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PLoS Biology, ISSN 1544-9173, 03/2012, Volume 10, Issue 3, p. e1001283
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve... 
LIGHT-CHAIN KINASE | GUANYLYL CYCLASE | I PROJECTION NEURONS | TRANSMITTER RELEASE | THERMAL NOCICEPTION | NOCICEPTIVE NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | CGMP | INFLAMMATORY PAIN | LONG-TERM POTENTIATION | GENE DELETION | Cell Adhesion Molecules - genetics | Phosphorylation | Substrate Specificity | Guanylate Cyclase - antagonists & inhibitors | Pain - metabolism | Phosphoproteins - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Cyclic GMP-Dependent Protein Kinases - genetics | Synaptic Transmission | Behavior, Animal | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Gene Deletion | Cyclic GMP-Dependent Protein Kinase Type I | Microfilament Proteins - metabolism | Aminoquinolines - pharmacology | Microfilament Proteins - genetics | Nociceptors - pathology | Nerve Fibers - pathology | Nerve Fibers - metabolism | Signal Transduction | Mice, Inbred C57BL | Guanylate Cyclase - metabolism | Phosphoproteins - genetics | Cell Adhesion Molecules - metabolism | Pain - pathology | Mice, Knockout | Patch-Clamp Techniques | Animals | Ganglia, Spinal - pathology | Long-Term Potentiation | Mice | Nociceptors - metabolism | Enzyme Activation | Nociceptors - drug effects | Inositol 1,4,5-Trisphosphate Receptors - genetics | Ganglia, Spinal - metabolism | Proteins | Pain | Kinases | Experiments | Colleges & universities | Brain | Enzymes | Animal models | Neurotransmitter release | Pain perception | Spinal cord | Glutamic acid receptors (ionotropic) | Neurons | Hypersensitivity | Long-term potentiation | N-Methyl-D-aspartic acid receptors | Inflammation | Spinal cord injury | Myosin-light-chain kinase | Second messengers | Protein kinase | Synaptic transmission | Cyclic GMP | Nociceptors | phosphodiesterase | Inositol 1,4,5-trisphosphate | P system | Synapses
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 11/2003, Volume 93, Issue 10, pp. 907 - 916
Journal Article
Oncogene, ISSN 0950-9232, 09/2009, Volume 28, Issue 35, pp. 3121 - 3131
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 21, pp. 3250 - 3267
Toxoplasma gondii encodes three protein kinase A catalytic (PKAc1‐3) and one regulatory (PKAr) subunits to integrate cAMP‐dependent signals. Here, we show that... 
cGMP‐dependent protein kinase G | Toxoplasma gondii | acylation | cAMP‐dependent protein kinase A | egress | cGMP-dependent protein kinase G | cAMP-dependent protein kinase A | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL DISSECTION | IDENTIFICATION | MICRONEME SECRETION | CELL BIOLOGY | INVASION | INHIBITORS | BINDING | EXPRESSION | DOMAINS | SUBUNIT | Phosphorylation | Humans | Phosphoproteins - metabolism | Protozoan Proteins - genetics | Cyclic GMP-Dependent Protein Kinases - metabolism | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics | Cyclic GMP-Dependent Protein Kinases - genetics | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism | Protozoan Proteins - metabolism | Fibroblasts - parasitology | Toxoplasma - growth & development | Host-Parasite Interactions | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - metabolism | Cyclic AMP - metabolism | Toxoplasma - metabolism | Acylation | Signal Transduction | 3',5'-Cyclic-GMP Phosphodiesterases - genetics | Gene Expression Regulation | Phosphoproteins - genetics | Life Cycle Stages - genetics | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Toxoplasma - genetics | Cyclic GMP - metabolism | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics | Cell Line, Transformed | Hydrogen-Ion Concentration | Protein kinase A | Regulators | Crosstalk | Protein kinase G | Acidification | Pellicle | Egress | Parasites | Kinases | Inactivation | pH effects | Proteins | Signal transduction | Hydrogen ions | Cyclic GMP | pH | Catalysis | Phosphodiesterase | Deactivation | Cyclic AMP | Metabolism | Signaling | Lysis | Intracellular | Microbiology, Virology & Host Pathogen Interaction
Journal Article
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 01/2018, Volume 42, pp. 281 - 291
Deficits in brain function that are associated with aging and age-related diseases benefit very little from currently available therapies, suggesting a better... 
Cerebellum | PDE8 | PDE7 | Mild cognitive impairment | PDE1 | Memory | Cortex | PDE3 | cGMP | Parkinson's Disease | cAMP | Huntington's disease | Striatum | Age-related cognitive decline | Cyclic nucleotides | PDE11 | Aging | Alzheimer's disease | Hippocampus | Phosphodiesterase | NITRIC-OXIDE SYNTHASE | DEPENDENT PROTEIN-KINASE | ELEMENT-BINDING PROTEIN | ADENYLYL-CYCLASE ACTIVITY | NATRIURETIC-PEPTIDE LEVELS | CELL BIOLOGY | SOLUBLE GUANYLYL CYCLASE | CAMP-RESPONSE ELEMENT | LONG-TERM POTENTIATION | CAMP | AMYLOID PRECURSOR PROTEIN | Humans | Natriuretic Peptide, Brain - metabolism | Heterotrimeric GTP-Binding Proteins - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Heterotrimeric GTP-Binding Proteins - genetics | Cyclic GMP-Dependent Protein Kinases - genetics | Brain - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Aging - genetics | Guanine Nucleotide Exchange Factors - metabolism | Atrial Natriuretic Factor - genetics | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Natriuretic Peptide, Brain - genetics | Neurodegenerative Diseases - pathology | Atrial Natriuretic Factor - metabolism | Signal Transduction | Gene Expression Regulation | Neurodegenerative Diseases - genetics | Adenylyl Cyclases - metabolism | Neurodegenerative Diseases - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Cyclic GMP - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Brain - pathology | Adenylyl Cyclases - genetics | Aging - metabolism | Brain | Medical colleges | Neurosciences | Analysis | Cyclic adenylic acid | G proteins | Adenylic acid | Protein kinases | Protein binding | Natriuretic peptides | Huntington’s Disease | memory | cerebellum | striatum | cyclic nucleotides | Parkinson’s Disease | age-related cognitive decline | cyclase | cortex | PDE5 | Alzheimer’s disease | hippocampus | PDE2 | PDE4 | natriuretic peptide | PDE9 | PDE10 | mild cognitive impairment | aging | phosphodiesterase
Journal Article
Circulation, ISSN 0009-7322, 07/2013, Volume 128, Issue 4, pp. 365 - 376
BACKGROUND—Proteasome functional insufficiency is implicated in a large subset of cardiovascular diseases and may play an important role in their pathogenesis.... 
desmin | proteasome inhibitors | cardiomyopathies | cyclic GMP-dependent protein kinase | proteins | SYSTEM | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | QUALITY-CONTROL | DILATED CARDIOMYOPATHY | 26S PROTEASOME | INHIBITION | DESMIN-RELATED CARDIOMYOPATHY | CARDIAC PROTEINOPATHY | PERIPHERAL VASCULAR DISEASE | MICE | POSTTRANSLATIONAL MODIFICATION | Proteostasis Deficiencies - metabolism | RNA, Small Interfering - genetics | Humans | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Male | Green Fluorescent Proteins - genetics | Sulfones - pharmacology | Cardiovascular Diseases - genetics | Cyclic GMP-Dependent Protein Kinases - metabolism | Cyclic GMP-Dependent Protein Kinases - genetics | Myocytes, Cardiac - enzymology | Sildenafil Citrate | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Adenoviridae - genetics | Phosphodiesterase 5 Inhibitors - pharmacology | Cardiovascular Diseases - metabolism | Myocytes, Cardiac - cytology | Purines - pharmacology | Cells, Cultured | Rats | Mice, Transgenic | Enzyme Activation - drug effects | Piperazines - pharmacology | Protein Processing, Post-Translational - physiology | Proteostasis Deficiencies - genetics | Animals | Desmin - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Enzyme Activation - physiology | Proteins | Physiological aspects | Research | Ubiquitin-proteasome system | Cardiovascular diseases | Protein kinases | desmin-related cardiomyopathy | proteasome | misfolded proteins | Protein kinase G
Journal Article