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Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 29 - 38
Abstract In cardiac myocytes, the second messenger cAMP is synthesized within the β-adrenergic signaling pathway upon sympathetic activation. It activates... 
Cardiovascular | β-adrenergic pathway | Cyclic nucleotides | Computational model | Signaling networks | Cardiac myocytes | Phosphodiesterase | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPUTATIONAL MODELS | HEART-FAILURE | beta-adrenergic pathway | CAMP EARLY REPRESSOR | CGMP PHOSPHODIESTERASES | PROTEIN-KINASES | FEEDBACK LOOP | CELL BIOLOGY | CARDIOMYOCYTE APOPTOSIS | NITRIC-OXIDE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | RAT VENTRICULAR MYOCYTES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphorylation | Humans | Myocardial Contraction - physiology | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Myocardium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Binding, Competitive | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Models, Cardiovascular | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Gene Expression Regulation | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Feedback, Physiological | Animals | Cyclic GMP - metabolism | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics
Journal Article
Clinical Science, ISSN 0143-5221, 12/2015, Volume 129, Issue 12, pp. 1061 - 1075
Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of... 
Vascular disease | Aging | Blood pressure | Genetic association | Phosphodiesterases | MEDICINE, RESEARCH & EXPERIMENTAL | blood pressure | OXIDATIVE-STRESS | ENDOTHELIAL DYSFUNCTION | genetic association | ATHEROSCLEROSIS | BLOOD-PRESSURE | ARTERIAL | vascular disease | DISEASE | phosphodiesterases | NITRIC-OXIDE | VINPOCETINE | aging | CONGESTIVE-HEART-FAILURE | ASSOCIATION | Blood Pressure | Endonucleases - deficiency | Endonucleases - genetics | Humans | Hyperplasia | Gene Expression Regulation, Neoplastic | DNA-Binding Proteins - deficiency | Dose-Response Relationship, Drug | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Aging - genetics | Carotid Artery Diseases - pathology | Cellular Senescence | Carotid Arteries - enzymology | Hypertension - enzymology | Hypertension - genetics | Myocytes, Smooth Muscle - drug effects | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Second Messenger Systems | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Genome-Wide Association Study | Vasodilator Agents - pharmacology | Carotid Intima-Media Thickness | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | DNA-Binding Proteins - genetics | Hypertension - physiopathology | Mice, Knockout | Hydrolysis | Phenotype | Animals | Cyclic GMP - metabolism | Carotid Artery Diseases - enzymology | Carotid Artery Diseases - genetics | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Carotid Arteries - pathology | Polymorphism, Single Nucleotide | Vasodilation - drug effects | In Vitro Techniques | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Muscle, Smooth, Vascular - enzymology | Aging - metabolism
Journal Article
Molecular Nutrition and Food Research, ISSN 1613-4125, 11/2011, Volume 55, Issue 11, pp. 1677 - 1689
Scope: Curcumin inhibits proliferation of many cancer cells. Cyclic nucleotide phosphodiesterases (PDEs), by hydrolyzing intracellular cyclic... 
CAMP/cGMP | DNMT1 | Rolipram | Nimodipine | Cancer | CANCER-CELLS | APOPTOSIS | HEMI-METHYLATED DNA | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | FOOD SCIENCE & TECHNOLOGY | DOWN-REGULATION | VASCULAR SMOOTH-MUSCLE | ARREST | SRA DOMAIN | ENDOTHELIAL-CELLS | GENE-EXPRESSION | cAMP/cGMP | Neoplasm Proteins - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor Proteins - metabolism | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Isoenzymes - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Melanoma - metabolism | Recombinant Proteins - metabolism | Cell Survival - drug effects | DNA (Cytosine-5-)-Methyltransferase 1 | Isoenzymes - genetics | Curcumin - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Phosphodiesterase Inhibitors - pharmacology | Nuclear Proteins - metabolism | Animals | Cyclic GMP - metabolism | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Isoenzymes - antagonists & inhibitors | Cell proliferation | Ca super(2+)/calmodulin-dependent phosphodiesterase | 3',5'-Cyclic-nucleotide phosphodiesterase | DNMT1 protein | Melanoma | Cyclic AMP | epigenetics | Signal transduction | Cyclic GMP | Cyclin A | Cell cycle | Cyclin-dependent kinase inhibitor p27 | DNA methyltransferase | Curcumin | phosphodiesterase | cyclin-dependent kinase inhibitors | Food | Life Sciences | Cellular Biology | Biochemistry, Molecular Biology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 3, pp. 1149 - 1164
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2017, Volume 174, Issue 15, pp. 2563 - 2575
Journal Article
Journal Article
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 03/2016, Volume 55, Issue 3, pp. 268 - 279
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47826
Background: We investigated the role of cyclic nucleotide phosphodiesterases (PDEs) in the spatiotemporal control of intracellular cAMP concentrations in rat... 
SELECTIVE INHIBITOR | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | ADENYLYL-CYCLASE | MULTIDISCIPLINARY SCIENCES | CARDIAC MYOCYTES | NITRIC-OXIDE | CGMP | DEPENDENT PROTEIN-KINASE | PROLIFERATION | CARDIOVASCULAR TISSUES | EXPRESSION | Aorta - metabolism | Adrenergic beta-Antagonists - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Time Factors | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Myocytes, Smooth Muscle - drug effects | Cyclic AMP - metabolism | Myocytes, Smooth Muscle - cytology | Cell Membrane - drug effects | Muscle, Smooth, Vascular - drug effects | Myocytes, Smooth Muscle - enzymology | Aorta - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | Adrenergic beta-Agonists - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Phosphodiesterase Inhibitors - pharmacology | Rats | Muscle, Smooth, Vascular - cytology | Cell Membrane - enzymology | Animals | Signal Transduction - drug effects | Isoproterenol - pharmacology | Signal Transduction - physiology | Aorta - cytology | Primary Cell Culture | Muscle, Smooth, Vascular - enzymology | Laboratories | Fluorescence | Smooth muscle | Antagonists | Isoproterenol | Kinases | Recovery | Experiments | Proteins | Dynamic control | Rodents | Aorta | Physiology | Inhibition | Fluorescence resonance energy transfer | Localization | Phosphodiesterase | 3',5'-Cyclic-nucleotide phosphodiesterase | Muscles | Cyclic AMP | Biophysics | Gene expression | Endothelium | Studies | Inhibitors | Coronary vessels | Nitric oxide | Adrenergic receptors | Kinetics | Intracellular | Energy transfer
Journal Article