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Best Practice and Research: Clinical Rheumatology, ISSN 1521-6942, 08/2017, Volume 31, Issue 4, pp. 596 - 609
Periodic fever syndromes are autoinflammatory diseases. The majority present in infancy or childhood and are characterised by recurrent episodes of fever and... 
Aphthous stomatitis | Pharyngitis and cervical adenitis (PFAPA) | Deficiency of adenosine deaminase 2 (DADA2) | Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) | Blau syndrome | Deficiency of IL-1 receptor antagonist (DIRA) | Familial Mediterranean fever (FMF) | Mevalonate kinase deficiency (MKD) | Cryopyrin-associated periodic syndromes (CAPS) | Deficiency of IL-36 receptor antagonist (DITRA) | Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome (CANDLE) | RECURRENT MULTIFOCAL OSTEOMYELITIS | TNF RECEPTOR | OPEN-LABEL | RHEUMATOLOGY | CONGENITAL DYSERYTHROPOIETIC ANEMIA | FAMILIAL MEDITERRANEAN FEVER | HYPERIMMUNOGLOBULINEMIA-D | CANAKINUMAB TREATMENT | AUTOINFLAMMATORY DISEASES | COLCHICINE-RESISTANT | Colchicine - therapeutic use | Humans | Child, Preschool | Fever - diagnosis | Infant | Familial Mediterranean Fever - drug therapy | Hereditary Autoinflammatory Diseases - diagnosis | Cryopyrin-Associated Periodic Syndromes - drug therapy | Immunity, Innate | Hereditary Autoinflammatory Diseases - drug therapy | Syndrome | Tumor Necrosis Factor-alpha - therapeutic use | Cryopyrin-Associated Periodic Syndromes - diagnosis | Familial Mediterranean Fever - diagnosis | Child | Fever - drug therapy | Autoimmunity | Amyloidosis | Autoantibodies | Colchicine | Biological response modifiers
Journal Article
Nature Medicine, ISSN 1078-8956, 2015, Volume 21, Issue 3, pp. 248 - 257
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 12/2011, Volume 70, Issue 12, pp. 2095 - 2102
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2017, Volume 214, Issue 11, pp. 3219 - 3238
The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | BAY 11-7082 | MECHANISM | GOUT | NEK7 | BLOCKING INTERLEUKIN-1 | KAPPA-B | INFLAMMASOMES | IMMUNOLOGY | ATP-BINDING | BETA | Small Molecule Libraries - pharmacology | Inflammasomes - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Immunoblotting | Diabetes Mellitus, Type 2 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Inflammation - metabolism | Inflammasomes - drug effects | Inflammation - drug therapy | HEK293 Cells | Adult | Molecular Structure | Thiazolidines - pharmacology | Thiazolidines - chemistry | Disease Models, Animal | Cryopyrin-Associated Periodic Syndromes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Thiones - chemistry | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Mice, Transgenic | Cryopyrin-Associated Periodic Syndromes - drug therapy | Inflammasomes - genetics | Mice, Knockout | Microscopy, Confocal | Small Molecule Libraries - chemistry | Animals | Cell Line, Tumor | Inflammation - genetics | Thiones - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Cryopyrin-Associated Periodic Syndromes - metabolism | Synovial fluid | Monocytes | Animal models | Inhibitors | Cryopyrin | Pathogenesis | Diabetes mellitus | Gout | Activation | Adenosine triphosphatase | Diseases | 311
Journal Article
Arthritis and Rheumatology, ISSN 2326-5191, 11/2017, Volume 69, Issue 11, pp. 2233 - 2240
Objective. Cryopyrin-associated periodic syndromes (CAPS) result from gain-of-function mutations in the NLRP3 gene, which causes excessive release of... 
RHEUMATOLOGY | GENE | PERIODIC SYNDROME | CANAKINUMAB | INFLAMMASOME | Fever - metabolism | Humans | Middle Aged | Child, Preschool | Caspase 1 - metabolism | Male | NF-kappa B - metabolism | Genetic Variation | Young Adult | Hearing Loss - metabolism | Cell Death - genetics | Gastrointestinal Diseases - drug therapy | Child | Cryopyrin-Associated Periodic Syndromes - genetics | Penetrance | Cryopyrin-Associated Periodic Syndromes - drug therapy | Kidney Diseases - immunology | Phenotype | Eye Diseases - genetics | Gastrointestinal Diseases - metabolism | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Adolescent | Fever - drug therapy | Cell Death - immunology | Infant | Hearing Loss - immunology | Case-Control Studies | Kidney Diseases - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Adult | Female | Fever - immunology | Gastrointestinal Diseases - immunology | Antirheumatic Agents - therapeutic use | Kidney Diseases - metabolism | Cryopyrin-Associated Periodic Syndromes - immunology | Eye Diseases - immunology | Interleukin-1beta - immunology | Kidney Diseases - drug therapy | Eye Diseases - metabolism | Treatment Outcome | Hearing Loss - drug therapy | Hearing Loss - genetics | Gastrointestinal Diseases - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Eye Diseases - drug therapy | Inflammasomes - immunology | Fever - genetics | Aged | Cryopyrin-Associated Periodic Syndromes - metabolism
Journal Article
Rheumatology (United Kingdom), ISSN 1462-0324, 08/2016, Volume 55, Issue 8, pp. 1499 - 1506
Objective. Anakinra is approved for the treatment of RA and cryopyrin-associated periodic syndromes (CAPS). While the anakinra safety profile is well... 
Headache | Injection site reactions (ISR) | Clinical trial | Cryopyrin-associated periodic syndromes (CAPS) | Infections | Safety | Adverse event (AE) | Anakinra | Neonatal- onset multisystem inflammatory disease (NOMID) | clinical trial | RHEUMATOID-ARTHRITIS | injection site reactions (ISR) | MULTICENTER | cryopyrin-associated periodic syndromes ( CAPS) | INTERLEUKIN-1 RECEPTOR ANTAGONIST | METHOTREXATE | RHEUMATOLOGY | neonatal-onset multisystem inflammatory disease (NOMID) | anakinra | DISEASES | safety | infections | DOUBLE-BLIND | headache | PLACEBO-CONTROLLED TRIAL | adverse event (AE) | Interleukin 1 Receptor Antagonist Protein - administration & dosage | Prospective Studies | Drug Administration Schedule | Antirheumatic Agents - administration & dosage | Humans | Middle Aged | Child, Preschool | Male | Treatment Outcome | Cryopyrin-Associated Periodic Syndromes - drug therapy | Arthralgia - chemically induced | Dose-Response Relationship, Drug | Young Adult | Pneumonia - chemically induced | Injections, Subcutaneous | Adolescent | Gastroenteritis - chemically induced | Patient Safety | Antirheumatic Agents - adverse effects | Interleukin 1 Receptor Antagonist Protein - adverse effects | Adult | Female | Headache Disorders - chemically induced | Child | 299 | Clinical Science | cryopyrin-associated periodic syndromes (CAPS)
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 09/2015, Volume 74, Issue 9, pp. 1714 - 1719
Journal Article
Clinical and Experimental Rheumatology, ISSN 0392-856X, 2017, Volume 35, Issue 6, pp. S27 - S31
Journal Article
Journal Article
Journal Article