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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2013, Volume 23, Issue 1, pp. 375 - 381
(−)-6-(7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5- ]pyridin-4-yl)-5-methyl-4,5-dihydropyridazin-3(2 )-one (KCA-1490) exhibits moderate dual PDE3/4-inhibitory... 
Phosphodiesterase (PDE) | Inhaled administration | Dual PDE3/4 inhibitor | Asthma | COPD | MORTALITY | CHRONIC HEART-FAILURE | BRONCHODILATORY ACTIVITY | DESIGN | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | 4,5-DIHYDRO-6-<4-(1H-IMIDAZOL-1-YL)PHENYL>-3(2H)-PYRIDAZINONES | OBSTRUCTIVE PULMONARY-DISEASE | POSITIVE INOTROPIC AGENTS | CORTICOSTEROIDS | CARDIOTONIC AGENTS | ROFLUMILAST | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Phosphodiesterase 3 Inhibitors - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Pyridines - chemistry | Structure-Activity Relationship | Phosphodiesterase 4 Inhibitors - chemical synthesis | Bronchodilator Agents - chemistry | Drug Design | Bronchoalveolar Lavage Fluid - cytology | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Phosphodiesterase 4 Inhibitors - chemistry | Anti-Inflammatory Agents - pharmacology | Administration, Inhalation | Rats | Bronchodilator Agents - pharmacology | Bronchodilator Agents - chemical synthesis | Phosphodiesterase 4 Inhibitors - pharmacology | Pyridazines - chemistry | Phosphodiesterase 3 Inhibitors - chemical synthesis | Animals | Anti-Inflammatory Agents - chemistry | Protein Binding | Leukocytes - drug effects | Anti-Inflammatory Agents - chemical synthesis | Anti-inflammatory drugs | Respiratory agents
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2012, Volume 22, Issue 7, pp. 2585 - 2589
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 3, pp. 528 - 538
PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We... 
inotropism and lusitropism | human heart failure | and β | metoprolol | adrenoceptors | phosphodiesterases 3 and 4 | noradrenaline and adrenaline | Adrenergic beta-1 Receptor Antagonists - adverse effects | Heart Failure - surgery | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Norepinephrine - pharmacology | Adrenergic alpha-Agonists - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Middle Aged | Adrenergic beta-1 Receptor Antagonists - pharmacology | Heart Failure - physiopathology | Myocardial Contraction - drug effects | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Adrenergic beta-Agonists - chemistry | Epinephrine - agonists | Receptors, Adrenergic, beta-2 - chemistry | Cardiotonic Agents - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Adrenergic beta-2 Receptor Antagonists - pharmacology | Adrenergic beta-Agonists - pharmacology | Heart Transplantation | Metoprolol - therapeutic use | Receptors, Adrenergic, beta-1 - metabolism | Drug Resistance - drug effects | Heart Failure - metabolism | Anti-Arrhythmia Agents - therapeutic use | Cardiotonic Agents - pharmacology | Metoprolol - adverse effects | Norepinephrine - agonists | Phosphodiesterase 4 Inhibitors - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Heart Failure - drug therapy | Heart Ventricles - physiopathology | Anti-Arrhythmia Agents - adverse effects | Adrenergic alpha-Agonists - pharmacology | Heart Ventricles - metabolism | In Vitro Techniques | Epinephrine - pharmacology | Heart Ventricles - drug effects | Research Paper with | β1 and β2 adrenoceptors
Journal Article
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2011, Volume 11, Issue 6, pp. 714 - 719
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2011, Volume 11, Issue 6, pp. 676 - 682
Highlights ► Acute hormonal regulation of PDE3B involves reversible protein phosphorylation and protein complex formation at different subcellular locations. ►... 
Internal Medicine | Medical Education | PROTEIN-KINASE-A | ACTIVATION | ADIPOCYTES | INSULIN-RESISTANCE | GLUCOSE-INTOLERANCE | STIMULATES LIPOLYSIS | PHARMACOLOGY & PHARMACY | NECROSIS-FACTOR-ALPHA | NUCLEOTIDE PHOSPHODIESTERASE 3B | CAMP | ADIPOSE-TISSUE | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Cyclic GMP - physiology | Obesity - drug therapy | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Adipocytes, White - enzymology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Molecular Targeted Therapy | Cyclic AMP - physiology | Adipocytes, White - drug effects | Protein Processing, Post-Translational - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Phosphorylation - drug effects | Hepatocytes - drug effects | Second Messenger Systems - drug effects | Diabetes Mellitus, Type 2 - enzymology | Energy Intake - drug effects | Phosphodiesterase 3 Inhibitors - therapeutic use | Obesity - metabolism | Cyclic AMP - antagonists & inhibitors | Animals | Obesity - enzymology | Diabetes Mellitus, Type 2 - drug therapy | Adipocytes, White - metabolism | Energy Metabolism - drug effects | Cyclic GMP - antagonists & inhibitors | Hepatocytes - enzymology | Homeostasis | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2013, Volume 288, Issue 5, pp. 3477 - 3488
Journal Article
Cellular Signalling, ISSN 0898-6568, 05/2014, Volume 26, Issue 5, pp. 1001 - 1010
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 12, p. e15178
The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated... 
STROKE | TISSUE-PLASMINOGEN ACTIVATOR | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | ENDOTHELIAL-CELLS | BIOLOGY | THROMBOLYSIS | CILOSTAZOL PROTECTS | RAT-BRAIN | BLOOD-BRAIN-BARRIER | NEURONAL DAMAGE | Astrocytes - cytology | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Tetrazoles - pharmacology | Tissue Plasminogen Activator - metabolism | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Pericytes - cytology | Microcirculation | Hemorrhage - drug therapy | Matrix Metalloproteinase 9 - metabolism | Animals | Microscopy, Electron - methods | Brain Ischemia - pathology | Infarction, Middle Cerebral Artery - drug therapy | Mice | Blood-Brain Barrier | Prevention | Brain | Cerebral ischemia | Tissue plasminogen activator | Endothelium | Neuroimaging | Occlusion | Drugs | Health sciences | Transformation | Phosphorylation | Laboratories | Neurosurgery | Kinases | Hemorrhage | Reperfusion | Ischemia | Blood-brain barrier | Cerebral blood flow | Rodents | University graduates | Phosphodiesterase | Edema | Spectroscopy | Enzymes | Stroke | Departments | Free radicals | Cytokines | Astrocytes | Pharmacology | Electron microscopy | Morbidity | Endothelial cells | Gelatinase B | Medicine | Injury prevention | Inhibitors | Pharmacy | Pericytes | Brain damage | Transformations | Microvasculature | Brain injury | Pharmaceuticals
Journal Article