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1. Full Text From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production
by Becker, Judith and Zelder, Oskar and Häfner, Stefan and Schröder, Hartwig and Wittmann, Christoph
Metabolic Engineering, ISSN 1096-7176, 2011, Volume 13, Issue 2, pp. 159 - 168
Here, we describe the development of a genetically defined strain of -lysine hyperproducing by systems metabolic engineering of the wild type. Implementation... 
In silico design | Rational strain optimization | Systems biology | Metabolic flux analysis | MUTANT | ESCHERICHIA-COLI | PATHWAY FLUXES | STRAIN IMPROVEMENT | PYRUVATE-KINASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | CARBON-SOURCES | IN-VIVO | EXPRESSION | CONTINUOUS-CULTURE | Corynebacterium glutamicum - metabolism | Lysine - genetics | Metabolic Networks and Pathways - genetics | Genetic Engineering | Lysine - biosynthesis | Corynebacterium glutamicum - genetics | Fermentation - genetics | Models, Biological | Glucose - metabolism | Industrial Microbiology - methods | Glucose metabolism | Enzymes | Lysine | Analysis | Glucose | Mathematical optimization | Dextrose | Index Medicus
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2. Full Text Corynebacterium glutamicum Tailored for Efficient Isobutanol Production
by Bastian Blombach and Tanja Riester and Stefan Wieschalka and Christian Ziert and Jung-Won Youn and Volker F. Wendisch and Bernhard J. Eikmanns
Applied and Environmental Microbiology, ISSN 0099-2240, 05/2011, Volume 77, Issue 10, pp. 3300 - 3310
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
OXYGEN-DEPRIVATION | TRANSFORMATION | ENGINEERED ESCHERICHIA-COLI | SUCCINATE PRODUCTION | L-LYSINE PRODUCTION | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | MICROBIOLOGY | EXPRESSION | PYRUVATE-DEHYDROGENASE COMPLEX | CARBON-FLUX DISTRIBUTION | Anaerobiosis | Lactococcus lactis - genetics | Recombinant Proteins - metabolism | Butanols - metabolism | Lactococcus lactis - enzymology | Chromosomes, Bacterial - genetics | Escherichia coli - enzymology | Corynebacterium glutamicum - genetics | Saccharomyces cerevisiae - genetics | Bacterial Proteins - genetics | Corynebacterium glutamicum - enzymology | Recombinant Proteins - genetics | Fungal Proteins - genetics | Corynebacterium glutamicum - metabolism | Metabolic Networks and Pathways - genetics | Escherichia coli - genetics | Plasmids | Glucose - metabolism | Saccharomyces cerevisiae - enzymology | Bacterial Proteins - metabolism | Fungal Proteins - metabolism | Corynebacteria | Escherichia coli | Analysis | Microbial respiration | Physiological aspects | Research | Enzyme activation | Enzymes | Microbiology | E coli | Genes | Glucose | Organic chemicals | Fermentation | Gene expression | Index Medicus | Biotechnology
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3. Full Text CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum
by Jiang, Yu and Qian, Fenghui and Yang, Junjie and Liu, Yingmiao and Dong, Feng and Xu, Chongmao and Sun, Bingbing and Chen, Biao and Xu, Xiaoshu and Li, Yan and Wang, Renxiao and Yang, Sheng
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 15179 - 15179
Corynebacterium glutamicum is an important industrial metabolite producer that is difficult to genetically engineer. Although the Streptococcus pyogenes (Sp)... 
REPLACEMENT | PROTEIN | ACCURATE DOCKING | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | GLIDE | CAS SYSTEMS | GENERATION | MODEL | PARAMETERS | LACTOBACILLUS-REUTERI | DNA, Single-Stranded - genetics | Genetic Engineering - methods | Genome, Bacterial - genetics | Corynebacterium glutamicum - genetics | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Endonucleases - metabolism | CRISPR-Cas Systems - genetics | Index Medicus
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4. Full Text Engineering Corynebacterium glutamicum for isobutanol production
by Smith, Kevin Michael and Cho, Kwang-Myung and Liao, James C
Applied Microbiology and Biotechnology, ISSN 0175-7598, 7/2010, Volume 87, Issue 3, pp. 1045 - 1055
The production of isobutanol in microorganisms has recently been achieved by harnessing the highly active 2-keto acid pathways. Since these 2-keto acids are... 
Biotechnology | Chemistry | Microbiology | Microbial Genetics and Genomics | Biofuel | C. glutamicum | Isobutanol | ESCHERICHIA-COLI | LYSINE FORMATION | ACETOLACTATE SYNTHASE | CELL-WALL | BACILLUS-SUBTILIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES | VALINE PRODUCTION | glutamicum | EXPRESSION | STRAIN | ACETOBUTYLICUM | Butanols - metabolism | Corynebacterium glutamicum - metabolism | Bacterial Proteins - metabolism | Genetic Engineering | Corynebacterium glutamicum - genetics | Bacterial Proteins - genetics | Biomass energy | Analysis | Escherichia coli | Studies | Microorganisms | Research & development--R&D | Biodiesel fuels | Genomics | Bacteria | Index Medicus | Alcohol dehydrogenase | Applied Genetics and Molecular Biotechnology
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5. Full Text Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)
by Cleto, Sara and Jensen, Jaide V.K and Wendisch, Volker F and Lu, Timothy K
ACS Synthetic Biology, ISSN 2161-5063, 05/2016, Volume 5, Issue 5, pp. 375 - 385
Corynebacterium glutamicum is an important organism for the industrial production of amino acids. Metabolic pathways in this organism are usually engineered by... 
sgRNA/dCas9 | metabolic engineering | CRISPRi | C. glutamicum | amino acid | SYSTEM | BACTERIA | RNA | ESCHERICHIA-COLI | BIOCHEMICAL RESEARCH METHODS | PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE | GENOME | PATHWAY | AMINO-ACIDS | DNA | EXPRESSION | Gene Expression Regulation, Bacterial - genetics | Lysine - genetics | Metabolic Engineering - methods | Metabolic Networks and Pathways - genetics | Corynebacterium glutamicum - genetics | Glutamic Acid - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | RNA - genetics | Index Medicus | dCas9 | sgRNA
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6. Full Text Distinct roles of two anaplerotic pathways in glutamate production induced by biotin limitation in Corynebacterium glutamicum
by Sato, Hiroki and Orishimo, Keita and Shirai, Tomokazu and Hirasawa, Takashi and Nagahisa, Keisuke and Shimizu, Hiroshi and Wachi, Masaaki
Journal of Bioscience and Bioengineering, ISSN 1389-1723, 2008, Volume 106, Issue 1, pp. 51 - 58
is a biotin auxotrophic bacterium in which glutamate production is induced under biotin-limited conditions. During glutamate production, anaplerotic reactions... 
anaplerotic pathway | glutamate production | metabolic flux | nuclear magnetic resonance | Corynebacterium glutamicum | biotin | OXYGEN-DEPRIVATION | ACID FERMENTATION | ENZYME-ACTIVITIES | 2-OXOGLUTARATE DEHYDROGENASE | FOOD SCIENCE & TECHNOLOGY | BREVIBACTERIUM LACTOFERMENTUM | LYSINE PRODUCTION | PYRUVATE-CARBOXYLASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELLULAR PERMEABILITY | CARBON-FLUX DISTRIBUTION | Corynebacterium glutamicum - metabolism | Corynebacterium glutamicum - genetics | Biotin - genetics | Phosphoenolpyruvate Carboxylase - metabolism | Biotin - metabolism | Signal Transduction - physiology | Citric Acid Cycle - physiology | Glutamic Acid - metabolism | Pyruvate Carboxylase - genetics | Genetic Enhancement - methods | Phosphoenolpyruvate Carboxylase - genetics | Pyruvate Carboxylase - metabolism | Genetic research | Amino acids | Biotin | Glutamate | Index Medicus
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7. Full Text Putrescine production by engineered Corynebacterium glutamicum
by Schneider, Jens and Wendisch, Volker F
Applied Microbiology and Biotechnology, ISSN 0175-7598, 10/2010, Volume 88, Issue 4, pp. 859 - 868
Here, we report the engineering of the industrially relevant Corynebacterium glutamicum for putrescine production. C. glutamicum grew well in the presence of... 
1,4-diaminobutane | Metabolic engineering | Putrescine | Corynebacterium glutamicum | OXYGEN-DEPRIVATION | ESCHERICHIA-COLI | UTILIZATION PATHWAY | METABOLIC PATHWAY | ORGANIC-ACIDS | LYSINE PRODUCTION | POLYAMINE DISTRIBUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | SOLUBLE STARCH | ALPHA-AMYLASE | Genes, Bacterial | Industrial Microbiology | Gene Expression | Ornithine Decarboxylase - metabolism | Escherichia coli - enzymology | Corynebacterium glutamicum - genetics | Bacterial Proteins - genetics | Repressor Proteins - genetics | Escherichia coli Proteins - metabolism | Fermentation | Argininosuccinate Synthase - metabolism | Corynebacterium glutamicum - growth & development | Corynebacterium glutamicum - metabolism | Argininosuccinate Synthase - genetics | Genetic Engineering | Escherichia coli - genetics | Recombination, Genetic | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Carboxy-Lyases - metabolism | Putrescine - biosynthesis | Repressor Proteins - metabolism | Enzymes | Enzyme inhibitors | Arginine | Escherichia coli | Universities and colleges | Glucose | Polyamines | Dextrose | Studies | Biotechnology | Genetic engineering | Catalysts | Biopolymers | Index Medicus
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8. Full Text Comprehensive analysis of the Corynebacterium glutamicum transcriptome using an improved RNAseq technique
by Pfeifer-Sancar, Katharina and Mentz, Almut and Rückert, Christian and Kalinowski, Jörn
BMC Genomics, ISSN 1471-2164, 12/2013, Volume 14, Issue 1, pp. 888 - 888
Background: The use of RNAseq to resolve the transcriptional organization of an organism was established in recent years and also showed the complexity and... 
High-throughput sequencing | RNA | Corynebacterium glutamicum | Transcriptome | CELL TRANSCRIPTOME | ESCHERICHIA-COLI | TRANSLATION INITIATION | SIGMA-FACTORS | REGULATORY MECHANISMS | NONCODING RNAS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | GENETICS & HEREDITY | BINDING-SITE | LEADERLESS MESSENGER-RNAS | BACTERIAL GENE-EXPRESSION | Sequence Analysis, RNA - methods | Promoter Regions, Genetic | Corynebacterium glutamicum - genetics | Gene Library | 5' Untranslated Regions | Operon | Transcription Initiation Site | RNA, Bacterial - genetics | High-Throughput Nucleotide Sequencing | Gene Regulatory Networks | Binding Sites | Corynebacteria | RNA sequencing | Operons | Genetic aspects | Genetic transcription | Properties | Methods | Amino acids | Instrument industry | Information management | Studies | Biotechnology | Prokaryotes | Genomics | Technological change | Genetic engineering | Genomes | Bacteriology | Index Medicus
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9. Full Text Isolation of fully synthetic promoters for high‐level gene expression in Corynebacterium glutamicum
by Yim, Sung Sun and An, Seul Ji and Kang, Misuk and Lee, Jinho and Jeong, Ki Jun
Biotechnology and Bioengineering, ISSN 0006-3592, 11/2013, Volume 110, Issue 11, pp. 2959 - 2969
From the fully synthetic promoter library, the promoters available in Corynebacterium glutamicum were successfully isolated by FACS‐based high‐throughput... 
secretion | FACS | synthetic promoter | Corynebacterium glutamicum | Synthetic promoter | Secretion | LIBRARIES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | L-THREONINE PRODUCTION | ESCHERICHIA-COLI | Artificial Gene Fusion | Promoter Regions, Genetic | Gene Expression | Metabolic Engineering - methods | Green Fluorescent Proteins - analysis | Corynebacterium glutamicum - genetics | RNA, Messenger - genetics | Endo-1,4-beta Xylanases - genetics | RNA, Messenger - analysis | Gene Expression Profiling | Green Fluorescent Proteins - genetics | Flow Cytometry | Antibodies - analysis | Antibodies - genetics | Endo-1,4-beta Xylanases - analysis | Gene expression | Bioengineering | RNA-protein interactions | Bacterial proteins | Gram-positive bacteria | Fluorescence | Deoxyribonucleic acid--DNA | Index Medicus | Proteins | Symbols | Amino acids | Libraries | Strength | Vitamins | Screening | Antibodies | Strategy
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10. Full Text Chassis organism from Corynebacterium glutamicum – a top‐down approach to identify and delete irrelevant gene clusters
by Unthan, Simon and Baumgart, Meike and Radek, Andreas and Herbst, Marius and Siebert, Daniel and Brühl, Natalie and Bartsch, Anna and Bott, Michael and Wiechert, Wolfgang and Marin, Kay and Hans, Stephan and Krämer, Reinhard and Seibold, Gerd and Frunzke, Julia and Kalinowski, Jörn and Rückert, Christian and Wendisch, Volker F and Noack, Stephan
Biotechnology Journal, ISSN 1860-6768, 02/2015, Volume 10, Issue 2, pp. 290 - 301
For synthetic biology applications, a robust structural basis is required, which can be constructed either from scratch or in a top‐down approach starting from... 
Chassis | Relevant genes | Growth studies | Microbial phenotyping | Corynebacterium glutamicum | ESCHERICHIA-COLI | BIOCHEMICAL RESEARCH METHODS | MOLECULAR ANALYSIS | OVERPRODUCTION | COMPLETE GENOME SEQUENCE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | CONSTRUCTION | BACTERIUM | SYNTHETIC BIOLOGY | STRAIN | SYSTEMS BIOLOGY | Corynebacterium glutamicum - growth & development | Sequence Deletion | Genome, Bacterial | Multigene Family | Genetic Engineering | Genetic Fitness | Corynebacterium glutamicum - genetics | Phylogeny | Genes, Essential | Genetic research | Genes | Genomics | Index Medicus
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11. Full Text CRISPR/Cas9-coupled recombineering for metabolic engineering of Corynebacterium glutamicum
by Cho, Jae Sung and Choi, Kyeong Rok and Prabowo, Cindy Pricilia Surya and Shin, Jae Ho and Yang, Dongsoo and Jang, Jaedong and Lee, Sang Yup
Metabolic Engineering, ISSN 1096-7176, 07/2017, Volume 42, pp. 157 - 167
Genome engineering of , an important industrial microorganism for amino acids production, currently relies on random mutagenesis and inefficient double... 
Metabolic engineering | Curable plasmids | CRISPR/Cas9 | Corynebacterium glutamicum | CoPaR | Recombineering | ACID | CRISPR INTERFERENCE | ESCHERICHIA-COLI | GENOME | ENHANCED PRODUCTION | CHROMOSOME | MAGE | CLONING | PRODUCTS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SYSTEMS | gamma-Aminobutyric Acid - genetics | Corynebacterium glutamicum - metabolism | Metabolic Engineering - methods | Corynebacterium glutamicum - genetics | gamma-Aminobutyric Acid - biosynthesis | CRISPR-Cas Systems | Gene Knockdown Techniques | GABA | Genomics | Anopheles | Index Medicus
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12. Full Text An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain
by Okino, Shohei and Noburyu, Ryoji and Suda, Masako and Jojima, Toru and Inui, Masayuki and Yukawa, Hideaki
Applied Microbiology and Biotechnology, ISSN 0175-7598, 12/2008, Volume 81, Issue 3, pp. 459 - 464
A Corynebacterium glutamicum strain (ΔldhA-pCRA717) that overexpresses the pyc gene encoding pyruvate carboxylase while simultaneously exhibiting a disrupted... 
Biotechnology | Chemistry | Microbiology | Microbial Genetics and Genomics | Corynebacterium glutamicum | Succinic acid | Pyruvate carboxylase | CARBONIC-ANHYDRASE | ESCHERICHIA-COLI | ANAEROBIOSPIRILLUM-SUCCINICIPRODUCENS | ORGANIC-ACIDS | WHEY | GENOME SEQUENCE | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GLUCOSE | OXYGEN DEPRIVATION | FERMENTATION | Corynebacterium glutamicum - growth & development | L-Lactate Dehydrogenase - metabolism | Corynebacterium glutamicum - metabolism | Industrial Microbiology | L-Lactate Dehydrogenase - genetics | Corynebacterium glutamicum - genetics | Succinic Acid - metabolism | Bacterial Proteins - genetics | Protein Engineering | Bacterial Proteins - metabolism | Fermentation | Studies | Bioengineering | Index Medicus
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13. Full Text Synthetic promoter libraries for Corynebacterium glutamicum
by Rytter, Jakob Vang and Helmark, Søren and Chen, Jun and Lezyk, Mateusz Jakub and Solem, Christian and Jensen, Peter Ruhdal
Applied Microbiology and Biotechnology, ISSN 0175-7598, 3/2014, Volume 98, Issue 6, pp. 2617 - 2623
The ability to modulate gene expression is an important genetic tool in systems biology and biotechnology. Here, we demonstrate that a previously published... 
Life Sciences | Biotechnology | Microbiology | Metabolic optimization | Microbial Genetics and Genomics | Corynebacterium glutamicum | Synthetic biology | Modulation of gene expression | MUTANTS | CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ESCHERICHIA-COLI | CORYNEFORM BACTERIA | SEQUENCE | GENE-EXPRESSION | TOOLS | Isopropyl Thiogalactoside - metabolism | Artificial Gene Fusion | Promoter Regions, Genetic | Gene Expression | Corynebacterium glutamicum - genetics | Gene Library | Transcriptional Activation - drug effects | Genetics, Microbial - methods | beta-Galactosidase - genetics | beta-Galactosidase - analysis | Molecular Biology - methods | Genes, Reporter | Genomic libraries | Promoters (Genetics) | Physiological aspects | Actinomycetes | Genetic aspects | Research | Gene expression | Studies | Analysis | Bacteria | Chemical synthesis | Optimization | Index Medicus
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