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Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2006, Volume 25, Issue 5, pp. 1126 - 1136
Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In higher eukaryotes, regulation of the licensing factor Cdt1 by... 
replication | Cdt1 | Geminin | cell cycle | proteolysis | Replication | Proteolysis | Cell cycle | REREPLICATION | PROTEIN | LICENSING FACTOR CDT1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RE-REPLICATION | COMPLEXES | EUKARYOTIC DNA-REPLICATION | CELL BIOLOGY | S-PHASE | DEGRADATION | CELL-CYCLE | Cell Cycle Proteins - pharmacology | Phosphorylation | Kidney - embryology | SKP Cullin F-Box Protein Ligases - genetics | Humans | Ubiquitin - metabolism | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Kidney - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Ultraviolet Rays | DNA Replication - radiation effects | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Fibroblasts - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cullin Proteins - antagonists & inhibitors | Cyclin A - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Cells, Cultured | Gene Silencing | SKP Cullin F-Box Protein Ligases - metabolism | DNA-Binding Proteins - genetics | S-Phase Kinase-Associated Proteins - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Peptide Hydrolases - chemistry | Cullin Proteins - genetics | Animals | S-Phase Kinase-Associated Proteins - genetics | Mice | Cyclin E - metabolism | DNA Damage | HeLa Cells | Proliferating Cell Nuclear Antigen - metabolism | Amino acids | Eukaryotes
Journal Article
BLOOD, ISSN 0006-4971, 02/2012, Volume 119, Issue 5, pp. 1151 - 1161
Mixed lineage leukemia (MLL) is a key epigenetic regulator of normal hematopoietic development and chromosomal translocations involving MLL are one of the most... 
TRANSFORMATION | PR-SET7 | CHROMOSOMAL TRANSLOCATIONS | REGULATOR | PHOSPHORYLATION | INTERACTS | GENE-EXPRESSION | FUSION PROTEIN | EXECUTION | ANKYRIN REPEAT | HEMATOLOGY | Myeloid-Lymphoid Leukemia Protein - metabolism | Transcription Factors - chemistry | SKP Cullin F-Box Protein Ligases - genetics | Humans | Protein Processing, Post-Translational - genetics | SKP Cullin F-Box Protein Ligases - physiology | Multiprotein Complexes - genetics | Cullin Proteins - physiology | Leukemia - metabolism | Myeloid-Lymphoid Leukemia Protein - chemistry | Elongin | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | Leukemia - etiology | Transfection | Proteolysis | HEK293 Cells | Cullin Proteins - metabolism | Hematopoietic Stem Cells - physiology | Hematopoiesis - physiology | Suppressor of Cytokine Signaling Proteins - chemistry | Leukemia - genetics | Transcription Factors - physiology | Histone-Lysine N-Methyltransferase | Cells, Cultured | Suppressor of Cytokine Signaling Proteins - genetics | Hematopoiesis - genetics | Hematopoietic Stem Cells - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Transcription Factors - genetics | Protein Processing, Post-Translational - physiology | SKP Cullin F-Box Protein Ligases - chemistry | Multiprotein Complexes - physiology | Cullin Proteins - chemistry | Cullin Proteins - genetics | Transcription Factors - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | K562 Cells | Suppressor of Cytokine Signaling Proteins - physiology | Suppressor of Cytokine Signaling Proteins - metabolism | Hematopoiesis and Stem Cells
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, p. e1004200
Microsporidia comprise a phylum of over 1400 species of obligate intracellular pathogens that can infect almost all animals, but little is known about the host... 
TRIGGERED IMMUNITY | IMMUNE-RESPONSE | LIFE-SPAN | MICROBIOLOGY | CELL-PROLIFERATION | LARGE GENE LISTS | TRANSLATIONAL INHIBITION | CAENORHABDITIS-ELEGANS | VIROLOGY | INTRACELLULAR BACTERIA | TRANSCRIPTION FACTOR | PARASITOLOGY | INNATE IMMUNITY | Caenorhabditis elegans Proteins - immunology | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin - metabolism | Caenorhabditis elegans Proteins - metabolism | Microsporidia - immunology | Autophagy - immunology | RNA Interference | Base Sequence | Caenorhabditis elegans - parasitology | Autophagy - genetics | Caenorhabditis elegans - virology | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Caenorhabditis elegans - immunology | Microsporidia - pathogenicity | Host-Pathogen Interactions | Animals | Sequence Analysis, RNA | Caenorhabditis elegans Proteins - antagonists & inhibitors | RNA, Small Interfering | Cullin Proteins - immunology | Transcription, Genetic - genetics | Caenorhabditis elegans Proteins - genetics | Ubiquitination - genetics | Caenorhabditis elegans Proteins - biosynthesis | Cullin Proteins - biosynthesis | Ubiquitin | Distribution | Genetic aspects | Research | Gene expression | Health aspects | Microsporidia | Medical research | Nematodes | Infections | Experiments | Autophagy | Viral infections | Worms
Journal Article