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Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1160 - 1169
Orthopedic implants containing biodegradable magnesium have been used for fracture repair with considerable efficacy; however, the underlying mechanisms by... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE-RELATED PEPTIDE | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNERVATION | OSTEOPOROSIS | CELL BIOLOGY | IN-VITRO | TRAUMATIC BRAIN-INJURY | ALLOYS | DIFFERENTIATION | OSTEOARTHRITIS | EXPRESSION | Bone Nails | Humans | Fracture Fixation, Intramedullary | Ganglia, Spinal - cytology | Cyclic AMP Response Element-Binding Protein - drug effects | Gene Knockdown Techniques | Transcription Factors - drug effects | Stem Cells | Fracture Healing - drug effects | Osteoporosis, Postmenopausal | Cation Transport Proteins - metabolism | Female | Neurons - metabolism | Calcitonin Gene-Related Peptide - metabolism | Neurons - drug effects | Osteogenesis - genetics | Osteoporotic Fractures | Calcitonin Gene-Related Peptide - drug effects | Ovariectomy | Calcitonin Gene-Related Peptide - pharmacology | Osteogenesis - drug effects | Capsaicin - toxicity | Femoral Fractures | Rats | Femur - drug effects | Sensory System Agents - toxicity | Receptor Activity-Modifying Protein 1 - genetics | Magnesium - pharmacology | Gene Knock-In Techniques | Periosteum - cytology | Transcription Factors - metabolism | Animals | Cell Differentiation - drug effects | Calcitonin Receptor-Like Protein - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | TRPM Cation Channels - metabolism | Fracture Healing - genetics | Denervation | Neuropeptides | Fracture fixation | Genetic aspects | Wound healing | Health aspects | Surgical implants | Femur | Transplants & implants | Biodegradability | Capsaicin | Genes | Menopause | Differentiation (biology) | Stem cell transplantation | Cortex (somatosensory) | Receptor activity modifying proteins | Proteins | Osteoporosis | Biomedical materials | Bone growth | Allografts | Dorsal root ganglia | Surgery | Calcitonin | Nerves | Sensory neurons | Biocompatibility | Ion channels | Magnesium | Bone (cortical) | Repair | Adenosine triphosphate | Biodegradation | Periosteum | Implantation | Bone healing | Ganglia | Calcitonin gene-related peptide | Bone implants | Fractures | Orthopedics | Stem cells | Healing | Bone | ATP | Transporter | Osteogenesis
Journal Article
Neuron, ISSN 0896-6273, 05/2009, Volume 62, Issue 3, pp. 335 - 348
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2008, Volume 11, Issue 3, pp. 334 - 343
Journal Article
Neuroscience, ISSN 0306-4522, 2004, Volume 124, Issue 3, pp. 549 - 560
Using hippocampal primary cell cultures at 14 days in vitro (div), we have investigated actions of 17-β estradiol (E; 10 nM) on the phosphorylation of CREB and... 
spinophilin | CaMKII | Akt | MAPK | dendritic spines | cell characterization | Cell characterization | Dendritic spines | Spinophilin | LONG-TERM | CREB PHOSPHORYLATION | ACTIVATED PROTEIN-KINASE | RAT | TRANSCRIPTION | RECEPTOR | ALPHA | SYNAPTIC PLASTICITY | NEUROSCIENCES | NEURONS | Protein Kinases - metabolism | Estrogens - pharmacology | Protein-Serine-Threonine Kinases | Dendrites - ultrastructure | Cyclic AMP Response Element-Binding Protein - drug effects | Genes, Regulator - genetics | Genes, Regulator - drug effects | Reaction Time - drug effects | Fetus | Microfilament Proteins - metabolism | Neurons - metabolism | Phosphorylation - drug effects | Estrogens - metabolism | Neurons - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Cell Differentiation - physiology | Proto-Oncogene Proteins - metabolism | Dendrites - drug effects | Dendrites - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Hippocampus - embryology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Reaction Time - physiology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Hippocampus - cytology | Nerve Tissue Proteins - metabolism | Proto-Oncogene Proteins c-akt | Hippocampus - metabolism | Protein Kinase Inhibitors | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cyclic AMP Response Element-Binding Protein - metabolism | Signal Transduction - physiology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2004, Volume 24, Issue 18, pp. 4324 - 4332
Journal Article
Journal Article
Journal Article
Stroke, ISSN 0039-2499, 09/2013, Volume 44, Issue 9, pp. 2573 - 2578
Background and Purpose Aging is one of the major risk factors for white matter injury in cerebrovascular disease. However, the effects of age on the mechanisms... 
Aging | Animal model | White matter diseases | Oligodendrocyte | Cyclic AMP response element-binding protein | CILOSTAZOL | oligodendrocyte | DECREASE | INJURY | CLINICAL NEUROLOGY | IMPAIRMENT | STROKE | HIPPOCAMPUS | MYELIN | NEUROGENESIS | PERIPHERAL VASCULAR DISEASE | aging | white matter diseases | animal model | DENTATE GYRUS | EXPRESSION | cyclic AMP response element-binding protein | Myelin Sheath - drug effects | Male | Cyclic AMP Response Element-Binding Protein - drug effects | Hypoxia, Brain - complications | Antimutagenic Agents - toxicity | Leukoencephalopathies - drug therapy | Neuroprotective Agents - pharmacology | Cognition Disorders - etiology | Neurogenesis - drug effects | Disease Models, Animal | Myelin Sheath - pathology | Mice, Inbred C57BL | Cells, Cultured | Cognition Disorders - pathology | Neural Stem Cells - drug effects | Cobalt - administration & dosage | Cognition Disorders - drug therapy | Cyclic AMP Response Element-Binding Protein - physiology | Neural Stem Cells - pathology | Aging - pathology | Cobalt - toxicity | Animals | Aging - physiology | Neurogenesis - physiology | Corpus Callosum - pathology | Leukoencephalopathies - etiology | Antimutagenic Agents - administration & dosage | Leukoencephalopathies - complications | Mice | Hypoxia, Brain - chemically induced | CREB signaling | white matter injury | prolonged cerebral hypoperfusion | oligodendrogenesis
Journal Article
Pain, ISSN 0304-3959, 2015, Volume 156, Issue 12, pp. 2572 - 2584
Treating neuropathic pain continues to be a major clinical challenge and underlying mechanisms of neuropathic pain remain elusive. We have recently... 
Neural excitability | Nerve injury | Wnt | Ryk | Synaptic plasticity | DORSAL-HORN NEURONS | NERVOUS-SYSTEM | THERMAL HYPERALGESIA | ROOT GANGLION NEURONS | EPHB1 RECEPTOR | BETA-CATENIN | NEUROSCIENCES | CLINICAL NEUROLOGY | HYPEREXCITABILITY | ANESTHESIOLOGY | LONG-TERM POTENTIATION | Wnt3A Protein - metabolism | Posterior Horn Cells - metabolism | Sciatic Nerve - injuries | Neuralgia - genetics | Spinal Cord - metabolism | Neuralgia - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Wnt3A Protein - antagonists & inhibitors | Neuronal Plasticity - drug effects | Wnt Signaling Pathway - physiology | Male | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - drug effects | Cyclic AMP Response Element-Binding Protein - drug effects | Wnt Proteins - metabolism | src-Family Kinases - drug effects | Neuronal Plasticity - physiology | src-Family Kinases - metabolism | Nerve Fibers, Unmyelinated - drug effects | Pain Threshold - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Behavior, Animal - drug effects | Sensory Receptor Cells - metabolism | Real-Time Polymerase Chain Reaction | Calcium Signaling | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Locomotion - drug effects | Receptors, N-Methyl-D-Aspartate - drug effects | Hyperalgesia - metabolism | Signal Transduction | Rats | Behavior, Animal - physiology | Receptor Protein-Tyrosine Kinases - metabolism | Rats, Sprague-Dawley | Patch-Clamp Techniques | Animals | MAP Kinase Signaling System - drug effects | Wnt Signaling Pathway - drug effects | Hyperalgesia - genetics | Receptor Protein-Tyrosine Kinases - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Wnt Proteins - antagonists & inhibitors | Astrocytes - metabolism | Ganglia, Spinal - metabolism | Protein Kinase C
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2008, Volume 31, Issue 2, pp. 278 - 285
Abstract Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal... 
Neurology | Antidepressant | CREB | Prefrontal cortex | Stress | Hippocampus | ERK | stress | hippocampus | prefrontal cortex | MAP KINASE | antidepressant | ANTIDEPRESSANT TREATMENT | ELEMENT-BINDING PROTEIN | ELEVATED PLUS-MAZE | ANXIETY-LIKE BEHAVIOR | SYNAPTIC PLASTICITY | NEUROSCIENCES | ANIMAL-MODELS | LONG-TERM POTENTIATION | ACTIVATED PROTEIN-KINASES | OPEN-FIELD | MAP Kinase Signaling System - physiology | Extracellular Signal-Regulated MAP Kinases - drug effects | Brain - enzymology | Depressive Disorder - drug therapy | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Cyclic AMP Response Element-Binding Protein - drug effects | Swimming - psychology | Depressive Disorder - enzymology | Up-Regulation - physiology | Phosphorylation - drug effects | Disease Models, Animal | Fluoxetine - pharmacology | Stress, Psychological - drug therapy | Rats | Down-Regulation - drug effects | Rats, Sprague-Dawley | Brain - drug effects | Down-Regulation - physiology | Up-Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Depressive Disorder - physiopathology | Cyclic AMP Response Element-Binding Protein - metabolism | Serotonin Uptake Inhibitors - pharmacology | Chronic Disease | Stress, Psychological - enzymology | Stress, Psychological - physiopathology | Fluoxetine | Depression, Mental
Journal Article
NEURON, ISSN 0896-6273, 09/2007, Volume 55, Issue 5, pp. 712 - 725
Current antidepressants are clinically effective only after several weeks of administration. Here, we show that serotonin(4) (5-HT4) agonists reduce immobility... 
NEURONAL-ACTIVITY | DEPRESSION | IN-VIVO | ELEMENT-BINDING PROTEIN | OLFACTORY BULBECTOMY | ANIMAL-MODEL | RAT-BRAIN | HIPPOCAMPAL NEUROGENESIS | NEUROSCIENCES | CAMP | NUCLEUS-ACCUMBENS | Serotonin 5-HT1 Receptor Agonists | Motor Activity - physiology | Motor Activity - drug effects | Depressive Disorder - drug therapy | Male | Hippocampus - drug effects | Cyclic AMP Response Element-Binding Protein - drug effects | Serotonin 5-HT4 Receptor Agonists | Serotonin Receptor Agonists - pharmacology | Brain - metabolism | Piperidines - pharmacology | Time Factors | Reaction Time - drug effects | Stress, Psychological - metabolism | Antidepressive Agents - pharmacology | Phosphorylation - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Disease Models, Animal | Aniline Compounds - pharmacology | Stress, Psychological - drug therapy | Brain - physiopathology | Rats | Reaction Time - physiology | Depressive Disorder - metabolism | Rats, Sprague-Dawley | Antidepressive Agents - therapeutic use | Brain - drug effects | Hippocampus - metabolism | Serotonin Receptor Agonists - therapeutic use | Animals | Piperidines - therapeutic use | Depressive Disorder - physiopathology | Serotonin - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Receptors, Serotonin, 5-HT4 - metabolism | Aniline Compounds - therapeutic use | Serotonin Uptake Inhibitors - pharmacology | Hippocampus - physiopathology | Stress, Psychological - physiopathology
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/1996, Volume 16, Issue 7, pp. 2365 - 2372
The present study demonstrates that chronic, but not acute, administration of several different classes of antidepressants, including serotonin- and... 
fluoxetine | ECS | imipramine | tranylcypromine | brain-derived neurotrophic factor | rolipra m | cAMP | desipramine | sertraline | AFFECTIVE-DISORDERS | TRANSCRIPTION | rolipram | PRIMATES | NEUROSCIENCES | CORTEX | PROLONGED GLUCOCORTICOID EXPOSURE | NEURONS | STRESS | Receptor, trkB | Electric Stimulation | Hippocampus - chemistry | Receptors, Nerve Growth Factor - drug effects | Molecular Sequence Data | RNA, Messenger - analysis | Male | Hippocampus - drug effects | Cyclic AMP Response Element-Binding Protein - drug effects | Desipramine - pharmacology | In Situ Hybridization | Time Factors | Base Sequence | Pyrrolidinones - pharmacology | Tranylcypromine - pharmacology | 1-Naphthylamine - pharmacology | Nerve Growth Factors - drug effects | Brain-Derived Neurotrophic Factor | Antidepressive Agents - pharmacology | Fluoxetine - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Receptor Protein-Tyrosine Kinases - drug effects | Nerve Tissue Proteins - drug effects | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Sertraline | Receptors, Nerve Growth Factor - genetics | 1-Naphthylamine - analogs & derivatives | Cyclic AMP Response Element-Binding Protein - genetics | Blotting, Northern | Animals | Rolipram | Receptor Protein-Tyrosine Kinases - genetics | Nerve Growth Factors - genetics | Hippocampus - physiology | Imipramine - pharmacology
Journal Article
Chemosphere, ISSN 0045-6535, 07/2019, Volume 226, pp. 201 - 209
Journal Article