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Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 607 - 611
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and... 
SELENITE-INDUCED CATARACTOGENESIS | MULTIDISCIPLINARY SCIENCES | MUTATION | PREVENTION | ALPHA-B-CRYSTALLIN | DOMINANT CONGENITAL CATARACT | HUMAN OXIDOSQUALENE CYCLASE | SEQUENCING DATA | CHINESE FAMILY | LENS | EXPRESSION | Crystallins - metabolism | Humans | Cataract - pathology | Molecular Sequence Data | Lanosterol - pharmacology | Male | Amyloid - chemistry | Amyloid - ultrastructure | Lens, Crystalline - pathology | Mutant Proteins - ultrastructure | Amyloid - metabolism | Protein Aggregation, Pathological - pathology | Base Sequence | Amyloid - drug effects | Adult | Female | Child | Crystallins - chemistry | Protein Aggregates - drug effects | Amino Acid Sequence | Cell Line | Crystallins - ultrastructure | Lanosterol - administration & dosage | Mutant Proteins - genetics | Lens, Crystalline - metabolism | Models, Molecular | Mutant Proteins - metabolism | Crystallins - genetics | Cataract - metabolism | Lanosterol - therapeutic use | Protein Aggregation, Pathological - drug therapy | Animals | Cataract - congenital | Pedigree | Mutant Proteins - chemistry | Dogs | Cataract - genetics | Cataract - drug therapy | Lens, Crystalline - drug effects | Proteins | Cataract | Physiological aspects | Development and progression | Genetic aspects | Research | Gene expression | Drug therapy | Cataracts | Studies | Older people | Mortality | Mutation | Cholesterol
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2016, Volume 129, Issue 20, pp. 3705 - 3720
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 367, Issue 1, pp. 1 - 11
Highlights • Sorafenib resistance of advanced HCC has raised global concern and understanding the underlying mechanism is in urgent need. • Several growth... 
Hematology, Oncology and Palliative Medicine | Advanced hepatocellular carcinoma (HCC) | Cancer stem cells (CSCs) | Acquired resistance | Microenvironment | Epithelial–mesenchymal transitions (EMT) and mesenchymal–epithelial transitions (MET) | Epithelial-mesenchymal transitions (EMT) and mesenchymal-epithelial transitions (MET) | PLUS SORAFENIB | PHASE-III | ALPHA-B-CRYSTALLIN | PROMOTES METASTASIS | Epithelial-mesenchymal transitions (EMT) and mesenchymal epithelial transitions (MET) | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | LIVER-CANCER CELLS | ONCOLOGY | DEPENDENT MECHANISM | UP-REGULATION | HEDGEHOG SIGNALING PATHWAY | Niacinamide - analogs & derivatives | Tumor Microenvironment - drug effects | Neoplastic Stem Cells - drug effects | Humans | Liver Neoplasms - drug therapy | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Drug Resistance, Neoplasm | Epithelial-Mesenchymal Transition - drug effects | Antineoplastic Agents - therapeutic use | Carcinoma, Hepatocellular - enzymology | Molecular Targeted Therapy | Animals | Carcinoma, Hepatocellular - drug therapy | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Carcinoma, Hepatocellular - pathology | Neoplastic Stem Cells - pathology | Liver Neoplasms - pathology | Liver Neoplasms - enzymology | Neoplastic Stem Cells - enzymology | Antimitotic agents | Antineoplastic agents | Cancer | Studies | Liver cancer | Drug resistance | Kinases
Journal Article
Journal Article
Journal Article
NeuroReport, ISSN 0959-4965, 01/2018, Volume 29, Issue 1, pp. 19 - 24
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e78217
Curcumin, the active principle present in the yellow spice turmeric, has been shown to exhibit various pharmacological actions such as antioxidant,... 
OXIDATIVE STRESS | IN-VITRO | OFFICINALIS | MULTIDISCIPLINARY SCIENCES | BIOAVAILABILITY | DISEASE | Cataract - blood | Crystallins - metabolism | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Antioxidants - metabolism | Biocompatible Materials - chemistry | Body Weight - drug effects | Insulin - blood | Protein Carbonylation - drug effects | Lens, Crystalline - pathology | Diabetes Mellitus, Experimental - blood | Sorbitol - metabolism | Nanoparticles - therapeutic use | Aldehyde Reductase - metabolism | Diabetes Mellitus, Experimental - complications | Crystallins - chemistry | Superoxide Dismutase - metabolism | Disease Models, Animal | Biodegradation, Environmental | Malondialdehyde - metabolism | Lactic Acid - chemistry | Curcumin - therapeutic use | Curcumin - pharmacology | Rats | Treatment Outcome | Disease Progression | Feeding Behavior - drug effects | Lens, Crystalline - enzymology | Cataract - complications | Animals | Polyglycolic Acid - chemistry | Cataract - prevention & control | Oxidative Stress - drug effects | Blood Glucose - metabolism | Cataract - drug therapy | Lens, Crystalline - drug effects | Nanoparticles | Antioxidants | Cataract | Polyols | Cataracts | Oxidative stress | Biodegradability | Proteins | Carcinogens | Rodents | Polyvinyl alcohol | Curcumin | Polymers | Biodegradation | Stress concentration | Nutrition | Diabetes mellitus | Oral administration | Dietary supplements | Pharmacology | Inflammation | Glycosylation | Bioavailability | Metabolism | Studies | Crystallin | Acids | Diet | Pharmacy | Diabetes | Laboratory animals | Cancer
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2011, Volume 31, Issue 43, pp. 15490 - 15498
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2013, Volume 182, Issue 4, pp. 1412 - 1424
Although anti-vascular endothelial growth factor (VEGF) treatments reduce pathological neovascularization in the eye and in tumors, the regression is often not... 
Pathology | DIABETIC-RETINOPATHY | HEAT-SHOCK PROTEINS | CELLS | ANGIOGENESIS | ENDOPLASMIC-RETICULUM-STRESS | ALPHA-B-CRYSTALLIN | MACULAR DEGENERATION | FACTOR RECEPTOR-1 | PATHOLOGY | GAMMA-SECRETASE | ENDOTHELIAL GROWTH-FACTOR | Extracellular Space - drug effects | Microvessels - pathology | alpha-Crystallin B Chain - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | X-Box Binding Protein 1 | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Proteolysis - drug effects | Extracellular Space - metabolism | Choroidal Neovascularization - pathology | Cattle | Lasers | Retinal Neovascularization - prevention & control | Vascular Endothelial Growth Factor A - pharmacology | Disease Models, Animal | Unfolded Protein Response - drug effects | Intracellular Space - drug effects | Endoplasmic Reticulum Stress - drug effects | Endothelial Cells - metabolism | Mice, Inbred C57BL | Choroidal Neovascularization - prevention & control | Lethal Dose 50 | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Up-Regulation - drug effects | Activating Transcription Factor 6 - metabolism | Animals | Signal Transduction - drug effects | Intracellular Space - metabolism | Mice | Retina - pathology | Retinal Neovascularization - pathology | Endothelial Cells - drug effects | RNA, Small Interfering - metabolism | Regular
Journal Article