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The New England journal of medicine, ISSN 1533-4406, 2016, Volume 375, Issue 26, pp. 2550 - 2560
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 9, p. e108201
.... Methods and Results: We generated cardiac-specific kinase-dead (kd) calcium/calmodulin-dependent protein kinase kinase-beta (CaMKK beta) transgenic... 
HYPERTROPHY | OXIDATIVE STRESS | RECEPTOR-GAMMA | MITOCHONDRIAL BIOGENESIS | PGC-1-ALPHA | CALMODULIN | GLUCOSE | MULTIDISCIPLINARY SCIENCES | ALPHA | CASCADE | MOLECULAR-CLONING | Up-Regulation | Phosphorylation | Mitochondria, Heart - metabolism | Heart Failure - physiopathology | Myosin Heavy Chains - genetics | Male | Adenosine Triphosphate | Ventricular Dysfunction, Left - genetics | Ventricular Remodeling - genetics | Mitochondria, Heart - genetics | Heart Failure - etiology | Heart Ventricles - pathology | Disease Models, Animal | Heart Failure - mortality | Promoter Regions, Genetic | Magnetic Resonance Spectroscopy | Signal Transduction | Gene Expression Regulation | Mice, Transgenic | Heart Failure - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics | Ventricular Dysfunction, Left - physiopathology | Animals | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Heart Ventricles - metabolism | Mice | Phosphates | Heart | Systems science | Calcium | Biosynthesis | Glucose | Kinases | Creatine | Magnetic resonance spectroscopy | Proteins | Morphogenesis | Mitochondria | Transgenic animals | Rodents | Calcium-binding protein | Myosin | Aorta | Ca2+/calmodulin-dependent protein kinase | Heart diseases | Informatics | Stretching | Calmodulin | Heart failure | Spectroscopy | Damage assessment | Adenosine monophosphate | AMP | Magnetic resonance | Transgenic mice | Phosphocreatine | Pressure | Medicine | Signaling | Adenosine kinase | Coronary vessels | Ventricle | Laboratory animals
Journal Article
British journal of cancer, ISSN 0007-0920, 02/2019, Volume 120, Issue 3, pp. 286 - 293
BACKGROUND: This phase I, open-label, dose-escalation study evaluated the safety, pharmacokinetics and pharmacodynamics of combination therapy with the HDM2... 
Thrombocytopenia/chemically induced | Humans | Middle Aged | Proto-Oncogene Proteins p21(ras)/genetics | Proto-Oncogene Proteins B-raf/genetics | MAP Kinase Kinase Kinases/antagonists & inhibitors | Male | Gene Expression Regulation, Neoplastic/drug effects | Tumor Suppressor Protein p53/genetics | Niacinamide/administration & dosage | Spiro Compounds/administration & dosage | Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors | Dose-Response Relationship, Drug | Indoles/administration & dosage | Protein Kinase Inhibitors/administration & dosage | Maximum Tolerated Dose | Neoplasms/classification | Adult | Female | Aged | Antineoplastic Combined Chemotherapy Protocols/administration & dosage | ACTIVATION | P53 PATHWAY | ONCOLOGY | RG7112 | Niacinamide - analogs & derivatives | Proto-Oncogene Proteins c-mdm2 - genetics | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Spiro Compounds - administration & dosage | Protein Kinase Inhibitors - adverse effects | Spiro Compounds - adverse effects | Indoles - administration & dosage | Tumor Suppressor Protein p53 - genetics | Neoplasms - genetics | Niacinamide - pharmacokinetics | Gene Expression Regulation, Neoplastic - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacokinetics | MAP Kinase Kinase Kinases - genetics | Niacinamide - adverse effects | Neoplasms - classification | Thrombocytopenia - chemically induced | Thrombocytopenia - pathology | Spiro Compounds - pharmacokinetics | Neoplasms - drug therapy | Niacinamide - administration & dosage | Protein Kinase Inhibitors - administration & dosage | Indoles - adverse effects | Proto-Oncogene Proteins B-raf - genetics | Indoles - pharmacokinetics | Neoplasms - pathology | Index Medicus | Targeted therapies | Outcomes research
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 6, pp. 4000 - 4011
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2002, Volume 99, Issue 25, pp. 15983 - 15987
.... To examine the role of AMP-activated protein kinase (AMPK), an evolutionarily conserved fuel sensor, in mitochondrial biogenesis we studied transgenic mice expressing a dominant-negative mutant of AMPK in muscle (DN-AMPK... 
Energy deprivation | Phosphates | Biological Sciences | Sodium | Transgenic animals | Grade point average | Muscles | Actins | Gene expression regulation | Creatine | Skeletal muscle | MP-activated protein kinase | Calcium/calmodulin-dependent protein kinase IV | β-guanidinopropionic acid | Peroxisome proliferator-activated γ receptor coactivator-1α | ACTIVATED PROTEIN-KINASE | NUCLEAR | MULTIDISCIPLINARY SCIENCES | GLUCOSE-TRANSPORT | ACETYL-COA CARBOXYLASE | AMP-activated protein kinase | AMINOLEVULINATE SYNTHASE EXPRESSION | CONTRACTILE ACTIVITY | calcium/calmodulin-dependent protein kinase IV | FATTY-ACID OXIDATION | ELECTRICAL-STIMULATION | peroxisome proliferator-activated gamma receptor coactivator-1 alpha | IN-VIVO | GENE-EXPRESSION | beta-guanidinopropionic acid | Propionates - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 4 | Guanidines - pharmacology | Muscle Proteins - deficiency | Genes, Dominant | Muscle, Skeletal - drug effects | Calcium-Calmodulin-Dependent Protein Kinases - biosynthesis | Enzyme Induction - drug effects | Mitochondria, Muscle - physiology | Adenylate Kinase - physiology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Muscle Proteins - physiology | Muscle, Skeletal - enzymology | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Muscle, Skeletal - ultrastructure | Mice, Transgenic | Transcription Factors - biosynthesis | Transcription Factors - genetics | Adenylate Kinase - deficiency | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Animals | Adenine Nucleotides - metabolism | Mice | Phosphocreatine - metabolism | Adenylate Kinase - genetics | Energy Metabolism - drug effects | Physiological aspects | Energy metabolism | Bioenergetics | calmodulin-dependent protein kinase IV | calcium | peroxisome proliferator-activated γ receptor coactivator-1α
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 05/2012, Volume 90, Issue 5, pp. 637 - 645
Journal Article