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1. Full Text GcgCreERT2knockin mice as a tool for genetic manipulation in pancreatic alpha cells
by Shiota, Chiyo and Prasadan, Krishna and Guo, Ping and Fusco, Joseph and Xiao, Xiangwei and Gittes, George K
Diabetologia, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
Cre/loxP | CreER | Pancreatic alpha cells | Proglucagon
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2. Full Text Nociceptor-specific gene deletion using heterozygous Na V1.8-Cre recombinase mice
by Stirling, L. Caroline and Forlani, Greta and Baker, Mark D and Wood, John N and Matthews, Elizabeth A and Dickenson, Anthony H and Nassar, Mohammed A
Pain, ISSN 0304-3959, 2005, Volume 113, Issue 1, pp. 27 - 36
Na 1.8 is a voltage-gated sodium channel expressed only in a subset of sensory neurons of which more than 85% are nociceptors. In order to delete genes in... 
Cre-loxP | Pain | Sodium channel | Behaviour | Knock-out
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3. Full Text Relaxin‐3 inputs target hippocampal interneurons and deletion of hilar relaxin‐3 receptors in “floxed‐RXFP3” mice impairs spatial memory
by Haidar, M and Guèvremont, G and Zhang, C and Bathgate, R.A.D and Timofeeva, E and Smith, C.M and Gundlach, A.L
Hippocampus, ISSN 1050-9631, 05/2017, Volume 27, Issue 5, pp. 529 - 546
ABSTRACT Hippocampus is innervated by γ‐aminobutyric acid (GABA) “projection” neurons of the nucleus incertus (NI), including a population expressing the... 
GABA/somatostatin interneurons | nucleus incertus | dentate gyrus | Cre/LoxP | RXFP3
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4. Full Text Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations
by Seidlitz, Therese and Chen, Yi-Ting and Uhlemann, Heike and Schölch, Sebastian and Kochall, Susan and Merker, Sebastian R and Klimova, Anna and Hennig, Alexander and Schweitzer, Christine and Pape, Kristin and Baretton, Gustavo B and Welsch, Thilo and Aust, Daniela E and Weitz, Jürgen and Koo, Bon-Kyoung and Stange, Daniel E
Gastroenterology, ISSN 0016-5085, 12/2019, Volume 157, Issue 6, pp. 1599 - 1614.e2
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5. Full Text Construction of transgenic Drosophila by using the site-specific integrase from phage phi C31
by Groth, AC and Fish, M and Nusse, R and Calos, MP
GENETICS, ISSN 0016-6731, 04/2004, Volume 166, Issue 4, pp. 1775 - 1782
The phiC31 integrase functions efficiently in vitro and in Escherichia coli, yeast, and mammalian cells, mediating unidirectional site-specific recombination... 
CRE/LOXP | COPLACEMENT | HUMAN-CELLS | DNA | GENETICS & HEREDITY | NONVIRAL GENETIC CORRECTION | GENOMIC INTEGRATION | HOMOLOGOUS RECOMBINATION | EPIDERMOLYSIS-BULLOSA | MELANOGASTER | EXPRESSION
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6. Full Text In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
by Maddalo, Danilo and Manchado, Eusebio and Concepcion, Carla P and Bonetti, Ciro and Vidigal, Joana A and Han, Yoon-Chi and Ogrodowski, Paul and Crippa, Alessandra and Rekhtman, Natasha and Stanchina, Elisa De and Lowe, Scott W and Ventura, Andrea
Nature, ISSN 0028-0836, 12/2014, Volume 516, Issue 7531, pp. 423 - 428
Chromosomal rearrangements have a central role in the pathogenesis of human cancers and often result in the expression of therapeutically actionable gene... 
CELL LUNG-CANCER | ANAPLASTIC LYMPHOMA KINASE | ALK | ACUTE-LEUKEMIA | STEM-CELLS | TRANSLOCATIONS | MULTIDISCIPLINARY SCIENCES | FUSION GENE | CRE-LOXP | MOUSE MODELS | TRANSGENIC MICE | Genetic Engineering - methods | Lung Neoplasms - drug therapy | NIH 3T3 Cells | Pyrazoles - therapeutic use | Lung Neoplasms - enzymology | CRISPR-Associated Proteins - genetics | Cells, Cultured | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Animals | Protein Kinase Inhibitors - therapeutic use | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Mice | Chromosome Inversion - genetics | Disease Models, Animal | Pyridines - therapeutic use | Translocation, Genetic - genetics | Genetic engineering | Lymphomas | Genetic aspects | Methods | Lungs | Rodents | Genomics | Adenoviruses | Lung cancer | Genomes | Drug dosages | Chromosomes | Tumors
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7. Full Text Differential CRE Expression in Lhrh-cre and GnRH-cre Alleles and the Impact on Fertility in Otx2-Flox Mice
by Hoffmann, Hanne M and Larder, Rachel and Lee, Jessica S and Hu, Rachael J and Trang, Crystal and Devries, Brooke M and Clark, Daniel D and Mellon, Pamela L
Neuroendocrinology, ISSN 0028-3835, 06/2019, Volume 108, Issue 4, pp. 328 - 342
There is an increasing trend in studies utilizing cell-specific deletion of genes through conditional gene deletion by CRE recombination. Despite numerous... 
Original Paper | GENE | Fertility | Lhrh | ENDOCRINOLOGY & METABOLISM | Gonadotropin-releasing hormone | Otx2 | NEUROSCIENCES | Cre-LoxP
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8. Full Text Improved Tol2-mediated enhancer trap identifies weakly expressed genes during liver and cell development and regeneration in zebrafish
by Zhong, Yadong and Zhong, Yadong and Huang, Wei and Huang, Wei and Du, Jiang and Du, Jiang and Wang, Zekun and Wang, Zekun and He, Jianbo and He, Jianbo and Luo, Lingfei and Luo, Lingfei
The Journal of biological chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 3, pp. 932 - 940
transposon | development | pancreatic β cell | Cre/loxP | endoderm | liver | regeneration | pancreas | zebrafish | gene expression profiling | enhancer trap
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9. Full Text Gcg(CreERT2) knockin mice as a tool for genetic manipulation in pancreatic alpha cells
by Shiota, C and Prasadan, K and Guo, P and Fusco, J and Xiao, XW and Gittes, GK
DIABETOLOGIA, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
Aims/hypothesis The Cre/loxP system, which enables tissue-specific manipulation of genes, is widely used in mice for diabetes research. Our aim was to develop... 
INSULIN | Cre/loxP | GLUCAGON-LIKE PEPTIDE-1 | GLUCOSE | BETA-CELLS | ENDOCRINE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | CreER(T2) | Pancreatic alpha cells | Proglucagon
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10. Full Text Generation of a transgenic mouse line for conditional expression of human IL-6
by MORI, Taiki and MURASAWA, Yusuke and IKAI, Rina and HAYAKAWA, Tomoko and NAKAMURA, Hiroyuki and OGISO, Noboru and NIIDA, Shumpei and WATANABE, Ken
Experimental Animals, ISSN 1341-1357, 2016
IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have... 
Cre-loxP system | conditional transgenic mouse | IL-6
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11. Full Text Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trablecular bone
by Maeda, Y and Nakamura, E and Nguyen, MT and Suva, LJ and Swain, FL and Razzaque, MS and Mackem, S and Lanske, B
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2007, Volume 104, Issue 15, pp. 6382 - 6387
Indian hedgehog (Ihh) is essential for chondrocyte and osteolblast proliferation/differentiation during prenatal enclochondral bone formation. The early... 
RAT | tamoxifen-inducible | ENDOCHONDRAL SKELETON | MULTIDISCIPLINARY SCIENCES | cartilage | endochondral bone | IHH | cre/loxP | PROLIFERATION | osteoblast | FACTOR RECEPTOR-3 | PTHRP | HORMONE-RELATED PROTEIN | DIFFERENTIATION | EXPRESSION
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12. Full Text Microglia, seen from the CX(3)CR1 angle
by Wolf, Y and Yona, S and Kim, KW and Jung, S
FRONTIERS IN CELLULAR NEUROSCIENCE, ISSN 1662-5102, 03/2013, Volume 7
Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX(3)CR1. Expression of the sole CX(3)CR1 ligand, the... 
CX3CR1 | FRACTALKINE RECEPTOR CXCR1 | AMYLOID DEPOSITION | YOLK-SAC | MONOCYTES | Cre-loxP knock-in mice | NEUROSCIENCES | EFFECTOR-CELLS | NEUROPATHIC PAIN | neuroimmunology | CXCR1 | MOUSE MODEL | GENE-EXPRESSION | microglia | neuropathology | BRAIN
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13. Full Text Evidence of a developmental origin for beta-cell heterogeneity using a dual lineage-tracing technology
by Chen, CD and Shiota, C and Agostinelli, G and Ridley, D and Jiang, YN and Mae, J and Prasadan, K and Xiao, XW and Gittes, GK
DEVELOPMENT, ISSN 0950-1991, 07/2019, Volume 146, Issue 13, p. dev164913
The Cre/loxP system has been used extensively in mouse models with a limitation of one lineage at a time. Differences in function and other properties among... 
Dre/RoxP | Dual lineage tracing | ISLETS | ENDOCRINE | Pdx1 | RECEPTOR | PROLIFERATION | DEVELOPMENTAL BIOLOGY | Ptf1a | beta-Cell heterogeneity | CRE | GROWTH-FACTOR | DIFFERENTIATION | Cre/LoxP | IN-VITRO DEDIFFERENTIATION
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14. Full Text Targeted and Repetitive Chromosomal Integration Enables High-Level Heterologous Gene Expression in Lactobacillus casei
by Xin, YP and Mu, YL and Kong, J and Guo, TT
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, ISSN 0099-2240, 05/2019, Volume 85, Issue 9
Lactobacillus casei is a potential cell factory for the production of enzymes and bioactive molecules using episomal plasmids, which suffer from genetic... 
SYSTEM | repetitive integration | Lactobacillus casei | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | MODEL | targeted chromosomal location | DELETION | POSITION | recombineering system | Cre/loxP system | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CONSTRUCTION | LACTOCOCCUS-LACTIS
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15. Full Text Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1nullmice
by Fujiwara, Akira and Hirawa, Nobuhito and Fujita, Megumi and Kobayashi, Yusuke and Okuyama, Yuki and Yatsu, Keisuke and Katsumata, Mari and Yamamoto, Yuichiro and Ichihara, Naoaki and Saka, Sanae and Toya, Yoshiyuki and Yasuda, Gen and Goshima, Yoshio and Tabara, Yasuharu and Miki, Tetsuro and Ueshima, Hirotsugu and Ishikawa, Yoshihiro and Umemura, Satoshi
Journal of Hypertension, ISSN 0263-6352, 2014, Volume 32, Issue 7, pp. 1415 - 1423
Hypertension | Endothelial nitric oxide synthase | Nitric oxide | Cre-loxP system | ATP2B1
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16. Full Text RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
by Takahashi, Nozomi and Vereecke, Lars and Bertrand, Mathieu J M and Duprez, Linde and Berger, Scott B and Divert, Tatyana and Gonçalves, Amanda and Sze, Mozes and Gilbert, Barbara and Kourula, Stephanie and Goossens, Vera and Lefebvre, Sylvie and Günther, Claudia and Becker, Christoph and Bertin, John and Gough, Peter J and Declercq, Wim and van Loo, Geert and Vandenabeele, Peter
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 95 - 99
Receptor interacting protein kinase 1 (RIPK1) has an essential role in the signalling triggered by death receptors and pattern recognition receptors(1,2).... 
UBIQUITINATION | NECROPTOSIS | MEDIATED RECOMBINATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | TNF-ALPHA | CRE-LOXP | NECROSIS-FACTOR RECEPTOR-1 | CELL-DEATH | Intestines - drug effects | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Inflammation - pathology | Epithelial Cells - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Caspase 8 - metabolism | Male | NF-kappa B - metabolism | Intestines - metabolism | Organoids - enzymology | Necrosis | Caspase 8 - genetics | Receptors, Tumor Necrosis Factor, Type I - deficiency | Inflammation - metabolism | Gene Deletion | Organoids - metabolism | Female | Homeostasis - drug effects | Epithelial Cells - cytology | Tumor Necrosis Factors - pharmacology | Cell Survival - drug effects | Epithelium - drug effects | Epithelium - pathology | Intestines - pathology | Epithelium - metabolism | Organoids - cytology | Epithelial Cells - pathology | Mice, Knockout | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Myeloid Differentiation Factor 88 - deficiency | Organoids - drug effects | Survival Analysis | Anti-Bacterial Agents - pharmacology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Intestines - cytology | Protein research | Physiological aspects | Homeostasis | Research | Epithelium | Protein kinases | Apoptosis | Proteins | Genotype & phenotype | Antibiotics | Transgenic animals | Rodents | Ligands | Colon | Kinases
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17. Full Text Polycistronic Lentiviral Vector for "Hit and Run'' Reprogramming of Adult Skin Fibroblasts to Induced Pluripotent Stem Cells
by Chang, CW and Lai, YS and Pawlik, KM and Liu, K and Sun, CW and Li, C and Schoeb, TR and Townes, TM
STEM CELLS, ISSN 1066-5099, 2009, Volume 27, Issue 5, pp. 1042 - 1049
We report the derivation of induced pluripotent stem (iPS) cells from adult skin fibroblasts using a single, polycistronic lentiviral vector encoding the... 
Transcription factors | DEFINED FACTORS | INDUCTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SOX2 | Lentiviral vector | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE MODEL | DISEASE | Cre-loxP system | NEURONS | GENERATION | HUMAN SOMATIC-CELLS | HEMATOLOGY | EXPRESSION | EFFICIENT | Induced pluripotency
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18. Full Text Easi-CRISPR: A robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins
by Quadros, Rolen M and Miura, Hiromi and Harms, Donald W and Akatsuka, Hisako and Sato, Takehito and Aida, Tomomi and Redder, Ronald and Richardson, Guy P and Inagaki, Yutaka and Sakai, Daisuke and Buckley, Shannon M and Seshacharyulu, Parthasarathy and Batra, Surinder K and Behlke, Mark A and Zeiner, Sarah A and Jacobi, Ashley M and Izu, Yayoi and Thoreson, Wallace B and Urness, Lisa D and Mansour, Suzanne L and Ohtsuka, Masato and Gurumurthy, Channabasavaiah B
Genome Biology, ISSN 1474-7596, 05/2017, Volume 18, Issue 1, pp. 92 - 15
Background: Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic... 
Easi-CRISPR | Homology directed repair | CRISPR/Cas9 | Long ssDNA donors | Reporter and recombinase knock-in | Conditional knockout | CRISPR ribonucleoproteins | Cre-LoxP | long ssDNA donors | KNOCK-IN | RECOMBINATION | ELECTROPORATION | TALENS | CLEAVAGE | GENOME | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | GENETICS & HEREDITY | CELL-CYCLE | EFFICIENCY | RESOURCE | Endonucleases - genetics | Recombinational DNA Repair | Mutagenesis, Insertional - methods | Microinjections | RNA, Guide - genetics | RNA, Guide - metabolism | DNA, Single-Stranded - metabolism | Zygote - metabolism | Mice, Transgenic - genetics | Ribonucleoproteins - metabolism | Endonucleases - metabolism | Genetic Loci | Mice, Transgenic - growth & development | DNA, Single-Stranded - genetics | Founder Effect | Animals | Clustered Regularly Interspaced Short Palindromic Repeats | Integrases - metabolism | Ribonucleoproteins - genetics | Gene Editing - methods | Mice | Zygote - growth & development | Integrases - genetics | Genes, Reporter | Animal models | Transcription factors | Transcription | Single-stranded DNA | Genes | Homologous recombination | Embryo cells | Insertion | Stem cell transplantation | Genomes | DNA repair | Consortia | Custom design | Efficiency | Rodents | Cell cycle | Trends | Deoxyribonucleic acid--DNA | CRISPR | Transgenic mice | Ribonucleoproteins | Progeny | Zygotes | Alleles | Stem cells
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19. Full Text Mutated K-ras Asp12 promotes tumourigenesis in Apc Min mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways
by Luo, Feijun and Brooks, David G and Ye, Hongtao and Hamoudi, Rifat and Poulogiannis, George and Patek, Charles E and Winton, Douglas J and Arends, Mark J
International Journal of Experimental Pathology, ISSN 0959-9673, 10/2009, Volume 90, Issue 5, pp. 558 - 574
Min | Intestine | K-ras | Adenoma | Cre/LoxP | Adenomatous polyposis coli
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20. Full Text Cre-lox neurogenetics: 20 years of versatile applications in brain research and counting
by Tsien, Joe Z
Frontiers in Genetics, ISSN 1664-8021, 2016, Volume 7
Defining and manipulating specific neurons in the brain have garnered enormous interest in recent years, because such an approach is now recognized as crucial... 
Learning and memory | Brainbow | Mouse brain | Neural circuits | Cre-loxP | Cognition | Optogenetics | Cre recombinase | mouse brain | learning and memory | neural circuits | optogenetics
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