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Diabetologia, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
Journal Article
Pain, ISSN 0304-3959, 2005, Volume 113, Issue 1, pp. 27 - 36
Na 1.8 is a voltage-gated sodium channel expressed only in a subset of sensory neurons of which more than 85% are nociceptors. In order to delete genes in... 
Cre-loxP | Pain | Sodium channel | Behaviour | Knock-out
Journal Article
Hippocampus, ISSN 1050-9631, 05/2017, Volume 27, Issue 5, pp. 529 - 546
ABSTRACT Hippocampus is innervated by γ‐aminobutyric acid (GABA) “projection” neurons of the nucleus incertus (NI), including a population expressing the... 
GABA/somatostatin interneurons | nucleus incertus | dentate gyrus | Cre/LoxP | RXFP3
Journal Article
GENETICS, ISSN 0016-6731, 04/2004, Volume 166, Issue 4, pp. 1775 - 1782
The phiC31 integrase functions efficiently in vitro and in Escherichia coli, yeast, and mammalian cells, mediating unidirectional site-specific recombination... 
CRE/LOXP | COPLACEMENT | HUMAN-CELLS | DNA | GENETICS & HEREDITY | NONVIRAL GENETIC CORRECTION | GENOMIC INTEGRATION | HOMOLOGOUS RECOMBINATION | EPIDERMOLYSIS-BULLOSA | MELANOGASTER | EXPRESSION
Journal Article
Journal Article
Neuroendocrinology, ISSN 0028-3835, 06/2019, Volume 108, Issue 4, pp. 328 - 342
There is an increasing trend in studies utilizing cell-specific deletion of genes through conditional gene deletion by CRE recombination. Despite numerous... 
Original Paper | GENE | Fertility | Lhrh | ENDOCRINOLOGY & METABOLISM | Gonadotropin-releasing hormone | Otx2 | NEUROSCIENCES | Cre-LoxP
Journal Article
DIABETOLOGIA, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2399 - 2408
Aims/hypothesis The Cre/loxP system, which enables tissue-specific manipulation of genes, is widely used in mice for diabetes research. Our aim was to develop... 
INSULIN | Cre/loxP | GLUCAGON-LIKE PEPTIDE-1 | GLUCOSE | BETA-CELLS | ENDOCRINE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | CreER(T2) | Pancreatic alpha cells | Proglucagon
Journal Article
Experimental Animals, ISSN 1341-1357, 2016
IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have... 
Cre-loxP system | conditional transgenic mouse | IL-6
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2007, Volume 104, Issue 15, pp. 6382 - 6387
Indian hedgehog (Ihh) is essential for chondrocyte and osteolblast proliferation/differentiation during prenatal enclochondral bone formation. The early... 
RAT | tamoxifen-inducible | ENDOCHONDRAL SKELETON | MULTIDISCIPLINARY SCIENCES | cartilage | endochondral bone | IHH | cre/loxP | PROLIFERATION | osteoblast | FACTOR RECEPTOR-3 | PTHRP | HORMONE-RELATED PROTEIN | DIFFERENTIATION | EXPRESSION
Journal Article
by Wolf, Y and Yona, S and Kim, KW and Jung, S
FRONTIERS IN CELLULAR NEUROSCIENCE, ISSN 1662-5102, 03/2013, Volume 7
Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX(3)CR1. Expression of the sole CX(3)CR1 ligand, the... 
CX3CR1 | FRACTALKINE RECEPTOR CXCR1 | AMYLOID DEPOSITION | YOLK-SAC | MONOCYTES | Cre-loxP knock-in mice | NEUROSCIENCES | EFFECTOR-CELLS | NEUROPATHIC PAIN | neuroimmunology | CXCR1 | MOUSE MODEL | GENE-EXPRESSION | microglia | neuropathology | BRAIN
Journal Article
DEVELOPMENT, ISSN 0950-1991, 07/2019, Volume 146, Issue 13, p. dev164913
The Cre/loxP system has been used extensively in mouse models with a limitation of one lineage at a time. Differences in function and other properties among... 
Dre/RoxP | Dual lineage tracing | ISLETS | ENDOCRINE | Pdx1 | RECEPTOR | PROLIFERATION | DEVELOPMENTAL BIOLOGY | Ptf1a | beta-Cell heterogeneity | CRE | GROWTH-FACTOR | DIFFERENTIATION | Cre/LoxP | IN-VITRO DEDIFFERENTIATION
Journal Article
by Xin, YP and Mu, YL and Kong, J and Guo, TT
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, ISSN 0099-2240, 05/2019, Volume 85, Issue 9
Lactobacillus casei is a potential cell factory for the production of enzymes and bioactive molecules using episomal plasmids, which suffer from genetic... 
SYSTEM | repetitive integration | Lactobacillus casei | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | MODEL | targeted chromosomal location | DELETION | POSITION | recombineering system | Cre/loxP system | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CONSTRUCTION | LACTOCOCCUS-LACTIS
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 95 - 99
Receptor interacting protein kinase 1 (RIPK1) has an essential role in the signalling triggered by death receptors and pattern recognition receptors(1,2).... 
UBIQUITINATION | NECROPTOSIS | MEDIATED RECOMBINATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | TNF-ALPHA | CRE-LOXP | NECROSIS-FACTOR RECEPTOR-1 | CELL-DEATH | Intestines - drug effects | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Inflammation - pathology | Epithelial Cells - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Caspase 8 - metabolism | Male | NF-kappa B - metabolism | Intestines - metabolism | Organoids - enzymology | Necrosis | Caspase 8 - genetics | Receptors, Tumor Necrosis Factor, Type I - deficiency | Inflammation - metabolism | Gene Deletion | Organoids - metabolism | Female | Homeostasis - drug effects | Epithelial Cells - cytology | Tumor Necrosis Factors - pharmacology | Cell Survival - drug effects | Epithelium - drug effects | Epithelium - pathology | Intestines - pathology | Epithelium - metabolism | Organoids - cytology | Epithelial Cells - pathology | Mice, Knockout | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Myeloid Differentiation Factor 88 - deficiency | Organoids - drug effects | Survival Analysis | Anti-Bacterial Agents - pharmacology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Intestines - cytology | Protein research | Physiological aspects | Homeostasis | Research | Epithelium | Protein kinases | Apoptosis | Proteins | Genotype & phenotype | Antibiotics | Transgenic animals | Rodents | Ligands | Colon | Kinases
Journal Article
STEM CELLS, ISSN 1066-5099, 2009, Volume 27, Issue 5, pp. 1042 - 1049
We report the derivation of induced pluripotent stem (iPS) cells from adult skin fibroblasts using a single, polycistronic lentiviral vector encoding the... 
Transcription factors | DEFINED FACTORS | INDUCTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SOX2 | Lentiviral vector | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE MODEL | DISEASE | Cre-loxP system | NEURONS | GENERATION | HUMAN SOMATIC-CELLS | HEMATOLOGY | EXPRESSION | EFFICIENT | Induced pluripotency
Journal Article
Genome Biology, ISSN 1474-7596, 05/2017, Volume 18, Issue 1, pp. 92 - 15
Background: Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic... 
Easi-CRISPR | Homology directed repair | CRISPR/Cas9 | Long ssDNA donors | Reporter and recombinase knock-in | Conditional knockout | CRISPR ribonucleoproteins | Cre-LoxP | long ssDNA donors | KNOCK-IN | RECOMBINATION | ELECTROPORATION | TALENS | CLEAVAGE | GENOME | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | GENETICS & HEREDITY | CELL-CYCLE | EFFICIENCY | RESOURCE | Endonucleases - genetics | Recombinational DNA Repair | Mutagenesis, Insertional - methods | Microinjections | RNA, Guide - genetics | RNA, Guide - metabolism | DNA, Single-Stranded - metabolism | Zygote - metabolism | Mice, Transgenic - genetics | Ribonucleoproteins - metabolism | Endonucleases - metabolism | Genetic Loci | Mice, Transgenic - growth & development | DNA, Single-Stranded - genetics | Founder Effect | Animals | Clustered Regularly Interspaced Short Palindromic Repeats | Integrases - metabolism | Ribonucleoproteins - genetics | Gene Editing - methods | Mice | Zygote - growth & development | Integrases - genetics | Genes, Reporter | Animal models | Transcription factors | Transcription | Single-stranded DNA | Genes | Homologous recombination | Embryo cells | Insertion | Stem cell transplantation | Genomes | DNA repair | Consortia | Custom design | Efficiency | Rodents | Cell cycle | Trends | Deoxyribonucleic acid--DNA | CRISPR | Transgenic mice | Ribonucleoproteins | Progeny | Zygotes | Alleles | Stem cells
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2016, Volume 7
Defining and manipulating specific neurons in the brain have garnered enormous interest in recent years, because such an approach is now recognized as crucial... 
Learning and memory | Brainbow | Mouse brain | Neural circuits | Cre-loxP | Cognition | Optogenetics | Cre recombinase | mouse brain | learning and memory | neural circuits | optogenetics
Journal Article
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