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Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, pp. 5680 - 5680
We recently identified a high prevalence of mutations affecting the catalytic (C alpha) subunit of protein kinase A (PKA) in cortisol-secreting adrenocortical... 
CYCLASE | CYCLIC-AMP | MCCUNE-ALBRIGHT SYNDROME | HOLOENZYME | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | ADRENAL-TUMORS | PHOSPHODIESTERASE | HYPERPLASIA | SOMATIC MUTATIONS | CAMP | Adrenocortical Adenoma - enzymology | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - chemistry | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Cushing Syndrome - enzymology | Cushing Syndrome - pathology | Adrenocortical Adenoma - genetics | Protein Stability | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - chemistry | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Adrenal Cortex Neoplasms - enzymology | Catalytic Domain | Cushing Syndrome - genetics | Adrenal Cortex Neoplasms - pathology | Adrenocortical Adenoma - pathology | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - genetics | Adrenal Cortex Neoplasms - genetics | Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - chemistry | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Cell Line, Tumor | Protein Binding | Mutation | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 21, pp. 3250 - 3267
Toxoplasma gondii encodes three protein kinase A catalytic ( PKA c1‐3) and one regulatory ( PKA r) subunits to integrate cAMP ‐dependent signals. Here, we show... 
Toxoplasma gondii | dependent protein kinase G | cGMP | cAMP | acylation | dependent protein kinase A | egress | cGMP-dependent protein kinase G | cAMP-dependent protein kinase A | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL DISSECTION | IDENTIFICATION | MICRONEME SECRETION | CELL BIOLOGY | INVASION | INHIBITORS | BINDING | EXPRESSION | DOMAINS | SUBUNIT | Phosphorylation | Humans | Phosphoproteins - metabolism | Protozoan Proteins - genetics | Cyclic GMP-Dependent Protein Kinases - metabolism | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics | Cyclic GMP-Dependent Protein Kinases - genetics | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism | Protozoan Proteins - metabolism | Fibroblasts - parasitology | Toxoplasma - growth & development | Host-Parasite Interactions | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism | Cyclic AMP - metabolism | Toxoplasma - metabolism | Acylation | Signal Transduction | 3',5'-Cyclic-GMP Phosphodiesterases - genetics | Gene Expression Regulation | Phosphoproteins - genetics | Life Cycle Stages - genetics | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Toxoplasma - genetics | Cyclic GMP - metabolism | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Cell Line, Transformed | Hydrogen-Ion Concentration | Protein kinase A | Regulators | Deactivation | Crosstalk | Protein kinase G | Cyclic AMP | Acidification | Pellicle | Egress | Parasites | Metabolism | Kinases | Inactivation | pH effects | Proteins | Signal transduction | Signaling | Hydrogen ions | Cyclic GMP | Lysis | Catalysis | Intracellular | Phosphodiesterase | Microbiology, Virology & Host Pathogen Interaction | cGMP‐dependent protein kinase G | cAMP‐dependent protein kinase A
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2011, Volume 364, Issue 23, pp. 2218 - 2226
Journal Article
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 09/2017, Volume 313, Issue 3, pp. F677 - F686
The failure of the polycystins (PCs) to function in primary cilia is thought to be responsible for autosomal dominant polycystic kidney disease (ADPKD).... 
Protein kinase A | Autosomal dominant polycystic kidney disease | CAMP | Cell signaling | Polycystic kidney disease | PHYSIOLOGY | POLYCYSTIC KIDNEY-DISEASE | PHOSPHODIESTERASE PDE1 | PHENOTYPE | CARNEY COMPLEX | autosomal dominant polycystic kidney disease | cAMP | PALLISTER-HALL SYNDROME | CYCLIC-AMP | EPITHELIAL-CELLS | polycystic kidney disease | PATHWAY | cell signaling | MOUSE MODEL | UROLOGY & NEPHROLOGY | protein kinase A | PRIMARY CILIA | Cell Proliferation | PAX2 Transcription Factor - metabolism | Kidney - pathology | TOR Serine-Threonine Kinases - metabolism | Humans | Kidney - enzymology | Middle Aged | Zinc Finger Protein Gli3 | Male | Carney Complex - diagnostic imaging | Mice, 129 Strain | Young Adult | Carney Complex - genetics | Liver Diseases - enzymology | Cysts - enzymology | Polycystic Kidney, Autosomal Dominant - enzymology | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism | Child | Wnt Signaling Pathway | Disease Models, Animal | Genetic Predisposition to Disease | Liver Diseases - genetics | TRPP Cation Channels - genetics | Mice, Knockout | Phenotype | Carney Complex - enzymology | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Cysts - diagnostic imaging | Adolescent | Cysts - genetics | Kruppel-Like Transcription Factors - genetics | Polycystic Kidney, Autosomal Dominant - pathology | Liver Diseases - diagnostic imaging | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Polycystic Kidney, Autosomal Dominant - genetics | Kruppel-Like Transcription Factors - metabolism | src-Family Kinases - metabolism | Adult | Female | Kidney - physiopathology | STAT3 Transcription Factor - metabolism | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - deficiency | Mice, Inbred C57BL | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Polycystic Kidney, Autosomal Dominant - physiopathology
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e39848
The bacterial adenylyl cyclase toxins CyaA from Bordetella pertussis and edema factor from Bacillus anthracis as well as soluble guanylyl cyclase... 
MAMMALIAN-TISSUES | SYSTEM | NUCLEOTIDES | ACTIVATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | CGMP | CYCLASE ACTIVITY | CYTIDINE 3',5'-MONOPHOSPHATE CCMP | CAMP | 5'-MONOPHOSPHATE | Cyclic CMP - chemistry | Signal Transduction | Isoenzymes - genetics | Humans | Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit - genetics | Gene Expression Regulation | Guanylate Cyclase - metabolism | Immunoblotting | Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit - metabolism | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Isoenzymes - metabolism | Sepharose - chemistry | Mass Spectrometry | HEK293 Cells | Cyclic CMP - metabolism | HL-60 Cells | Protein Binding | Guanylate Cyclase - genetics | Adenylate Cyclase Toxin - metabolism | HeLa Cells | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism | Cyclic adenylic acid | Binding proteins | Mass spectrometry | Protein kinases | Pyrimidine nucleotides | Protein binding | Protein kinase A | Cell culture | Leukemia | Amino acids | Nervous system | Kinases | Guanylate cyclase | Medical schools | Proteins | Pertussis | Toxicology | Life sciences | Drug therapy | Binding | Urine | Edema | Medical research | AMP | Cloning | Cyclic AMP | Regulatory subunits | Mass spectroscopy | Pharmacology | Chromatography | Protein kinase | Ligands | Toxins | Scientific imaging | Adenylate cyclase
Journal Article
Oncogene, ISSN 0950-9232, 02/2015, Volume 34, Issue 9, pp. 1160 - 1173
Journal Article
Biochemistry, ISSN 0006-2960, 08/2017, Volume 56, Issue 30, pp. 3885 - 3888
Journal Article