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Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases | Index Medicus
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 08/2007, Volume 293, Issue 2, pp. 844 - 853
In this study the stress protein response to unaccustomed maximal eccentric exercise in humans was investigated. Eleven healthy males performed 300 maximal... 
Eccentric actions | Stress proteins | Muscle damage | Skeletal muscle | OXIDATIVE STRESS | VITAMIN-E | PHYSIOLOGY | eccentric actions | STRESS-PROTEINS | INJURY | INCREASES | ALPHA-B-CRYSTALLIN | HUMAN SKELETAL-MUSCLE | stress proteins | muscle damage | HSP27 | GENE-EXPRESSION | skeletal muscle | INFLAMMATORY RESPONSE | Immunohistochemistry | alpha-Crystallin B Chain - genetics | Torque | Creatine Kinase - blood | Heat-Shock Proteins - metabolism | Humans | Adaptation, Physiological - physiology | HSP70 Heat-Shock Proteins - genetics | Male | alpha-Crystallin B Chain - metabolism | Neoplasm Proteins - metabolism | Pain - metabolism | RNA, Messenger - metabolism | HSP70 Heat-Shock Proteins - metabolism | Heat-Shock Proteins - genetics | Pain - physiopathology | Quadriceps Muscle - cytology | Quadriceps Muscle - physiology | Adult | Cytosol - metabolism | Exercise - physiology | Myofibrils - metabolism | HSP27 Heat-Shock Proteins | Neoplasm Proteins - genetics | Proteins | Exercise | Muscular system | Cellular biology | Stress | Index Medicus | Other Social Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Hälsovetenskaper | Heat-Shock Proteins/genetics/metabolism | Myofibrils/metabolism | MEDICINE | Sports Science | Tvärvetenskapliga studier inom samhällsvetenskap | Fysiologi och farmakologi | Physiology | Adaptation; Physiological/physiology | HSP70 Heat-Shock Proteins/genetics/metabolism | Health Sciences | Sports | Basic Medicine | alpha-Crystallin B Chain/genetics/metabolism | INTERDISCIPLINARY RESEARCH AREAS | Social Sciences | Sport and Fitness Sciences | Pain/metabolism/physiopathology | Fysiologi | Exercise/physiology | RNA; Messenger/metabolism | Idrottsvetenskap | Samhällsvetenskap | Idrott | TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN | MEDICIN | Social Sciences Interdisciplinary | Medicinska och farmaceutiska grundvetenskaper | Quadriceps Muscle/cytology/physiology | Creatine Kinase/blood | Cytosol/metabolism | Physiology and pharmacology | Annan samhällsvetenskap | Neoplasm Proteins/genetics/metabolism
Journal Article
FASEB Journal, ISSN 0892-6638, 11/2005, Volume 19, Issue 13, pp. 1854 - 1856
Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine. A deficiency of CBS leads to homocystinuria, an... 
glial cells | STEM-CELLS | seizure | neural stem cells | MICE DEFICIENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ALPHA-B-CRYSTALLIN | KAINIC ACID | hippocampal dentate gyrus | SEIZURE ACTIVITY | CELL BIOLOGY | HEAT-SHOCK PROTEINS | GROWTH-FACTOR ALPHA | FIBRILLARY ACIDIC PROTEIN | BIOLOGY | REACTIVE ASTROCYTES | homocystinuria | Immunohistochemistry | Up-Regulation | Brain - embryology | Corpus Callosum - metabolism | Oxidative Stress | Immunoblotting | Homocysteine - metabolism | Olfactory Bulb - metabolism | Homocystinuria - metabolism | Central Nervous System - embryology | Cerebral Cortex - metabolism | Brain - metabolism | Neuroglia - cytology | Dexamethasone - pharmacology | In Situ Hybridization | Gene Expression Regulation, Developmental | Glucocorticoids - metabolism | Transforming Growth Factor alpha - metabolism | Cyclic AMP - metabolism | Astrocytes - cytology | Cerebellum - metabolism | Kainic Acid - pharmacology | Epidermal Growth Factor - metabolism | Mice, Transgenic | Gene Expression Regulation, Enzymologic | Cell Lineage | Hippocampus - metabolism | Animals | Bromodeoxyuridine - pharmacology | Central Nervous System - cytology | Methionine - chemistry | Models, Biological | Cerebellum - cytology | Heterozygote | Ligands | Neuroglia - metabolism | Mice | Cystathionine beta-Synthase - biosynthesis | Cystathionine beta-Synthase - physiology | Microscopy, Fluorescence | Astrocytes - metabolism | Central Nervous System - enzymology | Index Medicus
Journal Article
Molecular vision, ISSN 1090-0535, 2019, Volume 25, Issue 1, pp. 118 - 128
Journal Article
Investigative Ophthalmology & Visual Science, ISSN 0146-0404, 09/2006, Volume 47, Issue 9, pp. 3951 - 3959
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2751 - 2761
Context: Although calorie restriction has proven beneficial for weight loss, long-term weight control is variable between individuals. Objective: To identify... 
SKELETAL-MUSCLE | TGF-BETA | MACROPHAGES | GLUCOSE | TISSUE GENE-EXPRESSION | ENDOCRINOLOGY & METABOLISM | FAT | RESTRICTION | FOLLISTATIN | ADIPOSE-TISSUE | ADIPOCYTE | Insulin-Like Growth Factor Binding Protein 3 - genetics | Obesity - diet therapy | alpha-Crystallin B Chain - genetics | Ubiquitin-Specific Proteases - genetics | Membrane Glycoproteins - metabolism | Caloric Restriction | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | alpha-Crystallin B Chain - metabolism | Gene Expression Profiling | Gene Regulatory Networks | RNA, Messenger - metabolism | Obesity - genetics | Subcutaneous Fat - metabolism | Osteonectin - genetics | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Microarray Analysis | Adult | Female | Membrane Proteins - metabolism | Ubiquitin-Specific Proteases - metabolism | Real-Time Polymerase Chain Reaction | Extracellular Matrix Proteins - metabolism | Biomarkers - metabolism | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Enzyme-Linked Immunosorbent Assay | Membrane Proteins - genetics | Down-Regulation | Extracellular Matrix Proteins - genetics | Osteonectin - metabolism | Membrane Glycoproteins - genetics | Obesity - metabolism | Polymorphism, Genetic | Quantitative Trait Loci | Adipose tissues | Intervention | Controllers | Nutrient deficiency | Adipose tissue | Transforming growth factor | Genes | Weight loss | Reverse transcription | Gene expression | Quantitative trait loci | Polymerase chain reaction | Proteins | Weight control | Diet | Ribonucleic acids | Osteonectin | Biomarkers | Insulin-like growth factor-binding protein 3 | Bioindicators | Enzyme-linked immunosorbent assay | Index Medicus | Abridged Index Medicus | Life Sciences
Journal Article
Diabetes, ISSN 0012-1797, 2014, Volume 63, Issue 9, pp. 3077 - 3090
Poorly controlled diabetes has long been known as a catabolic disorder with profound loss of muscle and fat body mass resulting from a simultaneous reduction... 
MAMMALIAN TARGET | SKELETAL-MUSCLE | MESSENGER-RNA TRANSLATION | ACTIVATION | INSULIN-TREATMENT | RAT RETINA | ENDOCRINOLOGY & METABOLISM | SECONDARY REDUCTION | COMPLEX 1 | RETINOPATHY | AXONAL-TRANSPORT | Diabetes Mellitus, Experimental - drug therapy | Retina - metabolism | TOR Serine-Threonine Kinases - metabolism | Diabetes Mellitus, Type 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Mechanistic Target of Rapamycin Complex 2 | Phosphoproteins - metabolism | Multiprotein Complexes - metabolism | Regulatory-Associated Protein of mTOR | Diabetes Mellitus, Experimental - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phlorhizin - pharmacology | Rapamycin-Insensitive Companion of mTOR Protein | beta-Crystallin B Chain - biosynthesis | alpha-Crystallin A Chain - biosynthesis | Diabetes Mellitus, Type 1 - genetics | RNA, Ribosomal - metabolism | Rats | Diabetes Mellitus, Type 1 - drug therapy | Hyperglycemia - metabolism | Animals | Carrier Proteins - metabolism | Protein Biosynthesis - drug effects | Receptor, Insulin - metabolism | Mice | Blood Glucose - metabolism | Insulin - therapeutic use | Eye Proteins - biosynthesis | Diabetic retinopathy | Hyperglycemia | Diabetes | Protein synthesis | Rodents | Apoptosis | Index Medicus | Abridged Index Medicus | Complications
Journal Article
Journal Article
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5795 - 5806
The pathogenesis of hepatosplenic T-cell lymphoma (HSTL), a rare entity mostly derived from gamma delta T cells and usually with a fatal outcome, remains... 
GAMMA-DELTA | TYROSINE KINASE | ALPHA-BETA | NON-HODGKINS-LYMPHOMA | NK-CELL | PI EXPRESSION | RECEPTOR | DRUG-RESISTANCE | HEMATOLOGY | NF-KAPPA-B | CLINICOPATHOLOGICAL ENTITY | Crystallins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | Receptors, Antigen, T-Cell, gamma-delta - genetics | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Molecular Targeted Therapy | Young Adult | Base Sequence | Biomarkers, Tumor - metabolism | Adult | Female | Liver Neoplasms - pathology | Membrane Proteins - metabolism | Genes, Neoplasm - genetics | Syk Kinase | Cell Lineage - genetics | Splenic Neoplasms - drug therapy | Liver Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Splenic Neoplasms - genetics | Liver Neoplasms - drug therapy | Lymphoma, T-Cell - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | Isochromosomes - genetics | Drug Resistance, Neoplasm - genetics | Lymphoma, T-Cell - drug therapy | Splenic Neoplasms - pathology | Chromosome Aberrations | Lymphoma, T-Cell - pathology | Aged | Biomarkers, Tumor - genetics | Cluster Analysis | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus | pathology | Lymphoma, T-Cell | Genes, Neoplasm | Drug Resistance, Neoplasm | Isochromosomes | Liver Neoplasms | genetics | Crystallins | Receptors, Antigen, T-Cell, alpha-beta | drug therapy | Tumor Markers, Biological | Intracellular Signaling Peptides and Proteins | antagonists & inhibitors | Membrane Proteins | Cell Lineage | Receptors, Antigen, T-Cell, gamma-delta | metabolism | Protein-Tyrosine Kinases | Splenic Neoplasms
Journal Article
Molecular Vision, ISSN 1090-0535, 2018, Volume 24, pp. 801 - 817
Purpose: Pseudoexfoliation (PEX) syndrome is an age-related progressive disease of the extracellular matrix with ocular manifestations. PEX is clinically... 
PEROXIREDOXIN SUBTYPES | OXIDATIVE STRESS | PEPTIDE-BONDS | LOXL1 POLYMORPHISMS | INCREASED RISK | BIOCHEMISTRY & MOLECULAR BIOLOGY | AQUEOUS-HUMOR | GENE-EXPRESSION | OPHTHALMOLOGY | APOLIPOPROTEIN-E GENOTYPES | OXIDASE-LIKE 1 | UP-REGULATION | Protein Aggregates | Apolipoproteins A - metabolism | Crystallins - metabolism | Apolipoproteins A - genetics | Humans | Peroxiredoxins - metabolism | Cataract - pathology | Extracellular Matrix - metabolism | Fibrinogen - chemistry | Male | Lens Capsule, Crystalline - metabolism | Extracellular Matrix - chemistry | Elastic Tissue - metabolism | Tandem Mass Spectrometry | Apolipoprotein A-I - genetics | Peroxiredoxins - genetics | Protein Aggregation, Pathological - pathology | Lens Capsule, Crystalline - chemistry | Aged, 80 and over | Female | Protein Aggregation, Pathological - genetics | Apolipoprotein A-I - chemistry | Crystallins - chemistry | Apolipoproteins A - chemistry | Gene Expression | Exfoliation Syndrome - metabolism | Exfoliation Syndrome - pathology | Hemoglobins - metabolism | Hemoglobins - genetics | Crystallins - genetics | Apolipoprotein A-I - metabolism | Cataract - metabolism | Fibrinogen - genetics | Peroxiredoxins - chemistry | Elastic Tissue - pathology | Hemoglobins - chemistry | Elastic Tissue - chemistry | Lens Capsule, Crystalline - pathology | Fibrinogen - metabolism | Cataract - genetics | Aged | Exfoliation Syndrome - genetics | Extracellular Matrix - pathology | Protein Aggregation, Pathological - metabolism | Index Medicus
Journal Article
Aging Cell, ISSN 1474-9718, 04/2017, Volume 16, Issue 2, pp. 349 - 359
The dry (nonneovascular) form of age‐related macular degeneration ( AMD ), a leading cause of blindness in the elderly, has few, if any, treatment options at... 
lysosomes; mechanistic target of rapamycin | visual cycle proteins | transcription factors EB (TFEB) and E3 (TFE3) | amino acid transporter (PAT4/SLC36A4) | age‐related macular degeneration | coordinated lysosomal expression and regulation (CLEAR) network | mouse model | signal transduction | retinal pigmented epithelium (RPE) | complex 1 (mTORC1) | photoreceptor degeneration | age-related macular degeneration | CLEARANCE | RAG GTPASES | ATPASE | TFEB | mechanistic target of rapamycin | AUTOPHAGY | RPE65 | LYSOSOMAL BIOGENESIS | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | MTORC1 ACTIVATION | SENSES | DEGRADATION | lysosomes | Crystallins - metabolism | Retinal Pigment Epithelium - metabolism | Phosphorylation | Epithelial Cells - metabolism | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Retinal Photoreceptor Cell Outer Segment - metabolism | Visual Pathways - metabolism | Epithelial Cells - ultrastructure | Gene Regulatory Networks | Amino Acid Transport Systems - metabolism | Mechanistic Target of Rapamycin Complex 1 | Mice, Knockout | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Animals | Lysosomes - metabolism | Retinal Pigment Epithelium - ultrastructure | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cytosol - metabolism | Retinal Pigment Epithelium - cytology | Aging - metabolism | Macular degeneration | Analysis | Blindness | Development and progression | Amino acids | Cellular signal transduction | DNA binding proteins | Adenosine triphosphatase | TOR protein | H+-transporting ATPase | Transcription factors | Lecithin | Epithelial cells | Lysosomes | Retina | Rapamycin | Electron microscopy | Acyltransferase | Epithelium | Retinal pigment epithelium | Vitamin A | Crystallin | Retinal degeneration | Photoreceptors | Cytoplasm | Geriatrics | Index Medicus | amino acid transporter (PAT4 | Original | SLC36A4
Journal Article