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Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2012, Volume 342, Issue 3, pp. 654 - 664
Nodakenin, a coumarin isolated from the roots of Angelicae gigas, has been reported to possess neuroprotective, antiaggregatory, antibacterial, and... 
ACTIVATION | CYTOKINES | CYCLOOXYGENASE-2 | RAW264.7 CELLS | NITRIC-OXIDE SYNTHASE | KINASE | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | MEDIATORS | SEPSIS | ANGELICA-GIGAS | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Interleukin-1beta - genetics | Promoter Regions, Genetic - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Drug Interactions | Ubiquitination - drug effects | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Dinoprostone - genetics | MAP Kinase Kinase Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Down-Regulation - genetics | Coumarins - pharmacology | Dinoprostone - metabolism | Macrophages - metabolism | Signal Transduction - drug effects | Nitric Oxide - genetics | Lipopolysaccharides - pharmacology | Mice | Transcription, Genetic - genetics | Dinoprostone - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Shock, Septic - prevention & control | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Shock, Septic - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Inflammation - drug therapy | Nitric Oxide Synthase Type II - antagonists & inhibitors | I-kappa B Proteins - antagonists & inhibitors | Shock, Septic - drug therapy | Glucosides - pharmacology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | I-kappa B Kinase - genetics | Down-Regulation - drug effects | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Inflammation - genetics | Macrophages - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Ubiquitination - genetics
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 03/2010, Volume 54, Issue 3, pp. 311 - 322
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly... 
Polyphenol | Ellagitannins | Bioavailability | Gene expression | Cancer | APOPTOSIS | CANCER CELLS | FOOD SCIENCE & TECHNOLOGY | CELL-CYCLE ARREST | CHEMOPREVENTION | HYPERPLASIA | P21 | GROWTH | GENE-EXPRESSION | CACO-2 CELLS | Coumarins - metabolism | Plant Extracts - chemistry | Prostatic Hyperplasia - urine | Prostatic Neoplasms - metabolism | Ellagic Acid - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Coumarins - chemistry | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Prostate - metabolism | Plant Extracts - administration & dosage | Juglans - chemistry | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Glucuronides - metabolism | Prostatic Neoplasms - urine | Hydrolyzable Tannins - chemistry | Biomarkers, Tumor - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Glucuronides - administration & dosage | Prostatic Neoplasms - prevention & control | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Beverages - analysis | Glucuronides - chemistry | Punicaceae - chemistry | Prostatic Neoplasms - surgery | Fruit - chemistry | Coumarins - administration & dosage | Ellagic Acid - chemistry | Rats | Glucuronides - urine | Nuclear Proteins - metabolism | Ellagic Acid - urine | Hydrolyzable Tannins - metabolism | Coumarins - urine | Proto-Oncogene Proteins c-myc - metabolism | Rats, Sprague-Dawley | Prostatic Hyperplasia - metabolism | Prostatic Hyperplasia - surgery | Hydrolyzable Tannins - administration & dosage | Animals | Intestines - microbiology | Aged | Proto-Oncogene Proteins c-myc - genetics
Journal Article
Phytomedicine, ISSN 0944-7113, 02/2014, Volume 21, Issue 3, pp. 240 - 246
Coumarins, also known as benzopyrones, are plant-derived products with several pharmacological properties, including antioxidant and anti-inflammatory... 
Inflammatory bowel disease | Antioxidant | Coumarin derivatives | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | 4-METHYLESCULETIN | INDUCTION | PLANT SCIENCES | TRINITROBENZENESULFONIC ACID MODEL | ESCULETIN | INFLAMMATORY-BOWEL-DISEASE | METABOLISM | GLUTATHIONE | INTEGRATIVE & COMPLEMENTARY MEDICINE | RAT COLITIS | SULFASALAZINE | PHARMACOLOGY & PHARMACY | Rats, Wistar | Glutathione - metabolism | Plant Extracts - pharmacology | Alkaline Phosphatase - metabolism | Colon - drug effects | Male | Esculin - therapeutic use | Biphenyl Compounds - metabolism | Inflammatory Bowel Diseases - metabolism | Esculin - pharmacology | Inflammation - metabolism | Lipid Peroxidation - drug effects | Anti-Inflammatory Agents - therapeutic use | Umbelliferones - therapeutic use | Phytotherapy | Inflammatory Bowel Diseases - prevention & control | Anti-Inflammatory Agents - pharmacology | Picrates - metabolism | Rats | Antioxidants - pharmacology | Inflammation - etiology | Colon - metabolism | Coumarins - therapeutic use | Coumarins - pharmacology | Umbelliferones - pharmacology | Antioxidants - therapeutic use | Colitis - etiology | Animals | Colitis - metabolism | Inflammation - prevention & control | Oxidative Stress - drug effects | Colitis - prevention & control | Plant Extracts - therapeutic use | Peroxidase - metabolism | Antioxidants | Coumarins | Care and treatment | Inflammation | Research | Health aspects
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, pp. E869 - E878
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the... 
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Biological Sciences | PNAS Plus
Journal Article
Plant Physiology, ISSN 0032-0889, 1/2014, Volume 164, Issue 1, pp. 160 - 172
Journal Article
Biochimie, ISSN 0300-9084, 10/2013, Volume 95, Issue 10, pp. 1848 - 1854
Journal Article