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Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 01/2019, Volume 14, Issue 2, pp. 217 - 223
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2018, Volume 28, Issue 21, pp. 3419 - 3424
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2017, Volume 27, Issue 3, pp. 632 - 635
[Display omitted] Reactive metabolites have been putatively linked to many adverse drug reactions including idiosyncratic toxicities for a number of drugs with... 
BTK | Bruton’s tyrosine kinase | Covalent binding | Glutathione adduct | Reactive metabolite
Journal Article
Modern Rheumatology, ISSN 1439-7595, 05/2019, Volume 29, Issue 3, pp. 510 - 522
Objectives: Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase required for intracellular signaling downstream of multiple immunoreceptors. We... 
Bruton's tyrosine kinase (BTK) | rheumatoid arthritis | lupus | covalent inhibitor | AUTOANTIBODIES | BTK FUNCTION | LOCALIZATION | PHAGOCYTOSIS | X-LINKED AGAMMAGLOBULINEMIA | RHEUMATOLOGY | PROTECTS | OSTEOCLASTOGENESIS | TEC | B-CELL ACTIVATION | MICE
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2012, Volume 84, Issue 11, pp. 1388 - 1399
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 07/2018, Volume 351, Issue 7, pp. e1700369 - n/a
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3052 - 3059
[Display omitted] A series of novel 4,5,6-trisubstituted pyrimidines were designed as potent covalent Bruton’s tyrosine kinase (BTK) inhibitors based on the... 
BTK | Molecular dynamics simulation | Covalent kinase inhibitor | Structure–activity relationship | Pyrimidine
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 10/2019, Volume 10, Issue 10, pp. 1467 - 1472
Bruton's tyrosine kinase (BTK) is a member of the TEC kinase family and is selectively expressed in a subset of immune cells. It is a key regulator of antigen... 
kinase inhibitor | ACTIVATION | CHEMISTRY, MEDICINAL | B-CELL | covalent inhibitor | BTK | irreversible inhibitor | MICE | kinase selectivity | TEC FAMILY
Journal Article
International Journal of Hematology, ISSN 0925-5710, 1/2016, Volume 103, Issue 1, pp. 86 - 94
Journal Article