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Publication DateBiomaterials, ISSN 0142-9612, 2010, Volume 31, Issue 30, pp. 7748 - 7757
Abstract We developed in this research a nanoparticle system for targeted drug delivery across the blood–brain barrier (BBB), which consists of the transferrin...
Advanced Basic Science | Dentistry | Surface modification | Cancer nanotechnology | Drug targeting | Nanomedicine | Biodegradable polymers | Docetaxel | VITRO | MATERIALS SCIENCE, BIOMATERIALS | PROTEIN | ENGINEERING, BIOMEDICAL | RECEPTOR-MEDIATED TRANSCYTOSIS | ENDOCYTOSIS | CANCER | TUMORS | CHEMOTHERAPY | TRANSPORT | IN-VIVO EVALUATION | PLGA NANOPARTICLES | Biocompatible Materials - metabolism | Coumarins - metabolism | Succinates - chemistry | Thiazoles - metabolism | Nanoparticles - chemistry | Biocompatible Materials - chemistry | Humans | Coumarins - chemistry | Male | Polyethylene Glycols - chemistry | Taxoids - metabolism | Drug Carriers - chemistry | Antineoplastic Agents - metabolism | Brain - metabolism | Tissue Distribution | Succinates - metabolism | Polyethylene Glycols - metabolism | Taxoids - chemistry | Brain - cytology | Drug Carriers - metabolism | Rats | Materials Testing | Antineoplastic Agents - chemistry | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Animals | Transferrin - chemistry | Thiazoles - chemistry | Transferrin - metabolism | Drug Delivery Systems - methods
Advanced Basic Science | Dentistry | Surface modification | Cancer nanotechnology | Drug targeting | Nanomedicine | Biodegradable polymers | Docetaxel | VITRO | MATERIALS SCIENCE, BIOMATERIALS | PROTEIN | ENGINEERING, BIOMEDICAL | RECEPTOR-MEDIATED TRANSCYTOSIS | ENDOCYTOSIS | CANCER | TUMORS | CHEMOTHERAPY | TRANSPORT | IN-VIVO EVALUATION | PLGA NANOPARTICLES | Biocompatible Materials - metabolism | Coumarins - metabolism | Succinates - chemistry | Thiazoles - metabolism | Nanoparticles - chemistry | Biocompatible Materials - chemistry | Humans | Coumarins - chemistry | Male | Polyethylene Glycols - chemistry | Taxoids - metabolism | Drug Carriers - chemistry | Antineoplastic Agents - metabolism | Brain - metabolism | Tissue Distribution | Succinates - metabolism | Polyethylene Glycols - metabolism | Taxoids - chemistry | Brain - cytology | Drug Carriers - metabolism | Rats | Materials Testing | Antineoplastic Agents - chemistry | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Animals | Transferrin - chemistry | Thiazoles - chemistry | Transferrin - metabolism | Drug Delivery Systems - methods
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Loading RightsPlant Physiology and Biochemistry, ISSN 0981-9428, 03/2015, Volume 88, pp. 27 - 35
The potentiality of COU to improve plant tolerance to salinity was investigated. Wheat grains were primed with COU (50 ppm) and then grown under different...
Flavonoids | POD | PAL | Coumarin | Wheat | Phenolics | Osmolytes | Salinity | ANTIOXIDANT ACTIVITY | OXIDATIVE STRESS | PHENOLIC-COMPOUNDS | SALT TOLERANCE | PLANT SCIENCES | PEROXIDASE | SALICYLIC-ACID | HELIANTHUS-ANNUUS | PLANTS | AMMONIA-LYASE ACTIVITIES | Potassium - metabolism | Sodium Chloride - adverse effects | Proline - metabolism | Antioxidants - metabolism | Plant Leaves | Stress, Physiological | Triticum - growth & development | Sodium - metabolism | Seedlings - growth & development | Plant Roots - drug effects | Triticum - metabolism | Peroxidases - metabolism | Salt-Tolerance | Plant Proteins - metabolism | Sodium Chloride - metabolism | Scopoletin - metabolism | Chlorophyll - metabolism | Phenols - metabolism | Seedlings - drug effects | Hydrogen Peroxide - metabolism | Catalase - metabolism | Coumarins - pharmacology | Flavonoids - metabolism | Seedlings - metabolism | Triticum - drug effects | Antioxidants | Isoflavones
Flavonoids | POD | PAL | Coumarin | Wheat | Phenolics | Osmolytes | Salinity | ANTIOXIDANT ACTIVITY | OXIDATIVE STRESS | PHENOLIC-COMPOUNDS | SALT TOLERANCE | PLANT SCIENCES | PEROXIDASE | SALICYLIC-ACID | HELIANTHUS-ANNUUS | PLANTS | AMMONIA-LYASE ACTIVITIES | Potassium - metabolism | Sodium Chloride - adverse effects | Proline - metabolism | Antioxidants - metabolism | Plant Leaves | Stress, Physiological | Triticum - growth & development | Sodium - metabolism | Seedlings - growth & development | Plant Roots - drug effects | Triticum - metabolism | Peroxidases - metabolism | Salt-Tolerance | Plant Proteins - metabolism | Sodium Chloride - metabolism | Scopoletin - metabolism | Chlorophyll - metabolism | Phenols - metabolism | Seedlings - drug effects | Hydrogen Peroxide - metabolism | Catalase - metabolism | Coumarins - pharmacology | Flavonoids - metabolism | Seedlings - metabolism | Triticum - drug effects | Antioxidants | Isoflavones
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Loading RightsJournal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2012, Volume 342, Issue 3, pp. 654 - 664
Nodakenin, a coumarin isolated from the roots of Angelicae gigas, has been reported to possess neuroprotective, antiaggregatory, antibacterial, and...
ACTIVATION | CYTOKINES | CYCLOOXYGENASE-2 | RAW264.7 CELLS | NITRIC-OXIDE SYNTHASE | KINASE | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | MEDIATORS | SEPSIS | ANGELICA-GIGAS | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Interleukin-1beta - genetics | Promoter Regions, Genetic - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Drug Interactions | Ubiquitination - drug effects | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Dinoprostone - genetics | MAP Kinase Kinase Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Down-Regulation - genetics | Coumarins - pharmacology | Dinoprostone - metabolism | Macrophages - metabolism | Signal Transduction - drug effects | Nitric Oxide - genetics | Lipopolysaccharides - pharmacology | Mice | Transcription, Genetic - genetics | Dinoprostone - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Shock, Septic - prevention & control | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Shock, Septic - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Inflammation - drug therapy | Nitric Oxide Synthase Type II - antagonists & inhibitors | I-kappa B Proteins - antagonists & inhibitors | Shock, Septic - drug therapy | Glucosides - pharmacology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | I-kappa B Kinase - genetics | Down-Regulation - drug effects | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Inflammation - genetics | Macrophages - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Ubiquitination - genetics
ACTIVATION | CYTOKINES | CYCLOOXYGENASE-2 | RAW264.7 CELLS | NITRIC-OXIDE SYNTHASE | KINASE | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | MEDIATORS | SEPSIS | ANGELICA-GIGAS | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Interleukin-1beta - genetics | Promoter Regions, Genetic - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Drug Interactions | Ubiquitination - drug effects | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Dinoprostone - genetics | MAP Kinase Kinase Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Down-Regulation - genetics | Coumarins - pharmacology | Dinoprostone - metabolism | Macrophages - metabolism | Signal Transduction - drug effects | Nitric Oxide - genetics | Lipopolysaccharides - pharmacology | Mice | Transcription, Genetic - genetics | Dinoprostone - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Shock, Septic - prevention & control | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Shock, Septic - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Inflammation - drug therapy | Nitric Oxide Synthase Type II - antagonists & inhibitors | I-kappa B Proteins - antagonists & inhibitors | Shock, Septic - drug therapy | Glucosides - pharmacology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | I-kappa B Kinase - genetics | Down-Regulation - drug effects | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Inflammation - genetics | Macrophages - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Ubiquitination - genetics
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Drug Metabolism and Disposition, ISSN 0090-9556, 08/2002, Volume 30, Issue 8, pp. 883 - 891
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The predominant hepatic form is CYP3A4,...
BIOTRANSFORMATION | STIMULATION | ACTIVE-SITE | ESCHERICHIA-COLI | PHARMACOLOGY & PHARMACY | HUMAN LIVER | IDENTIFICATION | CYTOCHROME P450 REDUCTASE | EXPRESSION | DRUG-DRUG INTERACTIONS | Tamoxifen - metabolism | Coumarins - metabolism | Estradiol - metabolism | Cytochrome P-450 CYP3A | Humans | Microsomes, Liver - metabolism | Diltiazem - metabolism | Cytochrome P-450 Enzyme System - metabolism | Clarithromycin - metabolism | Cytochromes b5 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Alprazolam - metabolism | Testosterone - metabolism | Triazolam - metabolism | Biotransformation | Midazolam - metabolism | Microsomes, Liver - enzymology | Nifedipine - metabolism | Kinetics | In Vitro Techniques
BIOTRANSFORMATION | STIMULATION | ACTIVE-SITE | ESCHERICHIA-COLI | PHARMACOLOGY & PHARMACY | HUMAN LIVER | IDENTIFICATION | CYTOCHROME P450 REDUCTASE | EXPRESSION | DRUG-DRUG INTERACTIONS | Tamoxifen - metabolism | Coumarins - metabolism | Estradiol - metabolism | Cytochrome P-450 CYP3A | Humans | Microsomes, Liver - metabolism | Diltiazem - metabolism | Cytochrome P-450 Enzyme System - metabolism | Clarithromycin - metabolism | Cytochromes b5 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Alprazolam - metabolism | Testosterone - metabolism | Triazolam - metabolism | Biotransformation | Midazolam - metabolism | Microsomes, Liver - enzymology | Nifedipine - metabolism | Kinetics | In Vitro Techniques
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Loading RightsMolecular Nutrition & Food Research, ISSN 1613-4125, 03/2010, Volume 54, Issue 3, pp. 311 - 322
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly...
Polyphenol | Ellagitannins | Bioavailability | Gene expression | Cancer | APOPTOSIS | CANCER CELLS | FOOD SCIENCE & TECHNOLOGY | CELL-CYCLE ARREST | CHEMOPREVENTION | HYPERPLASIA | P21 | GROWTH | GENE-EXPRESSION | CACO-2 CELLS | Coumarins - metabolism | Plant Extracts - chemistry | Prostatic Hyperplasia - urine | Prostatic Neoplasms - metabolism | Ellagic Acid - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Coumarins - chemistry | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Prostate - metabolism | Plant Extracts - administration & dosage | Juglans - chemistry | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Glucuronides - metabolism | Prostatic Neoplasms - urine | Hydrolyzable Tannins - chemistry | Biomarkers, Tumor - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Glucuronides - administration & dosage | Prostatic Neoplasms - prevention & control | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Beverages - analysis | Glucuronides - chemistry | Punicaceae - chemistry | Prostatic Neoplasms - surgery | Fruit - chemistry | Coumarins - administration & dosage | Ellagic Acid - chemistry | Rats | Glucuronides - urine | Nuclear Proteins - metabolism | Ellagic Acid - urine | Hydrolyzable Tannins - metabolism | Coumarins - urine | Proto-Oncogene Proteins c-myc - metabolism | Rats, Sprague-Dawley | Prostatic Hyperplasia - metabolism | Prostatic Hyperplasia - surgery | Hydrolyzable Tannins - administration & dosage | Animals | Intestines - microbiology | Aged | Proto-Oncogene Proteins c-myc - genetics
Polyphenol | Ellagitannins | Bioavailability | Gene expression | Cancer | APOPTOSIS | CANCER CELLS | FOOD SCIENCE & TECHNOLOGY | CELL-CYCLE ARREST | CHEMOPREVENTION | HYPERPLASIA | P21 | GROWTH | GENE-EXPRESSION | CACO-2 CELLS | Coumarins - metabolism | Plant Extracts - chemistry | Prostatic Hyperplasia - urine | Prostatic Neoplasms - metabolism | Ellagic Acid - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Coumarins - chemistry | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Prostate - metabolism | Plant Extracts - administration & dosage | Juglans - chemistry | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Glucuronides - metabolism | Prostatic Neoplasms - urine | Hydrolyzable Tannins - chemistry | Biomarkers, Tumor - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Glucuronides - administration & dosage | Prostatic Neoplasms - prevention & control | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Beverages - analysis | Glucuronides - chemistry | Punicaceae - chemistry | Prostatic Neoplasms - surgery | Fruit - chemistry | Coumarins - administration & dosage | Ellagic Acid - chemistry | Rats | Glucuronides - urine | Nuclear Proteins - metabolism | Ellagic Acid - urine | Hydrolyzable Tannins - metabolism | Coumarins - urine | Proto-Oncogene Proteins c-myc - metabolism | Rats, Sprague-Dawley | Prostatic Hyperplasia - metabolism | Prostatic Hyperplasia - surgery | Hydrolyzable Tannins - administration & dosage | Animals | Intestines - microbiology | Aged | Proto-Oncogene Proteins c-myc - genetics
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Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives
Phytomedicine, ISSN 0944-7113, 02/2014, Volume 21, Issue 3, pp. 240 - 246
Coumarins, also known as benzopyrones, are plant-derived products with several pharmacological properties, including antioxidant and anti-inflammatory...
Inflammatory bowel disease | Antioxidant | Coumarin derivatives | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | 4-METHYLESCULETIN | INDUCTION | PLANT SCIENCES | TRINITROBENZENESULFONIC ACID MODEL | ESCULETIN | INFLAMMATORY-BOWEL-DISEASE | METABOLISM | GLUTATHIONE | INTEGRATIVE & COMPLEMENTARY MEDICINE | RAT COLITIS | SULFASALAZINE | PHARMACOLOGY & PHARMACY | Rats, Wistar | Glutathione - metabolism | Plant Extracts - pharmacology | Alkaline Phosphatase - metabolism | Colon - drug effects | Male | Esculin - therapeutic use | Biphenyl Compounds - metabolism | Inflammatory Bowel Diseases - metabolism | Esculin - pharmacology | Inflammation - metabolism | Lipid Peroxidation - drug effects | Anti-Inflammatory Agents - therapeutic use | Umbelliferones - therapeutic use | Phytotherapy | Inflammatory Bowel Diseases - prevention & control | Anti-Inflammatory Agents - pharmacology | Picrates - metabolism | Rats | Antioxidants - pharmacology | Inflammation - etiology | Colon - metabolism | Coumarins - therapeutic use | Coumarins - pharmacology | Umbelliferones - pharmacology | Antioxidants - therapeutic use | Colitis - etiology | Animals | Colitis - metabolism | Inflammation - prevention & control | Oxidative Stress - drug effects | Colitis - prevention & control | Plant Extracts - therapeutic use | Peroxidase - metabolism | Antioxidants | Coumarins | Care and treatment | Inflammation | Research | Health aspects
Inflammatory bowel disease | Antioxidant | Coumarin derivatives | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | 4-METHYLESCULETIN | INDUCTION | PLANT SCIENCES | TRINITROBENZENESULFONIC ACID MODEL | ESCULETIN | INFLAMMATORY-BOWEL-DISEASE | METABOLISM | GLUTATHIONE | INTEGRATIVE & COMPLEMENTARY MEDICINE | RAT COLITIS | SULFASALAZINE | PHARMACOLOGY & PHARMACY | Rats, Wistar | Glutathione - metabolism | Plant Extracts - pharmacology | Alkaline Phosphatase - metabolism | Colon - drug effects | Male | Esculin - therapeutic use | Biphenyl Compounds - metabolism | Inflammatory Bowel Diseases - metabolism | Esculin - pharmacology | Inflammation - metabolism | Lipid Peroxidation - drug effects | Anti-Inflammatory Agents - therapeutic use | Umbelliferones - therapeutic use | Phytotherapy | Inflammatory Bowel Diseases - prevention & control | Anti-Inflammatory Agents - pharmacology | Picrates - metabolism | Rats | Antioxidants - pharmacology | Inflammation - etiology | Colon - metabolism | Coumarins - therapeutic use | Coumarins - pharmacology | Umbelliferones - pharmacology | Antioxidants - therapeutic use | Colitis - etiology | Animals | Colitis - metabolism | Inflammation - prevention & control | Oxidative Stress - drug effects | Colitis - prevention & control | Plant Extracts - therapeutic use | Peroxidase - metabolism | Antioxidants | Coumarins | Care and treatment | Inflammation | Research | Health aspects
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Loading RightsProceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, pp. E869 - E878
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the...
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Biological Sciences | PNAS Plus
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Biological Sciences | PNAS Plus
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Loading RightsPlant Physiology, ISSN 0032-0889, 1/2014, Volume 164, Issue 1, pp. 160 - 172
Although iron (Fe) is one of the most abundant elements in the earth's crust, its low solubility in soils restricts Fe uptake by plants. Most plant species...
Rhizosphere | Root exudates | Plant roots | Coumarins | Fluorescence | Hypochromic anemia | Iron | Plants | Acid soils | Chelates | ECOPHYSIOLOGY AND SUSTAINABILITY | FERRIC-CHELATE REDUCTASE | HOMEOSTASIS | EFFLUX TRANSPORTER | ACID | BICARBONATE | PHENOLICS | ROOTS | PLANTS | FE(III) REDUCING CAPACITY | DEFICIENCY | PLANT SCIENCES | Coumarins - metabolism | Arabidopsis Proteins - genetics | Dioxygenases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Plant Roots - metabolism | Plant Roots - genetics | Iron - metabolism | Arabidopsis - metabolism | DNA, Bacterial | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Umbelliferones - metabolism | Dioxygenases - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Epidermis - physiology | Plants, Genetically Modified | Gene Expression Regulation, Plant | Soil - chemistry | Iron - pharmacokinetics | Mutation | Scopoletin - metabolism | Hydrogen-Ion Concentration | Arabidopsis thaliana | Botanical research | Phytochemistry | Nutritional aspects | Iron in the body | Research | Health aspects
Rhizosphere | Root exudates | Plant roots | Coumarins | Fluorescence | Hypochromic anemia | Iron | Plants | Acid soils | Chelates | ECOPHYSIOLOGY AND SUSTAINABILITY | FERRIC-CHELATE REDUCTASE | HOMEOSTASIS | EFFLUX TRANSPORTER | ACID | BICARBONATE | PHENOLICS | ROOTS | PLANTS | FE(III) REDUCING CAPACITY | DEFICIENCY | PLANT SCIENCES | Coumarins - metabolism | Arabidopsis Proteins - genetics | Dioxygenases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Plant Roots - metabolism | Plant Roots - genetics | Iron - metabolism | Arabidopsis - metabolism | DNA, Bacterial | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Umbelliferones - metabolism | Dioxygenases - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Epidermis - physiology | Plants, Genetically Modified | Gene Expression Regulation, Plant | Soil - chemistry | Iron - pharmacokinetics | Mutation | Scopoletin - metabolism | Hydrogen-Ion Concentration | Arabidopsis thaliana | Botanical research | Phytochemistry | Nutritional aspects | Iron in the body | Research | Health aspects
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Loading RightsBiochimie, ISSN 0300-9084, 10/2013, Volume 95, Issue 10, pp. 1848 - 1854
Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present...
Glucose | Streptozotocin | Diabetes mellitus | Fraxetin | GLUCOSE-6-PHOSPHATE DEHYDROGENASE | SIMPLE COUMARINS | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYRICETIN | GLUCOKINASE | Carbohydrate Metabolism - drug effects | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Liver - enzymology | Rats, Wistar | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Glycated Hemoglobin A - metabolism | Alkaline Phosphatase - metabolism | Body Weight - drug effects | Male | Insulin - blood | Glycogen - metabolism | Liver - drug effects | Diabetes Mellitus, Experimental - chemically induced | Drug Administration Schedule | Rats | Glucokinase - metabolism | Aspartate Aminotransferases - metabolism | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Coumarins - pharmacology | Fructose-Bisphosphatase - metabolism | Animals | Diabetes Mellitus, Experimental - pathology | Glucosephosphate Dehydrogenase - metabolism | Alanine Transaminase - metabolism | Blood Glucose - metabolism | Phosphates | Glucose metabolism | Isoenzymes | Blood sugar | Glycogen | Physiological aspects | Hemoglobin | Aspartate | Carbohydrate metabolism | Diabetes | Fructose
Glucose | Streptozotocin | Diabetes mellitus | Fraxetin | GLUCOSE-6-PHOSPHATE DEHYDROGENASE | SIMPLE COUMARINS | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYRICETIN | GLUCOKINASE | Carbohydrate Metabolism - drug effects | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Liver - enzymology | Rats, Wistar | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Glycated Hemoglobin A - metabolism | Alkaline Phosphatase - metabolism | Body Weight - drug effects | Male | Insulin - blood | Glycogen - metabolism | Liver - drug effects | Diabetes Mellitus, Experimental - chemically induced | Drug Administration Schedule | Rats | Glucokinase - metabolism | Aspartate Aminotransferases - metabolism | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Coumarins - pharmacology | Fructose-Bisphosphatase - metabolism | Animals | Diabetes Mellitus, Experimental - pathology | Glucosephosphate Dehydrogenase - metabolism | Alanine Transaminase - metabolism | Blood Glucose - metabolism | Phosphates | Glucose metabolism | Isoenzymes | Blood sugar | Glycogen | Physiological aspects | Hemoglobin | Aspartate | Carbohydrate metabolism | Diabetes | Fructose
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Loading RightsChemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 81, pp. 11387 - 11390
In this study, we developed a multi-signal mitochondria-targeted fluorescent probe (NIR-Cys) for simultaneous detection of Cys and its metabolite, SO2. In the...
THIOLS | RAT | IN-VIVO | CYS | CHEMISTRY, MULTIDISCIPLINARY | SULFUR-DIOXIDE DERIVATIVES | SULFITE | Fluorescent Dyes - chemical synthesis | Coumarins - metabolism | Sulfur Dioxide - analysis | Humans | Fluorescence | Fluorescent Dyes - metabolism | Coumarins - chemistry | Chromans - metabolism | Acrylates - metabolism | Acrylates - chemical synthesis | Cysteine - metabolism | Coumarins - toxicity | Chromans - chemistry | Fluorescent Dyes - chemistry | Limit of Detection | Acrylates - chemistry | Cysteine - analysis | Liver - metabolism | Sulfur Dioxide - metabolism | Zebrafish | Mitochondria - metabolism | Acrylates - toxicity | Microscopy, Confocal - methods | Sulfites - chemistry | Animals | Fluorescent Dyes - toxicity | Microscopy, Fluorescence - methods | Coumarins - chemical synthesis | Sulfites - analysis | Cell Line, Tumor | Chromans - chemical synthesis | Mice | Chromans - toxicity
THIOLS | RAT | IN-VIVO | CYS | CHEMISTRY, MULTIDISCIPLINARY | SULFUR-DIOXIDE DERIVATIVES | SULFITE | Fluorescent Dyes - chemical synthesis | Coumarins - metabolism | Sulfur Dioxide - analysis | Humans | Fluorescence | Fluorescent Dyes - metabolism | Coumarins - chemistry | Chromans - metabolism | Acrylates - metabolism | Acrylates - chemical synthesis | Cysteine - metabolism | Coumarins - toxicity | Chromans - chemistry | Fluorescent Dyes - chemistry | Limit of Detection | Acrylates - chemistry | Cysteine - analysis | Liver - metabolism | Sulfur Dioxide - metabolism | Zebrafish | Mitochondria - metabolism | Acrylates - toxicity | Microscopy, Confocal - methods | Sulfites - chemistry | Animals | Fluorescent Dyes - toxicity | Microscopy, Fluorescence - methods | Coumarins - chemical synthesis | Sulfites - analysis | Cell Line, Tumor | Chromans - chemical synthesis | Mice | Chromans - toxicity
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Loading RightsPharmacological Reviews, ISSN 0031-6997, 03/2005, Volume 57, Issue 1, pp. 79 - 115
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for several diseases, and a...
PERFORMANCE LIQUID-CHROMATOGRAPHY | CONSTITUTIVE ANDROSTANE RECEPTOR | COUMARIN 7-HYDROXYLASE ACTIVITY | FLAVIN-CONTAINING MONOOXYGENASES | PHARMACOLOGY & PHARMACY | SINGLE NUCLEOTIDE POLYMORPHISM | ENVIRONMENTAL TOBACCO-SMOKE | SERUM COTININE LEVELS | HUMAN-LIVER-MICROSOMES | VITRO HEPATIC-METABOLISM | PREGNANE-X-RECEPTOR | Cytochrome P-450 CYP2A6 | Liver - enzymology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Biological Availability | Male | Metabolic Clearance Rate | Nicotine - pharmacology | Tissue Distribution | Smoking - metabolism | Absorption | Animals | Nicotine - metabolism | Ganglionic Stimulants - pharmacokinetics | Female | Ganglionic Stimulants - pharmacology | Mixed Function Oxygenases - genetics | Nicotine - pharmacokinetics | Ganglionic Stimulants - metabolism
PERFORMANCE LIQUID-CHROMATOGRAPHY | CONSTITUTIVE ANDROSTANE RECEPTOR | COUMARIN 7-HYDROXYLASE ACTIVITY | FLAVIN-CONTAINING MONOOXYGENASES | PHARMACOLOGY & PHARMACY | SINGLE NUCLEOTIDE POLYMORPHISM | ENVIRONMENTAL TOBACCO-SMOKE | SERUM COTININE LEVELS | HUMAN-LIVER-MICROSOMES | VITRO HEPATIC-METABOLISM | PREGNANE-X-RECEPTOR | Cytochrome P-450 CYP2A6 | Liver - enzymology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Biological Availability | Male | Metabolic Clearance Rate | Nicotine - pharmacology | Tissue Distribution | Smoking - metabolism | Absorption | Animals | Nicotine - metabolism | Ganglionic Stimulants - pharmacokinetics | Female | Ganglionic Stimulants - pharmacology | Mixed Function Oxygenases - genetics | Nicotine - pharmacokinetics | Ganglionic Stimulants - metabolism
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Loading RightsJournal of Experimental Botany, ISSN 0022-0957, 03/2016, Volume 67, Issue 5, pp. 1421 - 1432
Root exudate metabolite profiling suggests antagonistic roles for individual coumarins during phosphate and iron deficiency. Oligolignol accumulation and root...
Arabidopsis thaliana | lignification | hydroponic system | oligolignol | phosphate starvation | coumarin | root exudates | metabolite profiling | SECONDARY METABOLITES | LIGNIN OLIGOMERS | PHOSPHORUS | ACQUISITION | IRON | ORGANIC-ACIDS | PLANT SCIENCES | HIGHER-PLANTS | AVAILABILITY | STARVATION | FERULOYL-COA | Coumarins - metabolism | Arabidopsis - drug effects | Plant Roots - metabolism | Phloroglucinol - metabolism | Plant Exudates - metabolism | Metabolomics - methods | Arabidopsis - metabolism | Plant Roots - drug effects | Lignin - metabolism | Metabolome - drug effects | Hydroponics | Malates - metabolism | Meristem - metabolism | Citric Acid - metabolism | Meristem - drug effects | Phosphates - pharmacology | Plant Roots - growth & development | Arginine - metabolism | Cluster Analysis | Research Paper
Arabidopsis thaliana | lignification | hydroponic system | oligolignol | phosphate starvation | coumarin | root exudates | metabolite profiling | SECONDARY METABOLITES | LIGNIN OLIGOMERS | PHOSPHORUS | ACQUISITION | IRON | ORGANIC-ACIDS | PLANT SCIENCES | HIGHER-PLANTS | AVAILABILITY | STARVATION | FERULOYL-COA | Coumarins - metabolism | Arabidopsis - drug effects | Plant Roots - metabolism | Phloroglucinol - metabolism | Plant Exudates - metabolism | Metabolomics - methods | Arabidopsis - metabolism | Plant Roots - drug effects | Lignin - metabolism | Metabolome - drug effects | Hydroponics | Malates - metabolism | Meristem - metabolism | Citric Acid - metabolism | Meristem - drug effects | Phosphates - pharmacology | Plant Roots - growth & development | Arginine - metabolism | Cluster Analysis | Research Paper
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