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BBA - Molecular Cell Research, ISSN 0167-4889, 02/2019, Volume 1866, Issue 2, pp. 264 - 276
Exchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to... 
Cyclic AMP | Vascular endothelial cells | Inflammation | EPAC1 | Transcriptome | Cell adhesion molecules | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 33, pp. 13758 - 13773
Annexin A1 (AnxA1) is a glucocorticoid-regulated protein known for its anti-inflammatory and pro-resolving effects. We have shown previously that the... 
2/LIPOXIN A RECEPTOR | LIPOCORTIN 1 | SIGNALING PATHWAY | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORMYL PEPTIDE RECEPTOR | DOWN-REGULATION | NF-KAPPA-B | NUCLEOTIDE PHOSPHODIESTERASES | NEUTROPHIL APOPTOSIS | Annexin A1 - agonists | Annexin A1 - genetics | Apoptosis - drug effects | Humans | Male | Pleurisy - metabolism | Pleurisy - immunology | Rolipram - therapeutic use | Cyclic AMP - analogs & derivatives | Protein Processing, Post-Translational - drug effects | Pleurisy - drug therapy | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Cyclic AMP - metabolism | Neutrophils - metabolism | Macrophages - immunology | Neutrophil Infiltration - drug effects | Neutrophils - pathology | Cyclic AMP-Dependent Protein Kinases - metabolism | Phosphodiesterase 4 Inhibitors - chemistry | Lipopolysaccharides - toxicity | Macrophages - pathology | Bucladesine - antagonists & inhibitors | Bucladesine - therapeutic use | Neutrophils - drug effects | Cells, Cultured | Neutrophils - immunology | Annexin A1 - antagonists & inhibitors | Phosphodiesterase 4 Inhibitors - therapeutic use | Mice, Knockout | Pleurisy - pathology | Cyclic AMP - antagonists & inhibitors | Macrophages - metabolism | Animals | Annexin A1 - metabolism | Macrophages - drug effects | RAW 264.7 Cells | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Cyclic AMP - agonists | Rolipram - antagonists & inhibitors | Index Medicus | protein kinase A (PKA) | Signal Transduction | inflammation | annexin | apoptosis | cyclic AMP (cAMP) | neutrophil
Journal Article
Diabetes, ISSN 0012-1797, 11/2012, Volume 61, Issue 11, pp. 2842 - 2850
In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has been reported, along with controversial findings regarding its... 
SIGNAL-TRANSDUCTION | NAD(P)H OXIDASE | RESPIRATORY BURST | OXIDATIVE STRESS | PROTEIN | ISLETS | SUPEROXIDE-PRODUCTION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | DEPENDENT PATHWAY | Islets of Langerhans - drug effects | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Secretory Vesicles - metabolism | Insulin-Secreting Cells - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Islets of Langerhans - metabolism | Isoenzymes - metabolism | Islets of Langerhans - cytology | NADPH Oxidases - genetics | Insulin-Secreting Cells - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Insulin Secretion | Cyclic AMP-Dependent Protein Kinases - metabolism | Second Messenger Systems - drug effects | Glucagon-Like Peptide 1 - metabolism | Isoenzymes - genetics | Tissue Culture Techniques | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Gene Silencing | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Cyclic AMP - antagonists & inhibitors | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Secretory Vesicles - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Cyclic AMP - agonists | Isoenzymes - antagonists & inhibitors | Oxidases | Physiological aspects | Pancreatic beta cells | Research | Analysis | NADP (Coenzyme) | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Human Reproduction, ISSN 0268-1161, 04/2016, Volume 31, Issue 4, pp. 810 - 821
Abstract STUDY QUESTION Can bovine oocyte antioxidant defence and oocyte quality be improved by extending the duration of pre-in vitro maturation (IVM) with... 
cyclic AMP | gap-junctional communication | oocyte quality | glutathione | oocyte in vitro maturation | PORCINE OOCYTES | MATURING HAMSTER OOCYTES | POLYCYSTIC OVARIES | BOVINE OOCYTE | DEVELOPMENTAL COMPETENCE | GLUTATHIONE SYNTHESIS | OBSTETRICS & GYNECOLOGY | EMBRYO DEVELOPMENT | CYCLIC-AMP | REPRODUCTIVE BIOLOGY | IN-VITRO MATURATION | FOLLICLE DEVELOPMENT | Enzyme Activators - pharmacology | Buthionine Sulfoximine - pharmacology | Gap Junctions - metabolism | Glutathione - metabolism | Oocytes - cytology | Glutathione - agonists | Cumulus Cells - drug effects | Ectogenesis - drug effects | Cattle | Oocytes - drug effects | Female | Glutamate-Cysteine Ligase - metabolism | Cyclic AMP - metabolism | Cumulus Cells - physiology | In Vitro Oocyte Maturation Techniques | Colforsin - pharmacology | Oocytes - metabolism | Enzyme Inhibitors - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Glutathione - antagonists & inhibitors | Adenylyl Cyclases - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Hydrogen Peroxide - metabolism | Carbenoxolone - pharmacology | Animals | Fertilization in Vitro - drug effects | Adenylyl Cyclases - chemistry | Cyclic AMP - agonists | Oxidative Stress - drug effects | Gap Junctions - drug effects | Glutamate-Cysteine Ligase - antagonists & inhibitors | Hydrogen Peroxide - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2016, Volume 94, Issue 5, pp. 498 - 507
Hepatic stellate cells (HSCs) activation represents an essential event during alcoholic liver fibrosis (ALF). Previous studies have demonstrated that the rat... 
cellules de Kupffer | hepatic stellate cells | EPAC2 | EPAC1 | Rap1 | acétaldéhyde | acetaldehyde | Hepatic stellate cells | Acetaldehyde | FIBROSIS | PHYSIOLOGY | COLLAGEN | RAT | ALCOHOLIC LIVER-DISEASE | PATHOGENESIS | CYCLIC-AMP | BIOLOGICAL FUNCTIONS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | PROSTAGLANDIN E-2 | CAMP | rap1 GTP-Binding Proteins - antagonists & inhibitors | Actins - metabolism | Cyclic AMP-Dependent Protein Kinases - chemistry | Hepatic Stellate Cells - metabolism | Acetaldehyde - antagonists & inhibitors | Actins - genetics | Collagen Type II - metabolism | Collagen Type I - genetics | Cyclic AMP - analogs & derivatives | RNA Interference | Guanine Nucleotide Exchange Factors - metabolism | Collagen Type II - agonists | rap1 GTP-Binding Proteins - agonists | Actins - agonists | Collagen Type II - antagonists & inhibitors | Cyclic AMP - metabolism | Hepatic Stellate Cells - pathology | Hepatic Stellate Cells - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Second Messenger Systems - drug effects | Collagen Type I - metabolism | Acetaldehyde - toxicity | Liver Cirrhosis, Alcoholic - pathology | Collagen Type I - antagonists & inhibitors | Rats | Enzyme Activation - drug effects | Guanine Nucleotide Exchange Factors - agonists | Collagen Type II - genetics | Liver Cirrhosis, Alcoholic - prevention & control | Cyclic AMP - pharmacology | Actins - antagonists & inhibitors | Animals | Collagen Type I - agonists | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Cell Proliferation - drug effects | Cyclic AMP - agonists | Liver Cirrhosis, Alcoholic - metabolism | rap1 GTP-Binding Proteins - genetics | Cell proliferation | Cyclic adenylic acid | Observations | Health aspects | Stem cells | Signal transduction | Protein expression | Cell growth | Collagen | Liver | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11815 - 11828
In liver steatosis (i.e. fatty liver), hepatocytes accumulate many large neutral lipid storage organelles known as lipid droplets (LDs). LDs are important in... 
alcohol | lipid droplet | STIMULATED LIPOLYSIS | ADIPOSE TRIGLYCERIDE LIPASE | HEPATIC GLUCONEOGENESIS | hepatocyte | HORMONE-SENSITIVE LIPASE | PROTEIN-KINASE | ATGL | BIOCHEMISTRY & MOLECULAR BIOLOGY | adrenergic receptor | cyclic AMP (cAMP) | fatty liver | METABOLISM | G protein-coupled receptor (GPCR) | adipose triglyceride lipase (ATGL) | PROMOTES | LIPID DROPLETS | Lipolysis - drug effects | Humans | Sterol Esterase - metabolism | Cyclic AMP-Dependent Protein Kinases - chemistry | Hepatocytes - pathology | Male | Protein Transport - drug effects | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | Hepatocytes - cytology | Protein Processing, Post-Translational - drug effects | Female | Phosphorylation - drug effects | Fatty Liver, Alcoholic - pathology | Lipid Droplets - metabolism | Receptors, Adrenergic, beta - metabolism | Sterol Esterase - chemistry | Cyclic AMP - metabolism | Hepatocytes - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Lipid Droplets - drug effects | Receptors, Adrenergic, beta - chemistry | Second Messenger Systems - drug effects | Cells, Cultured | Adrenergic beta-Agonists - pharmacology | Lipid Droplets - pathology | Rats | Lipase - metabolism | Enzyme Activation - drug effects | Lipase - chemistry | Animals | Cell Line, Tumor | Cyclic AMP - agonists | Index Medicus | Cell Biology
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 08/2015, Volume 59, Issue 8, pp. 1443 - 1457
ScopeResveratrol (RSV), a natural polyphenol, has been reported to attenuate nonalcoholic fatty liver disease (NAFLD); however, its underlying mechanism is... 
NAFLD | Treatment | Hepatocyte | SIRT1 | Resveratrol | ACTIVATION | LIPID-METABOLISM | PROTEIN-KINASE | FOOD SCIENCE & TECHNOLOGY | NONALCOHOLIC FATTY LIVER | DIET | INFLAMMATION | DISEASE | AMPK | HEALTH | Sirtuin 1 - metabolism | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Stilbenes - therapeutic use | Antioxidants - metabolism | Humans | Stilbenes - metabolism | Mice, 129 Strain | Sirtuin 1 - genetics | Autophagy - drug effects | Fatty Acids, Nonesterified - metabolism | Liver - drug effects | RNA Interference | Enzyme Induction - drug effects | Sirtuin 1 - chemistry | Cyclic AMP - metabolism | Fatty Acids, Nonesterified - adverse effects | Microscopy, Electron, Transmission | Second Messenger Systems - drug effects | Liver - ultrastructure | Liver - metabolism | Enzyme Inhibitors - pharmacology | Non-alcoholic Fatty Liver Disease - metabolism | Adenylyl Cyclases - metabolism | Sirtuin 1 - antagonists & inhibitors | Hep G2 Cells | Cyclic AMP - antagonists & inhibitors | Antioxidants - therapeutic use | Animals | Adenylyl Cyclases - chemistry | Lipid Metabolism - drug effects | Fatty Acids, Nonesterified - antagonists & inhibitors | Cyclic AMP - agonists | Non-alcoholic Fatty Liver Disease - diet therapy | Adenylyl Cyclases - genetics | Dietary Supplements | Triglycerides | Liver diseases | Fatty acids | Liver | Index Medicus
Journal Article