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1. Full Text Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
by Chang, Eric L, Dr and Wefel, Jeffrey S, PhD and Hess, Kenneth R, Prof and Allen, Pamela K, PhD and Lang, Frederick F, Prof and Kornguth, David G, MD and Arbuckle, Rebecca B, MS and Swint, J Michael, Prof and Shiu, Almon S, Prof and Maor, Moshe H, Prof and Meyers, Christina A, Prof
Lancet Oncology, The, ISSN 1470-2045, 2009, Volume 10, Issue 11, pp. 1037 - 1044
Summary Background It is unclear whether the benefit of adding whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) for the control of... 
Hematology, Oncology and Palliative Medicine | SURGERY | MANAGEMENT | STEREOTACTIC RADIOSURGERY | ONCOLOGY | CLINICAL-TRIALS | RADIOTHERAPY | TUMORS | RADIATION-THERAPY | Humans | Middle Aged | Radiosurgery | Salvage Therapy | Memory - radiation effects | Male | Brain Neoplasms - surgery | Patient Selection | Brain Neoplasms - secondary | Time Factors | Radiotherapy, Adjuvant - adverse effects | Radiation Injuries - psychology | Aged, 80 and over | Adult | Female | Verbal Learning - radiation effects | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Cognition - radiation effects | Brain Neoplasms - psychology | Risk Assessment | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Cranial Irradiation - adverse effects | Radiation Injuries - etiology | Neuropsychological Tests | Bayes Theorem | Aged | Care and treatment | Metastasis | Radiotherapy | Surgery | Radiation | Brain | aphasia | Consciousness | Toxicity | Memory | Clinical trials | Cognition | Neuropathy | Statistics | Metastases | Necrosis | Learning | Algorithms | Bayesian analysis | Seizures | Index Medicus
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2. Full Text Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia
by Conklin, H.M and Krull, K.R and Reddick, W.E and Pei, D and Cheng, C and Pui, C.H
Journal of the National Cancer Institute, ISSN 0027-8874, 09/2012, Volume 104, Issue 18, pp. 1386 - 1395
Treatment of acute lymphoblastic leukemia (ALL) has included the use of prophylactic cranial irradiation in up to 20% of children with high-risk disease... 
ATTENTION | LONG-TERM SURVIVORS | NEUROPSYCHOLOGICAL PERFORMANCE | ONCOLOGY | FRONTAL-CORTEX | DEVELOPMENTAL MODEL | BRAIN MATURATION | SEX-DIFFERENCES | WHITE-MATTER VOLUME | WORKING-MEMORY | CHILDREN | Multivariate Analysis | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Age Factors | Humans | Precursor Cell Lymphoblastic Leukemia-Lymphoma - psychology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Child, Preschool | Dexamethasone - adverse effects | Infant | Male | Cytarabine - adverse effects | Patient Selection | Hydrocortisone - administration & dosage | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Time Factors | Attention - drug effects | Vincristine - administration & dosage | Female | Child | Injections, Spinal | Prednisone - administration & dosage | Dexamethasone - administration & dosage | Prednisone - adverse effects | Drug Administration Schedule | Risk Factors | Mercaptopurine - administration & dosage | Mercaptopurine - adverse effects | Logistic Models | Treatment Outcome | Cognition - drug effects | Cranial Irradiation - adverse effects | Remission Induction | Cytarabine - administration & dosage | Intelligence Tests | Methotrexate - adverse effects | Hydrocortisone - adverse effects | Adolescent | Sex Factors | Vincristine - adverse effects | Methotrexate - administration & dosage | Intelligence - drug effects | Care and treatment | Patient outcomes | Acute lymphocytic leukemia | Research | Cognition disorders | Risk factors | Cancer in children | Chemotherapy | Cognition & reasoning | Patients | Leukemia | Children & youth | Index Medicus
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3. Full Text Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): A phase II multi-institutional trial
by Gondi, Vinai and Pugh, Stephanie L and Tome, Wolfgang A and Caine, Chip and Corn, Ben and Kanner, Andrew and Rowley, Howard and Kundapur, Vijayananda and DeNittis, Albert and Greenspoon, Jeffrey N and Konski, Andre A and Bauman, Glenn S and Shah, Sunjay and Shi, Wenyin and Wendland, Merideth and Kachnic, Lisa and Mehta, Minesh P
Journal of Clinical Oncology, ISSN 0732-183X, 12/2014, Volume 32, Issue 34, pp. 3810 - 3816
Purpose Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be... 
PROPHYLACTIC CRANIAL IRRADIATION | LUNG-CANCER | ONCOLOGY | NEUROCOGNITIVE FUNCTION | RANDOMIZED-TRIAL | RADIOSURGERY | QUALITY-OF-LIFE | DYSFUNCTION | TUMORS | RADIATION-THERAPY | Memory Disorders - physiopathology | Neural Stem Cells - radiation effects | Radiation Injuries - mortality | Humans | Middle Aged | Male | Cognition | Mental Recall - radiation effects | Cranial Irradiation - methods | Radiotherapy, Intensity-Modulated - adverse effects | Brain Neoplasms - secondary | Time Factors | Radiation Injuries - psychology | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Cranial Irradiation - mortality | Radiotherapy, Intensity-Modulated - mortality | Memory Disorders - psychology | Risk Factors | Kaplan-Meier Estimate | Treatment Outcome | Memory Disorders - mortality | Cranial Irradiation - adverse effects | Radiation Injuries - etiology | Neuropsychological Tests | Memory Disorders - prevention & control | Memory Disorders - etiology | Dose Fractionation, Radiation | Radiation Injuries - prevention & control | Hippocampus - radiation effects | Quality of Life | Aged | Radiation Injuries - physiopathology | Hippocampus - physiopathology | Index Medicus | ORIGINAL REPORTS | Neur5 | Radn
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4. Full Text Rituximab, Methotrexate, Procarbazine, and Vincristine Followed by Consolidation Reduced-Dose Whole-Brain Radiotherapy and Cytarabine in Newly Diagnosed Primary CNS Lymphoma: Final Results and Long-Term Outcome
by Patrick G. Morris and Denise D. Correa and Joachim Yahalom and Jeffrey J. Raizer and David Schiff and Barbara Grant and Sean Grimm and Rose K. Lai and Anne S. Reiner and Kathy Panageas and Sasan Karimi and Richard Curry and Gaurav Shah and Lauren E. Abrey and Lisa M. DeAngelis and Antonio Omuro
Journal of Clinical Oncology, ISSN 0732-183X, 11/2013, Volume 31, Issue 31, pp. 3971 - 3979
Purpose A multicenter phase II study was conducted to assess the efficacy of rituximab, methotrexate, procarbazine, and vincristine (R-MPV) followed by... 
COGNITIVE FUNCTIONS | DEFERRED RADIOTHERAPY | IMMUNOCHEMOTHERAPY | MULTICENTER | THERAPY | ONCOLOGY | RECURRENT PRIMARY CNS | EUROPEAN ORGANIZATION | PHASE-II | CENTRAL-NERVOUS-SYSTEM | CHEMOTHERAPY | Procarbazine - administration & dosage | Chemoradiotherapy - adverse effects | Humans | Middle Aged | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Male | Time | Cytarabine - adverse effects | Cranial Irradiation - methods | Lymphoma - mortality | Lymphoma - therapy | Vincristine - administration & dosage | Adult | Female | Rituximab | Central Nervous System Neoplasms - therapy | Treatment Outcome | Cranial Irradiation - adverse effects | Cytarabine - administration & dosage | Disease-Free Survival | Methotrexate - adverse effects | Procarbazine - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Vincristine - adverse effects | Methotrexate - administration & dosage | Aged | Antibodies, Monoclonal, Murine-Derived - adverse effects | Central Nervous System Neoplasms - mortality | Index Medicus | Original Reports
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5. Full Text Cranial irradiation compromises neuronal architecture in the hippocampus
by Vipan Kumar Parihar and Charles L. Limoli
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12822 - 12827
Cranial irradiation is used routinely for the treatment of nearly all brain tumors, but may lead to progressive and debilitating impairments of cognitive... 
Dendritic spines | Neurons | Memory | Central nervous system | Irradiation | Pseudopodia | Dendrites | Radiotherapy | Radiation dosage | Hippocampus | Radiation injury | Radiation-induced cognitive dysfunction | Structural plasticity | SYNAPTIC PATHOLOGY | MENTAL-RETARDATION | MULTIDISCIPLINARY SCIENCES | TRANSPLANTATION | DENDRITIC SPINES | structural plasticity | MEMORY | DISEASE | radiation-induced cognitive dysfunction | NEUROGENESIS | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | radiation injury | BRAIN | Disks Large Homolog 4 Protein | Dendrites - metabolism | Dendrites - pathology | Dentate Gyrus - metabolism | Gamma Rays - adverse effects | Guanylate Kinases - biosynthesis | Mice, Transgenic | Radiation Injuries, Experimental - pathology | Cranial Irradiation - adverse effects | Nerve Net - pathology | Membrane Proteins - biosynthesis | Animals | Synaptophysin - biosynthesis | Gene Expression Regulation - radiation effects | Mice | Nerve Net - radiation effects | Dentate Gyrus - pathology | Dose-Response Relationship, Radiation | Radiation Injuries, Experimental - metabolism | Physiological aspects | Hippocampus (Brain) | Research | Health aspects | Neurophysiology | Brain research | Neurodegeneration | Morphology | Cognitive ability | Tumors | Index Medicus | Biological Sciences
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6. Full Text Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial
by Takahashi, Toshiaki, MD and Yamanaka, Takeharu, Prof and Seto, Takashi, MD and Harada, Hideyuki, MD and Nokihara, Hiroshi, MD and Saka, Hideo, MD and Nishio, Makoto, MD and Kaneda, Hiroyasu, MD and Takayama, Koichi, MD and Ishimoto, Osamu, MD and Takeda, Koji, MD and Yoshioka, Hiroshige, MD and Tachihara, Motoko, MD and Sakai, Hiroshi, MD and Goto, Koichi, MD and Yamamoto, Nobuyuki, Prof
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 5, pp. 663 - 671
Summary Background Results from a previous phase 3 study suggested that prophylactic cranial irradiation reduces the incidence of symptomatic brain metastases... 
Hematology, Oncology and Palliative Medicine | DIAGNOSIS | METAANALYSIS | THERAPY | COMPLETE REMISSION | CISPLATIN | ONCOLOGY | RISK | ASYMPTOMATIC BRAIN METASTASES | Lung Neoplasms - drug therapy | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - secondary | Early Termination of Clinical Trials | Brain Neoplasms - secondary | Aged, 80 and over | Medical Futility | Adult | Female | Survival Rate | Cranial Irradiation - adverse effects | Brain Neoplasms - prevention & control | Small Cell Lung Carcinoma - prevention & control | Magnetic Resonance Imaging | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Small Cell Lung Carcinoma - diagnostic imaging | Watchful Waiting | Aged | Platinum Compounds - administration & dosage | Care and treatment | Chemotherapy | Lung cancer | Oncology, Experimental | Radiation | Clinical trials | Metastasis | Research | College teachers | Radiotherapy | Cancer | Analysis | Index Medicus
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7. Full Text Phase III Comparison of Prophylactic Cranial Irradiation Versus Observation in Patients With Locally Advanced Non–Small-Cell Lung Cancer: Primary Analysis of Radiation Therapy Oncology Group Study RTOG 0214
by Elizabeth M. Gore and Kyounghwa Bae and Stuart J. Wong and Alexander Sun and James A. Bonner and Steven E. Schild and Laurie E. Gaspar and Jeffery A. Bogart and Maria Werner-Wasik and Hak Choy
Journal of Clinical Oncology, ISSN 0732-183X, 01/2011, Volume 29, Issue 3, pp. 272 - 278
Purpose This study was conducted to determine if prophylactic cranial irradiation (PCI) improves survival in locally advanced non-small-cell lung cancer... 
NEOADJUVANT CHEMOTHERAPY | ONCOLOGY | HIGH-RISK | FAILURE PATTERNS | BRAIN METASTASES | TERM-FOLLOW-UP | RANDOMIZED-TRIAL | RADIOTHERAPY | CARCINOMA | CEREBRAL METASTASES | MULTIMODALITY TREATMENT | Carcinoma, Non-Small-Cell Lung - radiotherapy | Humans | Middle Aged | Proportional Hazards Models | Lung Neoplasms - radiotherapy | Male | Cranial Irradiation - adverse effects | Brain Neoplasms - prevention & control | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Index Medicus | Original Reports
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8. Full Text Phase III Trial of Prophylactic Cranial Irradiation Compared With Observation in Patients With Locally Advanced Non–Small-Cell Lung Cancer: Neurocognitive and Quality-of-Life Analysis
by Alexander Sun and Kyounghwa Bae and Elizabeth M. Gore and Benjamin Movsas and Stuart J. Wong and Christina A. Meyers and James A. Bonner and Steven E. Schild and Laurie E. Gaspar and Jeffery A. Bogart and Maria Werner-Wasik and Hak Choy
Journal of Clinical Oncology, ISSN 0732-183X, 01/2011, Volume 29, Issue 3, pp. 279 - 286
Purpose There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and quality of life (QOL).... 
WHOLE-BRAIN RADIATION | VERBAL-LEARNING TEST | MULTICENTER RANDOMIZED-TRIAL | PREOPERATIVE CHEMOTHERAPY | SOUTHWEST-ONCOLOGY-GROUP | NEOADJUVANT CHEMOTHERAPY | ONCOLOGY | TERM-FOLLOW-UP | CEREBRAL METASTASIS | PSYCHOMETRIC VALIDATION | MULTIMODALITY TREATMENT | Carcinoma, Non-Small-Cell Lung - radiotherapy | Prospective Studies | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Male | Cognition | Brain Neoplasms - complications | Cranial Irradiation - adverse effects | Brain Neoplasms - prevention & control | Neuropsychological Tests | Brain Neoplasms - secondary | Memory Disorders - prevention & control | Carcinoma, Non-Small-Cell Lung - secondary | Cognition Disorders - prevention & control | Memory Disorders - etiology | Cognition Disorders - etiology | Aged, 80 and over | Quality of Life | Adult | Female | Aged | Index Medicus | Original Reports | Radn | Thor6
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9. Full Text Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a randomised clinical trial
by Le Péchoux, Cécile, Dr and Dunant, Ariane, MS and Senan, Suresh, Prof and Wolfson, Aaron, Prof and Quoix, Elisabeth, Prof and Faivre-Finn, Corinne, MD and Ciuleanu, Tudor, MD and Arriagada, Rodrigo, Prof and Jones, Richard, MD and Wanders, Rinus, MD and Lerouge, Delphine, MD and Laplanche, Agnès, MD and PCI Collaborative Grp and Prophylactic Cranial Irradiation (PCI) Collaborative Group
Lancet Oncology, ISSN 1470-2045, 2009, Volume 10, Issue 5, pp. 467 - 474
Summary Background The optimum dose of prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC) is unknown. A meta-analysis... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | ETOPOSIDE | METAANALYSIS | CISPLATIN | ONCOLOGY | PHASE-III | METASTASES | CUMULATIVE INCIDENCE | CARCINOMA | RADIATION | FAILURE | Radiotherapy Dosage | Carcinoma, Small Cell - secondary | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Combined Modality Therapy | Cranial Irradiation - adverse effects | Brain Neoplasms - prevention & control | Brain Neoplasms - secondary | Carcinoma, Small Cell - prevention & control | Aged, 80 and over | Adult | Female | Aged | Dose-Response Relationship, Radiation | Medical colleges | Chemotherapy | Cancer patients | Lung cancer | Cardiac patients | Clinical trials | Metastasis | Radiotherapy | Cancer | Index Medicus
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10. Full Text Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma
by Brown, Aaron P., MD and Barney, Christian L., BS and Grosshans, David R., MD, PhD and McAleer, Mary Frances, MD, PhD and de Groot, John F., MD and Puduvalli, Vinay K., MD and Tucker, Susan L., PhD and Crawford, Cody N., CMD and Khan, Meena, CMD and Khatua, Soumen, MD and Gilbert, Mark R., MD and Brown, Paul D., MD and Mahajan, Anita, MD
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2013, Volume 86, Issue 2, pp. 277 - 284
Purpose Efficacy and acute toxicity of proton craniospinal irradiation (p-CSI) were compared with conventional photon CSI (x-CSI) for adults with... 
Radiology | Hematology, Oncology and Palliative Medicine | SURVIVAL | ONCOLOGY | RADIOTHERAPY | PEDIATRIC MEDULLOBLASTOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ANDERSON-CANCER-CENTER | CHEMOTHERAPY | RADIATION-THERAPY | Humans | Middle Aged | Proton Therapy - adverse effects | Male | Medulloblastoma - blood | Cerebellar Neoplasms - blood | Cranial Irradiation - methods | Young Adult | Medulloblastoma - radiotherapy | Spine - radiation effects | Adult | Female | Retrospective Studies | Radiotherapy Planning, Computer-Assisted | Radiotherapy Dosage | Photons - adverse effects | Treatment Outcome | Cranial Irradiation - adverse effects | Esophagitis - etiology | Photons - therapeutic use | Nausea - etiology | Weight Loss | Adolescent | Vomiting - etiology | Proton Therapy - methods | Cerebellar Neoplasms - radiotherapy | Sects | Adults | Nuclear radiation | Medulloblastoma | Index Medicus | Acute toxicity | HEMOGLOBIN | REVIEWS | PATIENTS | VOMITING | DISEASE INCIDENCE | NEOPLASMS | PROTON BEAMS | RADIATION DOSES | TOXICITY | IRRADIATION | NAUSEA | RADIOLOGY AND NUCLEAR MEDICINE | BLOOD CELLS | BLOOD COUNT
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11. Full Text A Phase 3 Trial of Whole Brain Radiation Therapy and Stereotactic Radiosurgery Alone Versus WBRT and SRS With Temozolomide or Erlotinib for Non-Small Cell Lung Cancer and 1 to 3 Brain Metastases: Radiation Therapy Oncology Group 0320
by Sperduto, Paul W., MD, MPP and Wang, Meihua, PhD and Robins, H. Ian, MD, PhD and Schell, Michael C., PhD and Werner-Wasik, Maria, MD and Komaki, Ritsuko, MD and Souhami, Luis, MD and Buyyounouski, Mark K., MD and Khuntia, Deepak, MD and Demas, William, MD and Shah, Sunjay A., MD and Nedzi, Lucien A., MD and Perry, Gad, MD and Suh, John H., MD and Mehta, Minesh P., MD
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2013, Volume 85, Issue 5, pp. 1312 - 1318
Background A phase 3 Radiation Therapy Oncology Group (RTOG) study subset analysis demonstrated improved overall survival (OS) with the addition of... 
Radiology | Hematology, Oncology and Palliative Medicine | ONCOLOGY | RANDOMIZED-TRIAL | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Erlotinib Hydrochloride | Dacarbazine - therapeutic use | Humans | Middle Aged | Antineoplastic Agents - therapeutic use | Lung Neoplasms | Radiosurgery - adverse effects | Cranial Irradiation - methods | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Dacarbazine - analogs & derivatives | Brain Neoplasms - mortality | Radiosurgery - methods | Cranial Irradiation - mortality | Radiotherapy Dosage | Carcinoma, Non-Small-Cell Lung - mortality | Cranial Irradiation - adverse effects | Antineoplastic Agents, Alkylating - therapeutic use | Carcinoma, Non-Small-Cell Lung - therapy | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Brain Neoplasms - therapy | Aged | Combined Modality Therapy - methods | Radiosurgery - mortality | Care and treatment | Radiosurgery | Clinical trials | Lung cancer, Small cell | Metastasis | Lung cancer, Non-small cell | Sects | Erlotinib | Nuclear radiation | Analysis | Surgery | Product development | Temozolomide | Cancer | Index Medicus | SURGERY | PATIENTS | NEOPLASMS | DRUGS | LUNGS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | BLOOD-BRAIN BARRIER | TOXICITY | RADIOTHERAPY | BRAIN
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