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index medicus (314) 314
humans (288) 288
animals (266) 266
cullin proteins - metabolism (157) 157
mice (144) 144
skp cullin f-box protein ligases - metabolism (139) 139
cell biology (121) 121
ubiquitin-protein ligases - metabolism (117) 117
biochemistry & molecular biology (115) 115
ubiquitin (114) 114
proteins (105) 105
cullin proteins - genetics (96) 96
cell line (88) 88
skp cullin f-box protein ligases - genetics (88) 88
male (86) 86
ubiquitination (86) 86
signal transduction (84) 84
degradation (82) 82
cell line, tumor (79) 79
ligases (73) 73
muscle proteins - metabolism (73) 73
proteolysis (72) 72
article (69) 69
phosphorylation (68) 68
ubiquitin-protein ligases - genetics (68) 68
cancer (67) 67
oncology (67) 67
cullin (61) 61
female (60) 60
protein binding (59) 59
muscle proteins - genetics (58) 58
apoptosis (57) 57
cell cycle (57) 57
research (56) 56
tripartite motif proteins (56) 56
gene expression (52) 52
ubiquitins - metabolism (52) 52
cullin proteins - antagonists & inhibitors (51) 51
expression (50) 50
multidisciplinary sciences (50) 50
gene-expression (49) 49
activation (47) 47
nedd8 protein (47) 47
rna interference (47) 47
research article (46) 46
cells, cultured (45) 45
protein (44) 44
rats (44) 44
hek293 cells (43) 43
muscle, skeletal - metabolism (43) 43
pyrimidines - pharmacology (43) 43
biology (41) 41
cyclopentanes - pharmacology (41) 41
ubiquitin ligase (41) 41
ubiquitin ligases (41) 41
carrier proteins - metabolism (40) 40
cell proliferation (40) 40
genetic aspects (40) 40
physiological aspects (40) 40
cell cycle proteins - metabolism (39) 39
mutation (38) 38
proteasome endopeptidase complex - metabolism (38) 38
complex (36) 36
f-box proteins - metabolism (35) 35
physiology (35) 35
skp cullin f-box protein ligases - antagonists & inhibitors (35) 35
hela cells (34) 34
ubiquitin-protein ligase (34) 34
ubiquitin-protein ligases - antagonists & inhibitors (34) 34
atrophy (33) 33
kinases (33) 33
nedd8 (33) 33
rna, small interfering - genetics (33) 33
ubiquitin - metabolism (33) 33
health aspects (32) 32
amino acid sequence (31) 31
enzymes (31) 31
muscle, skeletal - drug effects (31) 31
analysis (30) 30
mice, inbred c57bl (30) 30
biochemistry (29) 29
medicine (29) 29
muscle, skeletal - pathology (29) 29
muscular atrophy - metabolism (29) 29
pathway (29) 29
rna, small interfering - metabolism (29) 29
cullin-ring ligases (28) 28
f-box proteins (28) 28
skeletal-muscle (28) 28
mln4924 (27) 27
molecular sequence data (27) 27
signal transduction - drug effects (27) 27
cell cycle proteins - genetics (26) 26
endocrinology & metabolism (26) 26
enzyme inhibitors - pharmacology (26) 26
f-box proteins - genetics (26) 26
scf (26) 26
ubiquitins - antagonists & inhibitors (26) 26
antineoplastic agents - pharmacology (25) 25
dna damage (25) 25
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 13, pp. 3527 - 3532
Skp1–Cul1–F-box (SCF) E3 ligases play key roles in multiple cellular processes through ubiquitination and subsequent degradation of substrate proteins.... 
Cul1 affinity | Fbxw11 | Fbxw7 | β-Trcp | SCF inhibitors | SYSTEM | BETA-TRCP1 | COMPLEX | DOMAIN | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | beta-Trcp | SUBSTRATE RECOGNITION | ROLES | FBW7 | F-Box-WD Repeat-Containing Protein 7 | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitins - genetics | Humans | Molecular Sequence Data | Ubiquitin-Protein Ligases - antagonists & inhibitors | Ubiquitins - chemistry | F-Box Proteins - antagonists & inhibitors | Peptide Library | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Genetic Variation | beta-Transducin Repeat-Containing Proteins - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Drug Design | Protein Engineering | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | beta-Transducin Repeat-Containing Proteins - genetics | Amino Acid Sequence | Ubiquitins - pharmacology | F-Box Proteins - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Ubiquitin-Protein Ligases - chemistry | SKP Cullin F-Box Protein Ligases - chemistry | beta-Transducin Repeat-Containing Proteins - chemistry | Cullin Proteins - chemistry | Sequence Homology, Amino Acid | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2006, Volume 25, Issue 5, pp. 1126 - 1136
Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In higher eukaryotes, regulation of the licensing factor Cdt1 by... 
replication | Cdt1 | Geminin | cell cycle | proteolysis | Replication | Proteolysis | Cell cycle | REREPLICATION | PROTEIN | LICENSING FACTOR CDT1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RE-REPLICATION | COMPLEXES | EUKARYOTIC DNA-REPLICATION | CELL BIOLOGY | S-PHASE | DEGRADATION | CELL-CYCLE | Cell Cycle Proteins - pharmacology | Phosphorylation | Kidney - embryology | SKP Cullin F-Box Protein Ligases - genetics | Humans | Ubiquitin - metabolism | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Kidney - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Ultraviolet Rays | DNA Replication - radiation effects | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Fibroblasts - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cullin Proteins - antagonists & inhibitors | Cyclin A - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Cells, Cultured | Gene Silencing | SKP Cullin F-Box Protein Ligases - metabolism | DNA-Binding Proteins - genetics | S-Phase Kinase-Associated Proteins - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Peptide Hydrolases - chemistry | Cullin Proteins - genetics | Animals | S-Phase Kinase-Associated Proteins - genetics | Mice | Cyclin E - metabolism | DNA Damage | HeLa Cells | Proliferating Cell Nuclear Antigen - metabolism | Amino acids | Eukaryotes
Journal Article
by Kang, SH and Lee, HA and Kim, M and Lee, E and Sohn, UD and Kim, I
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, ISSN 0193-1849, 06/2017, Volume 312, Issue 6, pp. E495 - E507
Cushing's syndrome is caused by overproduction of the adrenocorticotropic hormone (ACTH), which stimulates the adrenal grand to make cortisol. Skeletal muscle... 
glucocorticoid receptor | PHYSIOLOGY | PROTEIN | ANTAGONIST | skeletal muscle atrophy | COMPONENTS | Cushing's syndrome | AUTOPHAGY | FOXO TRANSCRIPTION FACTORS | HYPERTROPHY | GLUCOCORTICOID-RECEPTOR | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | forkhead box O3 | CROSSTALK | UP-REGULATION | Receptors, Glucocorticoid - antagonists & inhibitors | Cushing Syndrome - physiopathology | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Male | Muscle, Skeletal - metabolism | Receptors, Glucocorticoid - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Cushing Syndrome - metabolism | Promoter Regions, Genetic - drug effects | Receptors, Glucocorticoid - agonists | Forkhead Box Protein O3 - genetics | Chromatin Immunoprecipitation | Cushing Syndrome - pathology | RNA Interference | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | Forkhead Box Protein O3 - antagonists & inhibitors | Muscle Proteins - antagonists & inhibitors | Muscular Atrophy - etiology | Disease Models, Animal | Cell Line | Tripartite Motif Proteins - antagonists & inhibitors | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - agonists | Tripartite Motif Proteins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Rats, Sprague-Dawley | Forkhead Box Protein O3 - metabolism | Hormone Antagonists - pharmacology | Forkhead Box Protein O3 - agonists | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Response Elements - drug effects | Muscle Proteins - agonists | Animals | Active Transport, Cell Nucleus - drug effects | Muscle Fibers, Skeletal - pathology | Glucocorticoids - pharmacology | Genes, Reporter - drug effects | Tripartite Motif Proteins - metabolism | Muscle, Skeletal - pathology | Ubiquitin-Protein Ligases - genetics | Muscles | Physiological aspects | Atrophy, Muscular | Cushing syndrome
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3765 - 3773
S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-MEDIATED DEGRADATION | BOX PROTEIN SKP2 | ENTEROPATHY | DISRUPTION | P27 | MOUSE | SCURFY | EXPRESSION | CELL-CYCLE INHIBITION | P27(KIP1) | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Receptor, ErbB-2 - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Receptor, ErbB-2 - metabolism | Repressor Proteins - antagonists & inhibitors | Breast Neoplasms - metabolism | Genes, X-Linked | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Cell Transformation, Neoplastic - genetics | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Gene Silencing | Oncogene Proteins - metabolism | Repressor Proteins - genetics | Forkhead Transcription Factors - genetics | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Oncogene Proteins - antagonists & inhibitors | Cullin Proteins - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Ploidies | Cell Line, Tumor | Heterozygote | S-Phase Kinase-Associated Proteins - genetics | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology | Tumor suppressor genes | Breast cancer | Genetic aspects | Research | DNA binding proteins | Identification and classification | Health aspects | Risk factors
Journal Article
Nature Cell Biology, ISSN 1465-7392, 04/2013, Volume 15, Issue 4, pp. 430 - 439
Polo-like kinase 1 (PLK1) critically regulates mitosis through its dynamic localization to kinetochores, centrosomes and the midzone. The polo-box domain (PBD)... 
E3 LIGASE | CELL-DIVISION | COMPLEX | POLO-BOX DOMAIN | KINASE-1 | POLO-LIKE-KINASE-1 | ROLES | RING UBIQUITIN LIGASES | SPINDLE-ASSEMBLY CHECKPOINT | AURORA-B | CELL BIOLOGY | RNA, Small Interfering - genetics | Phosphorylation | Immunoprecipitation | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Cell Cycle Proteins - antagonists & inhibitors | Microtubules - metabolism | Ubiquitination | Spindle Apparatus - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Cullin Proteins - antagonists & inhibitors | Kinetochores - metabolism | Signal Transduction | Chromosomes, Human - genetics | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Blotting, Western | Centrosome - metabolism | Cullin Proteins - genetics | Sequence Homology, Amino Acid | Mitosis - physiology | Adaptor Proteins, Signal Transducing - genetics | Protein Array Analysis | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | Physiological aspects | Research | Ubiquitin-proteasome system | Mitosis | Protein kinases | Life Sciences
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2015, Volume 17, Issue 1, pp. 31 - 43
Journal Article
Nature, ISSN 0028-0836, 06/2016, Volume 534, Issue 7608, pp. 553 - 557
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1046 - 1054
It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified... 
MEDICINE, RESEARCH & EXPERIMENTAL | BROMODOMAIN INHIBITORS | ENDOMETRIAL CARCINOMAS | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | TUMORS | CELL BIOLOGY | BREAST-CANCER | GENOMIC LANDSCAPE | PROSTATE-CANCER | RESISTANCE | MUTATIONS | Immunohistochemistry | Neoplasms, Cystic, Mucinous, and Serous - metabolism | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Immunoprecipitation | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Epigenesis, Genetic | Humans | Endometrial Neoplasms - metabolism | Drug Resistance, Neoplasm | Immunoblotting | Male | Molecular Targeted Therapy | Carcinoma, Endometrioid - metabolism | Neoplasms, Cystic, Mucinous, and Serous - genetics | Ubiquitination | Prostatic Neoplasms - genetics | Endometrial Neoplasms - genetics | Mass Spectrometry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Chromatography, Liquid | Cullin Proteins - metabolism | Female | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Acetanilides - pharmacology | Carcinoma, Endometrioid - genetics | Carcinosarcoma - metabolism | Adenocarcinoma, Clear Cell - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Carcinosarcoma - genetics | Cell Proliferation - drug effects | Mutation | Adenocarcinoma, Clear Cell - genetics | RNA-Binding Proteins - metabolism | Care and treatment | Gene mutations | Proteolysis | Physiological aspects | Genetic aspects | Research | Cancer | Ubiquitin | Biodegradation | Inhibitor drugs | Endometrial cancer | Genomes | Pharmacology | Substrates | Mutants | Degradation | Proteins | Sensitivity | Missense mutation | Inhibitors | Bet protein | Gene mapping | Prostate cancer | Prostate | Endometrium | Ubiquitin-protein ligase
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 10/2004, Volume 287, Issue 4, pp. 591 - 601
Muscle atrophy results primarily from accelerated protein degradation and is associated with increased expression of two muscle-specific ubiquitin ligases... 
Glucocorticoids | Insulin | Phosphatidylinositol 3-kinase-Akt pathway | 3-methylhistidine | RAT SKELETAL-MUSCLE | PHYSIOLOGY | insulin | phosphatidylinositol 3-kinase-Akt pathway | PROTEASOME PATHWAY | DIABETIC-RATS | MYOFIBRILLAR PROTEINS | MESSENGER-RNAS | FOOD-DEPRIVATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | glucocorticoids | DEPENDENT PROTEOLYTIC SYSTEM | TNF-ALPHA | DENERVATION ATROPHY | Gene Expression Regulation, Enzymologic - drug effects | Insulin-Like Growth Factor I - pharmacology | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Muscle Proteins - biosynthesis | Tripartite Motif Proteins | Myoblasts - drug effects | RNA, Messenger - biosynthesis | Myoblasts - metabolism | Dexamethasone - pharmacology | Insulin Resistance - physiology | Methylhistidines - metabolism | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | Muscle Proteins - antagonists & inhibitors | Insulin - pharmacology | Muscle, Skeletal - enzymology | Muscle, Skeletal - growth & development | Muscular Atrophy - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Stimulation, Chemical | Ubiquitin-Protein Ligases - biosynthesis | Hypoglycemic Agents - pharmacology | Blotting, Northern | SKP Cullin F-Box Protein Ligases - biosynthesis | Myofibrils - metabolism | Ubiquitin - biosynthesis
Journal Article
by Zhao, Y and Xiong, X and Jia, L and Sun, Y
Cell Death and Disease, ISSN 2041-4889, 09/2012, Volume 3, Issue 9, pp. e386 - e386
MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE), inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin... 
mTOR | CRL E3 ligases | DEPTOR | Cullin neddylation | Autophagy | HIF1α | CANCER-CELLS | APOPTOSIS | ACTIVATION | autophagy | BETA-TRCP | E3 UBIQUITIN LIGASES | CELL BIOLOGY | HIF1 alpha | DEGRADATION | NEDD8-ACTIVATING ENZYME-INHIBITOR | SENESCENCE | MTOR INHIBITOR | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - metabolism | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tumor Suppressor Proteins - genetics | Tumor Suppressor Proteins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | HCT116 Cells | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Transcription Factors - antagonists & inhibitors | Cyclopentanes - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Transcription Factors - genetics | Transcription Factors - metabolism | Autophagy-Related Protein 5 | Cell Line, Tumor | HeLa Cells | RNA, Small Interfering - metabolism | mTOR; CRL E3 ligases | Original
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2410 - 2424
Cardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome system and is fundamental for cardiac adaptation to both... 
HEART | MEDICINE, RESEARCH & EXPERIMENTAL | MURINE MODEL | PRESSURE | UBIQUITIN-PROTEASOME SYSTEM | ESCRT | DEPENDENT CARDIAC-HYPERTROPHY | LIGASES | DYSFUNCTION | IDENTIFICATION | FAILURE | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | SKP Cullin F-Box Protein Ligases - physiology | Male | Muscle Proteins - deficiency | Autophagy - physiology | Cardiomyopathies - etiology | Cardiomyopathies - physiopathology | Lysosomes - metabolism | Endosomal Sorting Complexes Required for Transport - antagonists & inhibitors | Electrocardiography | Muscle Proteins - physiology | Disease Models, Animal | Nerve Tissue Proteins - antagonists & inhibitors | SKP Cullin F-Box Protein Ligases - deficiency | Mice, Inbred C57BL | Endosomal Sorting Complexes Required for Transport - metabolism | Tachycardia, Ventricular - etiology | Cardiomyopathies - pathology | Unfolded Protein Response | Nerve Tissue Proteins - genetics | Mice, Knockout | Muscle Proteins - genetics | Nerve Tissue Proteins - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - physiology | Endoplasmic Reticulum Stress | Mice | Apoptosis - physiology | Proteasome Endopeptidase Complex - metabolism | Autophagy (Cytology) | Protein research | Cardiomyopathy | Heart cells | Physiological aspects | Heart diseases | Health aspects | Risk factors | Proteins | Heart | Enzymes | Protein synthesis | Rodents | Colleges & universities | Cardiomyocytes | Kinases | Autophagy |