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Journal of Immunology, ISSN 0022-1767, 04/2011, Volume 186, Issue 8, pp. 4794 - 4804
Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes. In the therapy of systemic lupus erythematosus,... 
IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDES | CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | DNA | COMPLEXES | TOLL-LIKE RECEPTORS | H+-ATPASE | IFN-ALPHA INDUCER | IMMUNOLOGY | NUCLEIC-ACIDS | Humans | Toll-Like Receptor 9 - genetics | Toll-Like Receptor 3 - antagonists & inhibitors | Endosomes - metabolism | Quinolines - pharmacology | Chloroquine - pharmacology | Quinacrine - pharmacology | Transfection | Hydrogen-Ion Concentration - drug effects | HEK293 Cells | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptor 3 - genetics | Culture Media - chemistry | Imidazoles - metabolism | Toll-Like Receptor 8 - agonists | Binding, Competitive | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Cell Line | Antimalarials - metabolism | Toll-Like Receptor 7 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Cytokines - metabolism | Cells, Cultured | Imidazoles - pharmacology | Nucleic Acids - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptors - agonists | Antimalarials - pharmacology | Quinolines - metabolism | Animals | Toll-Like Receptors - genetics | Culture Media - pharmacology | Toll-Like Receptor 8 - genetics | Endosomes - chemistry | Toll-Like Receptor 9 - metabolism | Toll-Like Receptor 8 - metabolism | Serum - chemistry | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 108 - 112
As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues(1,2), cancer cells must adapt... 
COMPLEX I | DIABETIC-PATIENTS | BREAST-CANCER | OXIDATIVE-PHOSPHORYLATION | RESPIRATORY-CHAIN | METFORMIN | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | MUTATIONS | TUMORS | DEFICIENCY | Enzymes | Cell growth | Metabolites | Biomarkers | Genomes | Mitochondrial DNA | Mutation | Gene expression | Cancer | Tumors | Defects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7332, pp. 105 - 110
Studies in embryonic development have guided successful efforts to direct the differentiation of human embryonic and induced pluripotent stem cells (PSCs) into... 
VIVO | NEUROGENIN-3 | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | ENDODERM | DEFINED CONDITIONS | GENERATION | SPECIFICATION | FATE | EFFICIENT DIFFERENTIATION | ENDOCRINE-CELLS | Body Patterning - drug effects | Intestines - drug effects | Wnt Proteins - pharmacology | Embryonic Stem Cells - cytology | Humans | Endoderm - embryology | Intestines - embryology | Organogenesis - drug effects | Intestines - anatomy & histology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Endoderm - cytology | Fibroblast Growth Factor 4 - pharmacology | Cell Culture Techniques | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Microvilli - drug effects | Activins - pharmacology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Endoderm - drug effects | Culture Media - pharmacology | Morphogenesis - drug effects | Wnt3 Protein | Wnt3A Protein | Intestines - cytology | Physiological aspects | Intestines | Genetic aspects | Health aspects | Endoderm | Stem cells | Proteins | Studies | Index Medicus | posterior endoderm | intestine | FGF | transplantation | colon | drug transport | Wnt | progenitor cell
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 77, pp. 173 - 185
Abstract Transforming growth factor beta (TGF-β) has become one of the most widely utilized mediators of engineered cartilage growth. It is typically... 
Advanced Basic Science | Dentistry | Cartilage tissue engineering | Growth factor delivery | Finite element model | Biochemical gradients | Transforming growth factor beta | Heterogeneous growth | STEM-CELLS | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | SEEDED AGAROSE GELS | BINDING PROTEOGLYCANS | IN-VITRO | RABBIT ARTICULAR CHONDROCYTES | PLATE CHONDROCYTES | EXTRACELLULAR-MATRIX | TRANSIENT EXPOSURE | NUTRIENT CHANNELS | ORGAN-CULTURES | Transforming Growth Factor beta3 - pharmacology | Autocrine Communication | Chondrocytes - cytology | Tissue Engineering - methods | Cell Culture Techniques - instrumentation | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Cells, Cultured | Organoids - cytology | Recombinant Proteins - pharmacology | Transforming Growth Factor beta1 - secretion | Dose-Response Relationship, Drug | Chondrocytes - drug effects | Extracellular Matrix Proteins - secretion | Mesenchymal Stromal Cells - cytology | Animals | Osmolar Concentration | Cattle | Models, Biological | Computer Simulation | Cartilage - cytology | Culture Media - pharmacology | Chondrocytes - secretion | Transforming Growth Factor beta1 - pharmacology | Index Medicus | Cartilage | Biomedical materials | Cellular | Construction | Biosynthesis | Biochemistry | Culture | Concentration gradient | growth factor delivery | cartilage tissue engineering | biochemical gradients | finite element model | heterogeneous growth
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, pp. 16570 - 16570
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 43 - 49
Th17 cell differentiation is dependent on interleukin (IL)-6 and transforming growth factor (TGF)-beta, and it is modulated by activation of the aryl... 
MEDICINE, RESEARCH & EXPERIMENTAL | TRYPTOPHAN PHOTOPRODUCT | ACTIVATION | SINGLET OXYGEN | GENERATION | INDUCTION | IMMUNOLOGY | EXPRESSION | CONTEXT | Cytochrome P-450 CYP1A1 - genetics | Gene Expression - drug effects | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | T-Lymphocyte Subsets - cytology | Humans | Interleukins - metabolism | Receptors, Retinoic Acid - genetics | T-Lymphocytes, Helper-Inducer - drug effects | STAT5 Transcription Factor - metabolism | Receptors, Thyroid Hormone - genetics | T-Lymphocyte Subsets - drug effects | T-Lymphocytes, Helper-Inducer - cytology | Phosphorylation - drug effects | Culture Media - chemistry | Azo Compounds - pharmacology | Cell Differentiation - physiology | Pyrazoles - pharmacology | Interleukin-2 - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 | T-Lymphocytes, Helper-Inducer - metabolism | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Mice, Inbred Strains | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Aryl Hydrocarbon - physiology | Mice, Knockout | Receptors, Aryl Hydrocarbon - agonists | Interleukin-17 - metabolism | Animals | Cell Differentiation - drug effects | T-Lymphocyte Subsets - metabolism | Culture Media - pharmacology | Mice | Tryptophan - pharmacology | Carbazoles - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus | Brief Definitive Reports
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, pp. e18293 - e18293
Background: The production of cardiomyocytes from human induced pluripotent stem cells (hiPSC) holds great promise for patient-specific cardiotoxicity drug... 
DEFINED MEDIUM | MESODERM | MULTIDISCIPLINARY SCIENCES | ENDODERM | CARDIOMYOCYTE DIFFERENTIATION | INDUCTION | LINES | FUNCTIONAL-PROPERTIES | Body Patterning - drug effects | Oxygen - pharmacology | Antigens, CD34 - metabolism | Polyvinyl Alcohol - pharmacology | Humans | Fibroblast Growth Factor 2 - pharmacology | Mesoderm - drug effects | Mesoderm - cytology | Cell Culture Techniques - methods | Embryoid Bodies - metabolism | Embryoid Bodies - cytology | Adult | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Cell Line | Insulin - pharmacology | Induced Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - cytology | Transgenes - genetics | Fetal Blood - cytology | Cell Adhesion - drug effects | Bone Morphogenetic Protein 4 - pharmacology | Genetic Vectors - genetics | Embryoid Bodies - drug effects | Animals | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Fibroblasts - drug effects | Culture Media - pharmacology | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Electrophysiological Phenomena - drug effects | Physiological aspects | Bone morphogenetic proteins | Fibroblast growth factors | Embryonic stem cells | Analysis | Drugs | Neonates | Neuropathology | Variability | Embryo cells | Alcohol | Drug development | Blood | Contraction | Regeneration (physiology) | Engineering | Cord blood | Efficiency | Calcium-binding protein | Fibroblasts | Long QT syndrome | Modelling | Polyvinyl alcohol | Heart diseases | Biomedical engineering | Fibroblast growth factor 2 | CD34 antigen | Bone morphogenetic protein 4 | Anemia | Cardiomyocytes | Insulin | Embryos | Coronary artery disease | Medicine | Regeneration | Troponin | Troponin I | Plasmids | Stem cells | Epigenetics | Mutation | Differentiation | Pluripotency | Index Medicus
Journal Article