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Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 2009, Volume 382, Issue 1, pp. 205 - 214
Ionically crosslinked nanoparticles based on high and low molecular weight chitosans (CS) were formulated with plasmid DNA or dsDNA oligomers using the ionic... 
Nanoparticles | Gene delivery | Ionic gelation | Chitosan | pDNA | Oligonucleotides | SYSTEM | TRANSFECTION | CHITOSAN NANOPARTICLES | FORMULATION | CARRIERS | IN-VITRO | THERAPY | PHARMACOLOGY & PHARMACY | EFFICIENCY | VECTORS | Oligonucleotides - chemistry | Molecular Weight | Humans | Polyphosphates - administration & dosage | Endocytosis | Transfection - methods | Biological Transport | Time Factors | Serum Albumin, Bovine - chemistry | Polyphosphates - toxicity | Chitosan - metabolism | Genes, Reporter | Cell Line | Cross-Linking Reagents - chemistry | Cross-Linking Reagents - toxicity | Chitosan - administration & dosage | Gene Expression Regulation | Chitosan - toxicity | Plasmids - metabolism | Polyphosphates - metabolism | Cross-Linking Reagents - administration & dosage | Cross-Linking Reagents - metabolism | Microscopy, Confocal | Oligonucleotides - metabolism | Animals | Chitosan - chemistry | beta-Galactosidase - biosynthesis | Plasmids - chemistry | Mice | Mice, Inbred BALB C | Oligonucleotides - administration & dosage | beta-Galactosidase - genetics | Plasmids - administration & dosage | Polyphosphates - chemistry | Oligomers | Crosslinked polymers | Cell research | Glycosaminoglycans | Analysis | DNA | Pharmacy | Genetic research | Beta galactosidases | Anticoagulants (Medicine) | Gene expression | Index Medicus
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 03/2019, Volume 136, pp. 174 - 183
[Display omitted] Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis(hydroxymethyl)phosphonium chloride... 
Camptothecin | Chemotherapy | Drug delivery | Hydrogel | Mucoadhesivity | Oral administration | VITRO | RAT | PERMEABILITY ESTIMATION | CONTROLLED-RELEASE | MECHANISMS | GLUTARALDEHYDE | TRANSPORT | PHARMACOLOGY & PHARMACY | SINGLE-PASS VS | ABSORPTION | IN-SITU | Camptothecin - chemistry | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Rats, Wistar | Humans | Drug Carriers - administration & dosage | Male | Drug Carriers - chemistry | Dose-Response Relationship, Drug | Antineoplastic Agents, Phytogenic - administration & dosage | Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage | Camptothecin - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Cross-Linking Reagents - pharmacokinetics | Caco-2 Cells | Camptothecin - pharmacokinetics | Cross-Linking Reagents - chemistry | Administration, Oral | Chitosan - administration & dosage | Rats | Antineoplastic Agents, Phytogenic - chemistry | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacokinetics | Organophosphorus Compounds - chemistry | Cross-Linking Reagents - administration & dosage | Animals | Chitosan - chemistry | Chitosan - pharmacokinetics | Drug Carriers - pharmacokinetics | Organophosphorus Compounds - administration & dosage | Drug Delivery Systems - methods | Organophosphorus Compounds - pharmacokinetics | Index Medicus
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 01/2013, Volume 440, Issue 2, pp. 148 - 153
Journal Article
Biomaterials, ISSN 0142-9612, 2017, Volume 121, pp. 41 - 54
Abstract Undesired physiological instability of nanocarriers and premature drug leakage during blood circulation result in compromised therapeutic efficacy and... 
Advanced Basic Science | Dentistry | Diselenide bonds | Visible light | Crosslinking | Redox responsiveness | Combination chemotherapy | POLYPRODRUG AMPHIPHILES | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | DOXORUBICIN COMBINATIONS | BLOCK-COPOLYMER MICELLES | TRIGGERED RELEASE | LINKED POLYMERIC MICELLES | DYNAMIC COVALENT BONDS | POLYION COMPLEX VESICLES | SINGLE DISELENIDE | BIOMEDICAL APPLICATIONS | ANTITUMOR EFFICACY | Cross-Linking Reagents - radiation effects | Cell Survival - drug effects | Delayed-Action Preparations - radiation effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Camptothecin - chemistry | Cross-Linking Reagents - chemistry | Nanocapsules - administration & dosage | Drug Stability | Humans | Oxidation-Reduction - radiation effects | Delayed-Action Preparations - chemistry | Treatment Outcome | Doxorubicin - chemistry | Nanocapsules - chemistry | Delayed-Action Preparations - administration & dosage | Neoplasms, Experimental - pathology | MCF-7 Cells | Selenium Compounds - administration & dosage | Light | Camptothecin - administration & dosage | Selenium Compounds - chemistry | Nanocapsules - radiation effects | Neoplasms, Experimental - drug therapy | Doxorubicin - administration & dosage | Drugs | Physiological aspects | Anthracyclines | Crosslinked polymers | Chemotherapy | Cancer
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2007, Volume 124, Issue 1, pp. 69 - 80
Copolymers consisting of branched PEI 25 kDa grafted with high molecular weight PEG at a low degree of substitution were successfully synthesized using a... 
Gene delivery | Crosslinking | Pharmacokinetics | Poly(ethylene glycol) | Poly(ethylene imine) | poly(ethylene imine) | TRANSFECTION EFFICIENCY | CHEMISTRY, MULTIDISCIPLINARY | gene delivery | DNA DELIVERY | INTRAVENOUS-INJECTION | poly(ethylene glycol) | STERIC STABILIZATION | PLASMID DNA | pharmacokinetics | PHARMACOLOGY & PHARMACY | POLYETHYLENE-GLYCOL | crosslinking | TRIGGERED INTRACELLULAR ACTIVATION | NONVIRAL GENE DELIVERY | SYSTEMIC CIRCULATION | Molecular Weight | Biocompatible Materials - chemistry | Humans | Polyethylene Glycols - adverse effects | Polyethylene Glycols - chemistry | Green Fluorescent Proteins - genetics | Cross-Linking Reagents - chemical synthesis | Luciferases - genetics | Biocompatible Materials - chemical synthesis | Flow Cytometry | Transfection | Time Factors | Electrophoresis, Agar Gel | Polyethyleneimine - chemistry | Polyethyleneimine - chemical synthesis | Polyethyleneimine - adverse effects | Cell Survival - drug effects | Gene Transfer Techniques | Cross-Linking Reagents - chemistry | Cross-Linking Reagents - adverse effects | DNA - administration & dosage | Polyethylene Glycols - administration & dosage | Cross-Linking Reagents - administration & dosage | DNA - genetics | Particle Size | Microscopy, Confocal | DNA - chemistry | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Biocompatible Materials - administration & dosage | Polyethylene Glycols - chemical synthesis | Biocompatible Materials - adverse effects | Ethylene glycol | Crosslinked polymers | Polyethylene | Condensation | DNA
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2005, Volume 26, Issue 18, pp. 3941 - 3951
The injectable polymer scaffolds which are biocompatible and biodegradable are important biomaterials for tissue engineering and drug delivery. Hydrogels... 
Alginate | Oxidation | Drug delivery | Hydrogel | Gelatin | Cell encapsulation | alginate | VITRO | cell encapsulation | HYDROGELS | MATERIALS SCIENCE, BIOMATERIALS | ACID | LINKED GELATIN | ENGINEERING, BIOMEDICAL | STABILITY | oxidation | drug delivery | DELIVERY | hydrogel | POLYSACCHARIDES | DEGRADATION | BIOMATERIALS | gelatin | Biopolymers - chemistry | Cell Proliferation | Molecular Weight | Rats, Wistar | Alginates - adverse effects | Gelatin - adverse effects | Hexuronic Acids - administration & dosage | Drug Implants - administration & dosage | Male | Cell Culture Techniques - methods | Hepatocytes - cytology | Absorption | Drug Implants - chemistry | Hydrogels - administration & dosage | Surface Properties | Glucuronic Acid - adverse effects | Glucuronic Acid - administration & dosage | Glucuronic Acid - chemistry | Gelatin - chemistry | Hepatocytes - physiology | Cell Line | Cross-Linking Reagents - chemistry | Gelatin - administration & dosage | Tissue Engineering - methods | Cell Survival | Biopolymers - administration & dosage | Cross-Linking Reagents - adverse effects | Rats | Hexuronic Acids - chemistry | Hardness | Absorbable Implants | Drug Implants - adverse effects | Biopolymers - adverse effects | Alginates - administration & dosage | Hexuronic Acids - adverse effects | Animals | Alginates - chemistry | Fibroblasts - drug effects | Hydrogels - adverse effects | Fibroblasts - cytology | Mice | Porosity | Hydrogels - chemistry | Injections - methods
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2358 - 2364
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2015, Volume 42, pp. 3 - 9
Highlights • Regulatory T cells and effector T cells have a differential capacity to detoxify cyclophosphamide metabolites. • Gut microbiota plays an important... 
Hematology, Oncology and Palliative Medicine | Acrolein | Cyclophosphamide | Chemotherapy | T cells | GSH | DNA CROSS-LINKING | ALDEHYDE DEHYDROGENASE | FACILITATED ADOPTIVE IMMUNOTHERAPY | OVARIAN-CANCER | ANTITUMOR-ACTIVITY | BREAST-CANCER | HEMATOPOIETIC PROGENITOR CELLS | CANCER-PATIENTS | REACTIVE OXYGEN | ONCOLOGY | NF-KAPPA-B | Neoplasms - metabolism | Prodrugs - administration & dosage | T-Lymphocyte Subsets - immunology | Cyclophosphamide - administration & dosage | Oxidative Stress | Cross-Linking Reagents - pharmacology | Humans | Antineoplastic Agents, Alkylating - pharmacology | Antineoplastic Agents, Alkylating - administration & dosage | T-Lymphocytes, Regulatory - immunology | Dose-Response Relationship, Drug | T-Lymphocyte Subsets - drug effects | Adenosine Triphosphate - metabolism | Biotransformation | Neoplasms, Experimental - immunology | Cytotoxicity, Immunologic - drug effects | Acrolein - pharmacology | Drug Administration Schedule | Antineoplastic Agents, Alkylating - pharmacokinetics | Cross-Linking Reagents - administration & dosage | Neoplasms - drug therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Prodrugs - pharmacokinetics | Neoplasms - immunology | Cyclophosphamide - pharmacology | Cyclophosphamide - pharmacokinetics | DNA Damage | Cell Cycle - drug effects | Neoplasms, Experimental - drug therapy | Prodrugs - pharmacology | Microbiota (Symbiotic organisms)
Journal Article