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Journal der Deutschen Dermatologischen Gesellschaft, ISSN 1610-0379, 10/2018, Volume 16, Issue 10, pp. 1266 - 1268
Journal Article
Journal der Deutschen Dermatologischen Gesellschaft, ISSN 1610-0379, 10/2018, Volume 16, Issue 10, pp. 1266 - 1268
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2017, Volume 127, Issue 12, pp. 4488 - 4497
The NLRP3 inflammasome is a protein complex responsible for caspase-1-dependent maturation of the proinflammatory cytokines IL-1 beta and IL-18.... 
MEDICINE, RESEARCH & EXPERIMENTAL | INTERLEUKIN-1 | ACTIVATION | PROTEIN | DISEASE | ALPHA | COLD AUTOINFLAMMATORY SYNDROME | PYROPTOSIS | ETANERCEPT | ARTHRITIS | MAST-CELL | Tumor Necrosis Factor-alpha - metabolism | Cryopyrin-Associated Periodic Syndromes - genetics | Caspases - genetics | Tumor Necrosis Factor-alpha - genetics | Cryopyrin-Associated Periodic Syndromes - therapy | Caspase 1 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - biosynthesis | Interleukin-1beta - genetics | Inflammasomes - biosynthesis | Inflammasomes - genetics | Mice, Knockout | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | Caspases - metabolism | Caspase 1 - genetics | Interleukin-1beta - metabolism | Transcription, Genetic | Cryopyrin-Associated Periodic Syndromes - pathology | Mice | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cryopyrin-Associated Periodic Syndromes - metabolism | Comparative analysis | Tumor necrosis factor | Genetic transcription | Splenomegaly | Transcription | Caspase-11 | Pathogenesis | Body weight | Nervous system | Arthritis | Inflammatory diseases | Caspase-1 | Lipopolysaccharides | Proteins | Missense mutation | Etanercept | Rodents | Interleukin 1 | Tumor necrosis factor-TNF | Spleen | Cold | Cytokines | Cryopyrin | Caspase | Inflammation | Roles | Gene expression | Interleukin 18 | Survival analysis | TNF inhibitors | Skin | Mutation | Alzheimers disease | Apoptosis
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1896 - 17
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2017, Volume 214, Issue 11, pp. 3219 - 3238
The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | BAY 11-7082 | MECHANISM | GOUT | NEK7 | BLOCKING INTERLEUKIN-1 | KAPPA-B | INFLAMMASOMES | IMMUNOLOGY | ATP-BINDING | BETA | Small Molecule Libraries - pharmacology | Inflammasomes - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Immunoblotting | Diabetes Mellitus, Type 2 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Inflammation - metabolism | Inflammasomes - drug effects | Inflammation - drug therapy | HEK293 Cells | Adult | Molecular Structure | Thiazolidines - pharmacology | Thiazolidines - chemistry | Disease Models, Animal | Cryopyrin-Associated Periodic Syndromes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Thiones - chemistry | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Mice, Transgenic | Cryopyrin-Associated Periodic Syndromes - drug therapy | Inflammasomes - genetics | Mice, Knockout | Microscopy, Confocal | Small Molecule Libraries - chemistry | Animals | Cell Line, Tumor | Inflammation - genetics | Thiones - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Cryopyrin-Associated Periodic Syndromes - metabolism | Synovial fluid | Monocytes | Animal models | Inhibitors | Cryopyrin | Pathogenesis | Diabetes mellitus | Gout | Activation | Adenosine triphosphatase | Diseases | 311
Journal Article
Nature, ISSN 0028-0836, 12/2012, Volume 491, Issue 7427, pp. 123 - 127
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 11/2015, Volume 74, Issue 11, pp. 2043 - 2049
ObjectiveTo evaluate genetic, demographic and clinical features in patients with cryopyrin-associated periodic syndrome (CAPS) from the Eurofever Registry,... 
ARTICULAR SYNDROME | NLRP3 MUTATION | Research Support, Non-U.S. Gov't | LOW-LEVEL MOSAICISM | SYNDROMES CAPS | GENETIC-HETEROGENEITY | MUCKLE-WELLS-SYNDROME | COLD AUTOINFLAMMATORY SYNDROME | CIAS1 MUTATIONS | AA AMYLOIDOSIS | Journal Article | MULTISYSTEM INFLAMMATORY DISEASE | RHEUMATOLOGY | Arthralgia - etiology | Uveitis - etiology | Conjunctivitis - genetics | Headache - etiology | Exanthema - genetics | Myalgia - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Child, Preschool | Infant | Male | Papilledema - genetics | Arthritis - genetics | Meningitis - etiology | Exanthema - etiology | Young Adult | Arthritis - etiology | Germ-Line Mutation | Adult | Female | Registries | Retrospective Studies | Arthralgia - genetics | Child | Cryopyrin-Associated Periodic Syndromes - complications | Meningitis - genetics | Severity of Illness Index | Cryopyrin-Associated Periodic Syndromes - genetics | Europe | Genotype | Myalgia - etiology | Hearing Loss, Sensorineural - genetics | Headache - genetics | Cryopyrin-Associated Periodic Syndromes - physiopathology | Carrier Proteins - genetics | Phenotype | Hearing Loss, Sensorineural - etiology | Adolescent | Alleles | Heterozygote | Mutation | Uveitis - genetics | Conjunctivitis - etiology | Cohort Studies | Papilledema - etiology | Complications and side effects | Nervous system diseases | Care and treatment | Research | Cryopyrin-associated periodic syndromes | Studies | Genotype & phenotype | Statistical analysis | Disease | Cold | Meningitis | Family medical history | Hearing impairment | Fever | Chronic illnesses
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2013, Volume 72, Issue 5, pp. 678 - 685
Journal Article