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Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 39 - 50
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination.... 
PROTEINS | ACTIVATION | PROTEIN | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | ADAPTER | DEGRADATION | KEAP1 | DIMERIZATION | BTB DOMAIN | HEDGEHOG | CELL BIOLOGY | Transcription Factors - chemistry | Humans | Crystallography, X-Ray | Drosophila Proteins - metabolism | Mutation - physiology | Protein Multimerization - physiology | Protein Structure, Quaternary - physiology | Ubiquitination - physiology | Peptide Fragments - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Peptide Fragments - chemistry | Phosphoprotein Phosphatases - genetics | Consensus Sequence - physiology | Recombinant Fusion Proteins - genetics | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Phosphoprotein Phosphatases - chemistry | Protein Binding - physiology | Adaptor Proteins, Signal Transducing - chemistry | Histones - chemistry | Protein Interaction Domains and Motifs - physiology | Phosphoprotein Phosphatases - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Cullin Proteins - metabolism | Nuclear Proteins - genetics | Peptide Fragments - metabolism | Repressor Proteins - chemistry | Nuclear Proteins - metabolism | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Adaptor Proteins, Signal Transducing - genetics | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Chromatin | Phosphatases | Ligases | CHROMATIN | BASIC BIOLOGICAL SCIENCES | SUBSTRATES | FLEXIBILITY | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | LIGASES | DIMERS | PHOSPHATASES
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7383, pp. 98 - 102
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2005, Volume 435, Issue 7041, pp. 441 - 445
The plant hormone auxin regulates diverse aspects of plant growth and development. Recent studies indicate that auxin acts by promoting the degradation of the... 
SCFTIR1 | COMPLEX | MULTIDISCIPLINARY SCIENCES | GROWTH | DEGRADATION | AUX/IAA PROTEINS | MECHANISMS | ARABIDOPSIS | SCF UBIQUITIN-LIGASE | EXPRESSION | BINDING | Transcription, Genetic - drug effects | Temperature | Molecular Sequence Data | Spodoptera | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Binding - drug effects | Carrier Proteins - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - isolation & purification | Repressor Proteins - metabolism | Amino Acid Sequence | Cell Line | Arabidopsis Proteins - genetics | Indoleacetic Acids - metabolism | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - chemistry | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - isolation & purification | Carrier Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Animals | Carrier Proteins - metabolism | Arabidopsis Proteins - chemistry | Indoleacetic Acids - pharmacology | Carrier Proteins - isolation & purification | F-Box Proteins - isolation & purification | F-Box Proteins - genetics | Receptors, Cell Surface - genetics | Proteins | Hormones | Physical growth | Botany
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2016, Volume 61, Issue 1, pp. 84 - 97
Autophagy, a cellular self-eating mechanism, is important for maintaining cell survival and tissue homeostasis in various stressed conditions. Although the... 
VPS34 complex | ULK1 | autophagy | ubiquitination | Ubiquitination | Autophagy | BECLIN 1 | PHOSPHATIDYLINOSITOL 3-KINASE | PROTEIN ATG8 | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES AUTOPHAGY | KINASE | MAMMALIAN AUTOPHAGY | DYNAMICS | INHIBITS AUTOPHAGY | AMBRA1 | MTOR | CELL BIOLOGY | Autophagy-Related Proteins | Phosphorylation | Vesicular Transport Proteins - metabolism | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Muscular Atrophy - enzymology | Adaptor Proteins, Vesicular Transport - metabolism | Autophagy-Related Protein-1 Homolog | Transfection | RNA Interference | Time Factors | Proteolysis | HEK293 Cells | Cullin Proteins - metabolism | Diabetes Complications - genetics | Membrane Proteins - metabolism | Diabetes Complications - pathology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Muscle, Skeletal - enzymology | Signal Transduction | Mice, Inbred C57BL | Muscular Atrophy - pathology | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Muscular Atrophy - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Protein Transport | Cullin Proteins - genetics | Carrier Proteins - genetics | Feedback, Physiological | Animals | Carrier Proteins - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Ubiquitin-Protein Ligases - deficiency | Diabetes Complications - enzymology | HeLa Cells | Muscle, Skeletal - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Starvation | Ligases | Medical colleges | Cell death
Journal Article
Nature Genetics, ISSN 1061-4036, 05/2018, Volume 50, Issue 5, pp. 645 - 651
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3765 - 3773
S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-MEDIATED DEGRADATION | BOX PROTEIN SKP2 | ENTEROPATHY | DISRUPTION | P27 | MOUSE | SCURFY | EXPRESSION | CELL-CYCLE INHIBITION | P27(KIP1) | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Receptor, ErbB-2 - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Receptor, ErbB-2 - metabolism | Repressor Proteins - antagonists & inhibitors | Breast Neoplasms - metabolism | Genes, X-Linked | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Cell Transformation, Neoplastic - genetics | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Gene Silencing | Oncogene Proteins - metabolism | Repressor Proteins - genetics | Forkhead Transcription Factors - genetics | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Oncogene Proteins - antagonists & inhibitors | Cullin Proteins - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Ploidies | Cell Line, Tumor | Heterozygote | S-Phase Kinase-Associated Proteins - genetics | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology | Tumor suppressor genes | Breast cancer | Genetic aspects | Research | DNA binding proteins | Identification and classification | Health aspects | Risk factors
Journal Article
Journal Article