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Journal of Biological Chemistry, ISSN 0021-9258, 12/2005, Volume 280, Issue 49, pp. 40398 - 40401
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2014, Volume 53, Issue 6, pp. 1548 - 1551
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 124, Issue 3, pp. 587 - 599
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2014, Volume 448, Issue 4, pp. 430 - 436
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2005, Volume 25, Issue 5, pp. 1137 - 1148
The dual nature of the NMDA receptor as a mediator of excitotoxic cell death and activity-dependent cell survival likely results from divergent patterns of... 
Neuroprotection | CaMK | CREB | Neuron | Calcium | MAPK | Apoptosis | calcium | FOCAL CEREBRAL-ISCHEMIA | neuron | apoptosis | BDNF EXPRESSION | SYNAPTIC PLASTICITY | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | RAT HIPPOCAMPAL-NEURONS | FAMILY TRANSCRIPTION FACTOR | IN-VITRO | GLUTAMATE RECEPTORS | SIGNALING PATHWAY | neuroprotection | GENE-EXPRESSION | Transcription, Genetic - drug effects | Brain - embryology | Cyclic AMP Response Element-Binding Protein - chemistry | Synaptic Transmission - physiology | Apoptosis - drug effects | Recombinant Fusion Proteins - physiology | Action Potentials | Brain - metabolism | Cyclic AMP - physiology | Transfection | Protein Processing, Post-Translational - drug effects | Time Factors | Tacrolimus - pharmacology | Synaptic Transmission - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Calcium Signaling | Brain - cytology | Receptors, N-Methyl-D-Aspartate - drug effects | Gene Expression Regulation - physiology | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Phosphoserine - metabolism | Cyclic AMP Response Element-Binding Protein - physiology | Rats, Sprague-Dawley | Receptors, N-Methyl-D-Aspartate - physiology | Gene Expression Regulation - drug effects | Animals | Protein Kinases - physiology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Index Medicus | Cellular | Molecular
Journal Article
Science, ISSN 0036-8075, 4/2009, Volume 324, Issue 5924, pp. 213 - 215
Structure-based drug design traditionally uses static protein models as inspirations for focusing on "active" site targets. Allosteric regulation of biological... 
Proteins | Molecules | Enzymes | Perspective | Allosteric regulation | Active sites | Drug interactions | Macromolecules | Medical treatment | Ligands | Drug design | ALLOSTERIC REGULATION | BINDING MODES | IN-VITRO | HIGH-AFFINITY LIGANDS | MECHANISM | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | DYNAMICS | PROTEIN-PROTEIN INTERACTIONS | INHIBITORS | ANTAGONISTS | Apoproteins - chemistry | Cyclic AMP Response Element-Binding Protein - chemistry | Allosteric Regulation | Protein Multimerization | CREB-Binding Protein - chemistry | Piperazines - metabolism | Proto-Oncogene Proteins c-mdm2 - chemistry | Pyrimidines - metabolism | CREB-Binding Protein - metabolism | Thermodynamics | Enzyme Inhibitors - chemistry | Drug Design | Nuclear Magnetic Resonance, Biomolecular | Proto-Oncogene Proteins c-mdm2 - metabolism | Apoproteins - metabolism | Catalytic Domain | Signal Transduction | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Pyrimidines - pharmacology | Drug Discovery | Imatinib Mesylate | Piperazines - pharmacology | Proteins - metabolism | Small Molecule Libraries | Allosteric Site | Cyclic AMP Response Element-Binding Protein - metabolism | Protein Binding | Protein Conformation | Tumor Suppressor Protein p53 - chemistry | Benzamides | Proteins - chemistry | Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors | Drug delivery devices | Evaluation | Molecular dynamics | Nuclear magnetic resonance spectroscopy | Design and construction | Research | Structure | Methods | Pharmacology | Biomedical research | Molecular biology | Binding sites | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2006, Volume 103, Issue 17, pp. 6741 - 6746
Journal Article