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Analytical Biochemistry, ISSN 0003-2697, 2011, Volume 409, Issue 1, pp. 144 - 149
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 02/2011, Volume 20, Issue 4, pp. 719 - 730
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 2006, Volume 113, Issue 18, pp. 2221 - 2228
Background - Cyclic guanosine monophosphate (cGMP) is the common second messenger for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides,... 
Sildenafil | Phosphodiesterases | Cyclic GMP | Nitric oxide | Natriuretic peptides | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | cyclic GMP | CALCIUM CURRENT | DEPENDENT PROTEIN-KINASE | sildenafil | natriuretic peptides | SOLUBLE GUANYLYL CYCLASE | CGMP-SPECIFIC PHOSPHODIESTERASE | CA2+ CURRENT | phosphodiesterases | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | ADENOVIRUS-MEDIATED EXPRESSION | FROG VENTRICULAR MYOCYTES | NUCLEOTIDE-GATED CHANNELS | HEMATOLOGY | HUMAN ATRIAL MYOCYTES | Cyclic GMP - pharmacology | Heart Ventricles - cytology | Rats, Wistar | Cyclic Nucleotide Phosphodiesterases, Type 5 | Cyclic Nucleotide Phosphodiesterases, Type 2 | Humans | Recombinant Fusion Proteins - analysis | Recombinant Fusion Proteins - physiology | Male | Ion Channels - physiology | Natriuretic Peptide, Brain - pharmacology | Phosphoric Diester Hydrolases - physiology | Cell Compartmentation | Sildenafil Citrate | Purines | Biological Transport | Cell Membrane - metabolism | Atrial Natriuretic Factor - pharmacology | Nitric Oxide Donors - pharmacology | Sarcolemma - metabolism | Second Messenger Systems | Sulfones | Isoenzymes - physiology | Adenine - analogs & derivatives | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | Solubility | Phosphodiesterase Inhibitors - pharmacology | Rats | Adenine - pharmacology | Myocytes, Cardiac - chemistry | Piperazines - pharmacology | 1-Methyl-3-isobutylxanthine - pharmacology | Ion Channels - antagonists & inhibitors | Cyclic AMP - pharmacology | Animals | Ion Channels - analysis | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Cyclic Nucleotide-Gated Cation Channels | Myocytes, Cardiac - ultrastructure | Isoenzymes - antagonists & inhibitors | Ion Channel Gating - drug effects | Life Sciences | Cellular Biology | Cell Membrane | cytology | Ion Channels | cGMP | Recombinant Fusion Proteins | Heart Ventricles | Nitric Oxide Donors | Natriuretic Peptide, Brain | Atrial Natriuretic Factor | pharmacology | 3',5'-Cyclic-GMP Phosphodiesterase | chemistry | Sarcolemma | Phosphodiesterase Inhibitors | Myocytes, Cardiac | Piperazines | Isoenzymes | physiology | Adenine | Cyclic AMP | 1-Methyl-3-isobutylxanthine | drug effects | analysis | ultrastructure | antagonists & inhibitors | Phosphoric Diester Hydrolases | analogs & derivatives | metabolism | Ion Channel Gating
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 07/2017, Volume 11, Issue 7, p. e0005680
Background Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of... 
CAENORHABDITIS-ELEGANS | PHARMACOLOGICAL VALIDATION | SCHISTOSOMA-MANSONI | PROTEIN-KINASE | ALZHEIMERS-DISEASE | 5 INHIBITOR ANALOGS | MIRACIDIAL TRANSFORMATION | TRYPANOSOMA-BRUCEI PHOSPHODIESTERASES | CONSERVED REGIONS UCRS | PARASITOLOGY | TROPICAL MEDICINE | CAMP-SPECIFIC PHOSPHODIESTERASES | Schistosoma mansoni - drug effects | Schistosoma mansoni - physiology | Catalytic Domain | Caenorhabditis elegans - genetics | Schistosoma mansoni - anatomy & histology | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Caenorhabditis elegans - drug effects | Animals, Genetically Modified - genetics | Anthelmintics - pharmacology | Cloning, Molecular | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Locomotion - drug effects | Caenorhabditis elegans | Schistosomiasis | Care and treatment | Lung diseases, Obstructive | Genetic aspects | Research | Phosphodiesterases | Alzheimer's disease | Asthma | Drugs | Transgenic | Phosphodiesterase IV | Genomes | Parasites | Nucleotides | Drug development | Kinases | Gene sequencing | Parasitic diseases | Tropical environment | Degeneration | Chronic obstructive pulmonary disease | cDNA | Aquatic invertebrates | Catalysis | Phosphodiesterase | 3',5'-Cyclic-nucleotide phosphodiesterase | Lung diseases | Catechol | Gene expression | Diseases | Inhibitors | DNA | Obstructive lung disease | Nematodes | Hypothermia | Lines
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 3, pp. 528 - 538
Background and Purpose PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle... 
inotropism and lusitropism | human heart failure | phosphodiesterases 3 and 4 | noradrenaline and adrenaline | metoprolol | β1 and β2 adrenoceptors | and β | adrenoceptors | Adrenergic beta-1 Receptor Antagonists - adverse effects | Heart Failure - surgery | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Norepinephrine - pharmacology | Adrenergic alpha-Agonists - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Middle Aged | Adrenergic beta-1 Receptor Antagonists - pharmacology | Heart Failure - physiopathology | Myocardial Contraction - drug effects | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Adrenergic beta-Agonists - chemistry | Epinephrine - agonists | Receptors, Adrenergic, beta-2 - chemistry | Cardiotonic Agents - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Adrenergic beta-2 Receptor Antagonists - pharmacology | Adrenergic beta-Agonists - pharmacology | Heart Transplantation | Metoprolol - therapeutic use | Receptors, Adrenergic, beta-1 - metabolism | Drug Resistance - drug effects | Heart Failure - metabolism | Anti-Arrhythmia Agents - therapeutic use | Cardiotonic Agents - pharmacology | Metoprolol - adverse effects | Norepinephrine - agonists | Phosphodiesterase 4 Inhibitors - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Heart Failure - drug therapy | Heart Ventricles - physiopathology | Anti-Arrhythmia Agents - adverse effects | Adrenergic alpha-Agonists - pharmacology | Heart Ventricles - metabolism | In Vitro Techniques | Epinephrine - pharmacology | Heart Ventricles - drug effects | Research Paper with
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 47, pp. 39168 - 39174
Journal Article
Cellular Signalling, ISSN 0898-6568, 09/2014, Volume 26, Issue 9, pp. 2016 - 2029
Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in... 
Phosphodiesterase inhibitor | Apremilast | Spondyloarthropathies | Psoriasis | Preclinical drug evaluation | Psoriatic arthritis | PROTEIN-KINASE-A | CONTROLLED-TRIAL | CAMP-SPECIFIC PHOSPHODIESTERASE | NECROSIS-FACTOR-ALPHA | KAPPA-B | PSORIATIC-ARTHRITIS | CELL BIOLOGY | ORAL PHOSPHODIESTERASE-4 INHIBITOR | CYCLIC-AMP | THALIDOMIDE ANALOGS | B-MEDIATED TRANSCRIPTION | Thalidomide - metabolism | Humans | Male | Thalidomide - pharmacology | Lung Diseases - drug therapy | Thalidomide - analogs & derivatives | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Female | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Vomiting - prevention & control | B-Lymphocytes - metabolism | Disease Models, Animal | Cell Line | Cytokines - metabolism | Immunity, Innate - drug effects | Jurkat Cells | Phosphodiesterase 4 Inhibitors - therapeutic use | Mice, Transgenic | Phosphodiesterase 4 Inhibitors - metabolism | Ferrets | Phosphodiesterase 4 Inhibitors - pharmacology | B-Lymphocytes - drug effects | Adaptive Immunity - drug effects | Animals | B-Lymphocytes - immunology | Protein Binding | T-Lymphocytes - immunology | Mice | Thalidomide - therapeutic use | Dendritic cells | Analysis | Development and progression | Genetic engineering | B cells | Biological response modifiers | T cells
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3438 - 3442
Journal Article