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Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 29 - 38
Abstract In cardiac myocytes, the second messenger cAMP is synthesized within the β-adrenergic signaling pathway upon sympathetic activation. It activates... 
Cardiovascular | β-adrenergic pathway | Cyclic nucleotides | Computational model | Signaling networks | Cardiac myocytes | Phosphodiesterase | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPUTATIONAL MODELS | HEART-FAILURE | beta-adrenergic pathway | CAMP EARLY REPRESSOR | CGMP PHOSPHODIESTERASES | PROTEIN-KINASES | FEEDBACK LOOP | CELL BIOLOGY | CARDIOMYOCYTE APOPTOSIS | NITRIC-OXIDE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | RAT VENTRICULAR MYOCYTES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphorylation | Humans | Myocardial Contraction - physiology | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Myocardium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Binding, Competitive | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Models, Cardiovascular | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Gene Expression Regulation | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Feedback, Physiological | Animals | Cyclic GMP - metabolism | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics
Journal Article
Circulation Research, ISSN 0009-7330, 11/2009, Volume 105, Issue 10, pp. 956 - 964
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1120 - 1132
RATIONALE:Neointimal hyperplasia characterized by abnormal accumulation of vascular smooth muscle cells (SMCs) is a hallmark of occlusive disorders such as... 
Smooth muscle cell | Cyclic nucleotide phosphodiesterases, type 1C | Neointima formation | neointima formation | CARDIAC & CARDIOVASCULAR SYSTEMS | smooth muscle cell | TYROSINE PHOSPHORYLATION | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | DEPENDENT PROTEIN-KINASE | cyclic nucleotide phosphodiesterases, type 1C | CORONARY-ARTERY | ELUTING STENTS | CORECEPTOR FUNCTION | MEDIATED ENDOCYTOSIS | MOUSE MODEL | BETA PDGFR-BETA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | MACROPHAGE DIFFERENTIATION | Humans | Male | Lysosomes - physiology | Cyclic AMP - physiology | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | RNA Interference | Proteolysis | Cell Division | Neointima - enzymology | Models, Animal | Protein Stability | Myocytes, Smooth Muscle - cytology | Cyclic Nucleotide Phosphodiesterases, Type 1 - physiology | Carotid Artery Injuries - pathology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Induction | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Rats | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Endocytosis - physiology | Mice, Knockout | Protein Interaction Mapping | Neointima - physiopathology | Cyclic Nucleotide Phosphodiesterases, Type 1 - deficiency | Animals | Carotid Artery Injuries - enzymology | Signal Transduction - physiology | Mice | Cell Movement | smooth muscle cells | phosphodiesterase | cyclic nucleotide | and neointimal hyperplasia
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2012, Volume 123, Issue 6, pp. 1019 - 1029
Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP... 
traumatic brain injury | phosphodiesterase | cAMP | fluid‐percussion | inflammation | isoform | fluid-percussion | FUNCTIONAL RECOVERY | LOCALIZATION | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPLICE VARIANTS | NEUROSCIENCES | PDE4 INHIBITORS | ROLIPRAM | RAT-BRAIN | TNF-ALPHA | CAMP-SPECIFIC PHOSPHODIESTERASES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphoric Diester Hydrolases - biosynthesis | Male | Cyclic Nucleotide Phosphodiesterases, Type 1 - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Phosphorylation - genetics | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - biosynthesis | Disease Models, Animal | Phosphoric Diester Hydrolases - metabolism | Isoenzymes - genetics | Brain Injuries - enzymology | Rats | Phosphoric Diester Hydrolases - genetics | Brain Injuries - genetics | Brain Injuries - therapy | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Rats, Sprague-Dawley | Cyclic Nucleotide Phosphodiesterases, Type 3 - biosynthesis | Cyclic AMP - antagonists & inhibitors | Animals | Cyclic AMP - biosynthesis | Gene Expression Regulation, Enzymologic - genetics | Isoenzymes - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Isoenzymes - antagonists & inhibitors | Brain | Neurons | Analysis | Injuries | Neurochemistry | Enzymes | Brain damage | Gene expression | Trauma | Ca super(2+)/calmodulin-dependent phosphodiesterase | Phosphorylation | Traumatic brain injury | Cortex (parietal) | Cyclic AMP | Inflammation | Glia | Western blotting
Journal Article
Clinical Science, ISSN 0143-5221, 12/2015, Volume 129, Issue 12, pp. 1061 - 1075
Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of... 
Vascular disease | Aging | Blood pressure | Genetic association | Phosphodiesterases | MEDICINE, RESEARCH & EXPERIMENTAL | blood pressure | OXIDATIVE-STRESS | ENDOTHELIAL DYSFUNCTION | genetic association | ATHEROSCLEROSIS | BLOOD-PRESSURE | ARTERIAL | vascular disease | DISEASE | phosphodiesterases | NITRIC-OXIDE | VINPOCETINE | aging | CONGESTIVE-HEART-FAILURE | ASSOCIATION | Blood Pressure | Endonucleases - deficiency | Endonucleases - genetics | Humans | Hyperplasia | Gene Expression Regulation, Neoplastic | DNA-Binding Proteins - deficiency | Dose-Response Relationship, Drug | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Aging - genetics | Carotid Artery Diseases - pathology | Cellular Senescence | Carotid Arteries - enzymology | Hypertension - enzymology | Hypertension - genetics | Myocytes, Smooth Muscle - drug effects | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Second Messenger Systems | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Genome-Wide Association Study | Vasodilator Agents - pharmacology | Carotid Intima-Media Thickness | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | DNA-Binding Proteins - genetics | Hypertension - physiopathology | Mice, Knockout | Hydrolysis | Phenotype | Animals | Cyclic GMP - metabolism | Carotid Artery Diseases - enzymology | Carotid Artery Diseases - genetics | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Carotid Arteries - pathology | Polymorphism, Single Nucleotide | Vasodilation - drug effects | In Vitro Techniques | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Muscle, Smooth, Vascular - enzymology | Aging - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 52, pp. E12265 - E12274
Adrenal cortex steroids are essential for body homeostasis, and adrenal insufficiency is a life-threatening condition. Adrenal endocrine activity is maintained... 
Progenitors | Adrenal | Differentiation | PKA signaling | EZH2 | FAMILIAL GLUCOCORTICOID DEFICIENCY | PROGENITOR CELLS | differentiation | MULTIDISCIPLINARY SCIENCES | MOUSE | SELF-RENEWAL | DELETION | progenitors | ADRENOCORTICAL DEVELOPMENT | adrenal | ZONA GLOMERULOSA | MUTATIONS | EXPRESSION | REPRESSIVE COMPLEX 2 | Methyltransferases | Adrenal glands | Physiological aspects | Physiological research | Cellular signal transduction | Research | Protein kinases | Protein kinase A | Ca2 /calmodulin-dependent phosphodiesterase | Glucocorticoids | Cortex | Adrenal cortex | Differentiation (biology) | Homeostasis | Cell differentiation | Ablation | Progenitor cells | Signaling | Adrenocorticotropic hormone | Differential equations | Cells (biology) | Stem cells | Histone methyltransferase | Steroid hormones | Steroids | Animal genetics | Cyclic Nucleotide Phosphodiesterases, Type 1 | Genomics | Cyclic Nucleotide Phosphodiesterases, Type 3 | Male | Embryology and Organogenesis | Life Sciences | Zona Glomerulosa | Zona Fasciculata | Cyclic AMP-Dependent Protein Kinase RIbeta Subunit | Female | Genetics | Endocrinology and metabolism | Cell Differentiation | Adrenal Cortex | Signal Transduction | Mice, Inbred C57BL | Biochemistry, Molecular Biology | Enhancer of Zeste Homolog 2 Protein | Mice, Knockout | Human health and pathology | Animals | Development Biology | Cyclic Nucleotide Phosphodiesterases, Type 7 | Molecular biology | Cancer | Biological Sciences | PNAS Plus
Journal Article
Circulation, ISSN 0009-7322, 05/2007, Volume 115, Issue 17, pp. 2331 - 2339
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2017, Volume 174, Issue 15, pp. 2563 - 2575
Journal Article