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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 31, pp. 12662 - 12667
Chronic sleep deprivation perturbs the circadian clock and increases susceptibility to diseases such as diabetes, obesity, and cancer. Increased inflammation... 
Phosphorylation | Messenger RNA | Cytokines | Fibroblasts | Chronic diseases | Gene expression regulation | Inflammation | Diabetes | Macrophages | Immune system | Biological clock | TRANSCRIPTIONAL ACTIVITY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | ALPHA | INDIVIDUAL FIBROBLASTS | IN-VITRO | OBESITY | IMMUNE-SYSTEM | biological clock | INFLAMMATION | immune system | GENE-EXPRESSION | NF-KAPPA-B | Inflammation - pathology | Humans | NF-kappa B - immunology | Cryptochromes - genetics | NF-kappa B - metabolism | Transcription Factor RelA - genetics | Inflammation - metabolism | Phosphorylation - genetics | Adenylyl Cyclases - immunology | Transcription Factor RelA - immunology | Cyclic AMP - genetics | Phosphorylation - immunology | Cyclic AMP - metabolism | Cytokines - genetics | Cryptochromes - metabolism | Cytokines - immunology | Cell Line | Gene Expression Regulation | Inflammation - immunology | Adenylyl Cyclases - metabolism | Circadian Rhythm | Mice, Knockout | Animals | NF-kappa B - genetics | Transcription Factor RelA - metabolism | Cryptochromes - immunology | Cyclic AMP - immunology | Inflammation - genetics | Mice | Adenylyl Cyclases - genetics | Cytokines - biosynthesis | Circadian rhythms | Proteins | Physiological aspects | Genetic aspects | Research | Gene expression | Health aspects | Cells | Inflammatory diseases | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. 12548 - 12553
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1... 
B cell receptor | Cryptochrome | Autoimmune | SYSTEMIC-LUPUS-ERYTHEMATOSUS | autoimmune | MULTIDISCIPLINARY SCIENCES | MOUSE | RECEPTOR | IMMUNOMETABOLISM | B-CELLS | IMMUNE-SYSTEM | cryptochrome | DIFFERENTIATION | EXPRESSION | T-CELLS | LYMPHOCYTES | Antibodies, Antinuclear - biosynthesis | Spleen - immunology | Kidney - pathology | Kidney - immunology | Autoimmunity - genetics | Cryptochromes - genetics | Male | Circadian Clocks - genetics | Gene Expression Profiling | Autoimmune Diseases - genetics | B-Lymphocytes - pathology | Spleen - pathology | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | B-Lymphocytes - metabolism | Cryptochromes - deficiency | Lung - pathology | Signal Transduction | Gene Expression Regulation - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Circadian Clocks - immunology | Complement C1q - genetics | Receptors, Antigen, B-Cell - immunology | Mice, Knockout | Animals | B-Lymphocytes - immunology | Spleen - metabolism | Cryptochromes - immunology | Receptors, Antigen, B-Cell - genetics | Mice | Lung - immunology | Autoimmunity | Circadian rhythms | Physiological aspects | Genetic aspects | Research | Immunoglobulin M | Flow cytometry | Phosphorylation | Pathogenesis | Genes | Immunoglobulin G | Antibodies | Leukocytes | B-cell receptor | Proteins | Signal transduction | Cell activation | Systemic lupus erythematosus | Bone marrow | Antinuclear antibodies | Tyrosine | Spleen | Kidneys | Immune response | Organs | Circadian rhythm | White blood cells | Complement component C1q | Cytometry | Signaling | Chronic conditions | Lungs | Lymphocytes B | Cryptochromes | Infiltration | Autoimmune diseases | Peritoneum | Index Medicus | Biological Sciences
Journal Article
Immunology Letters, ISSN 0165-2478, 2014, Volume 163, Issue 1, pp. 76 - 83
Highlights • Sleep deprivation induces vascular inflammation. • CRY1 is decreased during sleep deprivation. • Overexpression of CRY1 inhibits sleep... 
Allergy and Immunology | NF-κB | Vascular inflammation | Cryptochrome | cAMP | Sleep deprivation | PKA | CAMP | C-REACTIVE PROTEIN | AORTIC ENDOTHELIAL-CELLS | DIABETIC MICE | MELATONIN | INDUCED COLITIS | KAPPA-B | IMMUNOLOGY | BRACHIAL-ARTERY | NF-kappa B | CARDIOVASCULAR-DISEASE | TNF-ALPHA | LUNG INFLAMMATION | Vasculitis - metabolism | Vasculitis - etiology | Cryptochromes - genetics | Vasculitis - prevention & control | Transcription Factor RelA - genetics | Vasculitis - immunology | Signal Transduction - immunology | Vasculitis - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Transcription Factor RelA - immunology | Cyclic AMP - genetics | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Sleep Deprivation - immunology | Endothelial Cells - metabolism | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Mice, Transgenic | Sleep Deprivation - genetics | Signal Transduction - genetics | Sleep Deprivation - metabolism | Sleep Deprivation - complications | Endothelial Cells - immunology | Animals | Transcription Factor RelA - metabolism | Cryptochromes - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Cyclic AMP - immunology | Mice | Endothelial Cells - pathology | Cryptochromes - biosynthesis | Inflammation | Vasodilators | Analysis | Cyclic adenylic acid | Adenylic acid | Endothelium | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2018, Volume 77, Issue Suppl 2, p. 1260
BackgroundClinical symptoms of rheumatoid arthritis (RA), such as join stiffness, swelling and pain, manifest in circadian pattern with the highest intensity... 
Circadian rhythms | Immunoregulation | CD8 antigen | Lymphocytes T | Circadian rhythm | CD14 antigen | Ribonucleic acid--RNA | CD4 antigen | Studies | Interleukin 6 | Cytometry | Monocytes | Period 1 protein | Immunology | Pain | Lymphocytes B | Lymphocytes | Rheumatoid arthritis | Cryptochromes | Period 3 protein | Period 2 protein | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e61679 - e61679
Journal Article