENICILLIUM-CHRYSOGENUM | Corynebacterium glutamicum - drug effects | Corynebacterium glutamicum - metabolism | Gene Expression Regulation, Bacterial - drug effects | Carbon Dioxide - metabolism | Corynebacterium glutamicum - genetics | Bioreactors - microbiology | Bicarbonates - metabolism | Transcription, Genetic | Catechol O-Methyltransferase Inhibitors | Gene Expression Profiling | Lysine - metabolism | Culture Media - chemistry | Studies | Membrane reactors | Biomass | Natural products | Carbon dioxide | Index Medicus
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6. Full Text Chassis organism from Corynebacterium glutamicum – a top‐down approach to identify and delete irrelevant gene clusters
by Unthan, Simon and Baumgart, Meike and Radek, Andreas and Herbst, Marius and Siebert, Daniel and Brühl, Natalie and Bartsch, Anna and Bott, Michael and Wiechert, Wolfgang and Marin, Kay and Hans, Stephan and Krämer, Reinhard and Seibold, Gerd and Frunzke, Julia and Kalinowski, Jörn and Rückert, Christian and Wendisch, Volker F and Noack, Stephan
Biotechnology Journal, ISSN 1860-6768, 02/2015, Volume 10, Issue 2, pp. 290 - 301
For synthetic biology applications, a robust structural basis is required, which can be constructed either from scratch or in a top‐down approach starting from... 
Chassis | Relevant genes | Growth studies | Microbial phenotyping | Corynebacterium glutamicum | ESCHERICHIA-COLI | BIOCHEMICAL RESEARCH METHODS | MOLECULAR ANALYSIS | OVERPRODUCTION | COMPLETE GENOME SEQUENCE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | CONSTRUCTION | BACTERIUM | SYNTHETIC BIOLOGY | STRAIN | SYSTEMS BIOLOGY | Corynebacterium glutamicum - growth & development | Sequence Deletion | Genome, Bacterial | Multigene Family | Genetic Engineering | Genetic Fitness | Corynebacterium glutamicum - genetics | Phylogeny | Genes, Essential | Genetic research | Genes | Genomics | Index Medicus
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7. Full Text Kinetic characterisation of recombinant Corynebacterium glutamicum NAD+-dependent LDH over-expressed in E. coli and its rescue of an lldD − phenotype in C. glutamicum: the issue of reversibility re-examined
by Sharkey, Michael A and Maher, Marcus A and Guyonvarch, Armel and Engel, Paul C
Archives of Microbiology, ISSN 0302-8933, 10/2011, Volume 193, Issue 10, pp. 731 - 740
The ldh gene of Corynebacterium glutamicum ATCC 13032 (gene symbol cg3219, encoding a 314 residue NAD+-dependent l-(+)-lactate dehydrogenase, EC 1.1.1.27) was... 
Life Sciences | Biochemistry, general | Biotechnology | Microbial Ecology | Unidirectional reaction | Microbiology | Corynebacterium glutamicum | Genetic complementation | Lactate dehydrogenase | Ecology | Enzyme kinetics | Cell Biology | OXYGEN DEPRIVATION CONDITIONS | ACTIVATION | FRUCTOSE-1,6-BISPHOSPHATE | ESCHERICHIA-COLI | MICROBIOLOGY | STREPTOCOCCUS-LACTIS | L-LACTATE DEHYDROGENASE | GENE | CLONING | PURIFICATION | OPERON | L-Lactate Dehydrogenase - metabolism | Recombinant Proteins - metabolism | Corynebacterium glutamicum - genetics | Oxidation-Reduction | Lactic Acid - metabolism | Open Reading Frames | Bacterial Proteins - genetics | Fructosediphosphates - pharmacology | Recombinant Proteins - genetics | Corynebacterium glutamicum - metabolism | L-Lactate Dehydrogenase - genetics | Escherichia coli - genetics | Cloning, Molecular | Escherichia coli - metabolism | Pyruvic Acid - metabolism | Bacterial Proteins - metabolism | Enzyme Activation | Kinetics | Mutation | Gene Expression Regulation, Bacterial | NAD - metabolism | Hydrogen-Ion Concentration | Allosteric properties | LDH gene | Ion-exchange chromatography | Pyruvic acid | Oxidation | Cooperativity | dehydrogenase | pH effects | Carbon sources | Expression vectors | Index Medicus | Microbiology and Parasitology | Biochemistry, Molecular Biology
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8. Full Text Characterization of Riboflavin (Vitamin B2) Transport Proteins from Bacillus subtilis and Corynebacterium glutamicum
by Christian Vogl and Simon Grill and Oliver Schilling and Jörg Stülke and Matthias Mack and Jürgen Stolz
Journal of Bacteriology, ISSN 0021-9193, 10/2007, Volume 189, Issue 20, pp. 7367 - 7375
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
NICOTINAMIDE RIBOSIDE | MESSENGER-RNA | MECHANISM | BIOSYNTHESIS | INNER-MEMBRANE-PROTEINS | GENE-EXPRESSION | LEVANASE OPERON | MICROBIOLOGY | HAEMOPHILUS-INFLUENZAE | INDUCTION | BINDING | Uncoupling Agents - pharmacology | Corynebacterium glutamicum - genetics | Bacterial Proteins - genetics | Substrate Specificity | Membrane Transport Proteins - physiology | Riboflavin - analogs & derivatives | Bacillus subtilis - genetics | Corynebacterium glutamicum - metabolism | Membrane Transport Proteins - biosynthesis | Biological Transport | Membrane Transport Proteins - genetics | Gene Deletion | Riboflavin - metabolism | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Bacterial Proteins - biosynthesis | Gene Expression Regulation, Bacterial | Bacillus subtilis - metabolism | Corynebacteria | Vitamin B2 | Carrier proteins | Bacillus subtilis | Physiological aspects | Genetic aspects | Properties | Proteins | Vitamin B | Genes | Bacteria | Biochemistry | Gene expression | Bacteriology | Index Medicus | Physiology and Metabolism
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9. Full Text Putrescine production by engineered Corynebacterium glutamicum
by Schneider, Jens and Wendisch, Volker F
Applied Microbiology and Biotechnology, ISSN 0175-7598, 10/2010, Volume 88, Issue 4, pp. 859 - 868
Here, we report the engineering of the industrially relevant Corynebacterium glutamicum for putrescine production. C. glutamicum grew well in the presence of... 
1,4-diaminobutane | Metabolic engineering | Putrescine | Corynebacterium glutamicum | OXYGEN-DEPRIVATION | ESCHERICHIA-COLI | UTILIZATION PATHWAY | METABOLIC PATHWAY | ORGANIC-ACIDS | LYSINE PRODUCTION | POLYAMINE DISTRIBUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | SOLUBLE STARCH | ALPHA-AMYLASE | Genes, Bacterial | Industrial Microbiology | Gene Expression | Ornithine Decarboxylase - metabolism | Escherichia coli - enzymology | Corynebacterium glutamicum - genetics | Bacterial Proteins - genetics | Repressor Proteins - genetics | Escherichia coli Proteins - metabolism | Fermentation | Argininosuccinate Synthase - metabolism | Corynebacterium glutamicum - growth & development | Corynebacterium glutamicum - metabolism | Argininosuccinate Synthase - genetics | Genetic Engineering | Escherichia coli - genetics | Recombination, Genetic | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Carboxy-Lyases - metabolism | Putrescine - biosynthesis | Repressor Proteins - metabolism | Enzymes | Enzyme inhibitors | Arginine | Escherichia coli | Universities and colleges | Glucose | Polyamines | Dextrose | Studies | Biotechnology | Genetic engineering | Catalysts | Biopolymers | Index Medicus
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10. Full Text Analysis of Novel Antioxidant Sesquarterpenes (C35 Terpenes) Produced in Recombinant Corynebacterium glutamicum
by Ravikumar, Sambandam and Woo, Han Min and Choi, Jong-il
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 11/2018, Volume 186, Issue 3, pp. 525 - 534
Novel synthetic isoprenoids have been synthesized in engineered microbial hosts by evolving terpene synthase or expressing heterologous terpene synthases.... 
Biochemistry, general | Biotechnology | Chemistry | CrtMN | Antioxidant activity | Corynebacterium glutamicum | C 35 carotenoids | carotenoids | C-35 carotenoids | DIGLUCOSIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCINAXANTHIN | MODEL | COMBINATION | EVOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CAROTENOID BIOSYNTHETIC PATHWAYS | EXPRESSION | Genetic Engineering - methods | Corynebacterium glutamicum - metabolism | Genes, Bacterial | Sesquiterpenes - metabolism | Corynebacterium glutamicum - genetics | Planococcus Bacteria - genetics | Recombination, Genetic | Antioxidants - metabolism | Carotenoids - genetics | Antioxidants | Terpenes | Chromosomes | Analysis | Phytochemistry | Terpene synthase | Genes | Color | Industrial applications | Gene expression | Pigmentation | Microorganisms | Carotenoids | Synthesis | Recombinant | Index Medicus
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11. Full Text Increased glucose utilization and cell growth of Corynebacterium glutamicum by modifying the glucose-specific phosphotransferase system (PTSGlc) genes
by Xu, Jianzhong and Zhang, Junlan and Liu, Dongdong and Zhang, Weiguo
Canadian Journal of Microbiology, ISSN 0008-4166, 2016, Volume 62, Issue 12, pp. 983 - 992
The phosphoenolpyruvate:glucose phosphotransferase system (PTS Glc ) is the major pathway of glucose uptake in Corynebacterium glutamicum. This study... 
glucose consumption rate | lysine | système de phosphotransférase sélectif au glucose | glucose-specific phosphotransferase system | lysine production | croissance cellulaire | Corynebacterium glutamicum | cell growth | production de | taux de consommation du glucose | Cell growth | Glucose consumption rate | L-lysine production | Glucose-specific phosphotransferase system | FRUCTOSE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LYSINE | MICROBIOLOGY | EXPRESSION | PHOSPHOENOLPYRUVATE | REGULATOR SUGR | Maltose - metabolism | Corynebacterium glutamicum - genetics | Bacterial Proteins - genetics | Corynebacterium glutamicum - enzymology | Fermentation | Corynebacterium glutamicum - growth & development | Amino Acids - metabolism | Biological Transport | Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism | Glucose - metabolism | Bacterial Proteins - metabolism | Lysine - metabolism | Mutation | Genes, Reporter | Phosphoenolpyruvate Sugar Phosphotransferase System - genetics | Corynebacteria | Physiological aspects | Glucose metabolism | Genetic aspects | Phosphotransferases | Metabolites | Mutagenesis | Genes | Gram-positive bacteria | Amino acids | Glucose | Index Medicus
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12. Full Text CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum
by Jiang, Yu and Qian, Fenghui and Yang, Junjie and Liu, Yingmiao and Dong, Feng and Xu, Chongmao and Sun, Bingbing and Chen, Biao and Xu, Xiaoshu and Li, Yan and Wang, Renxiao and Yang, Sheng
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 15179 - 15179
Corynebacterium glutamicum is an important industrial metabolite producer that is difficult to genetically engineer. Although the Streptococcus pyogenes (Sp)... 
REPLACEMENT | PROTEIN | ACCURATE DOCKING | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | GLIDE | CAS SYSTEMS | GENERATION | MODEL | PARAMETERS | LACTOBACILLUS-REUTERI | DNA, Single-Stranded - genetics | Genetic Engineering - methods | Genome, Bacterial - genetics | Corynebacterium glutamicum - genetics | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Endonucleases - metabolism | CRISPR-Cas Systems - genetics | Index Medicus
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13. Full Text The ncgl1108 (PheP Cg) gene encodes a new l-Phe transporter in Corynebacterium glutamicum
by Zhao, Zhi and Ding, Jiu-Yuan and Li, Tang and Zhou, Ning-Yi and Liu, Shuang-Jiang
Applied Microbiology and Biotechnology, ISSN 0175-7598, 6/2011, Volume 90, Issue 6, pp. 2005 - 2013
Corynebacterium glutamicum played a central role in the establishment of fermentative production of amino acids, and it is a model for genetic and... 
Biotechnology | Chemistry | Microbiology | Aromatic amino acid transporter | Microbial Genetics and Genomics | Corynebacterium glutamicum | l -Phenylalanine | AroP Cg | PheP Cg | L-Phenylalanine | AroP | PheP | SYSTEM | SEQUENCES | PERMEASE | IDENTIFICATION | GENOME | CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | ESCHERICHIA-COLI K-12 | AROP GENE | AroP(Cg) | PheP(Cg) | PROTEINS | Corynebacterium glutamicum - growth & development | Staining and Labeling - methods | Corynebacterium glutamicum - metabolism | Tyrosine - metabolism | Phenylalanine - metabolism | Corynebacterium glutamicum - genetics | Membrane Transport Proteins - genetics | Membrane Transport Proteins - metabolism | Carbon Radioisotopes - metabolism | Kinetics | Gene Knockout Techniques | Tryptophan - metabolism | Genetic research | Physiological aspects | Phenylalanine | Analysis | Studies | Amino acids | Bacteria | Genetics | Biosynthesis | Fermentation | Index Medicus
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14. Full Text Metabolic engineering to guide evolution – Creating a novel mode for L-valine production with Corynebacterium glutamicum
by Schwentner, Andreas and Feith, André and Münch, Eugenia and Busche, Tobias and Rückert, Christian and Kalinowski, Jörn and Takors, Ralf and Blombach, Bastian
Metabolic Engineering, ISSN 1096-7176, 05/2018, Volume 47, pp. 31 - 41
Evolutionary approaches are often undirected and mutagen-based yielding numerous mutations, which need elaborate screenings to identify relevant targets. We... 
Metabolic engineering | Directed evolution | L-valine production | Isocitrate dehydrogenase | Corynebacterium glutamicum | Glyoxylate shunt | SEQUENCE-ANALYSIS | ESCHERICHIA-COLI | BIOCHEMICAL-CHARACTERIZATION | CONSTRAINT-BASED MODELS | PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE | TRANSCRIPTIONAL REGULATOR | PYRUVATE-CARBOXYLASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | QUANTITATIVE PREDICTION | ACETATE METABOLISM | Corynebacterium glutamicum - metabolism | Directed Molecular Evolution - methods | Valine - genetics | Metabolic Engineering - methods | Valine - biosynthesis | Corynebacterium glutamicum - genetics | Metabolites | Genomics | Physiological aspects | Amino acids | Glucose | Nucleotide sequencing | Dextrose | DNA sequencing | Index Medicus
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