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Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 539 - 550
PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed... 
Dimer | Oligomerization | CAMP | Cyclic nucleotide phosphodiesterase 4 (PDE4) | Phosphodiesterase | DOMAIN | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | dimer | GEL-FILTRATION | DENSITY GRADIENT CENTRIFUGATION | cyclic nucleotide phosphodiesterase 4 (PDE4) | ROD CGMP-PHOSPHODIESTERASE-6 | cAMP | CGMP-BINDING | oligomerization | PHOSPHATIDIC-ACID BINDING | phosphodiesterase | CATALYTIC SITE | Phosphorylation | Molecular Weight | Humans | Protein Multimerization | Cercopithecus aethiops | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Cyclic AMP-Dependent Protein Kinases - genetics | Isoenzymes - metabolism | HEK293 Cells | Conserved Sequence | Luminescent Proteins - chemistry | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Dimerization | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Rats | Recombinant Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Recombinant Fusion Proteins - chemistry | Animals | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Enzyme Activation | COS Cells | Luminescent Proteins - metabolism | PDE4
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12202 - 12216
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1768, Volume 289, Issue 19, pp. 13112 - 13123
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1782, Volume 289, Issue 21, pp. 14771 - 14781
Small-molecule, ligand-activated G protein-coupled receptors are generally thought to be rapidly desensitized within a period of minutes through receptor... 
Heart - physiology | Myocardial Contraction - physiology | Myocardial Contraction - drug effects | Neurons - cytology | Myocardial Contraction - genetics | Fluorescence Resonance Energy Transfer | Membrane Proteins - metabolism | Neurons - metabolism | Phosphorylation - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Neurons - drug effects | Rolipram - pharmacology | Cyclic AMP - metabolism | Animals, Newborn | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Membrane Proteins - genetics | Cell Size - drug effects | Cells, Cultured | Adrenergic beta-Agonists - pharmacology | Receptors, Adrenergic, beta-1 - metabolism | Signal Transduction - genetics | Phosphodiesterase 4 Inhibitors - pharmacology | Blotting, Western | Mice, Knockout | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Isoproterenol - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Heart - drug effects | Myocytes, Cardiac - metabolism | Receptors, Adrenergic, beta-1 - genetics | Signal Transduction - physiology | Mice | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Catecholamines - pharmacology | Microscopy, Fluorescence | Cardiac Muscle | Protein Kinase A (PKA) | Signal Transduction | Adrenergic Receptor | Cyclic AMP (cAMP) | Phosphodiesterase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1782, Volume 289, Issue 21, pp. 14600 - 14611
Journal Article
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 4/2011, Volume 34, Issue 2, pp. 455 - 463
Journal Article
Journal Article
Journal Article
Journal Article
Cytokine, ISSN 1043-4666, 2003, Volume 23, Issue 4, pp. 138 - 149
Pro-inflammatory cytokines are important mediators of cutaneous cellular activities during many skin diseases. In the present study, we investigated the... 
UVB | cAMP/PKA pathways | Cytokines | NCTC 2544 cell | cAMP-elevating agents | CAMP/PKA pathways | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNOLOGY | MURINE PERITONEAL-MACROPHAGES | INTERLEUKIN-6 PRODUCTION | ULTRAVIOLET-LIGHT | BLOOD MONONUCLEAR-CELLS | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | MESSENGER-RNA | IN-VIVO | GENE-EXPRESSION | cytokines | TRANSCRIPTIONAL REGULATION | Up-Regulation | Keratinocytes - radiation effects | Humans | Tumor Necrosis Factor-alpha - genetics | Peptide Fragments - pharmacology | RNA, Messenger - radiation effects | RNA, Messenger - metabolism | Cyclic AMP - physiology | Isoquinolines - pharmacology | Ultraviolet Rays | Carrier Proteins - pharmacology | Cholera Toxin - pharmacology | Cytokines - genetics | RNA, Messenger - drug effects | Cell Line | Dinoprostone - pharmacology | Enzyme-Linked Immunosorbent Assay | Interleukin-6 - genetics | Down-Regulation | Intracellular Signaling Peptides and Proteins | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Blotting, Northern | Cyclic AMP-Dependent Protein Kinases - physiology | Keratinocytes - drug effects | Keratinocytes - metabolism | Sulfonamides | Interleukin-10 - genetics | Gene Expression Regulation - radiation effects | Bucladesine - pharmacology | Bioengineering | Interleukin-10 | Gene Expression Regulation | Cyclic AMP | Dinoprostone | Life Sciences | Bucladesine | Cholera Toxin | Cyclic AMP-Dependent Protein Kinases | Carrier Proteins
Journal Article